doc.ps1

$word = New-Object -ComObject Word.Application
$word.Visible = $false
$word.Visible = $true

$doc = $word.Documents.Open('C:\myDoc.docx')

$find = $word.Selection.Find
$word.Selection.HomeKey(6)  # wdStory

$find.Text = "{{NOM}}"
$find.Replacement.Text = "COLAS"
$find.Execute($find.Text, $false, $false, $false, $false, $false, $true, 1, $false, $find.Replacement.Text, 2)

$find.Text = "{{PRENOM}}"
$find.Replacement.Text = "Gaël"
$find.Execute($find.Text, $false, $false, $false, $false, $false, $true, 1, $false, $find.Replacement.Text, 2)

$outputPath = "C:\dev\final.docx"
$doc.SaveAs([ref]$outputPath)

$doc.PrintOut()
$doc.Close()
$word.Quit()