express.js

var express = require('express'),
    vm = require('vm'),
    app = express(),
    vhosts = {
        "www.house-of-code.org": vm.createContext({app: app, require: require}),
        "test.house-of-code.org": vm.createContext({app: app, require: require})
    };

var vhostWWW = vm.createScript("var express = require('express')," +
                               "    vhostApp = express();" +

                               "vhostApp.get('/', function(req, res) {" +
                               "    res.end('WWW');" +
                               "});" +

                               "app.use(express.vhost('www.house-of-code.org', vhostApp));");

vhostWWW.runInContext(vhosts["www.house-of-code.org"]);

var vhostTest = vm.createScript("var express = require('express')," +
                                "    vhostApp = express();" +

                                "vhostApp.get('/', function(req, res) {" +
                                "    res.end('test'); throw new Error('test');" +
                                "});" +

                                "app.use(express.vhost('test.house-of-code.org', vhostApp));");

vhostTest.runInContext(vhosts["test.house-of-code.org"]);

app.listen(8080);