Custom universal scripts for PyQt projects. -- pyqt_template.py: Generic boilerplate for new PyQt projects. -- compile.py: Generic compile script for .ui and .rsc files. -- build.py: Automated .app building & trimming for Py2App projects on OSX.

build.py

#!/usr/local/bin/python2
import os                       # For running system commands.
import argparse                 # For argument parsing.

# Configuration
_setup_file_ = 'setup.py'	# Your Py2App setup file.
_app_file_ = 'start.py'		# Should mirror the APP variable in your Py2App setup file.
_delete_ = ['Frameworks/QtDeclarative.framework', 'Frameworks/QtMultimedia.framework', 'Frameworks/QtScript.framework', 'Frameworks/QtSvg.framework','Frameworks/QtXml.framework', 'Frameworks/QtDesigner.framework', 'Frameworks/QtNetwork.framework',	 'Frameworks/QtScriptTools.framework','Frameworks/QtTest.framework', 'Frameworks/QtXmlPatterns.framework', 'Frameworks/QtHelp.framework', 'Frameworks/QtOpenGL.framework','Frameworks/QtSql.framework', 'Frameworks/QtWebKit.framework', 'Frameworks/libQtCLucene.4.dylib', 'Frameworks/phonon.framework', 'Frameworks/*.framework/*.prl']	# Files within [name].app/Contents/ to be deleted during the trimming process.

# DU function... uses the system's du command because Python's os.walk was giving
def checkDirSize(dir = '.'):
	f = os.popen("du -sh "+dir+" | awk '{print $1}'")
	return f.read().strip()

### Parsing command arguments
parser = argparse.ArgumentParser(description='Build and trim a PyQt .app')
#parser.add_argument('setupfile', metavar='SETUP FILE', type=str,
#					help='Target setup file for the Py2App build.')
parser.add_argument('p2a_flags', metavar='FLAGS', type=str,
					nargs='*', default='',
					help='Optional flags for Py2App.')
parser.add_argument('-d', '--donotbuild', action='store_const', const=True, required=False, default=False,
					help='Don\'t build the app.')
parser.add_argument('-n', '--notrim', action='store_const', const=True, required=False, default=False,
					help='Don\'t trim the un-wanted libraries from the app.')
parser.add_argument('-c', '--clean', action='store_const', const=True, required=False, default=False,
					help='Clear out the build directories.')
#parser.add_argument('-s', '--silent', action='store_const', const=True, required=False, default=False,
#					help='Suppress system command output.')

# Parsing argument values into the 'args' namespace object.
args = parser.parse_args()

# Get the .app name
app_name = _app_file_[:-3] + ".app/"

# Set the system command processor based on -s flag
#cmd_process = os.system if args.silent is False else os.popen
cmd_process = os.system

# Clean the build directores
if args.clean is True:
	f = cmd_process('rm -rf ./build ./dist')
	print '\n - Build directories have been cleaned.'

# Build the Py2App project
if args.donotbuild is False:
	f = cmd_process('python '+_setup_file_+' py2app '+' '+' '.join(args.p2a_flags))
	print '\n - App is now built. Current file size: '+checkDirSize('./dist/'+app_name)

# Trim the fat from the app
if args.notrim is False:
	for filename in _delete_:
		f = cmd_process('rm -rf ./dist/'+app_name+'/Contents/'+filename)
	print '\n - App has now been trimmed. Current file size: '+checkDirSize('./dist/'+app_name)

print '\n'

compile.py

import os

# Configuration
cmdPrefix = ''  # Leave blank if commands are in your PATH

# Code
def lsDir(dir = "."):
    list = []
    for dirname, dirnames, filenames in os.walk(dir):
        for filename in filenames:
            list.append(str(os.path.join(dirname, filename)).replace('\\','/'))
        # Runs a string replace that replaces any backslashes with forward slashes. For correct output on Windows hosts.
    return list

dirListing = lsDir()
uiFiles, rscFiles = [],[]
for file in dirListing:
    if file.find('.ui') is not -1:
        uiFiles.append(file)
    if file.find('.qrc') is not -1:
        rscFiles.append(file)

print 'Compiling interface files...'
for file in uiFiles:
    os.system(cmdPrefix+"pyuic4 "+file+" -o "+file.replace('.ui','.py'))

print 'Compiling resource files...'
for file in rscFiles:
    os.system(cmdPrefix+"pyrcc4 "+file+" -o "+file.replace('.qrc','_rc.py'))

pyqt_template.py

'''This is the main app init file. It is what powers the UI and interfaces with the tweakZip class file.'''
__author__ = 'Justin Swanson'

import os,sys

# Import Qt Modules
from PyQt4 import QtCore,QtGui

# Import the compiled UI module
from mainwindow.py import Ui_MainWindow

# Create a class for our main window
class Main(QtGui.QMainWindow):
	def __init__(self):
		QtGui.QMainWindow.__init__(self)

		# This is always the same
		self.ui=Ui_MainWindow()
		self.ui.setupUi(self)

def main():
	# Again, this is boilerplate, it's going to be the same on
	# almost every app you write
	app = QtGui.QApplication(sys.argv)
	window = Main()
	window.show()
	sys.exit(app.exec_())


if __name__ == "__main__":
	main()

This link proved useful for fixing the latest release of Py2App to work properly with PyQt: https://bitbucket.org/ronaldoussoren/py2app/pull-request/2/add-support-for-homebrew-installed-pyqt4