Gulp: Less + Prefixing + Minify

foo.less

// Initialize ... (just an example)
@import "components/normalize";
@import "variables";
@import "mixins";

// Load optional components

gulpfile.js

var gulp = require('gulp');

var plugins = {
    less: require('gulp-less'),
    cleancss: require('less-plugin-clean-css'),
    autoprefix: require('less-plugin-autoprefix')
};

var paths = {
    origin: {
        less: {
            base: './less/foo.less',
            importPaths: [
                './less',
                './less/components'
            ]
        }
    },

    destination: {
        less: './css'
    }
};

gulp.task('less', function() {
    return gulp.src(paths.origin.less.base)
        .pipe(plugins.less({
            paths: paths.origin.less.importPaths,
            plugins: [
                new plugins.autoprefix({browsers: ["last 10 versions"]}),
                new plugins.cleancss({advanced: true})
            ]
        }))
        .pipe(gulp.dest(paths.destination.less));
});

gulp.task('watch', function() {
    gulp.watch(paths.origin.less.base, ['less']);
    gulp.watch(paths.origin.less.importPaths, ['less']);
});

gulp.task('default', [
    'less',
    'watch'
]);

package.json

{
  "name": "foo",
  "description": "bar",
  "version": "0.0.1",
  "readme": "No readme data",
  "repository": {},
  "dependencies": {},
  "devDependencies": {
    "gulp": "^3.8.11",
    "gulp-less": "^3.0.1",
    "less-plugin-autoprefix": "^1.3.0",
    "less-plugin-clean-css": "^1.5.0"
  }
}