20個「大型RCT顯示無顯著效益或有害」的經典案例文獻引用(AMA格式)

supplements_not_help.bib

@article{Clegg2006,
  author = {Clegg, D. O. and Reda, D. J. and Harris, C. L. and others},
  title = {Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis},
  journal = {New England Journal of Medicine},
  year = {2006},
  volume = {354},
  number = {8},
  pages = {795--808},
  doi = {10.1056/NEJMoa052771},
  note = {葡萄糖胺/軟骨素（膝關節炎）：整體族群無減痛效益，僅中重度疼痛亞組顯示可能有效。}
}

@article{DeKosky2008,
  author = {DeKosky, S. T. and Williamson, J. D. and Fitzpatrick, A. L. and others},
  title = {Ginkgo biloba for prevention of dementia: a randomized controlled trial},
  journal = {JAMA},
  year = {2008},
  volume = {300},
  number = {19},
  pages = {2253--2262},
  doi = {10.1001/jama.2008.683},
  note = {銀杏（失智預防）：無法降低失智或阿茲海默症發生率。}
}

@article{Bent2006,
  author = {Bent, S. and Kane, C. and Shinohara, K. and others},
  title = {Saw palmetto for benign prostatic hyperplasia},
  journal = {New England Journal of Medicine},
  year = {2006},
  volume = {354},
  number = {6},
  pages = {557--566},
  doi = {10.1056/NEJMoa053085},
  note = {鋸棕櫚（良性攝護腺肥大）：一年治療對症狀與客觀指標皆無改善。}
}

@article{Barrett2010,
  author = {Barrett, B. and Brown, R. and Rakel, D. and others},
  title = {Echinacea for treating the common cold: a randomized trial},
  journal = {Annals of Internal Medicine},
  year = {2010},
  volume = {153},
  number = {12},
  pages = {769--777},
  doi = {10.7326/0003-4819-153-12-201012210-00003},
  note = {紫錐花（感冒治療）：病程與嚴重度無顯著差異。}
}

@article{JuthaniMehta2016,
  author = {Juthani-Mehta, M. and Van Ness, P. H. and Bianco, L. and others},
  title = {Effect of cranberry capsules on bacteriuria plus pyuria among older women in nursing homes: a randomized clinical trial},
  journal = {JAMA},
  year = {2016},
  volume = {316},
  number = {18},
  pages = {1879--1887},
  doi = {10.1001/jama.2016.16141},
  note = {蔓越莓膠囊（長照機構年長女性泌尿道感染預防）：無法降低菌尿症合併膿尿發生率。}
}

@article{Jackson2006,
  author = {Jackson, R. D. and LaCroix, A. Z. and Gass, M. and others},
  title = {Calcium plus vitamin D supplementation and the risk of fractures},
  journal = {New England Journal of Medicine},
  year = {2006},
  volume = {354},
  number = {7},
  pages = {669--683},
  doi = {10.1056/NEJMoa055218},
  note = {鈣片+維生素D（社區老年女性髖骨骨折預防）：整體未顯著降低髖骨骨折，腎結石風險上升。}
}

@article{Manson2019VitD,
  author = {Manson, J. E. and Cook, N. R. and Lee, I. M. and others},
  title = {Vitamin D supplements and prevention of cancer and cardiovascular disease},
  journal = {New England Journal of Medicine},
  year = {2019},
  volume = {380},
  number = {1},
  pages = {33--44},
  doi = {10.1056/NEJMoa1809944},
  note = {維生素D（癌症/心血管疾病一級預防）：對主要癌症與心血管終點無顯著降低。}
}

@article{Manson2019Omega3,
  author = {Manson, J. E. and Cook, N. R. and Lee, I. M. and others},
  title = {Marine n-3 fatty acids and prevention of cardiovascular disease and cancer},
  journal = {New England Journal of Medicine},
  year = {2019},
  volume = {380},
  number = {1},
  pages = {23--32},
  doi = {10.1056/NEJMoa1811403},
  note = {魚油Omega-3（心血管疾病一級預防）：一般劑量對主要心血管終點未下降。}
}

@article{Sesso2012,
  author = {Sesso, H. D. and Christen, W. G. and Bubes, V. and others},
  title = {Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial},
  journal = {JAMA},
  year = {2012},
  volume = {308},
  number = {17},
  pages = {1751--1760},
  doi = {10.1001/jama.2012.14805},
  note = {綜合維他命（心血管疾病預防）：對主要心血管事件無效。}
}

@article{Boden2011,
  author = {Boden, W. E. and Probstfield, J. L. and Anderson, T. and others},
  title = {Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy},
  journal = {New England Journal of Medicine},
  year = {2011},
  volume = {365},
  number = {24},
  pages = {2255--2267},
  doi = {10.1056/NEJMoa1107579},
  note = {菸鹼酸加在史他汀類藥物上（AIM-HIGH試驗）：未降低心血管事件。}
}

@article{HPS2THRIVE2014,
  author = {{HPS2-THRIVE Collaborative Group}},
  title = {Effects of extended-release niacin with laropiprant in high-risk patients},
  journal = {New England Journal of Medicine},
  year = {2014},
  volume = {371},
  number = {3},
  pages = {203--212},
  doi = {10.1056/NEJMoa1300955},
  note = {菸鹼酸/laropiprant（HPS2-THRIVE試驗）：無心血管好處，反增多種嚴重不良事件。}
}

@article{ATBC1994,
  author = {{The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group}},
  title = {The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers},
  journal = {New England Journal of Medicine},
  year = {1994},
  volume = {330},
  number = {15},
  pages = {1029--1035},
  doi = {10.1056/NEJM199404143301501},
  note = {β-胡蘿蔔素（吸菸者—ATBC試驗）：不僅無益，肺癌風險反上升。}
}

@article{Omenn1996,
  author = {Omenn, G. S. and Goodman, G. E. and Thornquist, M. D. and others},
  title = {Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease},
  journal = {New England Journal of Medicine},
  year = {1996},
  volume = {334},
  number = {18},
  pages = {1150--1155},
  doi = {10.1056/NEJM199605023341802},
  note = {β-胡蘿蔔素+維生素A（高風險族群—CARET試驗）：增加肺癌與死亡風險，試驗提早終止。}
}

@article{Hemila2013,
  author = {Hemil\"{a}, H. and Chalker, E.},
  title = {Vitamin C for preventing and treating the common cold},
  journal = {Cochrane Database of Systematic Reviews},
  year = {2013},
  volume = {2013},
  number = {1},
  pages = {CD000980},
  doi = {10.1002/14651858.CD000980.pub4},
  note = {維生素C（感冒預防與治療）：一般人群「不能預防」感冒，治療效果無一致性。}
}

@article{Bamford2013,
  author = {Bamford, J. T. and Ray, S. and Musekiwa, A. and others},
  title = {Oral evening primrose oil and borage oil for eczema},
  journal = {Cochrane Database of Systematic Reviews},
  year = {2013},
  volume = {2013},
  number = {4},
  pages = {CD004416},
  doi = {10.1002/14651858.CD004416.pub2},
  note = {月見草油/琉璃苣油（異位性皮膚炎）：Cochrane結論無效。}
}

@article{Fried2012,
  author = {Fried, M. W. and Navarro, V. J. and Afdhal, N. and others},
  title = {Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial},
  journal = {JAMA},
  year = {2012},
  volume = {308},
  number = {3},
  pages = {274--282},
  doi = {10.1001/jama.2012.8265},
  note = {水飛薊素/乳薊（慢性C型肝炎）：對ALT等肝功能指標無改善。}
}

@article{Korownyk2024,
  author = {Korownyk, C. and Allan, G. M. and Garrison, S. and others},
  title = {D-mannose for prevention of recurrent urinary tract infection among women: a randomized clinical trial},
  journal = {JAMA Internal Medicine},
  year = {2024},
  volume = {184},
  number = {9},
  pages = {1037--1044},
  doi = {10.1001/jamainternmed.2024.2695},
  note = {D-甘露糖（反覆性泌尿道感染預防）：2024年JAMA IM研究顯示無效，不應作為預防建議。}
}

@article{Gardner2007,
  author = {Gardner, C. D. and Lawson, L. D. and Block, E. and others},
  title = {Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial},
  journal = {Archives of Internal Medicine},
  year = {2007},
  volume = {167},
  number = {4},
  pages = {346--353},
  doi = {10.1001/archinte.167.4.346},
  note = {大蒜萃取物（降低LDL膽固醇）：六個月對LDL無臨床或統計顯著變化。}
}

@article{Wilkens2010,
  author = {Wilkens, P. and Scheel, I. B. and Grundnes, O. and Hellum, C. and Storheim, K.},
  title = {Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial},
  journal = {JAMA},
  year = {2010},
  volume = {304},
  number = {1},
  pages = {45--52},
  doi = {10.1001/jama.2010.893},
  note = {葡萄糖胺（慢性下背痛/退化性腰椎關節炎）：系統性回顧與RCT顯示無實質效益。}
}

@article{Pittler2000,
  author = {Pittler, M. H. and Ernst, E.},
  title = {Ginkgo biloba extract for the treatment of intermittent claudication: a meta-analysis of randomized trials},
  journal = {American Journal of Medicine},
  year = {2000},
  volume = {108},
  number = {4},
  pages = {276--281},
  doi = {10.1016/s0002-9343(99)00454-4},
  note = {銀杏（間歇性跛行/周邊動脈疾病）：Cochrane評估無臨床顯著好處。}
}