A killer GNU Screen Config

.screenrc

# the following two lines give a two-line status, with the current window highlighted
hardstatus alwayslastline
hardstatus string '%{= kG}[%{G}%H%? %1`%?%{g}][%= %{= kw}%-w%{+b yk} %n*%t%?(%u)%? %{-}%+w %=%{g}][%{B}%m/%d %{W}%C%A%{g}]'

# huge scrollback buffer
defscrollback 5000

# no welcome message
startup_message off

# 256 colors
attrcolor b ".I"
termcapinfo xterm 'Co#256:AB=\E[48;5;%dm:AF=\E[38;5;%dm'
defbce on

# mouse tracking allows to switch region focus by clicking
mousetrack on

# default windows
screen -t Shell1  1 bash
screen -t Shell2  2 bash
screen -t Python  3 python
screen -t Media   4 bash
select 0
bind c screen 1 # window numbering starts at 1 not 0
bind 0 select 10

# get rid of silly xoff stuff
bind s split

# layouts
layout autosave on
layout new one
select 1
layout new two
select 1
split
resize -v +8
focus down
select 4
focus up
layout new three
select 1
split
resize -v +7
focus down
select 3
split -v
resize -h +10
focus right
select 4
focus up

layout attach one
layout select one

# navigating regions with Ctrl-arrows
bindkey "^[[1;5D" focus left
bindkey "^[[1;5C" focus right
bindkey "^[[1;5A" focus up
bindkey "^[[1;5B" focus down

# switch windows with F3 (prev) and F4 (next)
bindkey "^[OR" prev
bindkey "^[OS" next

# switch layouts with Ctrl+F3 (prev layout) and Ctrl+F4 (next)
bindkey "^[O1;5R" layout prev
bindkey "^[O1;5S" layout next

# F2 puts Screen into resize mode. Resize regions using hjkl keys.
bindkey "^[OQ" eval "command -c rsz" # enter resize mode

# use hjkl keys to resize regions
bind -c rsz h eval "resize -h -5" "command -c rsz"
bind -c rsz j eval "resize -v -5" "command -c rsz"
bind -c rsz k eval "resize -v +5" "command -c rsz"
bind -c rsz l eval "resize -h +5" "command -c rsz"

# quickly switch between regions using tab and arrows
bind -c rsz \t    eval "focus"       "command -c rsz" # Tab
bind -c rsz -k kl eval "focus left"  "command -c rsz" # Left
bind -c rsz -k kr eval "focus right" "command -c rsz" # Right
bind -c rsz -k ku eval "focus up"    "command -c rsz" # Up
bind -c rsz -k kd eval "focus down"  "command -c rsz" # Down