Using the ASP.NET bundling and minifications is pretty straight forward, but here is a small guide that take care of a few gotchas when implementing bundles in your Umbraco project.
ASP.NET Bundling and Minifications is part of the Microsoft ASP.NET Web Optimization Framework and is installed via NuGet;
PM> Install-Package Microsoft.AspNet.Web.Optimization
Once this is done, you need to create a BundleConfig.cs in your App_Start1 folder. This is where you register your different bundles. It can be extremely simple, or it can be more complex, but the gist of it is this;