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cleanGeno modified to work with riself, risib, dh, and haploids, rather than just backcross
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###################################################################### | |
# | |
# cleanGeno: omit genotypes that are possibly in error, as indicated | |
# by apparent double-crossovers separated by a distance of | |
# no more than maxdist and having no more than maxmark | |
# interior typed markers | |
# | |
###################################################################### | |
cleanGeno <- | |
function(cross, chr, maxdist=2.5, maxmark=2, verbose=TRUE) | |
{ | |
if(!(class(cross)[1] %in% c("bc", "riself", "risib", "dh", "haploid"))) | |
stop("This function currently only works for crosses with two genotypes") | |
if(!missing(chr)) cleaned <- subset(cross, chr=chr) | |
else cleaned <- cross | |
thechr <- names(cleaned$geno) | |
totdrop <- 0 | |
maxmaxdist <- max(maxdist) | |
for(i in thechr) { | |
xoloc <- locateXO(cleaned, chr=i, full.info=TRUE) | |
nxo <- sapply(xoloc, function(a) if(is.matrix(a)) return(nrow(a)) else return(0)) | |
g <- pull.geno(cleaned, chr=i) | |
ndrop <- 0 | |
for(j in which(nxo > 1)) { | |
maxd <- xoloc[[j]][-1,"right"] - xoloc[[j]][-nrow(xoloc[[j]]),"left"] | |
wh <- maxd <= maxmaxdist | |
if(any(wh)) { | |
for(k in which(wh)) { | |
nt <- sum(!is.na(g[j,(xoloc[[j]][k,"ileft"]+1):(xoloc[[j]][k+1,"iright"]-1)])) | |
if(nt > 0 && any(nt <= maxmark & maxd[k] < maxdist)) { | |
cleaned$geno[[i]]$data[j,(xoloc[[j]][k,"ileft"]+1):(xoloc[[j]][k+1,"iright"]-1)] <- NA | |
ndrop <- ndrop + nt | |
totdrop <- totdrop + nt | |
} | |
} | |
} | |
} | |
if(verbose && ndrop > 0) { | |
totgen <- sum(ntyped(subset(cross, chr=i))) | |
cat(" ---Dropping ", ndrop, " genotypes (out of ", totgen, ") on chr ", i, "\n", sep="") | |
} | |
} | |
if(verbose && nchr(cleaned)>1 && totdrop > 0) { | |
totgen <- sum(ntyped(subset(cross, chr=thechr))) | |
cat(" ---Dropped ", totdrop, " genotypes (out of ", totgen, ") in total\n", sep="") | |
} | |
for(i in names(cleaned$geno)) | |
cross$geno[[i]] <- cleaned$geno[[i]] | |
cross | |
} |
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