test.cs

public class BusinessMappingTests
{
    public BusinessMappingTests()
    {
        Mapper.Initialize(cfg => cfg.AddProfile<BusinessMappingProfile>());
        Mapper.AssertConfigurationIsValid();
    }

    [Fact]
    public void Can_map_editmodel_to_business()
    {
        var model = new EditModel {};
        Mapper.Map<Business>(model);
    }

    [Fact]
    public void Can_map_business_to_editmodel()
    {
        var business = new Business();
        Mapper.Map<EditModel>(business);
    }
}

I use StuctureMap to just pick up and register the profiles.

 public class Mapping : Registry
    {
        public Mapping()
        {
            Scan(x => {
                x.TheCallingAssembly();
                x.AddAllTypesOf<Profile>();
            });            
        }
    }

Then I load them on startup like this.

public static class MappingConfig
    {
        public static void Setup()
        {
            var profiles = DependencyResolver.Current.GetServices<Profile>();
            Mapper.Initialize(cfg => {
                foreach (var profile in profiles)
                    cfg.AddProfile(profile);
            });
        }
    }

Easy Peesy....