An example agent that intercepts a method of the bootstrap class loader. Tested with Byte Buddy 1.14.11 on JDKs 8 to 21.

BootstrapAgent.java

package net.bytebuddy;

import net.bytebuddy.agent.ByteBuddyAgent;
import net.bytebuddy.agent.builder.AgentBuilder;
import net.bytebuddy.dynamic.ClassFileLocator;
import net.bytebuddy.dynamic.loading.ClassInjector;
import net.bytebuddy.implementation.MethodDelegation;
import net.bytebuddy.implementation.bind.annotation.SuperCall;
import net.bytebuddy.matcher.ElementMatchers;

import java.lang.instrument.Instrumentation;
import java.net.URL;
import java.util.Collections;
import java.util.concurrent.Callable;

import static net.bytebuddy.matcher.ElementMatchers.none;

/**
 * Inspired by <a href="https://github.com/apache/skywalking">Apache SkyWalking</a>, specifically
 * <a href="https://github.com/apache/skywalking/blob/bc64c6a12770031478d29e2f19004796584374c9/apm-sniffer/apm-agent-core/src/main/java/org/apache/skywalking/apm/agent/core/plugin/bootstrap/BootstrapInstrumentBoost.java">
 * this class</a>. Discussed in <a href="https://github.com/raphw/byte-buddy/issues/697">Byte Buddy issue #697</a>.
 * <p>
 * Successfully tested on JDKs 8 to 21. Should print:
 * <pre>
 * Intercepted!
 * GET
 * </pre>
 */
public class BootstrapAgent {
  public static void main(String[] args) throws Exception {
    premain(null, ByteBuddyAgent.install());
    Object urlConnection = new URL("http://www.google.com").openConnection();
    System.out.println(urlConnection.getClass().getMethod("getRequestMethod").invoke(urlConnection));
  }

  public static void premain(String arg, Instrumentation instrumentation) throws Exception {
    ClassInjector.UsingUnsafe.Factory factory = ClassInjector.UsingUnsafe.Factory.resolve(instrumentation);
    factory.make(null, null).injectRaw(
      Collections.singletonMap(
        MyInterceptor.class.getName(),
        ClassFileLocator.ForClassLoader.read(MyInterceptor.class)
      )
    );
    AgentBuilder agentBuilder = new AgentBuilder.Default();
    agentBuilder = agentBuilder.with(new AgentBuilder.InjectionStrategy.UsingUnsafe.OfFactory(factory));
    agentBuilder
      .ignore(none())
      .assureReadEdgeFromAndTo(instrumentation, Class.forName("java.net.HttpURLConnection"))
      .assureReadEdgeFromAndTo(instrumentation, MyInterceptor.class)
      .ignore(ElementMatchers.nameStartsWith("net.bytebuddy."))
      .type(ElementMatchers.nameContains("HttpURLConnection"))
      .transform((builder, typeDescription, classLoader, module, protectionDomain) -> builder
        .method(ElementMatchers.named("getRequestMethod"))
        .intercept(MethodDelegation.to(MyInterceptor.class))
      )
      .installOn(instrumentation);
  }

  public static class MyInterceptor {
    public static String intercept(@SuperCall Callable<String> zuper) throws Exception {
      System.out.println("Intercepted!");
      return zuper.call();
    }
  }
}

How? Where is your MCVE? Just show your ASM solution (on StackOverflow, not here) as a point of departure for how to transform that into an equivalent solution using another tool.

Just to prove that using ASM can enhance Java. lang.String. Here is my demo.
I've tried on HttpURLConnection, it's not works on JDK17, maybe it's appropriate to answer that question.
Thank you for your help. And let me know that if I have any problems next time, I should use StackOverFlow instead of Gist.

Thanks for proving that your agent has absolutely no effect.

I cloned the project, built it and then put it on the JVM command line with -javaagent:.../EnhanceStringAgent-1.0-SNAPSHOT.jar, running this sample program:

public class App {
  public static void main(String[] args) {
    System.out.println("Hello ".concat("world!"));
  }
}

The console log says:

Enhance: java/lang/String
Hello world!

I.e., the agent starts, of course, but the transformer never does anything. And why would it? Class String was loaded before already. Like I said, your agent should instrument the caller, not the callee in this case.

It works on me. Just want you to know that I'm not lying.And this strategy has been proven in Project.

That's so weird. I know the Class String was loaded before already. So it need to be retransformed, like this:

Class[] classes = instrumentation.getAllLoadedClasses();
for (Class clazz : classes) {
    if (instrumentation.isModifiableClass(clazz)) {
        instrumentation.retransformClasses(clazz);
    }
}

My sample program bellows , your sample program wokrs on my agent too.

public class Main {
    public static void main(String[] args) {
        while (true){
            String input = new Scanner(System.in).nextLine();
            System.out.println(input.concat(", hello!"));
        }
    }
}

Input:

ssss

Output

Enhance String::concat
ssss, hello!

Maybe my config is useful.
build agent with IDEA:

add VM option on sample project, -javaagent:C:\Users\A\Desktop\Code\Java\EnhanceStringAgent-main\target\EnhanceStringAgent-1.0-SNAPSHOT.jar

RUN sample project ，console log:

OK, I noticed that it started working for me locally when I downgraded my runtime from JDK 17 to 8, 11 or even 16. So I upgraded your code to use the latest ASM v9.6 and also bumped the ASM API version 8 in your project to Opcodes.ASM9. Now, it also works on JDKs 17 to 21. That is a starting point. I do not have any more time tonight to look into this any further, but tomorrow maybe I can spare a little bit of time.

I guess, I did something similar a few years ago in my testing tool Sarek, which I never got around to promote, even though it is feature-complete. (Only the API is not so easy to use. But I am degressing.) Basically, I can already say that if it works with ASM, there is no reason to believe that it will not work with Byte Buddy, too.

@Ch35Tnut, what you want is possible, like I said yesterday. But you need to avoid the interceptor approach in favour of an advice-based one and also make sure that you do not alter the original method signature. Finally, you need to issue retransformation, just like your custom ASM agent does.

See https://gist.github.com/kriegaex/8228c8ba664c730157c2fef3c5fd78e7.