A C file that creates an MD5 Hash efficiently. Credit to Joel : http://www.joel.lopes-da-silva.com/2010/09/07/compute-md5-or-sha-hash-of-large-file-efficiently-on-ios-and-mac-os-x/

FileMD5Hash.c

// Standard library
#include <stdint.h>
#include <stdio.h>

// Core Foundation
#include <CoreFoundation/CoreFoundation.h>

// Cryptography
#include <CommonCrypto/CommonDigest.h>

// In bytes
#define FileHashDefaultChunkSizeForReadingData 4096

// Function
CFStringRef FileMD5HashCreateWithPath(CFStringRef filePath,
                                      size_t chunkSizeForReadingData) {
    
    // Declare needed variables
    CFStringRef result = NULL;
    CFReadStreamRef readStream = NULL;
    
    // Get the file URL
    CFURLRef fileURL =
    CFURLCreateWithFileSystemPath(kCFAllocatorDefault,
                                  (CFStringRef)filePath,
                                  kCFURLPOSIXPathStyle,
                                  (Boolean)false);
    if (!fileURL) goto done;
    
    // Create and open the read stream
    readStream = CFReadStreamCreateWithFile(kCFAllocatorDefault,
                                            (CFURLRef)fileURL);
    if (!readStream) goto done;
    bool didSucceed = (bool)CFReadStreamOpen(readStream);
    if (!didSucceed) goto done;
    
    // Initialize the hash object
    CC_MD5_CTX hashObject;
    CC_MD5_Init(&hashObject);
    
    // Make sure chunkSizeForReadingData is valid
    if (!chunkSizeForReadingData) {
        chunkSizeForReadingData = FileHashDefaultChunkSizeForReadingData;
    }
    
    // Feed the data to the hash object
    bool hasMoreData = true;
    while (hasMoreData) {
        uint8_t buffer[chunkSizeForReadingData];
        CFIndex readBytesCount = CFReadStreamRead(readStream,
                                                  (UInt8 *)buffer,
                                                  (CFIndex)sizeof(buffer));
        if (readBytesCount == -1) break;
        if (readBytesCount == 0) {
            hasMoreData = false;
            continue;
        }
        CC_MD5_Update(&hashObject,
                      (const void *)buffer,
                      (CC_LONG)readBytesCount);
    }
    
    // Check if the read operation succeeded
    didSucceed = !hasMoreData;
    
    // Compute the hash digest
    unsigned char digest[CC_MD5_DIGEST_LENGTH];
    CC_MD5_Final(digest, &hashObject);
    
    // Abort if the read operation failed
    if (!didSucceed) goto done;
    
    // Compute the string result
    char hash[2 * sizeof(digest) + 1];
    for (size_t i = 0; i < sizeof(digest); ++i) {
        snprintf(hash + (2 * i), 3, "%02x", (int)(digest[i]));
    }
    result = CFStringCreateWithCString(kCFAllocatorDefault,
                                       (const char *)hash,
                                       kCFStringEncodingUTF8);
    
done:
    
    if (readStream) {
        CFReadStreamClose(readStream);
        CFRelease(readStream);
    }
    if (fileURL) {
        CFRelease(fileURL);
    }
    return result;
}

Usage.h

NSString *filePath = ...; // Let's assume filePath is defined...
CFStringRef md5hash = 
    FileMD5HashCreateWithPath((CFStringRef)filePath, 
                              FileHashDefaultChunkSizeForReadingData);
NSLog(@"MD5 hash of file at path \"%@\": %@", 
      filePath, (NSString *)md5hash);
CFRelease(md5hash);