Guide Custom Post Type

gistfile1.aw

<?php
// CUSTOM POST TYPE
add_action('init', 'matt_guide_register');
function matt_guide_register() {
	$labels = array(
		'name' => _x('Guide', 'post type general name'),
		'singular_name' => _x('Region', 'post type singular name'),
		'add_new' => _x('Add new region', 'region item'),
		'add_new_item' => __('Add new'),
		'edit_item' => __('Edit region'),
		'new_item' => __('New region'),
		'view_item' => __('View region'),
		'search_items' => __('Search regions'),
		'not_found' =>  __('Nothing found'),
		'not_found_in_trash' => __('Nothing found in Trash'),
		'parent_item_colon' => ''
	);
	$args = array(
		'labels' => $labels,
		'public' => true,
		'publicly_queryable' => true,
		'show_ui' => true,
		'query_var' => true,
		'capability_type' => 'page',
		'hierarchical' => true,
		'menu_position' => null,
		'rewrite' => array('slug' => 'guide', 'with_front' => true),
		'supports' => array('title','editor','thumbnail','page-attributes','revisions')
	); 
	register_post_type( 'guide' , $args );
}
?>

One more suggestion, instead of adding it once to the file and then loading a page to flush the rewrite rules, you can simply visit the permalinks setting page. It does that too :)