A quick example using neo4django with tastypie adapted from the tastypie tutorial (http://django-tastypie.readthedocs.org/en/latest/tutorial.html).

api.py

from tastypie.resources import ModelResource
from .models import Entry

class EntryResource(ModelResource):
    class Meta:
        queryset = Entry.objects.all()
        resource_name = 'entry'

models.py

from neo4django.auth.models import User
from neo4django.db import models
from django.template.defaultfilters import slugify

class Entry(models.NodeModel):
    user = models.Relationship(User, related_name='entries',
                               rel_type='authored_by', single=True)
    pub_date = models.DateTimeProperty(auto_now=True)
    title = models.StringProperty(indexed=True)
    slug = models.StringProperty()
    body = models.StringProperty()

    def __unicode__(self):
        return self.title

    def save(self, *args, **kwargs):
        if not self.slug:
            self.slug = slugify(self.title)[:50]

        return super(Entry, self).save(*args, **kwargs)

urls.py

from django.conf.urls import patterns, include

from myapp.api import EntryResource

entry_resource = EntryResource()

urlpatterns = patterns('',
    # The normal jazz here...
    #(r'^blog/', include('myapp.urls')),
    (r'^api/', include(entry_resource.urls)),
)