My custom MPK249 control script for Ableton Live. Only tested on Windows 10 & Live 10. It fixes the automap for device knobs to automap to the knobs able the 249's sliders. Go to C:\ProgramData\Ableton\Live 10 Suite\Resources\MIDI Remote Scripts\MPK249 and make a backup of that folder and put this script in the folder and restart Ableton.

MPK249.py

# Embedded file name: c:\Jenkins\live\output\win_64_static\Release\python-bundle\MIDI Remote Scripts\MPK249\MPK249.py
from __future__ import absolute_import, print_function, unicode_literals
from _Framework.ControlSurface import ControlSurface
from _Framework.Layer import Layer
from _Framework.DrumRackComponent import DrumRackComponent
from _Framework.TransportComponent import TransportComponent
from _Framework.DeviceComponent import DeviceComponent
from _Framework.MixerComponent import MixerComponent
from _Framework.MidiMap import MidiMap as MidiMapBase
from _Framework.MidiMap import make_button, make_encoder, make_slider
from _Framework.InputControlElement import MIDI_NOTE_TYPE, MIDI_CC_TYPE

class MidiMap(MidiMapBase):

    def __init__(self, *a, **k):
        super(MidiMap, self).__init__(*a, **k)
        self.add_button(u'Play', 0, 118, MIDI_CC_TYPE)
        self.add_button(u'Record', 0, 119, MIDI_CC_TYPE)
        self.add_button(u'Stop', 0, 117, MIDI_CC_TYPE)
        self.add_button(u'Loop', 0, 114, MIDI_CC_TYPE)
        self.add_button(u'Forward', 0, 116, MIDI_CC_TYPE)
        self.add_button(u'Backward', 0, 115, MIDI_CC_TYPE)
        self.add_matrix(u'Sliders', make_slider, 0, [[12,
          13,
          14,
          15,
          16,
          17,
          18,
          19]], MIDI_CC_TYPE)
        self.add_matrix(u'Encoders', make_encoder, 0, [[22,
          23,
          24,
          25,
          26,
          27,
          28,
          29]], MIDI_CC_TYPE)
        self.add_matrix(u'Arm_Buttons', make_button, 0, [[32,
          33,
          34,
          35,
          36,
          37,
          38,
          39]], MIDI_CC_TYPE)
        self.add_matrix(u'Drum_Pads', make_button, 1, [[81,
          83,
          84,
          86],
         [74,
          76,
          77,
          79],
         [67,
          69,
          71,
          72],
         [60,
          62,
          64,
          65]], MIDI_NOTE_TYPE)


class MPK249(ControlSurface):

    def __init__(self, *a, **k):
        super(MPK249, self).__init__(*a, **k)
        with self.component_guard():
            midimap = MidiMap()
            drum_rack = DrumRackComponent(name=u'Drum_Rack', is_enabled=False, layer=Layer(pads=midimap[u'Drum_Pads']))
            drum_rack.set_enabled(True)        
            transport = TransportComponent(name=u'Transport', is_enabled=False, layer=Layer(play_button=midimap[u'Play'], record_button=midimap[u'Record'], stop_button=midimap[u'Stop'], seek_forward_button=midimap[u'Forward'], seek_backward_button=midimap[u'Backward'], loop_button=midimap[u'Loop']))
            transport.set_enabled(True)
            device = DeviceComponent(name='Device', is_enabled=False, layer=Layer(parameter_controls=midimap['Encoders']))
            device.set_enabled(True)
            mixer_size = len(midimap[u'Sliders'])
            mixer = MixerComponent(mixer_size, name=u'Mixer', is_enabled=False, layer=Layer(volume_controls=midimap[u'Sliders'], arm_buttons=midimap[u'Arm_Buttons']))
            mixer.set_enabled(True)

They won't do anything on instruments alone. They are designed for macros. All the preset instruments have these.

What you can also do is check the logs for python errors. Nothing gets logged to the screen if the code is broken so you'll have to do some digging.

Hey, thanks for the hint. Still the macro knobs weren't moving. But adding the self.set_device_component(device) string made the trick also for me as maxcloutier13 pointed out!

Made an account just to thank you for this!! I just purchased an MPK249 yesterday and this solved so many issues I never would've solved on my own. Followed your instructions (placing in the MPK249 folder instead of the 261 folder) and it worked like a charm! Just need to figure out how to have additional mapped configs for other VSTs and plugins. Seriously, this is a lifesaver, thank you so much for your work!!!

Thank you sir <3