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How much time do I have?
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What's the venue like?
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At what time of day will I be presenting?
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Who is the audience?
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What's their background?
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What do they expect of me?
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Why was I asked to speak?
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What do I want them to do?
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What visual medium us most appropriate for this particular situation and audience?
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What is the fundamental purpose of my talk?
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What's the story here?
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The fundamental question: What is my absolutely central point?
The audience is unlikely to remember more than one point so you had better make it a good one!