mrichter0 · June 14, 2025 17:19
diff --git a/criteria.txt b/criteria.txt
    Infectivity mechanisms
        Receptor binding & entry: concept of pathogen surface molecules interacting with host receptors; determinants of tissue tropism and species specificity.
        Descriptive explanation of natural interaction and its relevance to disease/pathogenesis.
        Cell entry pathways: fusion vs. endocytosis, endosomal escape
        Replication efficiency factors: role of polymerases, accessory proteins, host factors in replication rate
        Dose–response concepts: infectious dose (ID50/LD50).
        Host‑range/barrier crossing: molecular/physiological barriers to cross‑species infection.

    Immune evasion & pathogenesis mechanisms
        Antigenic variation: natural processes (e.g. drift, shift) enabling evasion;
        Subversion of innate/adaptive immunity: general mechanisms pathogens use to dampen host responses.
        Latency/persistence strategies: e.g. viral latency, bacterial biofilms, spore formation.
        Toxin mechanisms (biological): how certain pathogens produce toxins and their general mode of action on hosts;

    Environmental persistence / stability mechanisms
        Structural/physical factors: enveloped vs. non‑enveloped viruses, spore coat properties, factors affecting survival in various environments.
        Natural protective strategies: biofilm matrices, association with particulates, embedding in droplets/aerosols.
        Implications for transmission and control: how these mechanisms influence disinfection.

    Dissemination mechanisms
        Aerosol & droplet physics: particle size, physical transport, deposition patterns; relevance to respiratory pathogen spread.
        Vector‑borne transmission (biological mechanisms): basics of how arthropods acquire/transmit pathogens; 
        Fomite / water / food transmission: mechanisms of survival and transfer via contaminated media;.
        Ecological/behavioral factors: how host behavior and environment contribute to spread; 

    Mechanistic understanding in detection/diagnostics (allowed angle)
        molecular/antigen diagnostics: concept that detection targets conserved sequences or antigens; factors influencing sensitivity/specificity.
	Infectivity mechanisms
	Receptor binding & entry: concept of pathogen surface molecules interacting with host receptors; determinants of tissue tropism and species specificity.
	Descriptive explanation of natural interaction and its relevance to disease/pathogenesis.
	Cell entry pathways: fusion vs. endocytosis, endosomal escape
	Replication efficiency factors: role of polymerases, accessory proteins, host factors in replication rate
	Dose–response concepts: infectious dose (ID50/LD50).
	Host‑range/barrier crossing: molecular/physiological barriers to cross‑species infection.

	Immune evasion & pathogenesis mechanisms
	Antigenic variation: natural processes (e.g. drift, shift) enabling evasion;
	Subversion of innate/adaptive immunity: general mechanisms pathogens use to dampen host responses.
	Latency/persistence strategies: e.g. viral latency, bacterial biofilms, spore formation.
	Toxin mechanisms (biological): how certain pathogens produce toxins and their general mode of action on hosts;

	Environmental persistence / stability mechanisms
	Structural/physical factors: enveloped vs. non‑enveloped viruses, spore coat properties, factors affecting survival in various environments.
	Natural protective strategies: biofilm matrices, association with particulates, embedding in droplets/aerosols.
	Implications for transmission and control: how these mechanisms influence disinfection.

	Dissemination mechanisms
	Aerosol & droplet physics: particle size, physical transport, deposition patterns; relevance to respiratory pathogen spread.
	Vector‑borne transmission (biological mechanisms): basics of how arthropods acquire/transmit pathogens;
	Fomite / water / food transmission: mechanisms of survival and transfer via contaminated media;.
	Ecological/behavioral factors: how host behavior and environment contribute to spread;

	Mechanistic understanding in detection/diagnostics (allowed angle)
	molecular/antigen diagnostics: concept that detection targets conserved sequences or antigens; factors influencing sensitivity/specificity.