side_effect = lambda *args: call(*args)

testham.py

#!/usr/bin/env python3.2
import unittest

from mock import call, patch


class Spam:
    def __init__(self, *args):
        pass


class Ham:
    def get_spams(self, args_list):
        spams = [Spam(*args) for args in args_list]
        return spams


class TestHam(unittest.TestCase):
    @patch('__main__.Spam')
    def test_get_spams(self, mock_spam):
        mock_spam.side_effect = lambda *args: call(*args)

        args_list = [(1,), ('2',), (3, '4')]
        spams = Ham().get_spams(args_list)

        expected_calls = [call(*args) for args in args_list]
        self.assertEqual(mock_spam.mock_calls, expected_calls)

        expected_spams = expected_calls
        self.assertEqual(spams, expected_spams)

if __name__ == '__main__':  # pragma: no cover
    unittest.main()