SafeDestroy.cs

    public static void SafeDestroy<T>(T obj) where T : Object
    {
        if (Application.isPlaying)
            Object.Destroy(obj);
        else
            Object.DestroyImmediate(obj);
    }
    
    // Call in OnValidate, OnTriggerEnter, etc, with StartCoroutine() out of play mode
    public static IEnumerator Catch22Destroy<T>(T obj) where T : Object
    {
        yield return null;
        SafeDestroy(obj);
    }