Created
March 6, 2015 12:37
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Calculate kinship coefficient for set of samples in VCF
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#!/bin/bash | |
bcftools norm -Ou -m -any $1 | # Split multi-allelic alleles | |
bcftools norm -Ou -f /resources/hg19/ucsc.hg19.fasta | # Normalize | |
bcftools annotate -Ob -x ID -I +'%CHROM:%POS:%REF:%ALT' | # Replace IDs with unique ID | |
plink --bcf /dev/stdin --keep-allele-order --double-id --allow-extra-chr 0 --make-bed --out variants | |
king -b variants.bed --kinship --prefix kinship | |
king -b variants.bed --individual |
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