Simple applescript to toggle the trackpad on a macbook on and off. This script uses the "Turn off Trackpad when USB Mouse is connected" feature of Mac OS. Tested on 10.12.6

ToggleTrackPad

tell application "System Events"
	tell process "System Preferences"
		try
			set visible to false
		end try
		tell application "System Preferences"
			delay 1
			reveal pane id "com.apple.preference.universalaccess"
		end tell
		delay 1
		get entire contents of window "Accessibility"
		select row 15 of table 1 of scroll area 1 of window "Accessibility"
		click checkbox 2 of tab group 1 of group 1 of window "Accessibility" of application process "System Preferences" of application "System Events"
	end tell
end tell
quit application "System Preferences"

Thanks for the update. Ive updated and tested the script on MacOS 12.0.1. I had to change the row (14 -> 15) for Monterey and add a delay to make it more robust when loading the "Accessibility" tab is slow.

Thank you so much, I have Catalina 10.15.17 maybe that's why you need 15 and I need 14, anyways very useful I couldn't find a way to make it work other than messing around with the SQLite file which has the preferences stored in it, that delay also is a great idea!