on_duplicate_key.py

# INSERT INTO table_tags (tag) VALUES ('tag_a'),('tab_b'),('tag_c') ON DUPLICATE KEY UPDATE tag=tag;

from sqlalchemy.ext.compiler import compiles
from sqlalchemy.sql.expression import Insert

@compiles(Insert)
def append_string(insert, compiler, **kw):
    s = compiler.visit_insert(insert, **kw)
    if 'append_string' in insert.kwargs:
        return s + " " + insert.kwargs['append_string']
    return s


my_connection.execute(my_table.insert(append_string = 'ON DUPLICATE KEY UPDATE foo=foo'), my_values)