Throw this in a folder and execute index.cfm and you'll see a multiple datasource error, even though only one datasource is used inside the cftransaction.

application.cfc

<cfcomponent>
	<cfset this.name = "mySpecialApp">
	<cfset this.datasource = "rc_cms">
	<cfset this.ormEnabled = true>
	
	<cffunction name="onError">
		<cfdump var="#arguments#">
	</cffunction>
</cfcomponent>

googleTranslateLanguagesOrm

<cfcomponent persistent="true" table="supportedLanguages" cacheuse="transactional">
	<!--- standard fields --->
	<cfproperty name="languageid" fieldtype="id" generator="identity">
	<cfproperty name="code" notnull="true">
	<cfproperty name="label" notnull="true">
	<cfproperty name="active" type="boolean" default="true" dbdefault="1" notnull="true">
</cfcomponent>

index.cfm

<!--- If you comment out this line you do not get the error --->
<cfset EntityLoad("googleTranslateLanguagesOrm")>

<cftransaction>
	<cftry>
		<cfquery name="local.qry" datasource="imagecdn">
			SELECT count(*) FROM jobs
		</cfquery>
		
		<cfcatch>
			<cftransaction action="rollback"/>
		</cfcatch>
	</cftry>
</cftransaction>

stop.cfm

<!--- call this file to reset the app while testing (if need be) --->
<cfset ApplicationStop()>