Skip to content

Instantly share code, notes, and snippets.

@paolorechia

paolorechia/trace_v4.json

Created January 24, 2024 21:00
Show Gist options
  • Save paolorechia/6688faeabc0ed04faa0ce547d5239b29 to your computer and use it in GitHub Desktop.
Save paolorechia/6688faeabc0ed04faa0ce547d5239b29 to your computer and use it in GitHub Desktop.
Download ZIP
Trace V4
Raw
trace_v4.json
{
"name": "chroma.add",
"context": {
"trace_id": "0x6fe07fe5da112de3cee41df611008cf4",
"span_id": "0x91b2de5e692be5a4",
"trace_state": "[]"
},
"kind": "SpanKind.INTERNAL",
"parent_id": null,
"start_time": "2024-01-24T20:58:45.609080Z",
"end_time": "2024-01-24T20:58:45.897297Z",
"status": {
"status_code": "UNSET"
},
"attributes": {
"db.system": "chroma",
"db.operation": "add",
"db.chroma.add.ids_count": 10,
"db.chroma.add.metadatas_count": 10,
"db.chroma.add.documents_count": 10
},
"events": [],
"links": [],
"resource": {
"attributes": {
"service.name": "chroma_sentence_transformer_app"
},
"schema_url": ""
}
}
{
"name": "chroma.query.segment._query",
"context": {
"trace_id": "0x4131c545ba764b2bfcaa62376a7ed613",
"span_id": "0x4a18e06e82fafa65",
"trace_state": "[]"
},
"kind": "SpanKind.INTERNAL",
"parent_id": "0x4d12fbcc05e33c9b",
"start_time": "2024-01-24T20:58:45.906563Z",
"end_time": "2024-01-24T20:58:45.907992Z",
"status": {
"status_code": "UNSET"
},
"attributes": {
"traceloop.workflow.name": "assess_claims",
"db.system": "chroma",
"db.operation": "_query",
"db.chroma.query.segment._query.collection_id": "8b7a04b7-8bbc-4f9a-8993-d3106c60cc78"
},
"events": [
{
"name": "vector_db.query.embeddings.0",
"timestamp": "2024-01-24T20:58:45.906718Z",
"attributes": {
"embeddings": [
-0.07656389474868774,
0.03013044409453869,
0.024781471118330956,
-0.018965281546115875,
-0.02126024104654789,
-0.03042079135775566,
-0.022514767944812775,
0.07737711817026138,
-0.013561157509684563,
0.021854771301150322,
0.004687628708779812,
-0.014641514047980309,
-0.0339173749089241,
0.05375305190682411,
-0.03208155557513237,
0.032443199306726456,
-0.10043550282716751,
0.0018190420232713223,
0.027101220563054085,
0.07966732978820801,
-0.047610148787498474,
0.012334578670561314,
0.07045113295316696,
-0.005440796259790659,
-0.015557944774627686,
0.08534332364797592,
0.06140578165650368,
-0.03797875717282295,
-0.01378727424889803,
-0.03887736052274704,
0.047344937920570374,
-0.036591921001672745,
-0.058674152940511703,
-0.048159390687942505,
0.03346467390656471,
-0.05868346616625786,
0.06199785694479942,
0.04070108383893967,
-0.03589262440800667,
0.047684427350759506,
0.07261378318071365,
0.004467228427529335,
0.04471304267644882,
-0.007377563044428825,
0.09161156415939331,
-0.051444754004478455,
0.010295206680893898,
-0.08752048015594482,
-0.013180055655539036,
-0.09739294648170471,
0.038951575756073,
0.01420243363827467,
-0.01756560057401657,
0.05457628518342972,
0.0066769421100616455,
0.012620351277291775,
-0.01410827599465847,
0.03199870511889458,
-0.0014760787598788738,
-0.04179000481963158,
0.09589722007513046,
-0.05055814981460571,
0.0022118950728327036,
-0.0050737191922962666,
0.017210936173796654,
0.08534815162420273,
-0.029143914580345154,
0.0038833762519061565,
-0.09331732243299484,
0.017002174630761147,
0.03477700799703598,
-0.001517489436082542,
0.003026559017598629,
0.05844282731413841,
0.09958579391241074,
0.014838282018899918,
-0.0044099087826907635,
0.11377041041851044,
0.04079899936914444,
0.11859692633152008,
-0.10069655627012253,
-0.06240063160657883,
-0.014374756254255772,
-0.043110188096761703,
-0.05335595831274986,
0.10281991213560104,
0.051787760108709335,
-0.008153879083693027,
-0.10824029892683029,
-0.0058134994469583035,
0.006937431171536446,
0.06542255729436874,
-0.10815652459859848,
-0.08664713054895401,
-0.041549116373062134,
-0.03149180859327316,
-0.05570053681731224,
-0.0024416521191596985,
0.028808200731873512,
-0.0714917927980423,
-0.030944034457206726,
-0.05603637173771858,
0.01596803404390812,
0.0719035416841507,
-0.00943478662520647,
-0.005982897710055113,
0.021858738735318184,
0.011321581900119781,
0.04660029709339142,
0.0334661640226841,
0.04835205525159836,
-0.0013483650982379913,
-0.025423187762498856,
0.06261694431304932,
-0.0881236344575882,
-0.01882035657763481,
-0.0054214210249483585,
0.023606333881616592,
0.02302350290119648,
-0.0585969053208828,
0.0729232132434845,
-0.0008138096309266984,
-0.04082378372550011,
0.03511872515082359,
-0.06876211613416672,
-0.0006969545502215624,
0.022884849458932877,
-2.2306564673577668e-33,
0.02500871568918228,
0.05055481567978859,
0.050004031509160995,
0.01103919092565775,
-0.020380347967147827,
-0.06886015087366104,
0.026986610144376755,
-0.03459390625357628,
0.0709647610783577,
0.0733024850487709,
-0.09925707429647446,
0.11818044632673264,
-0.021555278450250626,
0.07003851234912872,
-0.007463668938726187,
0.04034030809998512,
-0.015552639029920101,
-0.026106681674718857,
0.029405245557427406,
-0.0258973129093647,
0.04279124364256859,
-0.0032851172145456076,
0.012246459722518921,
0.08524343371391296,
0.03546115383505821,
-0.11626312136650085,
-0.0410032793879509,
-0.09017741680145264,
-0.07343723624944687,
-0.02159721404314041,
-0.007728493306785822,
0.034135714173316956,
0.04575313627719879,
0.018161781132221222,
-0.00866696611046791,
0.0024381952825933695,
-0.0833309143781662,
0.0481456033885479,
0.08865009248256683,
0.030792152509093285,
-0.02498655952513218,
-0.03321810066699982,
0.07600878924131393,
-0.011882576160132885,
0.016330527141690254,
-0.014313457533717155,
0.03376573696732521,
0.011453515850007534,
-0.013368276879191399,
-0.052388276904821396,
0.009955598041415215,
0.02571696974337101,
-0.003676887135952711,
-0.02861006185412407,
0.03213727846741676,
0.05366731807589531,
-0.016980348154902458,
0.009991318918764591,
-0.05991631746292114,
-0.06256776303052902,
-0.010681684128940105,
0.03530450537800789,
0.007038913667201996,
-0.01106725912541151,
-0.02855573780834675,
0.002044564811512828,
-0.0014926883159205317,
0.006375260651111603,
0.02092312090098858,
-0.01778745837509632,
0.025281231850385666,
0.06479023396968842,
-0.0637083500623703,
-0.06497765332460403,
0.07887054979801178,
-0.0027108851354569197,
0.03972998261451721,
-0.06476268172264099,
0.031816933304071426,
0.08506198227405548,
0.018578745424747467,
0.06295696645975113,
-0.10136695951223373,
-0.06991084665060043,
-0.03718876093626022,
-0.04591050371527672,
0.032939810305833817,
-0.006651250645518303,
-0.023204606026411057,
-0.008005364798009396,
0.05859944969415665,
-0.01268041506409645,
0.04815010353922844,
-0.003237393219023943,
0.0003994488506577909,
-7.023486451489529e-34,
0.021053941920399666,
-0.11156163364648819,
0.0760699063539505,
0.008595922961831093,
0.02077997475862503,
0.05312461778521538,
0.024565724655985832,
0.10678956657648087,
0.09198497235774994,
0.07593626528978348,
0.14305394887924194,
0.08538076281547546,
-0.04111291468143463,
-0.01790003478527069,
-0.0024679400958120823,
0.03383170813322067,
-0.042955461889505386,
-0.03168360888957977,
0.02778700925409794,
-0.05310977250337601,
-0.015702812001109123,
0.05444613844156265,
-0.10807258635759354,
-0.00015836568491067737,
-0.014925133436918259,
-0.005304217338562012,
-0.08184776455163956,
0.028276942670345306,
0.04506156966090202,
0.033641014248132706,
0.037451110780239105,
0.011506089009344578,
-0.0010400442406535149,
0.030190229415893555,
-0.031087521463632584,
-0.051742758601903915,
0.04629288613796234,
0.028108227998018265,
0.05704968050122261,
-0.008443423546850681,
-0.0029840997885912657,
-0.004514642059803009,
-0.0884280875325203,
0.015178530476987362,
-0.011800440959632397,
-0.10274935513734818,
-0.02899484895169735,
-0.005422500893473625,
0.040223803371191025,
-0.007638474926352501,
-0.0045486693270504475,
0.04359930008649826,
0.06585026532411575,
-0.07177790999412537,
0.03818337246775627,
0.00031686239526607096,
-0.02301015704870224,
-0.018119391053915024,
0.12755800783634186,
-0.02970259264111519,
-0.010156582109630108,
-0.05905620753765106,
0.09471755474805832,
0.028472181409597397,
-0.046761345118284225,
-0.0011484732385724783,
0.07145676761865616,
0.06743881851434708,
-0.10943566262722015,
-0.04018707945942879,
0.06428362429141998,
0.0614679716527462,
-0.02510351873934269,
-0.08624499291181564,
0.004846864379942417,
-0.052380114793777466,
-0.057486049830913544,
-0.05631883814930916,
-0.034918032586574554,
-0.09572739899158478,
0.11231037229299545,
0.07101132720708847,
-0.10874103009700775,
-0.07361612468957901,
0.08110704272985458,
-0.006490693427622318,
0.05368616804480553,
-0.001835042960010469,
-0.025014076381921768,
-0.02201497182250023,
0.05952779948711395,
0.022679870948195457,
0.034405417740345,
0.05801161006093025,
-0.016261672601103783,
-1.9267135442646577e-08,
-0.020924484357237816,
0.007820600643754005,
0.007650307379662991,
-0.08766214549541473,
-0.03859853744506836,
0.061062734574079514,
-0.022439545020461082,
-0.0050045037642121315,
0.010417941957712173,
-0.03360741212964058,
0.006875474005937576,
0.04897269606590271,
-0.05267564207315445,
5.6691173085710034e-05,
0.08323992788791656,
0.0012997452868148685,
-0.06343551725149155,
-0.05276073142886162,
-0.00644023297354579,
-0.05137207731604576,
-0.06017834320664406,
0.020528316497802734,
-0.06906646490097046,
-0.040461085736751556,
0.01353802066296339,
-0.06068901717662811,
-0.003798737656325102,
-0.07600804418325424,
0.00927174836397171,
-0.007799031678587198,
0.029246604070067406,
0.004852216690778732,
0.09407804161310196,
0.05601438879966736,
0.01980513334274292,
-0.047172557562589645,
0.049496594816446304,
0.019543152302503586,
-0.11856654286384583,
-0.05278535932302475,
-0.00988287478685379,
-0.017975404858589172,
-0.041780922561883926,
-0.05374245345592499,
-0.11366230994462967,
-0.09755972772836685,
0.0486016608774662,
0.0034040820319205523,
-0.07665848731994629,
0.03216847404837608,
-0.013870339840650558,
-0.05115455761551857,
-0.030844850465655327,
-0.042567938566207886,
-0.05529715493321419,
0.0664658173918724,
-0.062231287360191345,
0.029710007831454277,
0.02504698745906353,
-0.03864720091223717,
-0.005119333975017071,
0.0008893916965462267,
0.06500405818223953,
0.06179637834429741
]
}
},
{
"name": "vector_db.query.embeddings.1",
"timestamp": "2024-01-24T20:58:45.906824Z",
"attributes": {
"embeddings": [
0.005728148389607668,
-0.037142518907785416,
0.010478343814611435,
-0.020546674728393555,
0.005048793274909258,
-0.02933703362941742,
-0.07394452393054962,
0.03868193179368973,
-0.018183602020144463,
-0.047038305550813675,
0.01255076751112938,
-0.026517421007156372,
-0.02733997069299221,
-0.015073071233928204,
-0.03914570435881615,
0.04447564855217934,
-0.0653967410326004,
0.0065493518486619,
0.043097663670778275,
-0.05888194218277931,
-0.05868202820420265,
0.07758316397666931,
0.010155952535569668,
-0.004378842655569315,
-0.04622170701622963,
-0.07951498031616211,
0.06903441250324249,
0.07856544107198715,
0.017544684931635857,
-0.07425028830766678,
-0.006266638170927763,
0.12131844460964203,
0.025965698063373566,
-0.004512753803282976,
0.05368775501847267,
0.03977096453309059,
-0.0797034204006195,
-0.007970735430717468,
0.018682220950722694,
-0.046991556882858276,
0.05866941809654236,
0.03728475049138069,
0.02861282229423523,
0.0460393950343132,
-0.020929263904690742,
-0.03632248565554619,
-0.06986626237630844,
0.005301380064338446,
-0.030460862442851067,
0.026238588616251945,
-0.04482783377170563,
-0.05445508286356926,
-0.030705289915204048,
0.004878029227256775,
0.03800278529524803,
-0.08759623020887375,
-0.08918030560016632,
-0.08807501941919327,
0.010659008286893368,
-0.031672731041908264,
-0.011049814522266388,
-0.03753430023789406,
0.0021988865919411182,
-0.06165120750665665,
0.08754667639732361,
0.05429423600435257,
0.12079563736915588,
-0.08585105836391449,
0.07267133891582489,
0.02102687768638134,
-0.016493216156959534,
0.052105873823165894,
-0.04061949625611305,
0.08001447468996048,
0.04297907277941704,
0.09166549146175385,
-0.005793845281004906,
0.002235613064840436,
-0.0015307975700125098,
-0.05423959717154503,
-0.06063491851091385,
-0.037035103887319565,
0.036622099578380585,
0.03682617098093033,
-0.0231026541441679,
-0.036660607904195786,
0.02118821255862713,
0.018164511770009995,
0.014700604602694511,
0.046901535242795944,
-0.060536328703165054,
-0.027094539254903793,
0.12951770424842834,
-0.03002915531396866,
-0.06031958758831024,
0.07126391679048538,
0.07436108589172363,
0.0004690826463047415,
0.03110131248831749,
-0.012121242471039295,
0.020328357815742493,
-0.0008326729875989258,
0.08512859046459198,
0.06462313234806061,
0.011151611804962158,
-0.09254339337348938,
0.06340164691209793,
-0.08519924432039261,
-0.0767589583992958,
-0.06043917313218117,
-0.007428924553096294,
-0.012016749009490013,
0.02545480988919735,
0.03902771696448326,
-0.04153446853160858,
-0.14747291803359985,
-0.016442572697997093,
-0.03152792900800705,
-0.030972536653280258,
0.13567566871643066,
-0.04055787995457649,
-0.04440128430724144,
-0.001063146977685392,
0.0055594732984900475,
-0.08531486988067627,
0.014212393201887608,
-0.09641949087381363,
-1.3267862134916258e-34,
-0.005696226377040148,
-0.007650041952729225,
0.07282443344593048,
0.09956885129213333,
0.05205835402011871,
-0.08762653172016144,
-0.015024934895336628,
-0.004225614946335554,
-0.13287873566150665,
0.020597398281097412,
-0.05567470192909241,
-0.02047988586127758,
0.0033038067631423473,
0.09815693646669388,
-0.032038696110248566,
0.00610253494232893,
-0.009151970967650414,
0.061824411153793335,
-0.09529709070920944,
0.004432846326380968,
0.00030033226357772946,
-0.005098886322230101,
-0.030059002339839935,
-0.06145535036921501,
0.04627249389886856,
0.001126744318753481,
0.026511678472161293,
0.03196508064866066,
0.029882756993174553,
0.01305706612765789,
-0.03284737467765808,
0.04529442638158798,
-0.009194411337375641,
0.0212701465934515,
0.0032504484988749027,
0.08568450063467026,
0.09438759088516235,
-0.09567059576511383,
0.037338465452194214,
0.14377917349338531,
-0.01038413867354393,
0.0674123615026474,
0.03219537064433098,
-0.05247604846954346,
0.0617513433098793,
0.008856016211211681,
-0.0010508995037525892,
0.06500495225191116,
-0.06660547107458115,
0.02585306391119957,
-0.09096821397542953,
0.02815878950059414,
-0.045193325728178024,
0.03152628242969513,
0.012939431704580784,
-0.1318662017583847,
-0.059212248772382736,
-0.051124896854162216,
0.046509407460689545,
0.06223728135228157,
-0.01730969548225403,
0.00037205967237241566,
-0.010615820065140724,
0.02443629875779152,
0.04143765941262245,
-0.014814646914601326,
0.018328329548239708,
0.008082114160060883,
-0.009242560714483261,
0.08657275885343552,
0.04203624278306961,
-0.14003193378448486,
0.0186383668333292,
-0.06821178644895554,
-0.03444230183959007,
-0.033978138118982315,
0.05729173496365547,
0.032091714441776276,
-0.018803143873810768,
0.0486232228577137,
-0.08477437496185303,
0.032505061477422714,
-0.07026822119951248,
-0.016176093369722366,
-0.060280948877334595,
-0.06833910197019577,
0.02923189476132393,
-0.010483803227543831,
-0.06267906725406647,
-0.05823889002203941,
0.10997578501701355,
0.020207375288009644,
-0.05436159670352936,
-0.03757871687412262,
0.004412309266626835,
-2.1153322063474462e-33,
-0.10450656712055206,
0.02593368850648403,
0.0015025843167677522,
-0.02648227848112583,
-0.05568664148449898,
-0.03390875831246376,
0.005070575512945652,
0.009025507606565952,
-0.02830699272453785,
-0.05037091299891472,
0.024697815999388695,
0.005261321552097797,
0.04097600653767586,
-0.09645752608776093,
-0.07286123931407928,
-0.003317302092909813,
-0.014573381282389164,
0.05229075998067856,
0.004904903471469879,
0.04279924929141998,
0.07458241283893585,
0.03606468811631203,
0.025750737637281418,
0.0589170828461647,
-0.011172430589795113,
0.03127945587038994,
-0.06431350857019424,
0.017576999962329865,
-0.04057959094643593,
-0.011531435884535313,
-0.11524464190006256,
0.032880499958992004,
0.019702544435858727,
-0.030924810096621513,
0.004504518583416939,
-0.00225671730004251,
0.06901004910469055,
0.06852398812770844,
-0.02405381016433239,
0.011553118005394936,
-0.03575905039906502,
0.06998676061630249,
-0.02074601873755455,
0.0017237954307347536,
0.007257440593093634,
0.06082160398364067,
0.06326586753129959,
-0.015346232801675797,
0.08588962256908417,
-0.006088640540838242,
0.08064877986907959,
0.05954253301024437,
0.006188937928527594,
-0.01041751354932785,
-0.01090571004897356,
-0.08654823154211044,
0.05413242056965828,
-0.028786592185497284,
-0.04093560948967934,
0.06452414393424988,
-0.07000669091939926,
-0.042385783046483994,
0.05684937164187431,
0.04569469019770622,
0.019043756648898125,
-0.06470111012458801,
-0.046500351279973984,
-0.04100808501243591,
0.0006227375124581158,
-0.01825111359357834,
-0.022607194259762764,
-0.052275050431489944,
0.046335071325302124,
-0.03843308985233307,
0.03299693390727043,
-0.05861878767609596,
-0.062054622918367386,
-0.0003136731102131307,
-0.026944389566779137,
0.0038397449534386396,
0.045530471950769424,
-0.0439116545021534,
0.06065814942121506,
0.028744883835315704,
0.020293420180678368,
0.05387347191572189,
0.007558911107480526,
0.025406014174222946,
0.021957529708743095,
0.05169779062271118,
-0.03887337073683739,
0.013470379635691643,
-0.04481023922562599,
-0.01591533049941063,
-0.031336359679698944,
-2.56318095637198e-08,
0.04409157112240791,
0.02728934772312641,
0.009511432610452175,
0.022594697773456573,
-0.006081205792725086,
0.021482307463884354,
-0.10873822867870331,
0.08764041215181351,
0.025088049471378326,
0.027626631781458855,
0.06391289830207825,
0.03012484312057495,
-0.0097502451390028,
0.05561535805463791,
0.09619596600532532,
0.07260488718748093,
-0.013517232611775398,
0.007463208399713039,
-0.019498389214277267,
0.08523713797330856,
-0.08583492785692215,
0.04100168123841286,
0.032644785940647125,
-0.020627863705158234,
0.07197970896959305,
-0.02990262769162655,
0.000843127490952611,
0.0018735630437731743,
0.046009231358766556,
-0.06668579578399658,
0.02415579929947853,
-0.10177341848611832,
-0.022457225248217583,
0.03166576102375984,
-0.026569034904241562,
0.04291447252035141,
-0.03908227011561394,
0.004701282363384962,
-0.0630236491560936,
0.04454032704234123,
0.00730627216398716,
-0.056013140827417374,
-0.04252802953124046,
0.04030575975775719,
-0.05024595558643341,
-0.041632696986198425,
0.005064948927611113,
-0.03488202765583992,
-0.014233816415071487,
-0.028366921469569206,
-0.051726408302783966,
0.022979333996772766,
0.03829807788133621,
0.020846623927354813,
0.0862651988863945,
0.08527805656194687,
0.026096509769558907,
0.00535836536437273,
0.06102072075009346,
-0.01408446580171585,
0.10113329440355301,
0.024707848206162453,
-0.04266061633825302,
-0.03976547345519066
]
}
}
],
"links": [],
"resource": {
"attributes": {
"service.name": "chroma_sentence_transformer_app"
},
"schema_url": ""
}
}
{
"name": "chroma.query",
"context": {
"trace_id": "0x4131c545ba764b2bfcaa62376a7ed613",
"span_id": "0x4d12fbcc05e33c9b",
"trace_state": "[]"
},
"kind": "SpanKind.INTERNAL",
"parent_id": "0xa6b1d0b55ed23723",
"start_time": "2024-01-24T20:58:45.898007Z",
"end_time": "2024-01-24T20:58:45.908975Z",
"status": {
"status_code": "UNSET"
},
"attributes": {
"traceloop.workflow.name": "assess_claims",
"db.system": "chroma",
"db.operation": "query",
"db.chroma.query.query_texts_count": 2,
"db.chroma.query.n_results": 3,
"db.chroma.query.include": "['documents', 'distances']"
},
"events": [
{
"name": "db.chroma.query.result.0",
"timestamp": "2024-01-24T20:58:45.908955Z",
"attributes": {
"ids": [
"36474",
"4983",
"19238"
],
"distances": [
1.7072678804397583,
1.7307904958724976,
1.7318367958068848
],
"metadata": [],
"documents": [
"Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Realizing the full potential of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) requires efficient methods for genetic modification. However, techniques to generate cell type\u2013specific lineage reporters, as well as reliable tools to disrupt, repair or overexpress genes by gene targeting, are inefficient at best and thus are not routinely used. Here we report the highly efficient targeting of three genes in human pluripotent cells using zinc-finger nuclease (ZFN)\u2013mediated genome editing. First, using ZFNs specific for the OCT4 (POU5F1) locus, we generated OCT4-eGFP reporter cells to monitor the pluripotent state of hESCs. Second, we inserted a transgene into the AAVS1 locus to generate a robust drug-inducible overexpression system in hESCs. Finally, we targeted the PITX3 gene, demonstrating that ZFNs can be used to generate reporter cells by targeting non-expressed genes in hESCs and hiPSCs.",
"Microstructural development of human newborn cerebral white matter assessed in vivo by diffusion tensor magnetic resonance imaging.. Alterations of the architecture of cerebral white matter in the developing human brain can affect cortical development and result in functional disabilities. A line scan diffusion-weighted magnetic resonance imaging (MRI) sequence with diffusion tensor analysis was applied to measure the apparent diffusion coefficient, to calculate relative anisotropy, and to delineate three-dimensional fiber architecture in cerebral white matter in preterm (n = 17) and full-term infants (n = 7). To assess effects of prematurity on cerebral white matter development, early gestation preterm infants (n = 10) were studied a second time at term. In the central white matter the mean apparent diffusion coefficient at 28 wk was high, 1.8 microm2/ms, and decreased toward term to 1.2 microm2/ms. In the posterior limb of the internal capsule, the mean apparent diffusion coefficients at both times were similar (1.2 versus 1.1 microm2/ms). Relative anisotropy was higher the closer birth was to term with greater absolute values in the internal capsule than in the central white matter. Preterm infants at term showed higher mean diffusion coefficients in the central white matter (1.4 +/- 0.24 versus 1.15 +/- 0.09 microm2/ms, p = 0.016) and lower relative anisotropy in both areas compared with full-term infants (white matter, 10.9 +/- 0.6 versus 22.9 +/- 3.0%, p = 0.001; internal capsule, 24.0 +/- 4.44 versus 33.1 +/- 0.6% p = 0.006). Nonmyelinated fibers in the corpus callosum were visible by diffusion tensor MRI as early as 28 wk; full-term and preterm infants at term showed marked differences in white matter fiber organization. The data indicate that quantitative assessment of water diffusion by diffusion tensor MRI provides insight into microstructural development in cerebral white matter in living infants.",
"The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems.. Two human Golli (for gene expressed in the oligodendrocyte lineage)-MBP (for myelin basic protein) cDNAs have been isolated from a human oligodendroglioma cell line. Analysis of these cDNAs has enabled us to determine the entire structure of the human Golli-MBP gene. The Golli-MBP gene, which encompasses the MBP transcription unit, is approximately 179 kb in length and consists of 10 exons, seven of which constitute the MBP gene. The human Golli-MBP gene contains two transcription start sites, each of which gives rise to a family of alternatively spliced transcripts. At least two Golli-MBP transcripts, containing the first three exons of the gene and one or more MBP exons, are produced from the first transcription start site. The second family of transcripts contains only MBP exons and produces the well-known MBPs. In humans, RNA blot analysis revealed that Golli-MBP transcripts were expressed in fetal thymus, spleen, and human B-cell and macrophage cell lines, as well as in fetal spinal cord. These findings clearly link the expression of exons encoding the autoimmunogen/encephalitogen MBP in the central nervous system to cells and tissues of the immune system through normal expression of the Golli-MBP gene. They also establish that this genetic locus, which includes the MBP gene, is conserved among species, providing further evidence that the MBP transcription unit is an integral part of the Golli transcription unit and suggest that this structural arrangement is important for the genetic function and/or regulation of these genes."
]
}
},
{
"name": "db.chroma.query.result.1",
"timestamp": "2024-01-24T20:58:45.908970Z",
"attributes": {
"ids": [
"18670",
"54440",
"36474"
],
"distances": [
1.2687351703643799,
1.284802794456482,
1.388622522354126
],
"metadata": [],
"documents": [
"The DNA Methylome of Human Peripheral Blood Mononuclear Cells. DNA methylation plays an important role in biological processes in human health and disease. Recent technological advances allow unbiased whole-genome DNA methylation (methylome) analysis to be carried out on human cells. Using whole-genome bisulfite sequencing at 24.7-fold coverage (12.3-fold per strand), we report a comprehensive (92.62%) methylome and analysis of the unique sequences in human peripheral blood mononuclear cells (PBMC) from the same Asian individual whose genome was deciphered in the YH project. PBMC constitute an important source for clinical blood tests world-wide. We found that 68.4% of CpG sites and <0.2% of non-CpG sites were methylated, demonstrating that non-CpG cytosine methylation is minor in human PBMC. Analysis of the PBMC methylome revealed a rich epigenomic landscape for 20 distinct genomic features, including regulatory, protein-coding, non-coding, RNA-coding, and repeat sequences. Integration of our methylome data with the YH genome sequence enabled a first comprehensive assessment of allele-specific methylation (ASM) between the two haploid methylomes of any individual and allowed the identification of 599 haploid differentially methylated regions (hDMRs) covering 287 genes. Of these, 76 genes had hDMRs within 2 kb of their transcriptional start sites of which >80% displayed allele-specific expression (ASE). These data demonstrate that ASM is a recurrent phenomenon and is highly correlated with ASE in human PBMCs. Together with recently reported similar studies, our study provides a comprehensive resource for future epigenomic research and confirms new sequencing technology as a paradigm for large-scale epigenomics studies.",
"Empirical Bayesian models for analysing molecular serotyping microarrays. BACKGROUND Microarrays offer great potential as a platform for molecular diagnostics, testing clinical samples for the presence of numerous biomarkers in highly multiplexed assays. In this study applied to infectious diseases, data from a microarray designed for molecular serotyping of Streptococcus pneumoniae was used, identifying the presence of any one of 91 known pneumococcal serotypes from DNA extracts. This microarray incorporated oligonucleotide probes for all known capsular polysaccharide synthesis genes and required a statistical analysis of the microarray intensity data to determine which serotype, or combination of serotypes, were present within a sample based on the combination of genes detected. \n RESULTS We propose an empirical Bayesian model for calculating the probabilities of combinations of serotypes from the microarray data. The model takes into consideration the dependencies between serotypes, induced by genes they have in common, and by homologous genes which, although not identical, are similar to each other in sequence. For serotypes which are very similar in capsular gene composition, extra probes are included on the microarray, providing additional information which is integrated into the Bayesian model. For each serotype combination with high probability, a second model, a Bayesian random effects model is applied to determine the relative abundance of each serotype. \n CONCLUSIONS To assess the accuracy of the proposed analysis we applied our methods to experimental data from samples containing individual serotypes and samples containing combinations of serotypes with known levels of abundance. All but two of the known serotypes of S. pneumoniae that were tested as individual samples could be uniquely determined by the Bayesian model. The model also enabled the presence of combinations of serotypes within samples to be determined. Serotypes with very low abundance within a combination of serotypes can be detected (down to 2% abundance in this study). As well as detecting the presence of serotype combinations, an approximate measure of the percentage abundance of the serotypes within the combination can be obtained.",
"Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Realizing the full potential of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) requires efficient methods for genetic modification. However, techniques to generate cell type\u2013specific lineage reporters, as well as reliable tools to disrupt, repair or overexpress genes by gene targeting, are inefficient at best and thus are not routinely used. Here we report the highly efficient targeting of three genes in human pluripotent cells using zinc-finger nuclease (ZFN)\u2013mediated genome editing. First, using ZFNs specific for the OCT4 (POU5F1) locus, we generated OCT4-eGFP reporter cells to monitor the pluripotent state of hESCs. Second, we inserted a transgene into the AAVS1 locus to generate a robust drug-inducible overexpression system in hESCs. Finally, we targeted the PITX3 gene, demonstrating that ZFNs can be used to generate reporter cells by targeting non-expressed genes in hESCs and hiPSCs."
]
}
}
],
"links": [],
"resource": {
"attributes": {
"service.name": "chroma_sentence_transformer_app"
},
"schema_url": ""
}
}
{
"name": "assess_claims.workflow",
"context": {
"trace_id": "0x4131c545ba764b2bfcaa62376a7ed613",
"span_id": "0xa6b1d0b55ed23723",
"trace_state": "[]"
},
"kind": "SpanKind.INTERNAL",
"parent_id": null,
"start_time": "2024-01-24T20:58:45.897952Z",
"end_time": "2024-01-24T20:58:45.909181Z",
"status": {
"status_code": "UNSET"
},
"attributes": {
"traceloop.workflow.name": "assess_claims",
"traceloop.span.kind": "workflow",
"traceloop.entity.name": "assess_claims"
},
"events": [],
"links": [],
"resource": {
"attributes": {
"service.name": "chroma_sentence_transformer_app"
},
"schema_url": ""
}
}
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment