SafePrefabInstantiate.cs

    public static GameObject SafePrefabInstantiate(GameObject reference){
        return SafePrefabInstantiate(reference,Vector3.zero,Quaternion.identity);
    }

public static GameObject SafePrefabInstantiate (GameObject reference, 
                                                    Vector3 position,
                                                    Quaternion rotation) {
        #if UNITY_EDITOR
        if (Application.isPlaying) {
            return GameObject.Instantiate(reference, position, rotation);
        } else {
            GameObject obj = PrefabUtility.InstantiatePrefab(reference) as GameObject;
            obj.transform.position = position;
            obj.transform.rotation = rotation;
            return obj;
        }
        #else
        return Instantiate(reference);
        #endif
    }