App.cs

using System;
using Xamarin.Forms;

namespace TheGridTest
{
	public class App
	{
		public static Page GetMainPage ()
		{	

			Grid grid = new Grid
			{
				Padding = 50,
				VerticalOptions = LayoutOptions.FillAndExpand,
				HorizontalOptions = LayoutOptions.FillAndExpand,
				RowDefinitions = 
				{
					new RowDefinition { Height = new GridLength(100, GridUnitType.Absolute) },
					new RowDefinition { Height = new GridLength(100, GridUnitType.Absolute) }
				},
				ColumnDefinitions = 
				{
					new ColumnDefinition { Width = new GridLength(1, GridUnitType.Star) },
					new ColumnDefinition { Width = new GridLength(1, GridUnitType.Star) }
				},
				RowSpacing = 15
			};

			var lbl1 = new Label {
				Text = "One"
			};

			var lbl2 = new Label {
				Text = "Two",
				VerticalOptions = LayoutOptions.Center
			};

			var lbl3 = new Label {
				Text = "Three"
			};

			var lbl4 = new Label {
				VerticalOptions = LayoutOptions.End,
				Text = "Four"
			};

			grid.Children.Add (lbl1, 0, 0);
			grid.Children.Add (lbl2, 1, 0);
			grid.Children.Add (lbl3, 0, 1);
			grid.Children.Add (lbl4, 1, 1);


			return new ContentPage { 
				Content = grid
			};
		}
	}
}