PySide2 Script to Find Nuke's Main Window: This script iterates through top-level widgets to locate the main window, enabling further customization or interaction through Python.

get_nuke_main_window.py

from PySide2 import QtWidgets


def GetNukeMainWindow():
    """Finds and returns the main Nuke window.

    Iterates through all top-level widgets, checking for the Nuke main window
    based on its class name.

    Returns:
        QtWidgets.QWidget: The found main window of Nuke, or None if not found.
    """
    for widget in QtWidgets.QApplication.instance().topLevelWidgets():
        if widget.metaObject().classname() != 'Foundry::UI::DockMainWindow':
            continue
        return widget

    
if __name__ == '__main__':
    nuke_main_window = get_nuke_main_window()
    _override_shortkey = QtWidgets.QShortCut(QtGui.QKeySequence('Ctrl+q', nuke_main_window)