Use the scroll wheel the way it was intended. Run as an Administrator. This configures all mice scroll wheels to use Natural Scrolling or Australian Scrolling. Instead of the mouse wheel controlling the scrollbar thumb, it relates to the content you're viewing. Up on the scroll wheel equates to scrolling the page up.

NaturalScrolling.ps1

$mice = Get-PnpDevice | Where-Object {$_.FriendlyName -like "*mouse*"}
$updatedMice = @()

$ErrorActionPreference = "Stop"
foreach ($mouse in $mice) {
    $mouseDeviceParametersPath = $(Join-Path $(Join-Path "HKLM:\SYSTEM\CurrentControlSet\Enum\" $mouse.InstanceId) "Device Parameters")
    $mouseDeviceParameters = Get-ItemProperty $mouseDeviceParametersPath

    $flipFlopWheel = $mouseDeviceParameters.FlipFlopWheel

    if (($null -ne $flipFlopWheel) -And (0 -eq $flipFlopWheel)) {
        $flipFlopWheel = 1
        Set-ItemProperty $mouseDeviceParametersPath -Name "FlipFlopWheel" -Value $flipFlopWheel
        $updatedMice += $mouse
    }
}

if ($updatedMice.Count -gt 0) {
    foreach ($mouse in $updatedMice) {
        Write-Host "Disabling $(($mouse).FriendlyName)"
        $mouse | Disable-PnpDevice -Confirm:$false
    }

    Start-Sleep -Seconds 5

    foreach ($mouse in $updatedMice) {
        Write-Host "Enabling $(($mouse).FriendlyName)"
        $mouse | Enable-PnpDevice -Confirm:$false
    }
}

Updated to be a little smarter about how it changes parameters. This will only disable and then reenable if the mouse setting needed to be updated. This should clean up some of the noise and provides a cleaner output when this is ran.