http://beautyindesign.com/titanium/handling-html5-audio/

app.js

Ti.App.addEventListener("playSound", function(_event) {
	var soundPlayer = Ti.Media.createSound({
	    url: "/game/" + _event.soundFile
	});
	soundPlayer.play();

	soundPlayer.addEventListener("complete", function() {
		if(OS_ANDROID) {
			soundPlayer.release();
		}
	});
});

audioHTML5.js

var snd = new Audio( mySoundFile );
snd.load();
snd.play();

playSound.js

playSound: function(_soundFilePath) {
	if(Globals.GAMETYPE === "titanium") {
		Ti.App.fireEvent("playSound", {
			soundFile: _soundFilePath
		});
	} else {
		var snd = new Audio( _soundFilePath );
		snd.load();
		snd.play();
	}
}