Change values in a spreadsheet from a Python dictionary of old to new values

changespreadsheet.py

import re
import win32com.client as c

subs = """
One|1
Two|2
""".splitlines()

subs = {k: v for k, v in [y.split('|') for y in subs if len(y) > 0]}
xlApp = c.gencache.EnsureDispatch('Excel.Application')
xlApp.Visible = True
path = r'path.xlsx'
wk = xlApp.Workbooks.Open(path)
sh = wk.Worksheets('Sheet1 (2)')

eof = sh.Range('A65535').End(-4162).Row
for row in range(2,eof+1):
    for org, rep in subs.items():
        rx = re.compile(r'{0:s}'.format(org))
        desc = sh.Range(f'C{row}').Value
        if rx.search(desc):
            desc = re.sub(org, rep, desc)
            sh.Range(f'I{row}').Value = desc