Should probably be in every virtualenv, and always kept up to date: Pip Werkzeug PIL yolk Packages that may not be in virtualenv, but still installed via pip: ipdb ipython PyYaml rope ropemacs ropemode pyflakes pymacs mercurial pysqlite psycopg2 paramiko grin Not sure: (fabric, crypto, paramiko) python_dateutil Pip Werkzeug PIL