Google Native Client (NaCl) uses Software Fault Isolation (SFI) to sandbox untrusted native code. Each supported architecture has a unique SFI implementation. The closest existing analogy for ppc64le is the MIPS 32-bit port: both use fixed-length instructions, pure software isolation (no hardware segments), and dedicated mask registers.
NaCl currently supports: x86-32 (hardware segments), x86-64 (base register + zero-extension), ARM 32-bit (bic masking), and MIPS 32-bit (mask registers). No PPC support has ever existed.