Django + FCGI + Virtualenv on SUSE/RH. I use Ubuntu, but some customers have annoying policies about linux distros. Can't run Python 2.7 with mod_wsgi because the customer already has another python app using 2.6; my solution was resort to FCGI. Kind of like it, performance is not bad at all.

project_name.conf

<VirtualHost *:80>
    ServerAdmin admin@project_name.com
    ServerName project_name.com
    ServerAlias www.project_name.com

    # DocumentRoot: not the django project root, just to be safe
    DocumentRoot /var/app/project_name/fcgi

    # Logs
    ErrorLog /var/log/apache2/project_name-error_log
    CustomLog /var/log/apache2/project_name-access_log combined

    # don't loose time with IP address lookups
    HostnameLookups Off

    # needed for named virtual hosts
    UseCanonicalName Off

    # configures the footer on server-generated documents
    ServerSignature On

    # Media
    Alias /robots.txt /var/app/project_name/static/robots.txt
    Alias /static/ /var/app/project_name/static/
    <Directory "/var/app/project_name/static">
                Options FollowSymLinks
                AllowOverride None
                Order allow,deny
                Allow from all
    </Directory>
    Alias /media/ /var/app/project_name/media/
    <Directory "/var/app/project_name/media">
                Options FollowSymLinks
                AllowOverride None
                Order allow,deny
                Allow from all
    </Directory>

    DefaultInitEnv DEBUG 1
    DefaultInitEnv DB_HOST your_database_host
    DefaultInitEnv DB_USER your_database_username
    DefaultInitEnv DB_NAME your_database_name
    DefaultInitEnv DB_DRIVER postgresql_psycopg2
    DefaultInitEnv DB_PASS your_password
    DefaultInitEnv PATH /usr/bin:/bin

    <Directory /var/app/project_name/fcgi>
        AddHandler fcgid-script .fcgi
        Options FollowSymLinks +ExecCgi
        Order deny,allow
        Allow from all
        RewriteEngine On
        RewriteBase /
        RewriteCond %{REQUEST_URI} !(project_name.fcgi)
        RewriteRule ^(.*)$ project_name.fcgi/$1 [QSA,L]
    </Directory>

</VirtualHost>
                                                          

project_name.fcgi

#!/var/lib/python-virtualenvs/project_name/bin/python
import sys, os

import site
# Add the site-packages of the chosen virtualenv to work with
site.addsitedir('/var/lib/python-virtualenvs/project_name/lib/python2.7/site-packages')

activate_env=os.path.expanduser("/var/lib/python-virtualenvs/project_name/bin/activate_this.py")
execfile(activate_env, dict(__file__=activate_env))

# Add a custom Python path.
sys.path.insert(0, "/var/app/project_name")

# Switch to the directory of your project. (Optional.)
os.chdir("/var/app/project_name")

# Set the DJANGO_SETTINGS_MODULE environment variable.
os.environ.setdefault("DJANGO_SETTINGS_MODULE", "project_name.settings")

from django.core.servers.fastcgi import runfastcgi
runfastcgi(method="threaded", daemonize="false", environ=os.environ)

wsgi.py

import os

os.environ.setdefault("DJANGO_SETTINGS_MODULE", "project_name.settings")

from django.core.wsgi import get_wsgi_application
_application = get_wsgi_application()


def application(environ, start_response):
    for var in ('DEBUG', 'DB_DRIVER', 'DB_HOST', 'DB_NAME', 'DB_USER', 'DB_PASS', 'BROKER_URL', 'PHANTOM_URL',
                'SECRET_KEY', 'SITE_ID'):
        if var not in os.environ:
            os.environ[var] = environ[var]
    return _application(environ, start_response)