Looking at both a simple by-hand JSON serialization, and an "automatic" serialization via mirrors. Note: this is by design extremely limited and only for illustration in a mailing list thread. Your need are almost certainly different and will need something custom.

simple_serialization_tests.dart

import 'dart:convert';
import 'package:smoke/smoke.dart' as smoke;

@MirrorsUsed(targets: const [SimpleWithMirrors, Simple], override: '*')
import 'dart:mirrors';

class Simple {
  int id;
  String name;

  Simple();

  Simple.fromJson(Map json)
    : id = json['id'],
      name = json['name'];

  toJson() => {'id': id, 'name': name};
}

abstract class Serializable {
  static fromJson(object, Map json) {
    json.forEach((k, v) {
      smoke.write(object, smoke.nameToSymbol(k), v);
    });
    return object;
  }

  Map toJson() {
    var options = new smoke.QueryOptions(includeProperties: false);
    var res = smoke.query(runtimeType, options);
    var map = {};
    res.forEach((r) => map[smoke.symbolToName(r.name)] = smoke.read(this, r.name));
    return map;
  }
}

class SimpleWithMirrors extends Object with Serializable {
  int id;
  String name;
}

main() {
  var simple = new Simple()
    ..id = 1
    ..name = 'simple';

  var jsonString = JSON.encode(simple);

  print(jsonString);

  var s2 = new Simple.fromJson(JSON.decode(jsonString));

  print(s2);

  var s3 = new SimpleWithMirrors()
    ..id = 1
    ..name = 'simpleWithMirrors';
  var map = s3.toJson();
  print(map);
  var newJson = JSON.encode(map);

  var s4 = Serializable.fromJson(new SimpleWithMirrors(), JSON.decode(newJson));
  print(s4);

}