Some journals require a table of contents or highlights graphic in TIFF format. If you use Inkscape to generate such images on a Linux box like I do, then the following script (thanks to Matsen https://gist.github.com/matsen/4263955) is quite helpful in generating unbloated TIFF files with 300dpi.

svg2tiff.sh

#!/bin/sh

# Convert all arguments (assumed SVG) to a TIFF acceptable to PLOS
# Requires Inkscape and ImageMagick 6.8 (doesn't work with 6.6.9)

for i in $(ls *.svg | cut -d. -f1); do
  inkscape --without-gui --export-png="${i}.png" --export-dpi 300 --export-area-drawing ${i}.svg
  convert -compress LZW -alpha remove -trim ${i}.png ${i}.tiff
  mogrify -alpha off -geometry 1000x ${i}.tiff
  rm ${i}.png
done