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| [('R_group_phosphotase_3', 'R group phosphotase 3'), | |
| ('r0068', | |
| 'Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1'), | |
| ('r0082', | |
| 'Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42'), | |
| ('r0083', | |
| 'Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42'), | |
| ('r0084', | |
| 'Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42'), | |
| ('r0097', 'Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1'), | |
| ('r0163', | |
| '2-oxoglutarate dehydrogenase E1 component Citrate cycle (TCA cycle) EC:1.2.4.2'), | |
| ('r0196', | |
| 'Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37'), | |
| ('r0220', | |
| 'Propinol adenylate:CoA ligase (AMP-forming) Propanoate metabolism EC:6.2.1.17 EC:6.2.1.1'), | |
| ('r0221', | |
| 'Propinol adenylate:CoA ligase (AMP-forming) Propanoate metabolism EC:6.2.1.17'), | |
| ('r0242', | |
| 'Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1'), | |
| ('r0246', | |
| 'Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2'), | |
| ('r0267', | |
| 'CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2'), | |
| ('r0268', | |
| 'cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2'), | |
| ('r0317', | |
| 'citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4'), | |
| ('r0318', | |
| 'Propanoate:CoA ligase (AMP-forming) Propanoate metabolism EC:6.2.1.1 EC:6.2.1.17'), | |
| ('r0319', | |
| 'Propanoate:CoA ligase (AMP-forming) Propanoate metabolism EC:6.2.1.1 EC:6.2.1.17'), | |
| ('r0339', | |
| 'ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31'), | |
| ('r0340', | |
| 'ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31'), | |
| ('r0380', | |
| 'Lactose 6-phosphate galactohydrolase Galactose metabolism EC:3.2.1.23'), | |
| ('r0383', | |
| 'pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating) EC:1.2.4.1'), | |
| ('r0384', | |
| '2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2'), | |
| ('r0385', | |
| '3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4'), | |
| ('r0386', | |
| '4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4'), | |
| ('r0390', | |
| 'Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10'), | |
| ('r0392', | |
| 'D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3'), | |
| ('r0393', | |
| 'D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3'), | |
| ('r0400', | |
| 'N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2'), | |
| ('r0407', | |
| 'Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13'), | |
| ('r0408', 'ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11'), | |
| ('r0409', 'UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11'), | |
| ('r0422', | |
| 'Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42'), | |
| ('r0423', | |
| 'Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42'), | |
| ('r0424', | |
| 'Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42'), | |
| ('r0425', 'EC:1.1.1.42'), | |
| ('r0426', | |
| 'isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3'), | |
| ('r0451', | |
| '2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) Lysine degradation EC:1.2.4.2'), | |
| ('r0465', | |
| 'L-Histidine:4-aminobutanoate ligase (AMP-forming) Urea cycle and metabolism of amino groups EC:6.3.2.11'), | |
| ('r0466', | |
| 'alpha-Aminobutyryl histidine hydrolase Urea cycle and metabolism of amino groups EC:3.4.13.3'), | |
| ('r0510', | |
| 'steroyl-CoA,hydrogen-donor:oxygen oxidoreductase Polyunsaturated fatty acid biosynthesis EC:1.14.19.1'), | |
| ('r0511', | |
| 'steroyl-CoA,hydrogen-donor:oxygen oxidoreductase Polyunsaturated fatty acid biosynthesis EC:1.14.19.1'), | |
| ('r0517', | |
| 'Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37'), | |
| ('r0546', | |
| 'Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39'), | |
| ('r0548', | |
| 'Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5'), | |
| ('r0555', | |
| 'acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase Glycolysis / Gluconeogenesis / Alanine and aspartate metabolism / Pyruvate metabolism EC:2.3.1.12'), | |
| ('r0556', | |
| 'succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61'), | |
| ('r0557', | |
| 'Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61'), | |
| ('r0558', | |
| 'Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29'), | |
| ('r0559', 'aldehyde oxidase Tyrosine metabolism EC:1.2.3.1'), | |
| ('r0587', | |
| '4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1'), | |
| ('r0598', | |
| 'L-Fucose ketol-isomerase Fructose and mannose metabolism EC:5.3.1.25'), | |
| ('r0604', | |
| '(S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168'), | |
| ('r0610', | |
| 'CTP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11'), | |
| ('r0611', | |
| 'ITP:D-Tagatose 6-phosphate 1-phosphotransferase Galactose metabolism EC:2.7.1.11'), | |
| ('r0620', | |
| '2-oxoglutarate dehydrogenase E1 component Citrate cycle (TCA cycle) EC:1.2.4.2'), | |
| ('r0627', | |
| 'Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23'), | |
| ('r0642', | |
| '(S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3'), | |
| ('r0644', | |
| '(S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1'), | |
| ('r0648', | |
| '(5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Cyanoamino acid metabolism EC:2.3.2.2'), | |
| ('r0649', | |
| '(5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Cyanoamino acid metabolism EC:2.3.2.2'), | |
| ('r0656', | |
| '3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168'), | |
| ('r0668', | |
| 'CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43'), | |
| ('r0670', | |
| '(S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4'), | |
| ('r0683', | |
| 'Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3'), | |
| ('r0707', | |
| '2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1'), | |
| ('r0716', | |
| '(S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17'), | |
| ('r0737', '3-Ketolactose galactohydrolase Galactose metabolism EC:3.2.1.23'), | |
| ('r0752', | |
| '3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5'), | |
| ('r0753', | |
| '3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5'), | |
| ('r0754', | |
| '3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5'), | |
| ('r0755', | |
| '3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5'), | |
| ('r0756', | |
| '3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5'), | |
| ('r0757', | |
| '3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5'), | |
| ('r0774', | |
| 'Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37'), | |
| ('r0775', | |
| 'Formamidopyrimidine nucleoside triphosphate 7,8-8,9-dihydrolase Folate biosynthesis EC:3.5.4.16'), | |
| ('r0779', '3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4'), | |
| ('r0795', 'Spontaneous reaction'), | |
| ('r0800', 'Virtual reaction/potential definition'), | |
| ('r1109', | |
| 'Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6'), | |
| ('r1135', | |
| 'hydroxysteroid (17-beta) dehydrogenase 7 Biosynthesis of steroids EC:1.1.1.270'), | |
| ('r1164', 'EC:2.3.1.26'), | |
| ('r1165', 'EC:2.3.1.26'), | |
| ('r1166', 'EC:2.3.1.26'), | |
| ('r1167', 'EC:2.3.1.26'), | |
| ('r1168', 'EC:2.3.1.26'), | |
| ('r1169', 'EC:2.3.1.26'), | |
| ('r1170', 'EC:2.3.1.26'), | |
| ('r1171', 'EC:2.3.1.26'), | |
| ('r1172', 'EC:3.1.1.13'), | |
| ('r1173', 'EC:3.1.1.13'), | |
| ('r1174', 'EC:3.1.1.13'), | |
| ('r1175', 'EC:3.1.1.13'), | |
| ('r1176', 'EC:3.1.1.13'), | |
| ('r1177', 'EC:3.1.1.13'), | |
| ('r1178', 'EC:3.1.1.13'), | |
| ('r1179', 'EC:3.1.1.13'), | |
| ('r1180', 'EC:3.1.1.13'), | |
| ('r1181', 'EC:3.1.1.13'), | |
| ('r1182', 'EC:3.1.1.13'), | |
| ('r1183', 'EC:3.1.1.13'), | |
| ('r1184', 'EC:3.1.1.13'), | |
| ('r1321', 'Virtual reaction/potential definition'), | |
| ('r1322', 'Virtual reaction/potential definition'), | |
| ('r1323', 'Virtual reaction/potential definition'), | |
| ('r1324', 'Virtual reaction/potential definition'), | |
| ('r1325', 'Virtual reaction/potential definition'), | |
| ('r1326', 'Virtual reaction/potential definition'), | |
| ('r1327', 'Virtual reaction/potential definition'), | |
| ('r1328', 'Virtual reaction/potential definition'), | |
| ('r1329', 'Virtual reaction/potential definition'), | |
| ('r1332', 'Virtual reaction/potential definition'), | |
| ('r1377', | |
| 'S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22'), | |
| ('r1378', | |
| 'S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284'), | |
| ('r1391', 'amylo-1,6-glucosidase, 4-alpha-glucanotransferase EC:2.4.1.25'), | |
| ('r1392', 'amylo-1,6-glucosidase, 4-alpha-glucanotransferase EC:3.2.1.33'), | |
| ('r1411', | |
| 'D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D- galactosyl-D-glucosylceramide galactohydrolase EC:3.2.1.23'), | |
| ('r1418', 'Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1'), | |
| ('r1431', | |
| '2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1'), | |
| ('r1432', | |
| '2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1'), | |
| ('r1446', 'EC:1.3.3.6'), | |
| ('r1466', 'EC:2.3.1.86'), | |
| ('RE2848C', 'RE2848'), | |
| ('RE2849C', 'RE2849'), | |
| ('RE2850C', 'RE2850'), | |
| ('RE2851C', 'RE2851'), | |
| ('RE2852C', 'RE2852'), | |
| ('RE2853C', 'RE2853'), | |
| ('RE2854C', 'RE2854'), | |
| ('RE2856C', 'RE2856'), | |
| ('RE2857C', 'RE2857'), | |
| ('RE2858C', 'RE2858'), | |
| ('RE2859C', 'RE2859'), | |
| ('RE2860C', 'RE2860'), | |
| ('RE2861C', 'RE2861'), | |
| ('RE2862C', 'RE2862'), | |
| ('RE2863C', 'RE2863'), | |
| ('RE2864C', 'RE2864'), | |
| ('RE2865C', 'RE2865'), | |
| ('RE2866C', 'RE2866'), | |
| ('RE2867C', 'RE2867'), | |
| ('RE2868C', 'RE2868'), | |
| ('RE2869C', 'RE2869'), | |
| ('RE2870C', 'RE2870'), | |
| ('RE2871C', 'RE2871'), | |
| ('RE2872C', 'RE2872'), | |
| ('RE2873C', 'RE2873'), | |
| ('RE2874C', 'RE2874'), | |
| ('RE2875C', 'RE2875'), | |
| ('RE2876C', 'RE2876'), | |
| ('RE2877C', 'RE2877'), | |
| ('RE2878C', 'RE2878'), | |
| ('RE2880C', 'RE2880'), | |
| ('OAADC', 'oxaloacetate decarboxylase'), | |
| ('Tyr_ggnt', 'Tyr_ggnt'), | |
| ('fumt', 'Fumarate transport'), | |
| ('xmpt', 'Xanthosine 5-phosphate transport'), | |
| ('dcmpt', 'dCMP transport'), | |
| ('EX_fum_LPAREN_e_RPAREN_', 'Exchange of Fumarate'), | |
| ('EX_xmp_LPAREN_e_RPAREN_', 'Exchange of Xanthosine 5-phosphate'), | |
| ('EX_dcmp_LPAREN_e_RPAREN_', 'Exchange of dCMP'), | |
| ('biomass_reaction', 'Generic human biomass reaction'), | |
| ('biomass_protein', 'protein component of biomass'), | |
| ('biomass_DNA', 'DNA component of biomass'), | |
| ('biomass_RNA', 'RNA component of biomass'), | |
| ('biomass_carbohydrate', 'carbohydrate component of biomass'), | |
| ('biomass_lipid', 'lipid component of biomass'), | |
| ('biomass_other', 'other component of biomass'), | |
| ('ACSMCT1', 'acetate transport by SMCT1'), | |
| ('ADNCNT3tc', 'adenosine transport CNT3'), | |
| ('ALAB0AT3tc', 'alanine transport by B0AT3'), | |
| ('ALAPAT4te', 'transport of alanine via PAT4'), | |
| ('ARACHDFATPtc', 'arachidonate (n-C18:1) transport by FATP'), | |
| ('ARACHFATPtc', 'arachidate transport'), | |
| ('ARGB0AT3tc', 'arginine transport by B0AT3'), | |
| ('ASNB0AT3tc', 'asparagine transport by B0AT3'), | |
| ('BETBGTtc', 'betaine transport by BGT'), | |
| ('BUTSMCT1', 'butyrate transport by SMCT1'), | |
| ('CLCFTRte', 'chloride transport by CFTR'), | |
| ('CRNATBtc', 'carnitine transport by ATB0'), | |
| ('CYSB0AT3tc', 'cysteine transport by B0AT3'), | |
| ('CYSSNAT4te', 'cysteine transport by SNAT4'), | |
| ('CYTDt2r', 'cytidine transport in via proton symport, reversible'), | |
| ('DHEASABCCte', 'DHEA transport by ABCA11'), | |
| ('DOPAENT4tc', 'dopa transport by ENT4'), | |
| ('ESTRAABCtc', '17beta-estradiol 3-glucosiduronic acid transport by ABCA8'), | |
| ('ESTRGLCABCCte', | |
| '17beta-estradiol 3-glucosiduronic acid transport by ABCA11'), | |
| ('ESTROSABCCte', 'estrone-sulphate transport by ABCA11'), | |
| ('ESTRSABCtc', 'estrone-sulphate transport by ABCA8'), | |
| ('FOLABCCte', 'folate transport by ABCA11'), | |
| ('FOLOAT1tc', 'folate transport by OAT1'), | |
| ('FOLOAT2tc', 'folate transport by OATS'), | |
| ('FOLOATPtc', 'folate transport by OATP'), | |
| ('GABABGTtc', 'GABA transport by BGT'), | |
| ('GLNB0AT3tc', 'glutamine transport by B0AT3'), | |
| ('GLUB0AT3tc', 'glutamate transport by B0AT3'), | |
| ('GLYB0AT3tc', 'glycine transport by B0AT3'), | |
| ('GSNt2r', 'guanosine transport in via proton symport reversible'), | |
| ('H2OGLYAQPt', 'water and glycerol transport by AQP'), | |
| ('HDCAFAPMtc', 'hexadecanoate transport by FAT'), | |
| ('ILEB0AT2tc', 'isoleucine transport by B0AT2'), | |
| ('ILEB0AT3tc', 'iso-leucine transport by B0AT3'), | |
| ('INSt2', 'inosine transport in via proton symport, reversible'), | |
| ('LEUB0AT2tc', 'leucine transport by B0AT2'), | |
| ('LEUB0AT3tc', 'leucine transport by B0AT3'), | |
| ('LEUKABCtc', 'leukotriene transport by ABCA8'), | |
| ('LGNCFATPtc', 'lignocerate transport by FATP'), | |
| ('LGNCFATtc', 'lignocerate transport by FAT'), | |
| ('METB0AT2tc', 'methionine transport by B0AT2'), | |
| ('METB0AT3tc', 'methionine transport by B0AT3'), | |
| ('NACSMCTte', 'nicotinate transport by SMCT1'), | |
| ('OCDCAFAPMtc', 'octadecanoate tranport by FAT'), | |
| ('OCDCAFATPtc', 'stearate transport'), | |
| ('OCDCEAFATPtc', 'octadecenoate transport'), | |
| ('PCHOLABCtc', 'phsophatidylcholine transport by ABCA1'), | |
| ('PGLYCABCte', 'phosphatidylglycerol transport by ABCA3'), | |
| ('PHEB0AT3tc', 'phenylalanine transport by B0AT3'), | |
| ('PHEMEABCte', 'heme transport by ABCG2'), | |
| ('PMTFATPtc', 'palmitate transport by FATP'), | |
| ('PPASMCT1', 'propionate transport by SMCT1'), | |
| ('PROB0AT2tc', 'proline transport by B0AT2'), | |
| ('PROPAT4te', 'transport of proline via PAT4'), | |
| ('PSHSABCtc', 'phosphatidylserine transport by ABCA1'), | |
| ('PYRSMCT1', 'puryvate transport by SMCT1'), | |
| ('RETABCtc', 'vitamin transport by ABCA4'), | |
| ('SERB0AT3tc', 'serine transport by B0AT3'), | |
| ('SRTNENT4tc', 'serotonin transport by ENT4'), | |
| ('TCHOLABCtc', 'bile acid transport by ABCA8'), | |
| ('THMDt2r', 'thymidine transport in via proton symport reversible'), | |
| ('TRPB0AT3tc', 'tyrptophan transport by B0AT3'), | |
| ('TTDCAFATPtc', 'myristate transport'), | |
| ('TYRB0AT3tc', 'tyrosine transport by B0AT3'), | |
| ('URIt2r', 'uridine transport in via proton symport reversible'), | |
| ('VALB0AT2tc', 'valine transport by B0AT2'), | |
| ('VALB0AT3tc', 'valine transport by B0AT3'), | |
| ('12HTACRhr', 'oxidation of tacrolimus in hepatocytes'), | |
| ('12HTACRtu', | |
| 'efflux of 12-hydroxy tacrolimus into intestinal lumen by ABC transporter'), | |
| ('12HTACRtep', 'exit of 12-hydroxy tacrolimus into portal blood'), | |
| ('1331TAALThr', | |
| 'demethylation of 13-O-desmethyl-tacrolimus to 13,31-O-Didesmethyl-tacrolimus in hepatocytes'), | |
| ('1331TACRhr', | |
| 'demethylation of 31-O-desmethyl-tacrolimus to 13,31-O-Didesmethyl-tacrolimus in hepatocytes'), | |
| ('1331TACRteb', 'efflux of 13,31-O-Didesmethyl-tacrolimus into bile'), | |
| ('1331TACRtev', 'exit of 13,31-O-Didesmethyl-tacrolimus into hepatic vein'), | |
| ('13DMThr', | |
| 'demthylation of tacrolimus to 13-O-desmethyl tacrolimus in hepatocytes'), | |
| ('13DMTtu', | |
| 'efflux of 13-O-desmethyl tacrolimus into intestinal lumen by ABC transporter'), | |
| ('13DMTtep', 'exit of 13-O-desmethyl tacrolimus into portal blood'), | |
| ('14HMDZALThr', | |
| 'oxidation of 4-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes'), | |
| ('14HMDZhr', | |
| "oxidation of 1''-OH-midazolam to 1,4-Dihydroxy-midazolam in hepatocytes"), | |
| ('14MDZtev', 'efflux of 1,4-Dihydroxy-midazolam into hepatic vein'), | |
| ('1513DTALThr', | |
| 'demthylation of 15-O-desmethyl tacrolimus to 13,15-O-didesmethyl tacrolimus in hepatocytes'), | |
| ('1513DTACRhr', | |
| 'demthylation of 13-O-desmethyl tacrolimus to 13,15-O-didesmethyl tacrolimus in hepatocytes'), | |
| ('1513TACRtu', | |
| 'efflux of 13,15-O-didesmethyl tacrolimus into intestinal lumen by ABC transporter'), | |
| ('1513TACRtep', 'exit of 13,15-O-didesmethyl tacrolimus into portal blood'), | |
| ('1531TACRhr', | |
| 'demethylation of 15-O-desmethyl tacrolimus to 15, 31-O-Didesmethyl-tacrolimus in hepatocytes'), | |
| ('1531TACRteb', 'efflux of 15, 31-O-Didesmethyl-tacrolimus into bile'), | |
| ('1531TACRtev', 'exit of 15, 31-O-Didesmethyl-tacrolimus into hepatic vein'), | |
| ('1531TALThr', | |
| 'demethylation of 31-O-desmethyl tacrolimus to 15, 31-O-Didesmethyl-tacrolimus in hepatocytes'), | |
| ('15DMThr', | |
| 'demethylation of tacrolimus to 15-O-desmethyl tacrolimus in hepatocytes'), | |
| ('15DMTtu', | |
| 'efflux of 15-O-desmethyl tacrolimus into intestinal lumen by ABC transporter'), | |
| ('15DMTtep', 'exit of 15-O-desmethyl tacrolimus into portal blood'), | |
| ('1HIBUPGLUC_Sthv', | |
| 'release of 1-hydroxy S-ibuprofen-glucuronide into hepatic vein'), | |
| ('1HMDGLUChr', "glucuronidation of 1''-OH-midazolam in enterocytes"), | |
| ('1HMDZGLUChc', "uptake of 1''-OH-midazolam-glucuronide into hepatocytes"), | |
| ('1OHMDZhr', "oxidation of midazolam to 1''-OH-midazolam in hepatocytes"), | |
| ('1OHMDZtep', "efflux of 1''-OH-midazolam into portal blood"), | |
| ('2HATVLAChc', | |
| 'conversion of 2-hydroxy-atorvastatin-acid to its lactone form in hepatocytes'), | |
| ('2HATVACIDGLUChr', | |
| 'glucuronidation of 2-hydroxy-atorvastatin-acid in hepatocytes'), | |
| ('2HATVACIDGLUCteb', | |
| 'efflux of 2-hydroxy-atorvastatin-acyl-glucuronide into bile'), | |
| ('2HATVACIDOXDhc', | |
| 'oxidation of atorvastatin acid to 2-hydroxy-atorvastatin-acid in hepatocytes'), | |
| ('2HATVACIDhc', | |
| 'conversion of 2-hydroxy-atorvastatin-lactone to its acid form in hepatocytes'), | |
| ('2HATVACIDteb', 'efflux of 2-hydroxy-atorvastatin-acid into bile'), | |
| ('2HATVACIDtep', 'efflux of 2-hydroxy-atorvastatin-acid into portal blood'), | |
| ('2HATVACIDthc', 'uptake of 2-hydroxy-atorvastatin-acid into hepatocytes'), | |
| ('2HATVLACGLUChr', | |
| 'glucuronidation of 2-hydroxy-atorvastatin-lactone in hepatocytes'), | |
| ('2HATVLACGLUCteb', | |
| 'efflux of 2-hydroxy-atorvastatin-lactone-glucuronide into bile'), | |
| ('2HATVLACOXDhc', | |
| 'oxidation of atorvastatin lactone to 2-hydroxy-atorvastatin-lactone in hepatocytes'), | |
| ('2HATVLACteb', 'efflux of 2-hydroxy-atorvastatin-lactone into bile'), | |
| ('2HATVLACtep', 'efflux of 2-hydroxy-atorvastatin-lactone into portal blood'), | |
| ('2HATVLACthc', 'uptake of 2-hydroxy-atorvastatin-lactone into hepatocytes'), | |
| ('2HIBUPGLUC_Sthv', | |
| 'release of 2-hydroxy S-ibuprofen-glucuronide into hepatic vein'), | |
| ('31DMThr', | |
| 'demethylation of tacrolimus to 31-O-desmethyl tacrolimus in hepatocytes'), | |
| ('31DMTtu', | |
| 'efflux of 31-O-desmethyl tacrolimus into intestinal lumen by ABC transporter'), | |
| ('31DMTtep', 'exit of 31-O-desmethyl tacrolimus into portal blood'), | |
| ('35DHPVShc', | |
| "conversion of pravastatin to 3''-alpha-5''-beta-dihydroxy pravastatin in entercoytes"), | |
| ('35DHPVStep', | |
| "3''-alpha-5''-beta-dihydroxy pravastatin exit into portal blood"), | |
| ('35DHPVSthc', | |
| "uptake of 3''-alpha-5''-beta-dihydroxy pravastatin by hepatocytes"), | |
| ('35DSMVhep', "formation of 3'',5''-dihydrodoil simvastatin"), | |
| ('35DSMVteb', | |
| "efflux of 3'',5''-dihydrodiol-simvastatin-lactone form into bile"), | |
| ('3HIBUPGLUC_Sthv', | |
| 'release of 3-hydroxy S-ibuprofen-glucuronide into hepatic vein '), | |
| ('3HLVSTAChep', | |
| "conversion of 3''''-hydroxy-lovastatin lactone to acid form"), | |
| ('3HLVSTACtbc', "release of 3''''-hydroxy-lovastatin acid form into bile"), | |
| ('3HPVSTETCOAhcm', | |
| "beta oxidation of 3''-S-hydroxy-pravastatin-CoA to tatranor-CoA derivative in hepatocytes, mitochondria"), | |
| ('3HPVSTETCOAhcx', | |
| "beta oxidation of 3''-S-hydroxy-pravastatin-CoA to tetranor-CoA in hepatocytes, peroxisomes"), | |
| ('3HPVSTETteb', "efflux of 3''-S-hydroxy-pravastatin-tetranor into bile"), | |
| ('3HPVSTETtev', | |
| "exit of 3''-S-hydroxy-pravastatin-tetranor into hepatic vein"), | |
| ('3HPVShc', | |
| "oxidation of pravastatin to 3''-hydroxy pravastatin in hepatocytes"), | |
| ('3HPVSteb', "efflux of 3''-S-hydroxy-pravastatin into bile"), | |
| ('3HPVStep', "3''-hydroxy pravastatin exit into portal blood"), | |
| ('3HPVSthc', "uptake of 3''-hydroxy pravastatin by hepatocytes"), | |
| ('3HSMVACIDhep', | |
| "conversion of 3''-hydroxy simvastatin lactone to acid form"), | |
| ('3HSMVACIDteb', "efflux of 3''-hydroxy-simvastatin-acid form into bile"), | |
| ('3HSMVhep', | |
| "acid catalyzed rearrangement of 6''-beta-hydroxy-simvastatin to 3''-hydroxy simvastatin"), | |
| ('3ISPVShc', | |
| "isomerization of pravastatin to 3''-alpha-iso-pravastatin in hepatocytes"), | |
| ('3ISPVSteb', 'efflux of 3-alpha-iso-pravastatin into bile'), | |
| ('3ISPVStep', "3''-alpha-iso-pravastatin exit into portal blood"), | |
| ('3ISPVSthc', "uptake of 3''-alpha-iso-pravastatin by hepatocytes"), | |
| ('3MEACMPhc', 'formation of 3-methoxy-acetaminophen in hepatocytes'), | |
| ('3OHACMPhr', | |
| 'oxidation of acetaminophen to 3-OH-acetaminophen in hepatocytes'), | |
| ('3OHACMPtev', 'efflux of 3-OH-acetaminophen into hepatic vein'), | |
| ('4BHGLZABCt', 'excretion of 4-beta-OH-gliclazide into bile'), | |
| ('4BHGLZhr', | |
| 'oxidation of gliclazide to 4-beta-OH-gliclazide in hepatocytes'), | |
| ('4BHGLZtev', 'excretion of 4-beta-OH-gliclazide into hepatic vein'), | |
| ('4HATVACIDOXDhc', | |
| 'oxidation of atorvastatin acid to 4-hydroxy-atorvastatin-acid in hepatocytes'), | |
| ('4HATVACIDhc', | |
| 'conversion of 4-hydroxy-atorvastatin-lactone to its acid form in hepatocytes'), | |
| ('4HATVACIDteb', 'efflux of 4-hydroxy-atorvastatin-acid into bile'), | |
| ('4HATVACIDtep', 'efflux of 4-hydroxy-atorvastatin-acid into portal blood'), | |
| ('4HATVACIDthc', 'uptake of 4-hydroxy-atorvastatin-acid into hepatocytes'), | |
| ('4HATVLACOXDhc', | |
| 'oxidation of atorvastatin lactone to 4-hydroxy-atorvastatin-lactone in hepatocytes'), | |
| ('4HATVLAChc', | |
| 'conversion of 4-hydroxy-atorvastatin-lactone to its acid form in hepatocytes'), | |
| ('4HATVLACteb', 'efflux of 4-hydroxy-atorvastatin-lactone into bile'), | |
| ('4HATVLACtep', 'efflux of 4-hydroxy-atorvastatin-lactone into portal blood'), | |
| ('4HATVLACthc', 'uptake of 4-hydroxy-atorvastatin-lactone into hepatocytes'), | |
| ('4HMDGLUCtev', 'efflux of 4-OH-midazolam-glucuronide into hepatic vein'), | |
| ('4HMDZGLUChr', 'glucuronidation of 4-OH-midazolam in enterocytes'), | |
| ('4OHMDZhr', 'oxidation of midazolam to 4-OH-midazolam in hepatocytes'), | |
| ('4OHMDZtev', 'efflux of 4-OH-midazolam into hepatic vein'), | |
| ('56DHPVShc', | |
| 'oxidation of triol metabolite to 3-keto-5,6,-dihydroxy-pravastatin in hepatocytes'), | |
| ('56DHPVSteb', 'efflux of 3-keto-5,6,-dihydroxy-pravastatin into bile'), | |
| ('56DHPVStev', 'exit of 3-keto-5,6,-dihydroxy-pravastatin into hepatic vein'), | |
| ('56EPPVShc', | |
| 'oxidation of 3-alpha-iso-pravastatin to 5,6-epoxy-3-alpha-iso-pravastatin in hepatocytes'), | |
| ('56EPPVSteb', 'efflux of 5,6-epoxy-3-alpha-iso-pravastatin into bile'), | |
| ('56EPPVStev', 'exit of 5,6-epoxy-3-alpha-iso-pravastatin into hepatic vein'), | |
| ('5OHFVSGLUhc', 'glucuronidation of 5-hydroxy-fluvastatin'), | |
| ('5OHFVSGLUtev', | |
| 'exit of 5-hydroxy-fluvastatin-glucuronide into hepatic vein for excretion in urine'), | |
| ('5OHFVShc', | |
| 'oxidation of fluvastatin to 5-hydroxy-fluvastatin in hepatocytes'), | |
| ('5OHFVSteb', | |
| 'efflux of 5-hydroxy-fluvastatin into bile for excretion into faeces'), | |
| ('6AHGLZABCt', 'excretion of 6-alpha-OH-gliclazide into bile'), | |
| ('6AHGLZhr', | |
| 'oxidation of gliclazide to 6-alpha-OH-gliclazide in hepatocytes'), | |
| ('6AHGLZtev', 'excretion of 6-alpha-OH-gliclazide into hepatic vein'), | |
| ('6BHGLZABCt', 'excretion of 6-beta-OH-gliclazide into bile'), | |
| ('6BHGLZGLCABCt', 'excretion of 6-beta-OH-gliclazide-glucuronide into bile'), | |
| ('6BHGLZGLChr', | |
| 'glucuronidation of 6-beta-OH-gliclazide-glucuronide in hepatocytes'), | |
| ('6BHGLZGLCtev', | |
| 'excretion of 6-beta-OH-gliclazide-glucuronide into hepatic vein'), | |
| ('6BHGLZhr', | |
| 'oxidation of gliclazide to 6-beta-OH-gliclazide in hepatocytes'), | |
| ('6BHGLZtev', 'excretion of 6-beta-OH-gliclazide into hepatic vein'), | |
| ('6CSMVACIDhep', | |
| "conversion of 6''-beta-carboxy simvastatin lactone to acid form"), | |
| ('6CSMVACIDteb', | |
| "efflux of 6''-beta-carboxy-simvastatin-acid form into bile"), | |
| ('6CSMVhep', | |
| "oxidation of 6''-exomethylene simvastatin to 6''-beta-hydroxy carboxy simvastatin lactone form"), | |
| ('6EPSteb', 'efflux of 6-epipravastatin into bile'), | |
| ('6EPVStep', "6''-epi-pravastatin exit into portal blood"), | |
| ('6EPVShc', | |
| "isomerization of pravastatin to 6''-epi-pravastatin in hepatocytes"), | |
| ('6EPVSthc', "uptake of 6''-epi-pravastatin by hepatocytes"), | |
| ('6HLVSTAChep', | |
| "conversion of lactone form of 6''-beta-hydroxy-lovastatin to acid form"), | |
| ('6HLVSTthep', "uptake of 6''-beta-hydroxy-lovastatin by hepatocytes"), | |
| ('6HMSMVACIDhep', | |
| "conversion of 6''-beta-hydroxy-methyl simvastatin lactone to acid form"), | |
| ('6HMSMVACIDteb', | |
| "efflux of 6''-beta-hydroxy-methyl-simvastatin-acid into bile"), | |
| ('6HMSMVhep', | |
| "oxidation of 6''-exomethylene simvastatin to 6''-beta-hydroxy methyl simvastatin"), | |
| ('6HSMVACIDhep', | |
| "conversion of 6''-beta-hydroxy simvastatin lactone to acid form"), | |
| ('6HSMVACIDteb', "efflux of 6''-beta-hydroxy simvastatin acid into bile"), | |
| ('6HSMVhep', "oxidation of simvastatin to 6''-beta-hydroxy simvastatin"), | |
| ('6MELACAChep', | |
| "conversion of lactone form of 6''-exomethylene-lovastatin to acid form"), | |
| ('6MELVACtbc', "release of 6''-exomethylene-lovastatin-acid form into bile"), | |
| ('6MELVSTthep', "uptake of 6''-exomethylene-lovastatin by hepatocytes"), | |
| ('6MSMVhep', "oxidation of simvastatin to 6''-exomethylene lactone form"), | |
| ('6OHFVSGLUhc', 'glucuronidation of 6-hydroxy-fluvastatin'), | |
| ('6OHFVSGLUtev', | |
| 'exit of 6-hydroxy-fluvastatin-glucuronide into hepatic vein for excretion in urine'), | |
| ('6OHFVShc', | |
| 'oxidation of fluvastatin to 6-hydroxy-fluvastatin in hepatocytes'), | |
| ('6OHFVSteb', | |
| 'efflux of 6-hydroxy-fluvastatin into bile for excretion into faeces'), | |
| ('7AHGLZABCt', 'excretion of 7-alpha-OH-gliclazide into bile'), | |
| ('7AHGLZhr', | |
| 'oxidation of gliclazide to 7-alpha-OH-gliclazide in hepatocytes'), | |
| ('7AHGLZtev', 'excretion of 7-alpha-OH-gliclazide into hepatic vein'), | |
| ('7BHGLZABCt', 'excretion of 7-beta-OH-gliclazide into bile'), | |
| ('7BHGLZGLCABCt', 'excretion of 7-beta-OH-gliclazide-glucuronide into bile'), | |
| ('7BHGLZGLChr', | |
| 'glucuronidation of 7-beta-OH-gliclazide-glucuronide in hepatocytes'), | |
| ('7BHGLZGLCtev', | |
| 'excretion of 7-beta-OH-gliclazide-glucuronide into hepatic vein'), | |
| ('7BHGLZhr', | |
| 'oxidation of gliclazide to 7-beta-OH-gliclazide in hepatocytes'), | |
| ('7BHGLZtev', 'excretion of 7-beta-OH-gliclazide into hepatic vein'), | |
| ('7HPVShc', | |
| 'oxidation of 3-alpha-iso-pravastatin to 7-hydroxy-3-alpha-iso-pravastatin in hepatocytes'), | |
| ('7HPVSteb', 'efflux of 7-hydroxy-3-alpha-iso-pravastatin into bile'), | |
| ('7HPVStev', 'exit of 7-hydroxy-3-alpha-iso-pravastatin into hepatic vein'), | |
| ('ALLOP2tu', 'uptake of allopurinol by the enterocytes'), | |
| ('ACMPtu', 'efflux of acetaminophen by P-gp from the enterocytes into lumen'), | |
| ('ACMPGLUChr', 'glucuronidation of acetaminophen in hepatocytes'), | |
| ('ACMPGLUTdt', | |
| 'uptake of acetaminophen-glutathione-conjugate into the enterocytes'), | |
| ('ACMPGLUTtep', | |
| 'efflux of acetaminophen-glutathione-conjugate from enterocytes into portal blood'), | |
| ('ACMPGLUTthc', | |
| 'uptake of acetaminophen-glutathione-conjugate by the hepatocytes'), | |
| ('ACMPGLUtep', | |
| 'efflux of acetaminophen-glucuronide-conjugate from enterocytes into portal blood'), | |
| ('ACMPGLUthc', | |
| 'uptake of acetaminophen-glucuronide-conjugate by the hepatocytes'), | |
| ('ACMPShc', 'sulphation of acetaminophen in hepatocytes'), | |
| ('ACMPdt', 'uptake of acetaminophen by enterocytes'), | |
| ('ACMPthc', 'uptake of acetaminophen by the hepatocytes'), | |
| ('ALLOP1tu', 'uptake of allopurinol by the enterocytes'), | |
| ('ALLOPOXDhep', 'oxidation of allopurinol to oxypurinol in hepatocytes'), | |
| ('ALLOPtepvb', 'uptake of allopurinol by the hepatocytes'), | |
| ('AM19CSALThr', | |
| 'alternative pathway for formation of AM19 from AM1 in hepatocytes'), | |
| ('AM19CShr', 'oxidation of AM9 to AM19 (cyclosporine) in hepatocytes'), | |
| ('AM19CSteb', 'efflux of AM19-cyclosporine into bile'), | |
| ('AM1A4NCShc', 'demethylation of AM1A to AM1A4N in hepatocytes'), | |
| ('AM1A4NCSteb', 'efflux of AM1A4N-cyclosporine into bile'), | |
| ('AM1ACCShr', | |
| 'oxidation of AM1c to AM1Ac in hepatocytes (alternative mechanism)'), | |
| ('AM1ACCStev', 'efflux of AM1Ac-cyclosporine into hepatic vein'), | |
| ('AM1ACShr', 'formation of AM1A-cyclosporine in hepatocytes'), | |
| ('AM1ACSteb', 'efflux of AM1A-cyclosporine into bile'), | |
| ('AM1ACStep', 'efflux of AM1A (cyclosporine) into portal blood'), | |
| ('AM1ALCShr', 'formation of AM1AL-cyclosporine in hepatocytes'), | |
| ('AM1ALCSteb', 'efflux of AM1AL-cyclosporine into bile'), | |
| ('AM1ALCStep', 'efflux of AM1AL (cyclosporine) into portal blood'), | |
| ('AM1C4N9CShc', | |
| 'demethylation of AM1c9 to AM1c4N9 in hepatocytes (alternative mechanism)'), | |
| ('AM1C4N9CSteb', 'efflux of AM1c4N9-cyclosporine into bile'), | |
| ('AM1C9CShr', | |
| 'oxidation of AM1c to AM1c9 in hepatocytes (alternative mechanism)'), | |
| ('AM1C9CSteb', 'efflux of AM1c9-cyclosporine into bile'), | |
| ('AM1C9CStev', 'efflux of AM1c9-cyclosporine into hepatic vein'), | |
| ('AM1CCShr', 'oxidation of cyclosporine to AM1c in hepatocytes'), | |
| ('AM1CCSteb', 'efflux of AM1c-cyclosporine into bile'), | |
| ('AM1CCStev', 'efflux of AM1c-cyclosporine into hepatic vein'), | |
| ('AM1CGLChr', 'glucuronidation of AM1c in hepatocytes'), | |
| ('AM1CGLCteb', 'efflux of AM1c-glucuronide into bile'), | |
| ('AM1CSAhr', 'oxidation of cyclosporine to AM1 in hepatocytes'), | |
| ('AM1CSAtep', 'efflux of AM1 (cyclosporine) into portal blood'), | |
| ('AM4N9CShc', 'demethylation of AM9 to AM4N9 in hepatocytes'), | |
| ('AM4N9CShr', 'oxidation of AM4N to AM4N9 in hepatocytes'), | |
| ('AM4N9CStev', 'efflux of AM4N9-cyclosporine into hepatic vein'), | |
| ('AM4NC9CSteb', 'efflux of AM4N9-cyclosporine into bile'), | |
| ('AM4NCShr', 'demethylation of cyclosporine to AM4N in hepatocytes'), | |
| ('AM4NCSteb', 'efflux of AM4N-cyclosporine into bile'), | |
| ('AM4NCStep', 'efflux of AM4N (cyclosporine) into portal blood'), | |
| ('AM9CSAhr', 'oxidation of cyclosporine to AM9 in hepatocytes'), | |
| ('AM9CSAteb', 'efflux of AM9-cyclosporine into bile'), | |
| ('AM9CSAtep', 'efflux of AM9 (cyclosporine) into portal blood'), | |
| ('ATVACIDMCTtu', 'uptake of atorvastatin by enterocytes by MCT1'), | |
| ('ATVACIDOATPtu', 'uptake of atorvastatin by enterocytes'), | |
| ('ATVACIDhc', | |
| 'conversion of lactone to acid form of atorvastatin in hepatocytes'), | |
| ('ATVACIDhr', | |
| 'spontaneous conversion of atorvastatin ether glucuronide (G1) to atorvastatin-acid'), | |
| ('ATVACIDtdu', 'passive diffusion of atorvastatin into enterocytes'), | |
| ('ATVACIDtu', | |
| 'efflux of atorvastatin acid by P-gp from the enterocytes into lumen'), | |
| ('ATVACYLGLUChc', | |
| 'glucuronidation of atorvastatin to atorvastatin acyl glucuronide (G2) in hepatocytes'), | |
| ('ATVETHGLUChc', | |
| 'glucuronidation of atorvastatin to atorvastatin ether glucuronide (G1) in hepatocytes'), | |
| ('ATVLACGLCURhc', | |
| 'glucuronidation of atorvastatin lactone to atorvastain lactone ether glucuronide (G3) in hepatocytes'), | |
| ('ATVLACThc', 'uptake of atorvastatin-lactone into hepatocytes'), | |
| ('ATVLACh2r', | |
| 'spontaneous conversion of glucuronide (G2) to lactone form of atorvastatin'), | |
| ('ATVLAChc', 'lactonization of atorvastatin in hepatocytes'), | |
| ('ATVLAChr', | |
| 'spontaneous conversion of atorvastain lactone ether glucuronide (G3) to atorvastatin-lactone in hepatocytes'), | |
| ('ATVLACtdhc', 'passive diffusion of atorvastatin lactone into hepatocytes'), | |
| ('ATVLACtu', | |
| 'efflux of atorvastatin lactone by P-gp from the enterocytes into lumen'), | |
| ('Am19CStev', 'efflux of AM19-cyclosporine into hepatic vein'), | |
| ('Am1CSAteb', 'efflux of AM1-cyclosporine into bile'), | |
| ('CARBIBUP_SGLUthv', | |
| 'release of S-carboxy ibuprofen glucuronide into hepatic vein'), | |
| ('CARIBUP_Rthv', 'release of R-carboxy ibuprofen into hepatic vein'), | |
| ('CARIBUP_SGLUhep', 'glucuronidation of S-carboxy ibuprofen'), | |
| ('CARIBUP_Sthv', 'release of S-carboxy ibuprofen into hepatic vein'), | |
| ('CRGLZABCt', 'excretion of carboxy-gliclazide into bile'), | |
| ('CRGLZhr', | |
| 'oxidation of methyl-hydroxy-gliclazide to carboxy-gliclazide in hepatocytes'), | |
| ('CRGLZtev', 'excretion of carboxy-gliclazide into hepatic vein'), | |
| ('CRVS1M24hc', 'hydroxylation of cerivastatin-M1 to M24 in hepatocytes'), | |
| ('CRVS1tev', 'exit of cerivastatin-M1 into hepatic vein'), | |
| ('CRVS23M24hc', 'demethylation of cerivastatin-M23 to M24 in hepatocytes'), | |
| ('CRVSATPthc', 'cerivastatin uptake by hepatocytes by active transport'), | |
| ('CRVSATPtu', | |
| 'efflux of cerivastatin by P-gp or BCRP from the enterocytes into lumen'), | |
| ('CRVSM1SPhc', | |
| 'de-lactonization of cerivastatin-M22 to cerivastatin-M1 in hepatocytes'), | |
| ('CRVSM1hc', 'demethylation of cerivastatin to M1 in hepatocytes'), | |
| ('CRVSM1hr', 'beta-glucuronidase of cerivastatin-M1-glucuronide to M1 form'), | |
| ('CRVSM1teb', 'efflux of cerivastatin-M1 into bile'), | |
| ('CRVSM22hc', | |
| 'spontaneous conversion of glucuronide to cerivastatin-M22 in hepatocytes'), | |
| ('CRVSM23hc', 'hydroxylation of cerivastatin to M23 in hepatocytes'), | |
| ('CRVSM23hr', | |
| 'beta-glucuronidase of cerivastatin-M23-glucuronide to M23 form'), | |
| ('CRVSM23teb', 'efflux of cerivastatin-M23 into bile'), | |
| ('CRVSM23tev', 'exit of cerivastatin-M23 into hepatic vein'), | |
| ('CRVSM24teb', 'efflux of cerivastatin-M24 into bile'), | |
| ('CRVSM24tev', 'exit of cerivastatin-M24 into hepatic vein'), | |
| ('CRVSM31hc', | |
| 'spontaneous conversion of glucuronide to cerivastatin-M31 in hepatocytes'), | |
| ('CRVStu', 'cerivastatin uptake by enterocytes'), | |
| ('CRVSthc', 'cerivastatin uptake by hepatocytes'), | |
| ('CSASULPhc', | |
| 'conjugation of cyclosporine with sulphate for excretion in hepatocytes'), | |
| ('CSASULPteb', 'efflux of cyclosporine-sulphate into bile'), | |
| ('CSASULPtev', 'efflux of cyclosporine-sulphate into hepatic vein'), | |
| ('CSAtd', 'uptake of cyclosporine by the enterocytes'), | |
| ('CSAtu', 'efflux of cyclosporine by P-gp from the enterocytes into lumen'), | |
| ('CVM1GLUChc', 'glucuronidation of cerivastatin-M1'), | |
| ('CVM23GLUChc', 'glucuronidation of cerivastatin-M23'), | |
| ('CYSACMPAChc', | |
| 'acetylation of cysteine-conjugate-acetaminophen in hepatocytes'), | |
| ('CYSAMPtev', 'efflux of cysteine-conjugate-acetaminophen into hepatic vein'), | |
| ('DELACCRVSM23hc', | |
| 'de-lactonization of cerivastatin-M31 to cerivastatin-M23 in hepatocytes'), | |
| ('DEOXFVShc', 'formation of deoxy-fluvastatin-dinor'), | |
| ('DEOXFVStev', | |
| 'exit of deoxy-fluvastatin-dinor into hepatic vein for excretion in urine'), | |
| ('DESFVShc', | |
| 'oxidation of fluvastatin to N-desisopropyl-fluvastatin in hepatocytes'), | |
| ('DESFVSteb', | |
| 'efflux of N-desisopropyl-fluvastatin into bile for excretion into faeces'), | |
| ('DHGLZABCt', 'excretion of dehydro-gliclazide into bile'), | |
| ('DHGLZhc', | |
| 'dehydrogenation of gliclazide to dehydro-gliclazide in hepatocytes'), | |
| ('DHGLZtev', 'excretion of dehydro-gliclazide into hepatic vein'), | |
| ('DSPVSteb', 'efflux of desacyl dehydro-pravastatin into bile'), | |
| ('DSPVStev', 'exit of desacyl dehydro-pravastatin into hepatic vein'), | |
| ('EPOXTAChr', 'formation of epoxy derivative of tacrolimus in hepatocytes'), | |
| ('EPOXTACteb', | |
| 'efflux of 31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus into bile'), | |
| ('EPOXTACtev', | |
| 'exit of 31-O-Desmethyl,19-Hydroxy,37, 39-Epoxy-tacrolimus into hepatic vein'), | |
| ('FVSGLUChc', 'glucuronidation of fluvastatin'), | |
| ('FVSTETGLUhc', | |
| 'glucuronidation of des-isopropyl-dihydro-fluvastatin-tetranor'), | |
| ('FVSTETGLUtev', | |
| 'exit of des-isopropyl-dihydro-fluvastatin-tetranor-glucuronide into hepatic vein for excretion in urine'), | |
| ('FVSTETtev', | |
| 'exit of des-isopropyl-dihydro-fluvastatin-tetranor into hepatic vein for excretion in urine'), | |
| ('FVShc', 'hydrolysis of lactone to fluvastatin in hepatocytes'), | |
| ('FVSteb', 'efflux of fluvastatin into bile for excretion into faeces'), | |
| ('FVStep', 'efflux of fluvastatin from enterocytes into portal blood'), | |
| ('FVStu', 'uptake of fluvastatin by enterocytes'), | |
| ('GLC3MEACPhr', 'glucuronidation of 3-methoxy-acetaminophen in hepatocytes'), | |
| ('GLC3MEACPtev', | |
| 'efflux of glucuronide-conjugate of 3-methoxy-acetaminophen into hepatic vein'), | |
| ('GLZABCteb', 'excretion of gliclazide into bile'), | |
| ('GLZtd', 'uptake of gliclazide into enterocytes'), | |
| ('GTACMPhr', | |
| 'glucuronidation of thiomethyl-acetaminophen conjugate in hepatocytes'), | |
| ('GTACMPtev', | |
| 'efflux of glucuronide-thiomethyl-acetaminophen conjugate into hepatic vein'), | |
| ('IBUPGLUCtchep', 'uptake of ibuprofen acyl glucuronide into hepatocytes'), | |
| ('IBUPGLUCtpvb', | |
| 'release of iboprofen acyl glucuronides into the portal blood'), | |
| ('ISOLVSTAChep', | |
| "acid catalyzed rearrangement of 6''-beta-hydroxy-lovastatin-acid form"), | |
| ('ISOLVSTtbc', | |
| "release of 3''-hydroxy-iso-delta-4'',5''-hydroxy acid form of lovastatin into bile"), | |
| ('LST4EXPTDhc', 'uptake of Losartan-E3174 into hepatocytes via diffusion'), | |
| ('LST4EXPhr', | |
| 'oxidation of losartan to active metabolite EXP3174 (M6) in hepatocytes'), | |
| ('LST4EXPthc', 'uptake of Losartan-E3174 into hepatocytes'), | |
| ('LSTN1GLUChr', 'formation of losartan-N1-glucuronide in hepatocytes'), | |
| ('LSTN1GLUCtev', 'efflux of Losartan-N1-glucuronide into hepatic vein'), | |
| ('LSTNtu', 'efflux of losartan by P-gp from the enterocytes into lumen'), | |
| ('LSTNM1hr', 'oxidation of losartan to Losartan-M1 in hepatocytes'), | |
| ('LSTNM1tev', 'efflux of Losartan-M1 into hepatic vein'), | |
| ('LSTNM2hr', 'oxidation of losartan to Losartan-M2 in hepatocytes'), | |
| ('LSTNM2tev', 'efflux of Losartan-M2 into hepatic vein'), | |
| ('LSTNM4hr', 'glucuronidation of losartan-M6 to losartan-M4 in hepatocytes'), | |
| ('LSTNM4tev', | |
| 'efflux of Losartan-M4 (glucuronide derivative) into hepatic vein'), | |
| ('LSTNM5hr', 'oxidation of losartan to Losartan-M5 in hepatocytes'), | |
| ('LSTNM5tev', 'efflux of Losartan-M5 into hepatic vein'), | |
| ('LSTNM7TDhc', | |
| 'uptake of Losartan-N2-glucuronide / Losartan-M7 into hepatocytes via diffusion'), | |
| ('LSTNM7hr', | |
| 'glucuronidation of losartan to losartan-M7/Losartan-N2-glucuronide in hepatocytes'), | |
| ('LSTNM7thc', | |
| 'uptake of Losartan-N2-glucuronide / Losartan-M7 into hepatocytes'), | |
| ('LSTNRATt', 'uptake of losartan via antiport into enterocytes'), | |
| ('LSTNtd', 'uptake of losartan via diffusion into enterocytes'), | |
| ('LVACLAChep', | |
| 'reconversion of open acid form to lactone form of lovastatin'), | |
| ('LVSTACIDhep', | |
| 'conversion of pro-durg lovastatin to active hydroxyacid form in hepatocytes'), | |
| ('LVSTACIDtu', | |
| 'efflux of lovastatin acid by P-gp from the enterocytes into lumen'), | |
| ('LVSTACOXD6Hhep', | |
| "hydroxylation of lovastatin-hydroxyacid form to 6''-beta-hydroxy-lovastatin-acid form"), | |
| ('LVSTACOXD6MEhep', | |
| "hydroxylation of lovastatin-hydroxyacid form to 6''-beta-hydroxy-lovastatin-acid form"), | |
| ('LVSTOXD3Hhep', | |
| "oxidation of lovastatin to 3''''-hydroxy-lovastatin in hepatocytes"), | |
| ('LVSTOXD6Hhep', | |
| "oxidation of lovastatin to 6''-beta-hydroxy-lovastatin in hepatocytes"), | |
| ('LVSTOXD6METhep', | |
| "oxidation of lovastatin to 6''-exomethylene-lovastatin in hepatocytes"), | |
| ('LVSTPGPtu', | |
| 'efflux of lovastatin lactone by P-gp from the enterocytes into lumen'), | |
| ('LVSTtu', 'uptake of lovastatin by enterocytes'), | |
| ('MDZGLCtev', 'efflux of midazolam-glucuronide into hepatic vein'), | |
| ('MDZtd', 'uptake of midazolam by enterocytes'), | |
| ('MDZtu', 'efflux of midazolam by P-gp from the enterocytes into lumen'), | |
| ('MERACMPtep', | |
| 'efflux of acetaminophen-mercapturate-conjugate from enterocytes into portal blood'), | |
| ('MERACMPthc', | |
| 'uptake of acetaminophen-mercapturate-conjugate by the hepatocytes'), | |
| ('MHGLZABCt', 'excretion of Methyl-hydroxy-gliclazide into bile'), | |
| ('MHGLZhr', | |
| 'oxidation of gliclazide to methyl-hydroxy-gliclazide in hepatocytes'), | |
| ('MHGLZtev', 'excretion of Methyl-hydroxy-gliclazide into hepatic vein'), | |
| ('NDERSVhc', 'demethylation of rosuvastatin in hepatocytes'), | |
| ('NDERSVteb', 'efflux of N-desmethyl-rosuvastatin into bile'), | |
| ('NFDLACtep', 'exit of lactone form of nifedipine into portal vein'), | |
| ('OXYP1CONJ', 'conjugation of oxypurinol to oxypurinol-1-riboside'), | |
| ('OXYP2CONJ', 'conjugation of oxypurinol to oxypurinol-7-riboside'), | |
| ('OXYPR1tehv', 'release of oxypurinol-1-riboside into hepatic vein'), | |
| ('OXYPR7tehv', 'release of oxypurinol-7-riboside into hepatic vein'), | |
| ('OXYPthc', 'uptake of oxypurinol by hepatocytes'), | |
| ('OXYPtepv', 'release of oxypurinol into portal blood'), | |
| ('PROFVShc', | |
| 'thioesterase/ hydrolase for release of des-isoproylpropionic-acid-fluvastatin in hepatocytes'), | |
| ('PROFVStev', | |
| 'exit of des-isoproylpropionic-acid-fluvastatin into hepatic vein'), | |
| ('PTVSTATPtu', | |
| 'efflux of pitavastatin by BCRP from the enterocytes into lumen'), | |
| ('PTVSTGLUChc', 'glucuronidation of pitavastatin in hepatocytes'), | |
| ('PTVSTLAChc', | |
| 'spontaneous conversion of glucuronide to lactone form of pitavastatin in hepatocytes'), | |
| ('PTVSTLACtev', 'exit of pravastatin-lactone into hepatic vein'), | |
| ('PTVSTM13hr', | |
| 'oxidation of pitavastatin to pitavastatin-M13 in hepatocytes'), | |
| ('PTVSTM3eb', 'efflux of pitavastatin-M3 into bile'), | |
| ('PTVSTM3hc', 'oxidation of pitavastatin to pitavastatin-M3 in hepatocytes'), | |
| ('PTVSThc', | |
| 'hydrolysis of latone to free acid form of pitavastatin in hepatocytes'), | |
| ('PTVSTtep', 'efflux of pitavastatin from enterocytes into portal blood'), | |
| ('PTVSTtu', 'uptake of pitavastatin by enterocytes'), | |
| ('PVSATPtu', 'pravastatin efflux into lumen for excretion into feces'), | |
| ('PVSGLUChc', 'glucuronidation of pravastatin in hepatocytes'), | |
| ('PVSGLUCteb', 'efflux of pravastatin glucuronide into bile'), | |
| ('PVSGLUCtev', 'exit of pravastatin glucuronide into hepatic vein'), | |
| ('PVSHtu', | |
| 'uptake of pravastatin by enterocytes via proton coupled mechanism'), | |
| ('PVSOATPtu', 'uptake of pravastatin by enterocytes'), | |
| ('PVStep', 'pravastatin exit into portal blood'), | |
| ('RSVATPtu', | |
| 'efflux of rosuvastatin by BCRP from the enterocytes into lumen'), | |
| ('RSVGLUChc', 'glucuronidation of rosuvastatin in hepatocytes'), | |
| ('RSVLAChv', | |
| 'spontaneous conversion to rosuvastatin-5S-lactone in hepatocytes'), | |
| ('RSVLACteb', 'efflux of rosuvastatin-5S-lactone into bile'), | |
| ('RSVSPONhc', 'conversion of lactone to open acid form of rosuvastatin'), | |
| ('RSVhc', 'beta-glucuronidase of rosuvastatin-glucuronide in hepatocytes'), | |
| ('RSVtev', 'exit of rosuvastatin into hepatic vein'), | |
| ('RSVtu', 'uptake of rosuvastatin by enterocytes'), | |
| ('S3MEACMPhc', 'sulphation of 3-methoxy-acetaminophen in hepatocytes'), | |
| ('S3MEACMPtev', | |
| 'efflux of sulphate-conjugate-3-methoxy-acetaminophen into hepatic vein'), | |
| ('SMVACIDATPteb', 'efflux of simvastatin dihydroxy acid form into bile'), | |
| ('SMVACIDhep', | |
| 'beta-glucuronidation of simvastatin-acyl-glucuronide to simvastatin dihydroxy acid form'), | |
| ('SMVACIDtev', 'efflux of simvastatin dihydroxy acid form into hepatic vein'), | |
| ('SMVtu', 'efflux of simvastatin by P-gp from the enterocytes into lumen'), | |
| ('SMVGLUCLAChep', | |
| 'spontaneous conversion of glucuronide to lactone form of simvastatin'), | |
| ('SMVGLUChep', 'glucuronidation of the open acid form of simvastatin'), | |
| ('SMVHYDROhep', 'conversion of simvastatin pro-drug to active form'), | |
| ('SMVLAChep', 'conversion of open acid form to lactone form of simvastatin'), | |
| ('SMVtv', 'uptake of simvastatin by enterocytes'), | |
| ('SMVthep', 'uptake of simvastatin by hepatocytes'), | |
| ('STACMPhc', | |
| 'sulphation of thiomethyl-acetaminophen conjugate in hepatocytes'), | |
| ('STACMPtev', | |
| 'efflux of sulphate-thiomethyl-acetaminophen conjugate into hepatic vein'), | |
| ('SULPACMPtev', 'efflux of acetaminophen-sulphate into hepatic vein'), | |
| ('TACRDtsc', 'uptake of tacrolimus by enterocytes'), | |
| ('TACRtu', 'efflux of tacrolimus into intestinal lumen by P-gp'), | |
| ('TAURIBUP_Sthv', | |
| 'release of taurine conjugate of S-ibuprofen into hepatic vein'), | |
| ('THRFVShc', 'threo isomer formation of fluvastatin'), | |
| ('THRFVStev', | |
| 'exit of threo-isomer of fluvastain into hepatic vein for excretion in urine'), | |
| ('THSACMPhr', | |
| 'formation of thiomethyl-sulphoxide-conjugate of acetaminophen in hepatocytes'), | |
| ('TLACFVShc', | |
| 'spontaneous conversion of glucuronide to trans-lactone-fluvastatin in hepatocytes'), | |
| ('TLACFVStev', | |
| 'exit of trans-lactone-fluvastatin into hepatic vein for excretion in urine'), | |
| ('TMDM1OATt', 'efflux of Torasemide-M1 into hepatic vein'), | |
| ('TMDM1hr', 'tolyl methylhydroxylation of torasemide in hepatocytes'), | |
| ('TMDM3OATt', 'efflux of Torasemide-M3 into hepatic vein'), | |
| ('TMDM3hr', 'hydroxylation of torasemide to torasemide-M3 in hepatocytes'), | |
| ('TMDM5OATt', 'efflux of Torasemide-M5 into hepatic vein'), | |
| ('TMDM5hr', 'oxidation of torasemide-M1 to M5 in hepatocytes'), | |
| ('TMDOATPtsc', 'uptake of torasemide into enterocytes via antiport'), | |
| ('TMDOATtev', 'efflux of Torasemide into hepatic vein'), | |
| ('TMDOATthc', 'uptake of torasemide into hepatocytes via OAT1'), | |
| ('TMDtd', 'uptake of torasemide into enterocytes via diffusion'), | |
| ('TRIPVShc', 'formation of triol metabolite of pravastatin in hepatocytes'), | |
| ('TRIPVSteb', 'efflux of triol metabolite of pravastatin into bile'), | |
| ('TRIPVStev', 'exit of triol metabolite of pravastatin into hepatic vein'), | |
| ('TSACGLUCtev', | |
| 'efflux of thiomethyl-sulphoxide-acetaminophen-glucuronide into hepatic vein'), | |
| ('TSACMGLUChr', | |
| 'glucuronidation of thiomethyl-sulphoxide-conjugate of acetaminophen in hepatocytes'), | |
| ('TSACMSULhc', | |
| 'sulphation of thiomethyl-sulphoxide-conjugate of acetaminophen in hepatocytes'), | |
| ('TSACMSULtev', | |
| 'efflux of thiomethyl-sulphoxide-acetaminophen-sulphate into hepatic vein'), | |
| ('12HTACRitr', '12HTACRitr'), | |
| ('13HTACRitr', '13HTACRitr'), | |
| ('14HMDZitr', '14HMDZitr'), | |
| ('1513TACRitr', '1513TACRitr'), | |
| ('1531TACRitr', '1531TACRitr'), | |
| ('1HIBUPGLUitr', '1HIBUPGLUitr'), | |
| ('1HMDGLUCitr', '1HMDGLUCitr'), | |
| ('2HATVACIDGLUCitr', '2HATVACIDGLUCitr'), | |
| ('2HATVLACGLUCitr', '2HATVLACGLUCitr'), | |
| ('2HIBUPGLUC_Sitr', '2HIBUPGLUC_Sitr'), | |
| ('35DHPVSitr', '35DHPVSitr'), | |
| ('35DSMVitr', '35DSMVitr'), | |
| ('3HIBUPGLUC_Sitr', '3HIBUPGLUC_Sitr'), | |
| ('3HLVSTitr', '3HLVSTitr'), | |
| ('3HPVSitr', '3HPVSitr'), | |
| ('3HPVSCOAitm', '3HPVSCOAitm'), | |
| ('3HPVSCOAitx', '3HPVSCOAitx'), | |
| ('3HPVSTETCOAitm', '3HPVSTETCOAitm'), | |
| ('3HPVSTETCOAitx', '3HPVSTETCOAitx'), | |
| ('3HSMVitr', '3HSMVitr'), | |
| ('3ISPVSitr', '3ISPVSitr'), | |
| ('3MEACMPitr', '3MEACMPitr'), | |
| ('3OHACMPitr', '3OHACMPitr'), | |
| ('4BHGLZitr', '4BHGLZitr'), | |
| ('4HATVACIDitr', '4HATVACIDitr'), | |
| ('4HATVLACitr', '4HATVLACitr'), | |
| ('4HMDGLUCitr', '4HMDGLUCitr'), | |
| ('4OHMDZitr', '4OHMDZitr'), | |
| ('56DHPVSitr', '56DHPVSitr'), | |
| ('56EPPVSitr', '56EPPVSitr'), | |
| ('5OHFVSitr', '5OHFVSitr'), | |
| ('5OHFVSGLUitr', '5OHFVSGLUitr'), | |
| ('6AHGLZitr', '6AHGLZitr'), | |
| ('6BHGLZGLCitr', '6BHGLZGLCitr'), | |
| ('6CSMVitr', '6CSMVitr'), | |
| ('6HLVSTitr', '6HLVSTitr'), | |
| ('6HLVSTACIDitr', '6HLVSTACIDitr'), | |
| ('6HMSMVitr', '6HMSMVitr'), | |
| ('6HSMVitr', '6HSMVitr'), | |
| ('6MELVACIDitr', '6MELVACIDitr'), | |
| ('6MELVSTitr', '6MELVSTitr'), | |
| ('6OHFVSitr', '6OHFVSitr'), | |
| ('6OHFVSGLUitr', '6OHFVSGLUitr'), | |
| ('7AHGLZitr', '7AHGLZitr'), | |
| ('7BHGLZGLCitr', '7BHGLZGLCitr'), | |
| ('7HPVSitr', '7HPVSitr'), | |
| ('ACMPitr', 'ACMPitr'), | |
| ('ACMPGLUitr', 'ACMPGLUitr'), | |
| ('AM19CSitr', 'AM19CSitr'), | |
| ('AM1ACCSitr', 'AM1ACCSitr'), | |
| ('AM1ACSitr', 'AM1ACSitr'), | |
| ('AM1ALCSitr', 'AM1ALCSitr'), | |
| ('AM1C9CSitr', 'AM1C9CSitr'), | |
| ('AM1CGLCitr', 'AM1CGLCitr'), | |
| ('AM4N9CSitr', 'AM4N9CSitr'), | |
| ('AM4NCSitr', 'AM4NCSitr'), | |
| ('CARIBUP_Sitr', 'CARIBUP_Sitr'), | |
| ('CARIBUPGLU_Sitr', 'CARIBUPGLU_Sitr'), | |
| ('CRGLZitr', 'CRGLZitr'), | |
| ('CRVSitr', 'CRVSitr'), | |
| ('CRVSM22itr', 'CRVSM22itr'), | |
| ('CRVSM24itr', 'CRVSM24itr'), | |
| ('CRVSM31itr', 'CRVSM31itr'), | |
| ('CSAitr', 'CSAitr'), | |
| ('DEOXFVSitx', 'DEOXFVSitx'), | |
| ('DESFVSitr', 'DESFVSitr'), | |
| ('DSPVSitr', 'DSPVSitr'), | |
| ('EPOXTACitr', 'EPOXTACitr'), | |
| ('FVSitx', 'FVSitx'), | |
| ('FVSCOAitx', 'FVSCOAitx'), | |
| ('FVSTETitr', 'FVSTETitr'), | |
| ('FVSTETGLUitr', 'FVSTETGLUitr'), | |
| ('GLC3MEACPitr', 'GLC3MEACPitr'), | |
| ('GLZitr', 'GLZitr'), | |
| ('GTACMPitr', 'GTACMPitr'), | |
| ('IBUPGLUCitr', 'IBUPGLUCitr'), | |
| ('LSTN1GLUCitr', 'LSTN1GLUCitr'), | |
| ('LSTNitr', 'LSTNitr'), | |
| ('LSTNM1itr', 'LSTNM1itr'), | |
| ('LSTNM2itr', 'LSTNM2itr'), | |
| ('LSTNM4itr', 'LSTNM4itr'), | |
| ('LSTNM5itr', 'LSTNM5itr'), | |
| ('LSTNM7itr', 'LSTNM7itr'), | |
| ('LVSTitr', 'LVSTitr'), | |
| ('LVSTACIDitr', 'LVSTACIDitr'), | |
| ('MDZitr', 'MDZitr'), | |
| ('MDZGLCitr', 'MDZGLCitr'), | |
| ('NDERSVitr', 'NDERSVitr'), | |
| ('PROFVSCOAitx', 'PROFVSCOAitx'), | |
| ('PTVSTLACitr', 'PTVSTLACitr'), | |
| ('PTVSTM13itr', 'PTVSTM13itr'), | |
| ('PTVSTM13te', 'PTVSTM13te'), | |
| ('PTVSTM3itr', 'PTVSTM3itr'), | |
| ('PVSitr', 'PVSitr'), | |
| ('PVSGLUCitr', 'PVSGLUCitr'), | |
| ('RSVLACitr', 'RSVLACitr'), | |
| ('TACRitr', 'TACRitr'), | |
| ('THSACMPitr', 'THSACMPitr'), | |
| ('TLACFVSitr', 'TLACFVSitr'), | |
| ('TMACMPitr', 'TMACMPitr'), | |
| ('TMDitr', 'TMDitr'), | |
| ('TMDM1itr', 'TMDM1itr'), | |
| ('TMDM3itr', 'TMDM3itr'), | |
| ('TMDM5itr', 'TMDM5itr'), | |
| ('TSACMGLUCitr', 'TSACMGLUCitr'), | |
| ('3HPVSCOAhc', '3HPVSCOAhc'), | |
| ('3HPVSTEThc', '3HPVSTEThc'), | |
| ('ACMPGLUTTRsc', 'ACMPGLUTTRsc'), | |
| ('FVSCOAhc', 'FVSCOAhc'), | |
| ('MDZGLChr', 'MDZGLChr'), | |
| ('1OHMDZitr', '1OHMDZitr'), | |
| ('CYSACMPitr', 'CYSACMPitr'), | |
| ('ACMPGLUTitr', 'ACMPGLUTitr'), | |
| ('NAPQIhr', 'NAPQIhr'), | |
| ('H2O2itr', 'H2O2itr'), | |
| ('UDPRIBc', 'UDPRIBc'), | |
| ('GLYitr', 'GLYitr'), | |
| ('PAPSitr', 'PAPSitr'), | |
| ('PAPitr', 'PAPitr'), | |
| ('13DMTitr', '13DMTitr'), | |
| ('15DMTitr', '15DMTitr'), | |
| ('ATVACIDitr', 'ATVACIDitr'), | |
| ('ATVLACitr', 'ATVLACitr'), | |
| ('31DMTitr', '31DMTitr'), | |
| ('SMVitr', 'SMVitr'), | |
| ('6BHGLZitr', '6BHGLZitr'), | |
| ('7BHGLZitr', '7BHGLZitr'), | |
| ('AM1CCSitr', 'AM1CCSitr'), | |
| ('LST4EXPitr', 'LST4EXPitr'), | |
| ('MHGLZitr', 'MHGLZitr'), | |
| ('RSVitr', 'RSVitr'), | |
| ('TRIPVSitr', 'TRIPVSitr'), | |
| ('SMVACIDitr', 'SMVACIDitr'), | |
| ('PTVSTitr', 'PTVSTitr'), | |
| ('FVSitr', 'FVSitr'), | |
| ('AM1CSAitr', 'AM1CSAitr'), | |
| ('AM9CSAitr', 'AM9CSAitr'), | |
| ('2HATVACIDitr', '2HATVACIDitr'), | |
| ('EX_hx_LPAREN_e_RPAREN_', 'exchange reaction for hexanoate (n-C6:0)'), | |
| ('FACOAL100i', 'fatty-acid--CoA ligase (decanoate, n-C10:0)'), | |
| ('FACOAL120i', 'fatty-acid--CoA ligase (dodecanoate, n-C12:0)'), | |
| ('FACOAL60i', 'fatty-acid--CoA ligase (hexanoate, n-C6:0)'), | |
| ('HXt', 'hexanoate transport via diffusion'), | |
| ('C60CRNt', 'C160 transport into the mitochondria'), | |
| ('C60CPT2', 'carnitine O-hexanoyl transferase'), | |
| ('C100CRNt', 'C160 transport into the mitochondria'), | |
| ('C100CPT2', 'carnitine O-hexanoyl transferase'), | |
| ('C120CRNt', 'transport into the mitochondria (carnitine)'), | |
| ('C120CPT2', 'carnitine transferase'), | |
| ('AIRCr_PRASCS', | |
| 'phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazolesuccinocarboxamide synthase'), | |
| ('FAOXC10080m', 'R_FAOXC10080m'), | |
| ('FAOXC10080x', 'R_FAOXC10080x'), | |
| ('FAOXC101_3Em', 'R_FAOXC101_3Em'), | |
| ('FAOXC101_4Em', 'R_FAOXC101_4Em'), | |
| ('FAOXC101_4Zm', 'R_FAOXC101_4Zm'), | |
| ('FAOXC101_4Zx', 'R_FAOXC101_4Zx'), | |
| ('FAOXC102_4Z_7Zm', 'R_FAOXC102_4Z_7Zm'), | |
| ('FAOXC102_4Z_7Zx', 'R_FAOXC102_4Z_7Zx'), | |
| ('FAOXC11090m', 'R_FAOXC11090m'), | |
| ('FAOXC120100m', 'R_FAOXC120100m'), | |
| ('FAOXC120100x', 'R_FAOXC120100x'), | |
| ('FAOXC121_3Em', 'R_FAOXC121_3Em'), | |
| ('FAOXC121_3Zm', 'R_FAOXC121_3Zm'), | |
| ('FAOXC121_5Em', 'R_FAOXC121_5Em'), | |
| ('FAOXC122_3E_6Em', 'R_FAOXC122_3E_6Em'), | |
| ('FAOXC122_3Z_6Zm', 'R_FAOXC122_3Z_6Zm'), | |
| ('FAOXC122_3Z_6Zx', 'R_FAOXC122_3Z_6Zx'), | |
| ('FAOXC123_3Z_6Z_9Zm', 'R_FAOXC123_3Z_6Z_9Zm'), | |
| ('FAOXC123_3Z_6Z_9Zx', 'R_FAOXC123_3Z_6Z_9Zx'), | |
| ('FAOXC130110m', 'R_FAOXC130110m'), | |
| ('FAOXC140120m', 'R_FAOXC140120m'), | |
| ('FAOXC140120x', 'R_FAOXC140120x'), | |
| ('FAOXC141_5Em', 'R_FAOXC141_5Em'), | |
| ('FAOXC141_5Zm', 'R_FAOXC141_5Zm'), | |
| ('FAOXC141_7Em', 'R_FAOXC141_7Em'), | |
| ('FAOXC142_5E_8Em', 'R_FAOXC142_5E_8Em'), | |
| ('FAOXC142_5Z_8Zm', 'R_FAOXC142_5Z_8Zm'), | |
| ('FAOXC142_5Z_8Zx', 'R_FAOXC142_5Z_8Zx'), | |
| ('FAOXC143_5Z_8Z_11Zm', 'R_FAOXC143_5Z_8Z_11Zm'), | |
| ('FAOXC143_5Z_8Z_11Zx', 'R_FAOXC143_5Z_8Z_11Zx'), | |
| ('FAOXC150130m', 'R_FAOXC150130m'), | |
| ('FAOXC160140m', 'R_FAOXC160140m'), | |
| ('FAOXC160140x', 'R_FAOXC160140x'), | |
| ('FAOXC161_7Em', 'R_FAOXC161_7Em'), | |
| ('FAOXC161_7Zm', 'R_FAOXC161_7Zm'), | |
| ('FAOXC161_9Em', 'R_FAOXC161_9Em'), | |
| ('FAOXC161140m', 'R_FAOXC161140m'), | |
| ('FAOXC162_7E_10Em', 'R_FAOXC162_7E_10Em'), | |
| ('FAOXC162_7Z_10Zm', 'R_FAOXC162_7Z_10Zm'), | |
| ('FAOXC163_4Z_7Z_10Zm', 'R_FAOXC163_4Z_7Z_10Zm'), | |
| ('FAOXC163_4Z_7Z_10Zx', 'R_FAOXC163_4Z_7Z_10Zx'), | |
| ('FAOXC163_7Z_10Z_13Zm', 'R_FAOXC163_7Z_10Z_13Zm'), | |
| ('FAOXC164_4Z_7Z_10Z_13Zm', 'R_FAOXC164_4Z_7Z_10Z_13Zm'), | |
| ('FAOXC164_4Z_7Z_10Z_13Zx', 'R_FAOXC164_4Z_7Z_10Z_13Zx'), | |
| ('FAOXC170150m', 'R_FAOXC170150m'), | |
| ('FAOXC181_11Em', 'R_FAOXC181_11Em'), | |
| ('FAOXC181_9Em', 'R_FAOXC181_9Em'), | |
| ('FAOXC181_9Zm', 'R_FAOXC181_9Zm'), | |
| ('FAOXC182_9E_12Em', 'R_FAOXC182_9E_12Em'), | |
| ('FAOXC182_9Z_12Zm', 'R_FAOXC182_9Z_12Zm'), | |
| ('FAOXC183_6Z_9Z_12Zm', 'R_FAOXC183_6Z_9Z_12Zm'), | |
| ('FAOXC183_6Z_9Z_12Zx', 'R_FAOXC183_6Z_9Z_12Zx'), | |
| ('FAOXC183_9Z_12Z_15Zm', 'R_FAOXC183_9Z_12Z_15Zm'), | |
| ('FAOXC184_3Z_6Z_9Z_12Zm', 'R_FAOXC184_3Z_6Z_9Z_12Zm'), | |
| ('FAOXC184_3Z_6Z_9Z_12Zx', 'R_FAOXC184_3Z_6Z_9Z_12Zx'), | |
| ('FAOXC184_6Z_9Z_12Z_15Zm', 'R_FAOXC184_6Z_9Z_12Z_15Zm'), | |
| ('FAOXC184_6Z_9Z_12Z_15Zx', 'R_FAOXC184_6Z_9Z_12Z_15Zx'), | |
| ('FAOXC185_3Z_6Z_9Z_12Z_15Zm', 'R_FAOXC185_3Z_6Z_9Z_12Z_15Zm'), | |
| ('FAOXC185_3Z_6Z_9Z_12Z_15Zx', 'R_FAOXC185_3Z_6Z_9Z_12Z_15Zx'), | |
| ('FAOXC201181x', 'R_FAOXC201181x'), | |
| ('FAOXC204_5Z_8Z_11Z_14Zm', 'R_FAOXC204_5Z_8Z_11Z_14Zm'), | |
| ('FAOXC204_5Z_8Z_11Z_14Zx', 'R_FAOXC204_5Z_8Z_11Z_14Zx'), | |
| ('FAOXC204184m2', 'R_FAOXC204184m2'), | |
| ('FAOXC205_5Z_8Z_11Z_14Z_17Zm', 'R_FAOXC205_5Z_8Z_11Z_14Z_17Zm'), | |
| ('FAOXC205_5Z_8Z_11Z_14Z_17Zx', 'R_FAOXC205_5Z_8Z_11Z_14Z_17Zx'), | |
| ('FAOXC220200x', 'R_FAOXC220200x'), | |
| ('FAOXC221201x', 'R_FAOXC221201x'), | |
| ('FAOXC225_4Z_7Z_10Z_13Z_16Zm', 'R_FAOXC225_4Z_7Z_10Z_13Z_16Zm'), | |
| ('FAOXC225_4Z_7Z_10Z_13Z_16Zx', 'R_FAOXC225_4Z_7Z_10Z_13Z_16Zx'), | |
| ('FAOXC241221x', 'R_FAOXC241221x'), | |
| ('FAOXC4020m', 'R_FAOXC4020m'), | |
| ('FAOXC5030m', 'R_FAOXC5030m'), | |
| ('FAOXC6040m', 'R_FAOXC6040m'), | |
| ('FAOXC61_3Zm', 'R_FAOXC61_3Zm'), | |
| ('FAOXC7050m', 'R_FAOXC7050m'), | |
| ('FAOXC8060m', 'R_FAOXC8060m'), | |
| ('FAOXC81_5Zm', 'R_FAOXC81_5Zm'), | |
| ('FAOXC9070m', 'R_FAOXC9070m'), | |
| ('FAOXCPRIST1x', 'R_FAOXCPRIST1x'), | |
| ('FAOXCPRIST2x', 'R_FAOXCPRIST2x'), | |
| ('FAOXCPRIST3x', 'R_FAOXCPRIST3x')] |
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