Tweetbot can use regular expressions to mute tweets in your timeline and mentions.

more-mute-regex.md

##Simply annoying Tweets

Annoyingly extended words (4+ of the same letter in a phrase): OOOOHHHHMMMMYYYYGGGGOOOODDDD

([a-z])/1{4}

Tweet w/ just a single hashtag: #omgthissucks

^ *#[^ ]+$

Not a regex, but self retweets: In case you missed it I pooped this morning :)

In case you missed it

##App Location Updates

(updated for multiple words in Location name) Path app location updates: (at Location) - path.com/foo

\(at [a-zA-z0-9_ ]*\) — http://[^ ]+$

Foursquare app location updates: w/ @twittername 4sq.com/foo

w/ @[^@]+ http://[^ ]+$

More Foursquare app location updates: w/ 8 others 4sq.com/foo

w/ [0-9]+ others http://[^ ]+$

Yet more Foursquare app location updates (seriously...): (@ Location w/ 4 others) 4sq.com/foo

\(@ [a-zA-Z0-9_/ ] w/ [0-9]+ others*\) http://[^ ]+$

tweetbot-mute-regex.md

Hashtag abuse

Three or more hashtags.

#[^#]+#[^#]+#

Long hashtags (15+ characters): #hashtagpunchline

#[^ ]{15}

CamelCase hashtags (3+ Words): #NotSelfAware

#[^a-z ]+[^A-Z ]+[^a-z ]+[^A-Z ]+[^a-z ]+[^ ]*

Painful to read

Unforgivable word shortening: I'm near ur place r u busy?

\sur\s
\sr\s
\su\s

Mass conversations (4+ Mentions): @guy @dude @otherguy @man totally.

@[^@]+@[^@]+@[^@]+@

Retweet chains (2+ RTs): OMG RT @teengirlsquad RT @beebz I'm thinking of you.

RT[^RT]+RT

Mentions with only a URL (spam): @imathis tinyurl.com/spam

^@imathis *https?://[^ ]+$