multi-update.clj

(defmacro multi-update
 [m & update-forms]
 `(-> ~m ~@(map #(cons 'update-in %) update-forms)))

(multi-update {:a 10 :b 20 :c 30}
              ([:a] + 1)
              ([:b] + 1 1)
              ([:c] + 1 2))

; {:a 11 :b 22 :c 33}

You could do this, but most of the time it is overkill. All you're really doing is losing the update-ins that occur on those three lines. But what you lose is readability, because the reader needs to understand what multi-update does. Yes, it is a little less code/duplication, but I personally don't think the tradeoff is worth it.