Script to delete all of your tweets. Requires Python 3.x, Twython, and API keys.

delete_tweets.py

#Schuyler Mortimer
from twython import Twython
import sys

#get from twitter developer site
APP_KEY = ''
APP_SECRET = ''
TOKEN = ''
TOKEN_SECRET = ''

def batch_delete(twitter):

	#ran into a 200 tweet limit, loop gets around this
	while True:

		#get the timeline
		try:
			timeline = twitter.get_user_timeline(count=200)
		except:
			print("You made a mistake.")
			sys.exit()

		if len(timeline) == 0:
			print("No tweets left to delete")
			break

		#delete the timeline
		for tweet in timeline:
			status = int(tweet['id_str'])
			twitter.destroy_status(id=status)
			print('Tweet deleted: ' + str(status))
		print(len(timeline))


def main():
	twitter = Twython(APP_KEY, APP_SECRET, TOKEN, TOKEN_SECRET)
	batch_delete(twitter)

if __name__ == '__main__':
	main()

I found this useful!

Thanks. Was useful to me as well.