my.cnf working with large Drupal databases

my.cnf

# The MySQL server
[mysqld]
port  	= 3306
socket		= /tmp/mysql.sock
skip-external-locking
key_buffer_size = 256M
max_allowed_packet = 64M
table_open_cache = 256
table_cache = 4096
sort_buffer_size = 64M
read_buffer_size = 64M
read_rnd_buffer_size = 64M
myisam_sort_buffer_size = 64M
thread_cache_size = 8
query_cache_size= 64M
# Try number of CPU's*2 for thread_concurrency
thread_concurrency = 8
wait_timeout = 120