NPoco with Autofac and ASP.NET MVC https://code.google.com/p/autofac/wiki/MvcIntegration

global.asax.cs

public class MvcApplication : HttpApplication
{
    protected void Application_Start()
    {
        AreaRegistration.RegisterAllAreas();
        RegisterRoutes(RouteTable.Routes);

        SetupIoc();
    }
    
    private void SetupIoc()
    {
        var builder = new ContainerBuilder();
    
        builder.Register(c => new Database("CONNECTION_STRING_KEY"))
            .As<IDatabase>()
            .InstancePerHttpRequest();
        
        builder.RegisterModule(new AutofacWebTypesModule());
        builder.RegisterSource(new ViewRegistrationSource());
        builder.RegisterType<ExtensibleActionInvoker>()
            .As<IActionInvoker>();

        builder.RegisterControllers(typeof(MvcApplication).Assembly)
            .InjectActionInvoker()
            .PropertiesAutowired()
            .OnActivated(e =>
            {
                dynamic viewBag = ((Controller)e.Instance).ViewBag;
                viewBag.SiteTitle = "Example Site";
            });
        
        var container = builder.Build();
        DependencyResolver.SetResolver(new AutofacDependencyResolver(container));
    }
}