app.py

from flask import Flask
from flask.ext.sqlalchemy import SQLAlchemy


app = Flask(__name__)
app.config['SQLALCHEMY_BINDS'] = {
    'postgres': 'postgresql+psycopg2://wazinit:wazinit@localhost/test_binds',
    'mysql': 'mysql://hivelocity:test@localhost/hivelocity_shared',
}
db = SQLAlchemy(app)


class PostgresModel(db.Model):
    __tablename__ = 'postgres_model'
    __bind_key__ = 'postgres'

    id = db.Column(db.Integer, primary_key=True)


class MySQLModel(db.Model):
    __tablename__ = 'mysql_model'
    __bind_key__ = 'mysql'

    id = db.Column(db.Integer, primary_key=True)
    my_enum = db.Column(db.Enum('A', 'B'))


if __name__ == '__main__':
    db.create_all()

requirements.txt

Flask-SQLAlchemy
psycopg2
MySQL-python