pypreload

#!/bin/bash
# usage: pypreload <code> <cmd> [<arg> [<arg> […]]]
#
# See <https://docs.python.org/3/library/site.html> for how the "sitecustomize"
# module works.
#
set -euo pipefail

code="$1"
shift

tmplib="$(mktemp -dt "$(basename "$0")"-XXXXXX)"

cat > "$tmplib/sitecustomize.py" <<~~
# written by $0 to run: $*
$code

# remove ourselves from consideration
import sys, os.path
del sys.modules["sitecustomize"]
sys.path.remove(os.path.dirname(__file__))

# import any sitecustomize we masked
import sitecustomize
~~

PYTHONPATH="$tmplib${PYTHONPATH:+:}${PYTHONPATH:-}"
export PYTHONPATH

exec "$@"

https://github.com/tsibley/PY_PRELOAD