gistfile1.py

# Loop over each object and either update or create.

try:
    obj = MyObject.objects.get(pk=id)
    obj.value1 = 1
    obj.value2 = 2
except MyObject.DoesNotExist:
    obj = MyObject(value1=1, value2=2, ...)

# Update the object
obj.save()
    
# You could also use get_or_create here:
# https://docs.djangoproject.com/en/dev/ref/models/querysets/#get-or-create

obj, created = MyObject.objects.get_or_create(value1=1, value2=2)