Use Virtualenvironment wrapper.
Installation.
$ cat requirements.txt
gunicorn
$ pip install -r requirements.txt
Sample Config: /etc/systemd/system/gunicorn.service
[Unit]
Description=gunicorn daemon
After=network.target
[Service]
User=centos
Group=centos
WorkingDirectory=/svpack/projects/gunicorn
ExecStart=/svpack/.virtualenvs/boto/bin/gunicorn --workers 3 --bind unix:/svpack/projects/gunicorn/mysock.sock wsgi
[Install]
WantedBy=multi-user.target
systemctl start gunicorn
systemctl enable gunicorn
systemctl status gunicorn