Silverstripe 4 uses an older version of Swift Mailer (v5) not v6 so you'll find the latest Postmark SDK won't work out of the box.
You'll receive something like the following when you come to do $email->send()
ERROR [Notice]: Object of class GuzzleHttp\Psr7\Response could not be converted to int
Line 45 in framework/src/Control/Email/SwiftMailer.php
Not to fear! With a bit of configuration and a wrapper class we can get this to work. Apply the email.yml config to your project and but the PostmarkMailTransport.php
class in your project code.