On how MKAnnotationView works with autolayout

ViewController.m

//
//  ViewController.m
//  AnnotationHell
//
//  Created by Xavier Jurado on 07/11/15.
//  Copyright © 2015 Xavier Jurado. All rights reserved.
//

#import <MapKit/MapKit.h>
#import <Masonry/Masonry.h>
#import "ViewController.h"

#define FerHomeCoordinate2D CLLocationCoordinate2DMake(34.1170966, -118.2561648)

#pragma mark - Model

@interface Annotation : NSObject <MKAnnotation>

@end

@implementation Annotation

- (CLLocationCoordinate2D)coordinate
{
    return FerHomeCoordinate2D;
}

@end

#pragma mark - View

@interface AnnotationView : MKAnnotationView
@property (nonatomic, strong) UILabel *topLabel;
@property (nonatomic, strong) UILabel *bottomLabel;
@property (nonatomic, strong) UIImageView *imageView;
@end

@implementation AnnotationView

- (instancetype)initWithAnnotation:(id<MKAnnotation>)annotation reuseIdentifier:(NSString *)reuseIdentifier
{
    self = [super initWithAnnotation:annotation reuseIdentifier:reuseIdentifier];
    if (self) {
        
        self.translatesAutoresizingMaskIntoConstraints = NO;
        
        _topLabel = [[UILabel alloc] init];
        _topLabel.translatesAutoresizingMaskIntoConstraints = NO;
        _topLabel.text = @"Fer & Lena's home";
        
        _bottomLabel = [[UILabel alloc] init];
        _bottomLabel.translatesAutoresizingMaskIntoConstraints = NO;
        _bottomLabel.text = @"💑";
        
        _imageView = [[UIImageView alloc] init];
        _imageView.translatesAutoresizingMaskIntoConstraints = NO;
        _imageView.image = [UIImage imageNamed:@"fer.jpeg"];
        _imageView.clipsToBounds = YES;
        
        [self addSubview:_topLabel];
        [self addSubview:_bottomLabel];
        [self addSubview:_imageView];
        
        self.backgroundColor = [UIColor whiteColor];
        self.layer.shadowOpacity = 0.3;
        
        [self setupLayout];
    }
    return self;
}

- (void)setupLayout
{
    [self.imageView mas_makeConstraints:^(MASConstraintMaker *make) {
        make.left.equalTo(self.mas_left);
        make.top.equalTo(self.mas_top);
        make.bottom.equalTo(self.mas_bottom);
        make.size.mas_equalTo(CGSizeMake(50, 50));
    }];
    
    [self.topLabel mas_makeConstraints:^(MASConstraintMaker *make) {
        make.top.equalTo(self.mas_top).with.offset(2);
        make.left.equalTo(self.imageView.mas_right).with.offset(5);
        make.right.equalTo(self.mas_right).with.offset(-5);
    }];
    
    [self.bottomLabel mas_makeConstraints:^(MASConstraintMaker *make) {
        make.bottom.equalTo(self.mas_bottom).with.offset(-2);
        make.left.equalTo(self.imageView.mas_right).with.offset(5);;
        make.right.equalTo(self.mas_right).with.offset(-5);
    }];
}

@end

#pragma mark - Controller

@interface ViewController () <MKMapViewDelegate>

@property (nonatomic, weak) IBOutlet MKMapView *mapView;

@end

@implementation ViewController

- (void)viewDidLoad {
    [super viewDidLoad];
    [self.mapView addAnnotation:[Annotation new]];
    [self.mapView showAnnotations:self.mapView.annotations animated:NO];
}

- (nullable MKAnnotationView *)mapView:(MKMapView *)mapView viewForAnnotation:(id <MKAnnotation>)annotation
{
    return [[AnnotationView alloc] initWithAnnotation:annotation reuseIdentifier:@"AnnotationView"];
}

@end

that's very helpful. thanks!