descript.ion

To unfollow everybody on Twitter
 - goto https://twitter.com/following
 - make sure you haven't loaded mobile version of website
 - open up Developer tools (in Chrome press Control+Shift+J)
 - put content of unflw.js script into Console and hit Enter
 - feel free to close website after some time
 

unflw.js

(function () {
function scrlAndUnflw () {
  window.scrollTo(0, Math.max(
    document.body.scrollHeight, document.documentElement.scrollHeight,
    document.body.offsetHeight, document.documentElement.offsetHeight,
    document.body.clientHeight, document.documentElement.clientHeight
  ));

  Array.prototype.forEach.call(document.querySelectorAll('.ProfileCard-content'), profile => {
    if (profile.querySelectorAll('.FollowStatus').length) {
      return;
    }
    profile.querySelector('.following .user-actions-follow-button').click();
  });
}

scrlAndUnflw();
return setInterval(scrlAndUnflw, 1000);
}());