make a list of 5 things you're grateful for

grateful.py

from sys import argv
from os.path import exists


script, filename = argv

print "What are five things you're grateful for today?"
print "First:"
First = raw_input("> ")

print "Second:"
Second = raw_input("> ")

print "Third:"
Third = raw_input("> ")

print "Fourth:"
Fourth = raw_input("> ")

print "Fifth:"
Fifth = raw_input("> ")

print "These are things things you're grateful for on:"
print "1.%s\n2.%s\n3.%s\n4.%s\n5.%s\n" % (First, Second, Third, Fourth, Fifth)

f = open('grateful.txt', 'a')
f.write("1. %s\n2. %s\n3. %s\n4. %s\n5. %s\n" % (First, Second, Third, Fourth, Fifth)) 
f.write("\n==============================================\n")
f.close()

filename is not used

line 26, check out the usage of 'with'. see the example at the bottom. http://effbot.org/zone/python-with-statement.htm

Also, consider using loops to make your code clearer.

I don't think line 2 from os.path import exists is necessary.