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February 15, 2023 03:31
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Pathway Commons Extract Interactions with Specific Nodes
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| PARTICIPANT_A INTERACTION_TYPE PARTICIPANT_B INTERACTION_DATA_SOURCE INTERACTION_PUBMED_ID PATHWAY_NAMES MEDIATOR_IDS | |
| ACTA2 in-complex-with CALD1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with ITGA1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with ITGB5 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with LMOD1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with MYH11 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with MYL10 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with MYL12A Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with MYL12B Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with MYL5 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with MYL6B Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with MYL6 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with MYL7 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with MYL9 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with MYLPF Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with PXN Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with SORBS1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with SORBS3 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with TLN1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with TPM1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with TPM2 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with TPM3 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with TPM4 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTA2 in-complex-with VCL Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTB in-complex-with ACTL6A Reactome NA DNA Damage Recognition in GG-NER;HATs acetylate histones;UCH proteinases http://pathwaycommons.org/pc12/Complex_4c12424917020e95491c8c4a7576bbca;http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with ACTR2 Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTB in-complex-with ACTR3 Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTB in-complex-with ACTR5 Reactome NA DNA Damage Recognition in GG-NER;UCH proteinases http://pathwaycommons.org/pc12/Complex_4c12424917020e95491c8c4a7576bbca | |
| ACTB in-complex-with ACTR8 Reactome NA DNA Damage Recognition in GG-NER;UCH proteinases http://pathwaycommons.org/pc12/Complex_4c12424917020e95491c8c4a7576bbca | |
| ACTB in-complex-with ARPC1A Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTB in-complex-with ARPC1B Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTB in-complex-with ARPC2 Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTB in-complex-with ARPC3 Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTB in-complex-with ARPC4 Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTB in-complex-with ARPC5 Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTB in-complex-with BAIAP2 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB in-complex-with BRD8 Reactome NA HATs acetylate histones http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with BRK1 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB in-complex-with CCT2 Reactome NA Folding of actin by CCT/TriC;Prefoldin mediated transfer of substrate to CCT/TriC http://pathwaycommons.org/pc12/Complex_779fea791f212549cfdcce282dd39d56;http://pathwaycommons.org/pc12/Complex_6f5a6b254b7c2f878327bea64152e87c;http://pathwaycommons.org/pc12/Complex_9692739c8e858c0ef10366a54650ca09 | |
| ACTB in-complex-with CCT3 Reactome NA Folding of actin by CCT/TriC;Prefoldin mediated transfer of substrate to CCT/TriC http://pathwaycommons.org/pc12/Complex_779fea791f212549cfdcce282dd39d56;http://pathwaycommons.org/pc12/Complex_6f5a6b254b7c2f878327bea64152e87c;http://pathwaycommons.org/pc12/Complex_9692739c8e858c0ef10366a54650ca09 | |
| ACTB in-complex-with CCT4 Reactome NA Folding of actin by CCT/TriC;Prefoldin mediated transfer of substrate to CCT/TriC http://pathwaycommons.org/pc12/Complex_779fea791f212549cfdcce282dd39d56;http://pathwaycommons.org/pc12/Complex_6f5a6b254b7c2f878327bea64152e87c;http://pathwaycommons.org/pc12/Complex_9692739c8e858c0ef10366a54650ca09 | |
| ACTB in-complex-with CCT5 Reactome NA Folding of actin by CCT/TriC;Prefoldin mediated transfer of substrate to CCT/TriC http://pathwaycommons.org/pc12/Complex_779fea791f212549cfdcce282dd39d56;http://pathwaycommons.org/pc12/Complex_6f5a6b254b7c2f878327bea64152e87c;http://pathwaycommons.org/pc12/Complex_9692739c8e858c0ef10366a54650ca09 | |
| ACTB in-complex-with CCT6A Reactome NA Folding of actin by CCT/TriC;Prefoldin mediated transfer of substrate to CCT/TriC http://pathwaycommons.org/pc12/Complex_779fea791f212549cfdcce282dd39d56;http://pathwaycommons.org/pc12/Complex_6f5a6b254b7c2f878327bea64152e87c;http://pathwaycommons.org/pc12/Complex_9692739c8e858c0ef10366a54650ca09 | |
| ACTB in-complex-with CCT6B Reactome NA Folding of actin by CCT/TriC;Prefoldin mediated transfer of substrate to CCT/TriC http://pathwaycommons.org/pc12/Complex_779fea791f212549cfdcce282dd39d56;http://pathwaycommons.org/pc12/Complex_6f5a6b254b7c2f878327bea64152e87c;http://pathwaycommons.org/pc12/Complex_9692739c8e858c0ef10366a54650ca09 | |
| ACTB in-complex-with CCT7 Reactome NA Folding of actin by CCT/TriC;Prefoldin mediated transfer of substrate to CCT/TriC http://pathwaycommons.org/pc12/Complex_779fea791f212549cfdcce282dd39d56;http://pathwaycommons.org/pc12/Complex_6f5a6b254b7c2f878327bea64152e87c;http://pathwaycommons.org/pc12/Complex_9692739c8e858c0ef10366a54650ca09 | |
| ACTB in-complex-with CCT8 Reactome NA Folding of actin by CCT/TriC;Prefoldin mediated transfer of substrate to CCT/TriC http://pathwaycommons.org/pc12/Complex_779fea791f212549cfdcce282dd39d56;http://pathwaycommons.org/pc12/Complex_6f5a6b254b7c2f878327bea64152e87c;http://pathwaycommons.org/pc12/Complex_9692739c8e858c0ef10366a54650ca09 | |
| ACTB in-complex-with CDC42 Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate Formins;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa;http://pathwaycommons.org/pc12/Complex_dab2a72f066cad4138e042ccc43e3003 | |
| ACTB controls-state-change-of CETN2 Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB controls-production-of CHEBI:15346 Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of COPS2 Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB controls-state-change-of COPS3 Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB controls-state-change-of COPS4 Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB controls-state-change-of COPS5 Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB controls-state-change-of COPS6 Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB controls-state-change-of COPS7A Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB controls-state-change-of COPS7B Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB controls-state-change-of COPS8 Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB controls-state-change-of CUL4A Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB controls-state-change-of CUL4B Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB in-complex-with CYFIP1 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB in-complex-with CYFIP2 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB controls-state-change-of DDB1 Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB controls-state-change-of DDB2 Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB in-complex-with DIAPH1 Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_2d40f9960f8b662473af2d266a4b6883 | |
| ACTB in-complex-with DMAP1 Reactome NA HATs acetylate histones http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with EP400 Reactome NA HATs acetylate histones http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with EPC1 Reactome NA HATs acetylate histones http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with EVL Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_2d40f9960f8b662473af2d266a4b6883 | |
| ACTB in-complex-with FMNL1 Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_c521afb9c5361679299a6864dc9d5b40 | |
| ACTB in-complex-with FMNL2 Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_dab2a72f066cad4138e042ccc43e3003 | |
| ACTB in-complex-with FMNL3 Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_ea016e62200880eb2720edb53b72d32b | |
| ACTB controls-state-change-of GPS1 Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB in-complex-with GRB2 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB controls-state-change-of HIST1H2AA Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H2AB Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H2AC Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H2AD Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H2AE Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H2AG Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H2AH Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H2AI Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H2AJ Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H2AK Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H2AL Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H2AM Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H4A Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H4B Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H4C Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H4D Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H4E Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H4F Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H4H Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H4I Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H4J Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H4K Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST1H4L Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST2H2AA3 Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST2H2AA4 Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST2H2AB Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST2H2AC Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST2H4A Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST2H4B Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST3H2A Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB controls-state-change-of HIST4H4 Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| ACTB in-complex-with IGF2BP1 Reactome NA Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA http://pathwaycommons.org/pc12/Complex_5fd1e9ac4e14d41f0f15566c8ebf16bd | |
| ACTB in-complex-with ING3 Reactome NA HATs acetylate histones http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with INO80B Reactome NA DNA Damage Recognition in GG-NER;UCH proteinases http://pathwaycommons.org/pc12/Complex_4c12424917020e95491c8c4a7576bbca | |
| ACTB in-complex-with INO80C Reactome NA DNA Damage Recognition in GG-NER;UCH proteinases http://pathwaycommons.org/pc12/Complex_4c12424917020e95491c8c4a7576bbca | |
| ACTB in-complex-with INO80D Reactome NA DNA Damage Recognition in GG-NER;UCH proteinases http://pathwaycommons.org/pc12/Complex_4c12424917020e95491c8c4a7576bbca | |
| ACTB in-complex-with INO80E Reactome NA DNA Damage Recognition in GG-NER;UCH proteinases http://pathwaycommons.org/pc12/Complex_4c12424917020e95491c8c4a7576bbca | |
| ACTB in-complex-with INO80 Reactome NA DNA Damage Recognition in GG-NER;UCH proteinases http://pathwaycommons.org/pc12/Complex_4c12424917020e95491c8c4a7576bbca | |
| ACTB in-complex-with ITSN1 Reactome NA EPHB-mediated forward signaling http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTB in-complex-with KAT5 Reactome NA HATs acetylate histones http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with MCRS1 Reactome NA DNA Damage Recognition in GG-NER;UCH proteinases http://pathwaycommons.org/pc12/Complex_4c12424917020e95491c8c4a7576bbca | |
| ACTB in-complex-with MEAF6 Reactome NA HATs acetylate histones http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with MORF4L1 Reactome NA HATs acetylate histones http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with MORF4L2 Reactome NA HATs acetylate histones http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with MRGBP Reactome NA HATs acetylate histones http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with MRTFA Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_54784b9da2f0a5ea9c6acadb7a97c9f2 | |
| ACTB in-complex-with MYO1C Reactome NA B-WICH complex positively regulates rRNA expression http://pathwaycommons.org/pc12/Complex_b199578f60feb7b3707e62d004bd2bed | |
| ACTB in-complex-with NCK1 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB in-complex-with NCKAP1L Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB in-complex-with NCKAP1 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB in-complex-with NCKIPSD Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB in-complex-with NFRKB Reactome NA DNA Damage Recognition in GG-NER;UCH proteinases http://pathwaycommons.org/pc12/Complex_4c12424917020e95491c8c4a7576bbca | |
| ACTB in-complex-with PFDN1 Reactome NA Prefoldin mediated transfer of substrate to CCT/TriC http://pathwaycommons.org/pc12/Complex_b0d440a389738ad2d772aaee65d78df2 | |
| ACTB in-complex-with PFDN2 Reactome NA Prefoldin mediated transfer of substrate to CCT/TriC http://pathwaycommons.org/pc12/Complex_b0d440a389738ad2d772aaee65d78df2 | |
| ACTB in-complex-with PFDN4 Reactome NA Prefoldin mediated transfer of substrate to CCT/TriC http://pathwaycommons.org/pc12/Complex_b0d440a389738ad2d772aaee65d78df2 | |
| ACTB in-complex-with PFDN5 Reactome NA Prefoldin mediated transfer of substrate to CCT/TriC http://pathwaycommons.org/pc12/Complex_b0d440a389738ad2d772aaee65d78df2 | |
| ACTB in-complex-with PFDN6 Reactome NA Prefoldin mediated transfer of substrate to CCT/TriC http://pathwaycommons.org/pc12/Complex_b0d440a389738ad2d772aaee65d78df2 | |
| ACTB in-complex-with PFN1 Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_f84bd7e9b02a22a9ad78a82b9b6087a7 | |
| ACTB in-complex-with PFN2 Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_f84bd7e9b02a22a9ad78a82b9b6087a7 | |
| ACTB controls-state-change-of RAC1 Reactome 21148482 RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Catalysis_6776c62db4d83e126e8356128c1b34cc;http://identifiers.org/reactome/R-HSA-5665809 | |
| ACTB in-complex-with RAC1 Reactome NA RHO GTPases Activate Formins;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_c521afb9c5361679299a6864dc9d5b40 | |
| ACTB controls-state-change-of RAD23A Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB controls-state-change-of RAD23B Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB controls-state-change-of RBX1 Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB in-complex-with RHOA Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_2d40f9960f8b662473af2d266a4b6883 | |
| ACTB in-complex-with RHOC Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_ea016e62200880eb2720edb53b72d32b | |
| ACTB in-complex-with RUVBL1 Reactome NA DNA Damage Recognition in GG-NER;HATs acetylate histones;UCH proteinases http://pathwaycommons.org/pc12/Complex_4c12424917020e95491c8c4a7576bbca;http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with RUVBL2 Reactome NA HATs acetylate histones http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with SRGAP2 Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_101a7005cc3825bf6097f2c06ec7947b | |
| ACTB in-complex-with TCP1 Reactome NA Folding of actin by CCT/TriC;Prefoldin mediated transfer of substrate to CCT/TriC http://pathwaycommons.org/pc12/Complex_779fea791f212549cfdcce282dd39d56;http://pathwaycommons.org/pc12/Complex_6f5a6b254b7c2f878327bea64152e87c;http://pathwaycommons.org/pc12/Complex_9692739c8e858c0ef10366a54650ca09 | |
| ACTB in-complex-with TFPT Reactome NA DNA Damage Recognition in GG-NER;UCH proteinases http://pathwaycommons.org/pc12/Complex_4c12424917020e95491c8c4a7576bbca | |
| ACTB in-complex-with TRRAP Reactome NA HATs acetylate histones http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with UCHL5 Reactome NA UCH proteinases http://pathwaycommons.org/pc12/Complex_954011e2172cfdf5286b96fe3c25fff1 | |
| ACTB in-complex-with VBP1 Reactome NA Prefoldin mediated transfer of substrate to CCT/TriC http://pathwaycommons.org/pc12/Complex_b0d440a389738ad2d772aaee65d78df2 | |
| ACTB in-complex-with VPS72 Reactome NA HATs acetylate histones http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with WASF1 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB in-complex-with WASF2 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB in-complex-with WASF3 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB in-complex-with WASL Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTB in-complex-with WAS Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB in-complex-with WIPF1 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB in-complex-with WIPF2 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB in-complex-with WIPF3 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTB controls-state-change-of XPC Reactome 10391953;12732143;12944386;14742321;15811629;15882621;16223728;17882165;19109893;19609301;20855601;21135142;21388382 DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5691006;http://identifiers.org/reactome/R-HSA-5696636 | |
| ACTB in-complex-with YEATS4 Reactome NA HATs acetylate histones http://pathwaycommons.org/pc12/Complex_9be44e3f6191949cf88a1033f63047fb | |
| ACTB in-complex-with YY1 Reactome NA DNA Damage Recognition in GG-NER;UCH proteinases http://pathwaycommons.org/pc12/Complex_4c12424917020e95491c8c4a7576bbca | |
| ACTG1 in-complex-with ACTR2 Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTG1 in-complex-with ACTR3 Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTG1 in-complex-with ARPC1A Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTG1 in-complex-with ARPC1B Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTG1 in-complex-with ARPC2 Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTG1 in-complex-with ARPC3 Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTG1 in-complex-with ARPC4 Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTG1 in-complex-with ARPC5 Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_69130a20b8360d49568d08ace28f36c0;http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTG1 in-complex-with BAIAP2 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG1 in-complex-with BRK1 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG1 in-complex-with CDC42 Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate Formins;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa;http://pathwaycommons.org/pc12/Complex_dab2a72f066cad4138e042ccc43e3003 | |
| ACTG1 in-complex-with CYFIP1 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG1 in-complex-with CYFIP2 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG1 in-complex-with DIAPH1 Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_2d40f9960f8b662473af2d266a4b6883 | |
| ACTG1 in-complex-with EVL Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_2d40f9960f8b662473af2d266a4b6883 | |
| ACTG1 in-complex-with FMNL1 Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_c521afb9c5361679299a6864dc9d5b40 | |
| ACTG1 in-complex-with FMNL2 Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_dab2a72f066cad4138e042ccc43e3003 | |
| ACTG1 in-complex-with FMNL3 Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_ea016e62200880eb2720edb53b72d32b | |
| ACTG1 in-complex-with GRB2 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG1 in-complex-with ITSN1 Reactome NA EPHB-mediated forward signaling http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTG1 in-complex-with MRTFA Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_54784b9da2f0a5ea9c6acadb7a97c9f2 | |
| ACTG1 in-complex-with NCK1 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG1 in-complex-with NCKAP1L Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG1 in-complex-with NCKAP1 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG1 in-complex-with NCKIPSD Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG1 in-complex-with PFN1 Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_f84bd7e9b02a22a9ad78a82b9b6087a7 | |
| ACTG1 in-complex-with PFN2 Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_f84bd7e9b02a22a9ad78a82b9b6087a7 | |
| ACTG1 controls-state-change-of RAC1 Reactome 21148482 RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Catalysis_6776c62db4d83e126e8356128c1b34cc;http://identifiers.org/reactome/R-HSA-5665809 | |
| ACTG1 in-complex-with RAC1 Reactome NA RHO GTPases Activate Formins;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_c521afb9c5361679299a6864dc9d5b40 | |
| ACTG1 in-complex-with RHOA Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_2d40f9960f8b662473af2d266a4b6883 | |
| ACTG1 in-complex-with RHOC Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_ea016e62200880eb2720edb53b72d32b | |
| ACTG1 in-complex-with SRGAP2 Reactome NA RHO GTPases Activate Formins http://pathwaycommons.org/pc12/Complex_101a7005cc3825bf6097f2c06ec7947b | |
| ACTG1 in-complex-with WASF1 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG1 in-complex-with WASF2 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG1 in-complex-with WASF3 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG1 in-complex-with WASL Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| ACTG1 in-complex-with WAS Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG1 in-complex-with WIPF1 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG1 in-complex-with WIPF2 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG1 in-complex-with WIPF3 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTG2 in-complex-with CALD1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with ITGA1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with ITGB5 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with LMOD1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with MYH11 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with MYL10 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with MYL12A Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with MYL12B Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with MYL5 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with MYL6B Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with MYL6 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with MYL7 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with MYL9 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with MYLPF Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with PXN Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with SORBS1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with SORBS3 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with TLN1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with TPM1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with TPM2 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with TPM3 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with TPM4 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| ACTG2 in-complex-with VCL Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_31d66cd5a279d9da536a7808146a93e4;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects ACTA2 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects ACTG2 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects ACTN2 Reactome NA Long-term potentiation;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;Striated Muscle Contraction;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Complex_e242f1b69c19f98d5f989fff7d0c1117;http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects ACTN3 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects ADCY1 Reactome NA CREB1 phosphorylation through the activation of Adenylate Cyclase http://pathwaycommons.org/pc12/Complex_8d5d353b0ce9934f9fe9b2a4253be508 | |
| CHEBI:29108 chemical-affects ADCY8 Reactome NA CREB1 phosphorylation through the activation of Adenylate Cyclase http://pathwaycommons.org/pc12/Complex_8d5d353b0ce9934f9fe9b2a4253be508 | |
| CHEBI:29108 chemical-affects AGGF1 Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects AGK Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects AGTRAP Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects AKAP9 Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects AKT1 Reactome NA Extra-nuclear estrogen signaling;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;VEGFR2 mediated vascular permeability;eNOS activation http://pathwaycommons.org/pc12/Complex_99b641268762438314c57ba32f29bdc2;http://pathwaycommons.org/pc12/Complex_13806499f16d949b960c4e81302282e1;http://pathwaycommons.org/pc12/Complex_4f484ee1ad8c540ebbb9cf91e086e240 | |
| CHEBI:29108 chemical-affects ALOX5AP Reactome NA Synthesis of Leukotrienes (LT) and Eoxins (EX);Synthesis of Lipoxins (LX) http://pathwaycommons.org/pc12/Complex_d5cea0c1d341c16f938c056854bc30d1 | |
| CHEBI:29108 chemical-affects ALOX5 Reactome NA Synthesis of Leukotrienes (LT) and Eoxins (EX);Synthesis of Lipoxins (LX) http://pathwaycommons.org/pc12/Complex_aa3b13c23c29d37bf3409b984edd8a20;http://pathwaycommons.org/pc12/Complex_840aaff637a74b5f5cae3c25c1e6308f;http://pathwaycommons.org/pc12/Complex_9d713e0e21fe62f858b316ab99bbe7d8 | |
| CHEBI:29108 chemical-affects ALPI Reactome NA Synthesis of PA http://pathwaycommons.org/pc12/Complex_b238609d1f3b3d684ef561ab82edd563 | |
| CHEBI:29108 chemical-affects ANTXR1 Reactome NA Uptake and function of anthrax toxins http://pathwaycommons.org/pc12/Complex_8e3f0773294e02a60dbf67e88f0ad27a;http://pathwaycommons.org/pc12/Complex_8a499411924e25e1f29853dcca995d5f;http://pathwaycommons.org/pc12/Complex_6d7d505488c3ccf536a66366d9a0737b | |
| CHEBI:29108 chemical-affects ANTXR2 Reactome NA Uptake and function of anthrax toxins http://pathwaycommons.org/pc12/Complex_71032e8f77bc7b080f4f704500e6f3ef;http://pathwaycommons.org/pc12/Complex_688cdd3bd94c29acb55f0d8abec59960;http://pathwaycommons.org/pc12/Complex_288c13b0237cac3289992c15e9f1ad74 | |
| CHEBI:29108 chemical-affects ANXA1 Reactome 14506282;19380584;22421042 Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-5263628;http://identifiers.org/reactome/R-HSA-5333036 | |
| CHEBI:29108 chemical-affects ANXA2 Reactome 14506282;19380584;22421042 Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-5263628;http://identifiers.org/reactome/R-HSA-5333036 | |
| CHEBI:29108 chemical-affects ANXA6 Reactome 14506282;19380584;22421042 Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-5263628;http://identifiers.org/reactome/R-HSA-5333036 | |
| CHEBI:29108 chemical-affects AOC1 Reactome NA Phase I - Functionalization of compounds http://pathwaycommons.org/pc12/Complex_a990896d207d96880e307b07bdf1162e | |
| CHEBI:29108 chemical-affects AOC3 Reactome NA Phase I - Functionalization of compounds http://pathwaycommons.org/pc12/Complex_d548b86688d9cd1274dec17dbacf2378 | |
| CHEBI:29108 chemical-affects AP2A1 Reactome 16055064 Trafficking of GluR2-containing AMPA receptors http://pathwaycommons.org/pc12/Catalysis_8e4f2b41a642b052ea0a9c9077258fa2;http://pathwaycommons.org/pc12/Catalysis_159940d16c72d644b5774ca1a71f1722;http://identifiers.org/reactome/R-HSA-421007;http://identifiers.org/reactome/R-HSA-416639 | |
| CHEBI:29108 chemical-affects AP2A2 Reactome 16055064 Trafficking of GluR2-containing AMPA receptors http://pathwaycommons.org/pc12/Catalysis_8e4f2b41a642b052ea0a9c9077258fa2;http://pathwaycommons.org/pc12/Catalysis_159940d16c72d644b5774ca1a71f1722;http://identifiers.org/reactome/R-HSA-421007;http://identifiers.org/reactome/R-HSA-416639 | |
| CHEBI:29108 chemical-affects AP2B1 Reactome 16055064 Trafficking of GluR2-containing AMPA receptors http://pathwaycommons.org/pc12/Catalysis_159940d16c72d644b5774ca1a71f1722;http://identifiers.org/reactome/R-HSA-416639 | |
| CHEBI:29108 chemical-affects AP2M1 Reactome 16055064 Trafficking of GluR2-containing AMPA receptors http://pathwaycommons.org/pc12/Catalysis_159940d16c72d644b5774ca1a71f1722;http://identifiers.org/reactome/R-HSA-416639 | |
| CHEBI:29108 chemical-affects AP2S1 Reactome 16055064 Trafficking of GluR2-containing AMPA receptors http://pathwaycommons.org/pc12/Catalysis_159940d16c72d644b5774ca1a71f1722;http://identifiers.org/reactome/R-HSA-416639 | |
| CHEBI:29108 chemical-affects AP3B1 Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects APBB1IP Reactome NA GRB2:SOS provides linkage to MAPK signaling for Integrins;Integrin alphaIIb beta3 signaling;p130Cas linkage to MAPK signaling for integrins http://pathwaycommons.org/pc12/Complex_6c5ceab1ba2073e49cb1896a925dc573;http://pathwaycommons.org/pc12/Complex_2357686c4db0ca1c4d0ab9a210130449;http://pathwaycommons.org/pc12/Complex_16978f376c59bd9933e4875566f69baf;http://pathwaycommons.org/pc12/Complex_97a0978414a8036daa7bf22a7d04587e;http://pathwaycommons.org/pc12/Complex_23c4b5044f972d0062e4816c7ae0ad45 | |
| CHEBI:29108 chemical-affects APCS Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_3cb4fe4b5662d3fd19984db38a4b2e8d | |
| CHEBI:29108 chemical-affects ARAF Reactome 10205168;10712905;11032810;12244094;12551923;15710605;15899852;16093354;17097642;18294816;18662992;19158341;20820846;21779496;22592532;23993095;7542586;8876196;9020159;9234708;9823899 MAP2K and MAPK activation;RAF activation http://pathwaycommons.org/pc12/Complex_1c9f438d1db34b7384fdfa8bb13a2f0d;http://identifiers.org/reactome/R-HSA-5672969;http://pathwaycommons.org/pc12/Catalysis_1c35b9ddce2a70d0629b481931d815c1;http://pathwaycommons.org/pc12/Complex_d7c23e33867ba9a0550337f60e5447f8;http://pathwaycommons.org/pc12/Complex_c0cf37acbfc4c8467f39affddaced3ca | |
| CHEBI:29108 chemical-affects ARHGEF7 Reactome 18184567 Activation of RAC1 downstream of NMDARs http://pathwaycommons.org/pc12/Catalysis_17560a6f06a9b07d5921c9dd913a7a18;http://identifiers.org/reactome/R-HSA-9619783 | |
| CHEBI:29108 chemical-affects ARSA Reactome NA Glycosphingolipid metabolism;The activation of arylsulfatases http://pathwaycommons.org/pc12/Complex_8917b4c0c7f1e097d62142734387cb6e;http://pathwaycommons.org/pc12/Complex_1779027a4959c4b0d2b11b22bdac9b14 | |
| CHEBI:29108 chemical-affects ARSB Reactome NA CS/DS degradation;MPS VI - Maroteaux-Lamy syndrome http://pathwaycommons.org/pc12/Complex_2252af184c318362fa7405c98bdd52b8;http://pathwaycommons.org/pc12/Complex_7f3822f64fe7487d0fe57f858c6a14cd | |
| CHEBI:29108 chemical-affects ATG7 Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects BCAR1 Reactome NA p130Cas linkage to MAPK signaling for integrins http://pathwaycommons.org/pc12/Complex_eb80cd0a390f14591a5f1d0029aee81e;http://pathwaycommons.org/pc12/Complex_8ae3c4f511734941a6320e249fcd4c01 | |
| CHEBI:29108 chemical-affects BCL2L11 Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects BRAF Reactome 10205168;10712905;11032810;11325826;12244094;12551923;15035987;15630448;15710605;15899852;16093354;16364920;16508002;17018604;17097642;18294816;18662992;18974108;19158341;19933846;20130576;20141835;20179705;20526349;20820846;21424530;21779496;22043453;22510884;22592532;22745804;23583981;23680146;23993095;24135138;24202393;24345920;24957944;25204415;25435214;25907612;7542586;8876196;9020159;9234708;9823899 MAP2K and MAPK activation;Paradoxical activation of RAF signaling by kinase inactive BRAF;RAF activation;Signaling by BRAF and RAF fusions;Signaling by RAS mutants;Signaling by high-kinase activity BRAF mutants;Signaling by moderate kinase activity BRAF mutants http://pathwaycommons.org/pc12/Catalysis_4b66558229db0440bcfbace623060ef0;http://pathwaycommons.org/pc12/Complex_24eebdb420a48d1df31ce470b63917e2;http://pathwaycommons.org/pc12/Catalysis_d1076b99bcec87a38eaa26ff1c4a4070;http://pathwaycommons.org/pc12/Complex_2d6078881f15d454db237f3d3dfd388e;http://pathwaycommons.org/pc12/Complex_3811ddf05925c006e5b9ba92ef63ffad;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://identifiers.org/reactome/R-HSA-6802941;http://identifiers.org/reactome/R-HSA-6802924;http://pathwaycommons.org/pc12/Complex_d7c23e33867ba9a0550337f60e5447f8;http://pathwaycommons.org/pc12/Complex_f388bb088eaf2764bccb3723e9dec7a4;http://pathwaycommons.org/pc12/Complex_c735504e9aa67a7c9cd901858ccebf74;http://identifiers.org/reactome/R-HSA-6802927;http://pathwaycommons.org/pc12/Complex_99f08589f0e5024718269b930d0288e8;http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_1c9f438d1db34b7384fdfa8bb13a2f0d;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://pathwaycommons.org/pc12/Catalysis_fd9991c8fd61be157ed4b2e5be7acef9;http://pathwaycommons.org/pc12/Complex_a9afcce8661dd885cef40e47037a185f;http://pathwaycommons.org/pc12/Complex_411c1b271808c064387f09c3c20b6304;http://pathwaycommons.org/pc12/Complex_07bcf74dbac68a47917e1f7a40acd849;http://pathwaycommons.org/pc12/Complex_3adde65e3e4efaeeb03ad9e8acf79d2a;http://identifiers.org/reactome/R-HSA-5672969;http://pathwaycommons.org/pc12/Catalysis_1c35b9ddce2a70d0629b481931d815c1;http://pathwaycommons.org/pc12/Complex_a02123277a4a9e4a0fdba06dcb2d40cd;http://pathwaycommons.org/pc12/Complex_c0cf37acbfc4c8467f39affddaced3ca;http://pathwaycommons.org/pc12/Complex_3fcbd062120dcb929eabeb6cba72d4c3;http://identifiers.org/reactome/R-HSA-6802916 | |
| CHEBI:29108 chemical-affects C1QA Reactome 1249422;13726743 Classical antibody-mediated complement activation http://pathwaycommons.org/pc12/Complex_861b0deadae62c11b30bcb693d087c85;http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects C1QB Reactome 1249422;13726743 Classical antibody-mediated complement activation http://pathwaycommons.org/pc12/Complex_861b0deadae62c11b30bcb693d087c85;http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects C1QC Reactome 1249422;13726743 Classical antibody-mediated complement activation http://pathwaycommons.org/pc12/Complex_861b0deadae62c11b30bcb693d087c85;http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects C1R Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects C1S Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects C2CD5 Reactome NA Translocation of SLC2A4 (GLUT4) to the plasma membrane http://pathwaycommons.org/pc12/Complex_c1f5b6aecda234d817784c6507959141;http://pathwaycommons.org/pc12/Complex_222b3fee9e4957a6c84c09cf44566881 | |
| CHEBI:29108 chemical-affects C2 Reactome 10925294;12396008;6019133;70787 Initial triggering of complement http://pathwaycommons.org/pc12/Catalysis_6b7806d55a3fb847acf0e5f583a50414;http://identifiers.org/reactome/R-HSA-166792 | |
| CHEBI:29108 chemical-affects C4A Reactome 12396008;14280442;15199963;7391570;9041627 Initial triggering of complement http://pathwaycommons.org/pc12/Catalysis_581f64f3a57414528624665e985b51f5;http://identifiers.org/reactome/R-HSA-166753 | |
| CHEBI:29108 chemical-affects C4B_2 Reactome 12396008;14280442;15199963;7391570;9041627 Initial triggering of complement http://pathwaycommons.org/pc12/Catalysis_581f64f3a57414528624665e985b51f5;http://identifiers.org/reactome/R-HSA-166753 | |
| CHEBI:29108 chemical-affects C4B Reactome 12396008;14280442;15199963;7391570;9041627 Initial triggering of complement http://pathwaycommons.org/pc12/Catalysis_581f64f3a57414528624665e985b51f5;http://identifiers.org/reactome/R-HSA-166753 | |
| CHEBI:29108 chemical-affects C5 Reactome 10776801;20870944;22802338;26489954 Regulation of Complement cascade http://pathwaycommons.org/pc12/Catalysis_3a761b4459428b21eb6271dd2861fbfe;http://identifiers.org/reactome/R-HSA-8852716 | |
| CHEBI:29108 chemical-affects CALB1 Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_9666465be5634b0634210a91c71052ef | |
| CHEBI:29108 chemical-affects CALD1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_289f94620fbc2a851e4518aa59741b59 | |
| CHEBI:29108 chemical-affects CALM1 Reactome NA Activation of AMPK downstream of NMDARs;Activation of RAC1 downstream of NMDARs;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CLEC7A (Dectin-1) induces NFAT activation;CREB1 phosphorylation through the activation of Adenylate Cyclase;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;Ca2+ pathway;CaM pathway;CaMK IV-mediated phosphorylation of CREB;Calcineurin activates NFAT;Calmodulin induced events;Cam-PDE 1 activation;DARPP-32 events;Extra-nuclear estrogen signaling;FCERI mediated Ca+2 mobilization;Inactivation, recovery and regulation of the phototransduction cascade;Ion homeostasis;Long-term potentiation;Negative regulation of NMDA receptor-mediated neuronal transmission;PKA activation;Phase 0 - rapid depolarisation;RHO GTPases activate IQGAPs;RHO GTPases activate PAKs;Ras activation upon Ca2+ influx through NMDA receptor;Smooth Muscle Contraction;Synthesis of IP3 and IP4 in the cytosol;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;Translocation of SLC2A4 (GLUT4) to the plasma membrane;Unblocking of NMDA receptors, glutamate binding and activation;Uptake and function of anthrax toxins;VEGFR2 mediated cell proliferation;VEGFR2 mediated vascular permeability;eNOS activation http://pathwaycommons.org/pc12/Complex_cd13c0a1de0aac6e7b295f691d6412b3;http://pathwaycommons.org/pc12/Complex_2a657d2c9443d60161b08371d4863df8;http://pathwaycommons.org/pc12/Complex_8936a583fc92f48c4eef4ef06754f939;http://pathwaycommons.org/pc12/Complex_2292550180462b099e9a0fb9128e0817;http://pathwaycommons.org/pc12/Complex_5ff86d70cd9f72c2ac7ced1095c99fe5;http://pathwaycommons.org/pc12/Complex_c3ffa706c1204a5c4e3904ddcbb8a7f2;http://identifiers.org/reactome/R-HSA-5358685;http://identifiers.org/reactome/R-HSA-2316352;http://pathwaycommons.org/pc12/Complex_c80787d022c4a3c18912f6430e5fccf3;http://pathwaycommons.org/pc12/Complex_54273960ab5529190adf4bbfd6f36eea;http://pathwaycommons.org/pc12/Complex_100fd7311332739b3a9736a6c042da78 | |
| CHEBI:29108 chemical-affects CAMK1 Reactome NA Activation of RAC1 downstream of NMDARs;Negative regulation of NMDA receptor-mediated neuronal transmission http://pathwaycommons.org/pc12/Complex_7186cf728a2326b1a9903f02d5259d68;http://pathwaycommons.org/pc12/Complex_22fb7868da116f6b5eae3cc13cfc029b | |
| CHEBI:29108 chemical-affects CAMK2A Reactome NA Ca2+ pathway;CaMK IV-mediated phosphorylation of CREB;Ion homeostasis;Long-term potentiation;Negative regulation of NMDA receptor-mediated neuronal transmission;Paradoxical activation of RAF signaling by kinase inactive BRAF;Phase 0 - rapid depolarisation;RAF activation;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;Regulation of MECP2 expression and activity;Signaling by BRAF and RAF fusions;Signaling by RAS mutants;Signaling by moderate kinase activity BRAF mutants;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Complex_fde25a6278cba0c3790006d2fc188a6b;http://pathwaycommons.org/pc12/Complex_b26a71b84e441dbc672615cce19cf62e;http://pathwaycommons.org/pc12/Complex_2566477fd158ce887faa702c95e5b4d6;http://pathwaycommons.org/pc12/Complex_6da21362959c97d5900a202285706d4c;http://pathwaycommons.org/pc12/Complex_e242f1b69c19f98d5f989fff7d0c1117;http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded;http://pathwaycommons.org/pc12/Complex_d3ea62c59f675fe3dc473103d9ed1714;http://pathwaycommons.org/pc12/Complex_994257c02be119c360f77f52cc2c1977;http://pathwaycommons.org/pc12/Complex_df70f59da3716168ef07fa6e7bdd4a4b | |
| CHEBI:29108 chemical-affects CAMK2B Reactome NA CaMK IV-mediated phosphorylation of CREB;Ion homeostasis;Long-term potentiation;Negative regulation of NMDA receptor-mediated neuronal transmission;Paradoxical activation of RAF signaling by kinase inactive BRAF;Phase 0 - rapid depolarisation;RAF activation;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;Regulation of MECP2 expression and activity;Signaling by BRAF and RAF fusions;Signaling by RAS mutants;Signaling by moderate kinase activity BRAF mutants;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Complex_b26a71b84e441dbc672615cce19cf62e;http://pathwaycommons.org/pc12/Complex_2566477fd158ce887faa702c95e5b4d6;http://pathwaycommons.org/pc12/Complex_6da21362959c97d5900a202285706d4c;http://pathwaycommons.org/pc12/Complex_e242f1b69c19f98d5f989fff7d0c1117;http://pathwaycommons.org/pc12/Complex_ab57e4c8c9ab78353d2658825ab49dfc;http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded;http://pathwaycommons.org/pc12/Complex_d3ea62c59f675fe3dc473103d9ed1714;http://pathwaycommons.org/pc12/Complex_df70f59da3716168ef07fa6e7bdd4a4b | |
| CHEBI:29108 chemical-affects CAMK2D Reactome NA CaMK IV-mediated phosphorylation of CREB;Ion homeostasis;Long-term potentiation;Negative regulation of NMDA receptor-mediated neuronal transmission;Paradoxical activation of RAF signaling by kinase inactive BRAF;Phase 0 - rapid depolarisation;RAF activation;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;Regulation of MECP2 expression and activity;Signaling by BRAF and RAF fusions;Signaling by RAS mutants;Signaling by moderate kinase activity BRAF mutants;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Complex_b26a71b84e441dbc672615cce19cf62e;http://pathwaycommons.org/pc12/Complex_2566477fd158ce887faa702c95e5b4d6;http://pathwaycommons.org/pc12/Complex_6da21362959c97d5900a202285706d4c;http://pathwaycommons.org/pc12/Complex_e242f1b69c19f98d5f989fff7d0c1117;http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded;http://pathwaycommons.org/pc12/Complex_d3ea62c59f675fe3dc473103d9ed1714;http://pathwaycommons.org/pc12/Complex_df70f59da3716168ef07fa6e7bdd4a4b | |
| CHEBI:29108 chemical-affects CAMK2G Reactome NA CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CaMK IV-mediated phosphorylation of CREB;Ion homeostasis;Long-term potentiation;Negative regulation of NMDA receptor-mediated neuronal transmission;Paradoxical activation of RAF signaling by kinase inactive BRAF;Phase 0 - rapid depolarisation;RAF activation;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;Regulation of MECP2 expression and activity;Signaling by BRAF and RAF fusions;Signaling by RAS mutants;Signaling by moderate kinase activity BRAF mutants;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Complex_b26a71b84e441dbc672615cce19cf62e;http://pathwaycommons.org/pc12/Complex_2566477fd158ce887faa702c95e5b4d6;http://pathwaycommons.org/pc12/Complex_7133e0b27eb2b4d81e93df6f5bd80c2f;http://pathwaycommons.org/pc12/Complex_6da21362959c97d5900a202285706d4c;http://pathwaycommons.org/pc12/Complex_e242f1b69c19f98d5f989fff7d0c1117;http://pathwaycommons.org/pc12/Complex_59758cef9e23d39e3ba9c67258854e02;http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded;http://pathwaycommons.org/pc12/Complex_d3ea62c59f675fe3dc473103d9ed1714;http://pathwaycommons.org/pc12/Complex_df70f59da3716168ef07fa6e7bdd4a4b | |
| CHEBI:29108 chemical-affects CAMK4 Reactome NA CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CaMK IV-mediated phosphorylation of CREB;Loss of phosphorylation of MECP2 at T308;Negative regulation of NMDA receptor-mediated neuronal transmission;Regulation of MECP2 expression and activity http://pathwaycommons.org/pc12/Complex_0e1ede3c915b1eb7791572918656efec;http://pathwaycommons.org/pc12/Complex_2880b2021153999470c4c2c448b6ac8c;http://pathwaycommons.org/pc12/Complex_f8add8b304528e5c1c551cd1d286e349 | |
| CHEBI:29108 chemical-affects CAMKK1 Reactome NA Activation of RAC1 downstream of NMDARs;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CaMK IV-mediated phosphorylation of CREB http://pathwaycommons.org/pc12/Complex_67a0b782115c54f761aa62b98847b836;http://pathwaycommons.org/pc12/Complex_41c464f043cfdb37db60c05a420fa3c3;http://pathwaycommons.org/pc12/Complex_9678b7be5815c177b0bf892bfc7737da;http://pathwaycommons.org/pc12/Complex_d84153347761b5df3f42973797651178 | |
| CHEBI:29108 chemical-affects CAMKK2 Reactome NA Activation of AMPK downstream of NMDARs;Activation of RAC1 downstream of NMDARs;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CaMK IV-mediated phosphorylation of CREB http://pathwaycommons.org/pc12/Complex_b341d48c3bf81e753aaa03f0a4d7615f;http://pathwaycommons.org/pc12/Complex_67a0b782115c54f761aa62b98847b836;http://pathwaycommons.org/pc12/Complex_41c464f043cfdb37db60c05a420fa3c3;http://pathwaycommons.org/pc12/Complex_9678b7be5815c177b0bf892bfc7737da;http://pathwaycommons.org/pc12/Complex_d84153347761b5df3f42973797651178 | |
| CHEBI:29108 chemical-affects CAPN10 Reactome NA Degradation of the extracellular matrix http://pathwaycommons.org/pc12/Complex_dd4de3370e6e6a0310f2ef9f85b6276d | |
| CHEBI:29108 chemical-affects CAPN11 Reactome NA Degradation of the extracellular matrix http://pathwaycommons.org/pc12/Complex_dd4de3370e6e6a0310f2ef9f85b6276d | |
| CHEBI:29108 chemical-affects CAPN12 Reactome NA Degradation of the extracellular matrix http://pathwaycommons.org/pc12/Complex_dd4de3370e6e6a0310f2ef9f85b6276d | |
| CHEBI:29108 chemical-affects CAPN13 Reactome NA Degradation of the extracellular matrix http://pathwaycommons.org/pc12/Complex_dd4de3370e6e6a0310f2ef9f85b6276d | |
| CHEBI:29108 chemical-affects CAPN14 Reactome NA Degradation of the extracellular matrix http://pathwaycommons.org/pc12/Complex_dd4de3370e6e6a0310f2ef9f85b6276d | |
| CHEBI:29108 chemical-affects CAPN15 Reactome NA Degradation of the extracellular matrix http://pathwaycommons.org/pc12/Complex_dd4de3370e6e6a0310f2ef9f85b6276d | |
| CHEBI:29108 chemical-affects CAPN1 Reactome NA Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Formation of the cornified envelope http://pathwaycommons.org/pc12/Complex_41bb186b4a04bf82bee9da3920c5489c;http://pathwaycommons.org/pc12/Complex_dd4de3370e6e6a0310f2ef9f85b6276d;http://pathwaycommons.org/pc12/Complex_ead6e8eb25ced1fa56be1664957537c8 | |
| CHEBI:29108 chemical-affects CAPN2 Reactome NA Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models http://pathwaycommons.org/pc12/Complex_178c5ac6ce58ffe422418ac5092aebac;http://pathwaycommons.org/pc12/Complex_dd4de3370e6e6a0310f2ef9f85b6276d | |
| CHEBI:29108 chemical-affects CAPN3 Reactome NA Degradation of the extracellular matrix http://pathwaycommons.org/pc12/Complex_dd4de3370e6e6a0310f2ef9f85b6276d | |
| CHEBI:29108 chemical-affects CAPN5 Reactome NA Degradation of the extracellular matrix http://pathwaycommons.org/pc12/Complex_dd4de3370e6e6a0310f2ef9f85b6276d | |
| CHEBI:29108 chemical-affects CAPN6 Reactome NA Degradation of the extracellular matrix http://pathwaycommons.org/pc12/Complex_dd4de3370e6e6a0310f2ef9f85b6276d | |
| CHEBI:29108 chemical-affects CAPN7 Reactome NA Degradation of the extracellular matrix http://pathwaycommons.org/pc12/Complex_dd4de3370e6e6a0310f2ef9f85b6276d | |
| CHEBI:29108 chemical-affects CAPN8 Reactome NA Degradation of the extracellular matrix http://pathwaycommons.org/pc12/Complex_dd4de3370e6e6a0310f2ef9f85b6276d | |
| CHEBI:29108 chemical-affects CAPN9 Reactome NA Degradation of the extracellular matrix http://pathwaycommons.org/pc12/Complex_dd4de3370e6e6a0310f2ef9f85b6276d | |
| CHEBI:29108 chemical-affects CAPNS1 Reactome NA Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Formation of the cornified envelope http://pathwaycommons.org/pc12/Complex_178c5ac6ce58ffe422418ac5092aebac;http://pathwaycommons.org/pc12/Complex_e04abaaccbc70689cc9d077e84f9b556;http://pathwaycommons.org/pc12/Complex_41bb186b4a04bf82bee9da3920c5489c;http://pathwaycommons.org/pc12/Complex_ead6e8eb25ced1fa56be1664957537c8 | |
| CHEBI:29108 chemical-affects CAPNS2 Reactome NA Degradation of the extracellular matrix;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models http://pathwaycommons.org/pc12/Complex_178c5ac6ce58ffe422418ac5092aebac;http://pathwaycommons.org/pc12/Complex_e04abaaccbc70689cc9d077e84f9b556;http://pathwaycommons.org/pc12/Complex_ead6e8eb25ced1fa56be1664957537c8 | |
| CHEBI:29108 chemical-affects CARD11 Reactome 16356855 Activation of NF-kappaB in B cells http://pathwaycommons.org/pc12/Catalysis_b1c8f06a634948a4793ebfc43cc547f5;http://identifiers.org/reactome/R-HSA-1168635 | |
| CHEBI:29108 chemical-affects CASR Reactome NA Class C/3 (Metabotropic glutamate/pheromone receptors);G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_17219fd239aef3b0325cc1dd45f38e8d | |
| CHEBI:29108 chemical-affects CAST Reactome NA Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models http://pathwaycommons.org/pc12/Complex_da22001557b6d1134a06aac18a4497ac | |
| CHEBI:29108 chemical-affects CAV1 Reactome NA VEGFR2 mediated vascular permeability;eNOS activation http://pathwaycommons.org/pc12/Complex_30b628c7535e2437234d3692be1cf89a;http://pathwaycommons.org/pc12/Complex_1646611a468b89f143cf0939f70ffe3a | |
| CHEBI:29108 chemical-affects CAV3 Reactome 11532985;14506282;19380584;22421042 Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-5263628;http://identifiers.org/reactome/R-HSA-5333034;http://identifiers.org/reactome/R-HSA-5333036;http://identifiers.org/reactome/R-HSA-5263633 | |
| CHEBI:29108 chemical-affects CBLL1 Reactome NA InlA-mediated entry of Listeria monocytogenes into host cells http://pathwaycommons.org/pc12/Complex_601c32ed8a019e633c50baef0031c87a;http://pathwaycommons.org/pc12/Complex_295dd2691a37cfdd0dee083861adb098 | |
| CHEBI:29108 chemical-affects CD209 Reactome NA CD209 (DC-SIGN) signaling http://pathwaycommons.org/pc12/Complex_b8dea77a28d962a01cf3247d302fe795 | |
| CHEBI:29108 chemical-affects CD44 Reactome NA Hyaluronan uptake and degradation http://pathwaycommons.org/pc12/Complex_8eea59cd1481d67d38c5fb297b709834 | |
| CHEBI:29108 chemical-affects CDC42 Reactome 17244649;21730051;8756646;9199170;9368021 RHO GTPases activate IQGAPs http://identifiers.org/reactome/R-HSA-5626507;http://identifiers.org/reactome/R-HSA-5626550;http://pathwaycommons.org/pc12/Complex_072c82f475ea60d741ff46a81c833d05 | |
| CHEBI:29108 chemical-affects CDH1 Reactome NA Degradation of the extracellular matrix;InlA-mediated entry of Listeria monocytogenes into host cells;RHO GTPases activate IQGAPs http://pathwaycommons.org/pc12/Complex_64a33f3cb6367a3227f9a1e27fe368ca;http://pathwaycommons.org/pc12/Complex_3d56659d5c547085ef77861af77828f7;http://pathwaycommons.org/pc12/Complex_39c7eecf1a22923abfec3392feadda96;http://pathwaycommons.org/pc12/Complex_c0d0f550a5e094eb2d2a7aa9a03f44a4;http://pathwaycommons.org/pc12/Complex_d14fd20e7d04c6b6c80ae25eba644705;http://pathwaycommons.org/pc12/Complex_140d42c016ff50a61e7d7c0ef84195f6;http://pathwaycommons.org/pc12/Complex_7f404674b51c9d33c8cd11d69d9539c7;http://pathwaycommons.org/pc12/Complex_275081c16e7a7ed15f0682a385459966 | |
| CHEBI:29108 chemical-affects CDK5R1 Reactome 10830966;21338355 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models http://identifiers.org/reactome/R-HSA-8863012;http://identifiers.org/reactome/R-HSA-8868141;http://pathwaycommons.org/pc12/Catalysis_2caae2da55c2778017ef72720d186a35 | |
| CHEBI:29108 chemical-affects CHP1 Reactome NA Hyaluronan uptake and degradation http://pathwaycommons.org/pc12/Complex_a50c7275536473e43807e231391cb528 | |
| CHEBI:29108 chemical-affects CLCA1 Reactome 11842292;11956057;15318163;15919655;19307298;23112050 Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-5336160;http://identifiers.org/reactome/R-HSA-5333671 | |
| CHEBI:29108 chemical-affects CLCA2 Reactome 11842292;11956057;15318163;15919655;19307298;23112050 Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-5336160;http://identifiers.org/reactome/R-HSA-5333671 | |
| CHEBI:29108 chemical-affects CLCA3P Reactome 11842292;11956057;15318163;15919655;19307298;23112050 Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-5336160;http://identifiers.org/reactome/R-HSA-5333671 | |
| CHEBI:29108 chemical-affects CLCA4 Reactome 11842292;11956057;15318163;15919655;19307298;23112050 Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-5336160;http://identifiers.org/reactome/R-HSA-5333671 | |
| CHEBI:29108 chemical-affects CLCN6 Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects CNGA1 Reactome NA Inactivation, recovery and regulation of the phototransduction cascade http://pathwaycommons.org/pc12/Complex_5c8925ddf1cbb88d5655b2ae05cbe244 | |
| CHEBI:29108 chemical-affects CNGB1 Reactome NA Inactivation, recovery and regulation of the phototransduction cascade http://pathwaycommons.org/pc12/Complex_5c8925ddf1cbb88d5655b2ae05cbe244 | |
| CHEBI:29108 chemical-affects COLEC10 Reactome NA Initial triggering of complement;Lectin pathway of complement activation http://pathwaycommons.org/pc12/Complex_a19d0177c7b82f06623c1318fa02e849 | |
| CHEBI:29108 chemical-affects COLEC11 Reactome NA Initial triggering of complement;Lectin pathway of complement activation http://pathwaycommons.org/pc12/Complex_a19d0177c7b82f06623c1318fa02e849 | |
| CHEBI:29108 chemical-affects CPLX1 Reactome 12519779;16990140;17478680;17891149 Glutamate Neurotransmitter Release Cycle http://identifiers.org/reactome/R-HSA-210503;http://identifiers.org/reactome/R-HSA-210430 | |
| CHEBI:29108 chemical-affects CPNE1 Reactome 12440769;9430674 Glycerophospholipid biosynthesis http://identifiers.org/reactome/R-HSA-5333678;http://identifiers.org/reactome/R-HSA-5336148 | |
| CHEBI:29108 chemical-affects CPNE3 Reactome 12440769;9430674 Glycerophospholipid biosynthesis http://identifiers.org/reactome/R-HSA-5333678;http://identifiers.org/reactome/R-HSA-5336148 | |
| CHEBI:29108 chemical-affects CPNE6 Reactome 12440769;9430674 Glycerophospholipid biosynthesis http://identifiers.org/reactome/R-HSA-5333678;http://identifiers.org/reactome/R-HSA-5336148 | |
| CHEBI:29108 chemical-affects CPNE7 Reactome 12440769;9430674 Glycerophospholipid biosynthesis http://identifiers.org/reactome/R-HSA-5333678;http://identifiers.org/reactome/R-HSA-5336148 | |
| CHEBI:29108 chemical-affects CREB1 Reactome 11160957;11698596;12082174;12150772;12842905;15879576;17908236;19001277;19244110;2573431;7551568;9687510;9733829;9770464;9829964 AKT phosphorylates targets in the nucleus;CREB phosphorylation;CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling;CREB1 phosphorylation through the activation of Adenylate Cyclase;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CaMK IV-mediated phosphorylation of CREB;Constitutive Signaling by AKT1 E17K in Cancer;Estrogen-dependent nuclear events downstream of ESR-membrane signaling;Gastrin-CREB signalling pathway via PKC and MAPK;NCAM signaling for neurite out-growth;PKA-mediated phosphorylation of CREB;Transcriptional activation of mitochondrial biogenesis http://pathwaycommons.org/pc12/Catalysis_0bcb426f62204035f9a004843803cb04;http://identifiers.org/reactome/R-HSA-442724 | |
| CHEBI:29108 chemical-affects CRK Reactome NA p130Cas linkage to MAPK signaling for integrins http://pathwaycommons.org/pc12/Complex_0eb309b26e879724f3ee0c7b888d0c69 | |
| CHEBI:29108 chemical-affects CRP Reactome NA Classical antibody-mediated complement activation http://pathwaycommons.org/pc12/Complex_c9dcaad8123edb772e3f188d55c30413 | |
| CHEBI:29108 chemical-affects CSK Reactome NA Integrin alphaIIb beta3 signaling http://pathwaycommons.org/pc12/Complex_2357686c4db0ca1c4d0ab9a210130449;http://pathwaycommons.org/pc12/Complex_23c4b5044f972d0062e4816c7ae0ad45 | |
| CHEBI:29108 chemical-affects CTNNA1 Reactome NA RHO GTPases activate IQGAPs http://pathwaycommons.org/pc12/Complex_78b807dda62b3000e9291f79b667b8db | |
| CHEBI:29108 chemical-affects CTNNB1 Reactome NA InlA-mediated entry of Listeria monocytogenes into host cells;RHO GTPases activate IQGAPs http://pathwaycommons.org/pc12/Complex_dd5989fd89363378a7b8d66d06f7957b;http://pathwaycommons.org/pc12/Complex_78b807dda62b3000e9291f79b667b8db;http://pathwaycommons.org/pc12/Complex_72252a597af31ca7a925dc40f25213f4;http://pathwaycommons.org/pc12/Complex_0a044c91da8ad7e06e3eec9e188d60fd;http://pathwaycommons.org/pc12/Complex_f088f46808925ad7dcab46340430d531 | |
| CHEBI:29108 chemical-affects CTNND1 Reactome NA InlA-mediated entry of Listeria monocytogenes into host cells http://pathwaycommons.org/pc12/Complex_dd5989fd89363378a7b8d66d06f7957b;http://pathwaycommons.org/pc12/Complex_0a044c91da8ad7e06e3eec9e188d60fd | |
| CHEBI:29108 chemical-affects CYBA Reactome NA RHO GTPases Activate NADPH Oxidases http://pathwaycommons.org/pc12/Complex_940658ed0ee8c537e938ffbb68d0ab84 | |
| CHEBI:29108 chemical-affects CYBB Reactome NA RHO GTPases Activate NADPH Oxidases http://pathwaycommons.org/pc12/Complex_940658ed0ee8c537e938ffbb68d0ab84 | |
| CHEBI:29108 chemical-affects DES Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects DLG1 Reactome NA Long-term potentiation;Negative regulation of NMDA receptor-mediated neuronal transmission;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Complex_b26a71b84e441dbc672615cce19cf62e;http://pathwaycommons.org/pc12/Complex_e242f1b69c19f98d5f989fff7d0c1117;http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded | |
| CHEBI:29108 chemical-affects DLG2 Reactome NA Long-term potentiation;Negative regulation of NMDA receptor-mediated neuronal transmission;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Complex_b26a71b84e441dbc672615cce19cf62e;http://pathwaycommons.org/pc12/Complex_e242f1b69c19f98d5f989fff7d0c1117;http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded | |
| CHEBI:29108 chemical-affects DLG3 Reactome NA Long-term potentiation;Negative regulation of NMDA receptor-mediated neuronal transmission;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Complex_b26a71b84e441dbc672615cce19cf62e;http://pathwaycommons.org/pc12/Complex_e242f1b69c19f98d5f989fff7d0c1117;http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded | |
| CHEBI:29108 chemical-affects DLG4 Reactome NA Long-term potentiation;Negative regulation of NMDA receptor-mediated neuronal transmission;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Complex_b26a71b84e441dbc672615cce19cf62e;http://pathwaycommons.org/pc12/Complex_e242f1b69c19f98d5f989fff7d0c1117;http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded | |
| CHEBI:29108 chemical-affects DMD Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_1a2dfeb8092eea766c7560c066c83a46 | |
| CHEBI:29108 chemical-affects DVL2 Reactome 12958364;17199046 WNT5A-dependent internalization of FZD4 http://identifiers.org/reactome/R-HSA-5138432;http://pathwaycommons.org/pc12/Catalysis_378d8b8a83ffcc6b7ad6194e098e558c | |
| CHEBI:29108 chemical-affects DYSF Reactome 11532985;14506282;19380584;22421042 Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-5263628;http://identifiers.org/reactome/R-HSA-5333034;http://identifiers.org/reactome/R-HSA-5333036;http://identifiers.org/reactome/R-HSA-5263633 | |
| CHEBI:29108 chemical-affects EMD Reactome 22986494;8034666;8463284 Depolymerisation of the Nuclear Lamina http://identifiers.org/reactome/R-HSA-5229194;http://pathwaycommons.org/pc12/Catalysis_ca4c2b90ced928f3342033ba2ded919f | |
| CHEBI:29108 chemical-affects ENTPD1 Reactome NA Phosphate bond hydrolysis by NTPDase proteins http://pathwaycommons.org/pc12/Complex_b3559ee063168eaade04d997ba5213ca | |
| CHEBI:29108 chemical-affects ENTPD2 Reactome NA Phosphate bond hydrolysis by NTPDase proteins http://pathwaycommons.org/pc12/Complex_79b7690bc664a895e713eef68e37da80 | |
| CHEBI:29108 chemical-affects ENTPD3 Reactome NA Phosphate bond hydrolysis by NTPDase proteins http://pathwaycommons.org/pc12/Complex_a8878b9eb63ec0a3b23fb5220decbe11 | |
| CHEBI:29108 chemical-affects ENTPD4 Reactome NA Phosphate bond hydrolysis by NTPDase proteins http://pathwaycommons.org/pc12/Complex_b114660962a052a223ac8d68d33ef210 | |
| CHEBI:29108 chemical-affects ENTPD5 Reactome NA Phosphate bond hydrolysis by NTPDase proteins http://pathwaycommons.org/pc12/Complex_d13724e03cff0d8e214ca64acb0b6b31 | |
| CHEBI:29108 chemical-affects ENTPD6 Reactome NA Phosphate bond hydrolysis by NTPDase proteins http://pathwaycommons.org/pc12/Complex_6274754bb4774a025f178b9f729ffdf8 | |
| CHEBI:29108 chemical-affects ENTPD7 Reactome NA Phosphate bond hydrolysis by NTPDase proteins http://pathwaycommons.org/pc12/Complex_5910f593d0a1c7b3cf2f1c8ce8db35d6 | |
| CHEBI:29108 chemical-affects ENTPD8 Reactome NA Phosphate bond hydrolysis by NTPDase proteins http://pathwaycommons.org/pc12/Complex_2784d8a6a70000e264c9f046e9f99a26 | |
| CHEBI:29108 chemical-affects ESRP1 Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects EVPL Reactome 10196183;10510474;10588656;11443109;12210515;2461365;6105840;73346 Formation of the cornified envelope http://pathwaycommons.org/pc12/Catalysis_399933b4d215d5b33201c64821d4b301;http://identifiers.org/reactome/R-HSA-6810894 | |
| CHEBI:29108 chemical-affects EXOC1 Reactome NA Translocation of SLC2A4 (GLUT4) to the plasma membrane http://identifiers.org/reactome/R-HSA-5358685;http://identifiers.org/reactome/R-HSA-2316352 | |
| CHEBI:29108 chemical-affects EXOC2 Reactome NA Translocation of SLC2A4 (GLUT4) to the plasma membrane http://identifiers.org/reactome/R-HSA-5358685;http://identifiers.org/reactome/R-HSA-2316352 | |
| CHEBI:29108 chemical-affects EXOC3 Reactome NA Translocation of SLC2A4 (GLUT4) to the plasma membrane http://identifiers.org/reactome/R-HSA-5358685;http://identifiers.org/reactome/R-HSA-2316352 | |
| CHEBI:29108 chemical-affects EXOC4 Reactome NA Translocation of SLC2A4 (GLUT4) to the plasma membrane http://identifiers.org/reactome/R-HSA-5358685;http://identifiers.org/reactome/R-HSA-2316352 | |
| CHEBI:29108 chemical-affects EXOC5 Reactome NA Translocation of SLC2A4 (GLUT4) to the plasma membrane http://identifiers.org/reactome/R-HSA-5358685;http://identifiers.org/reactome/R-HSA-2316352 | |
| CHEBI:29108 chemical-affects EXOC6 Reactome NA Translocation of SLC2A4 (GLUT4) to the plasma membrane http://identifiers.org/reactome/R-HSA-5358685;http://identifiers.org/reactome/R-HSA-2316352 | |
| CHEBI:29108 chemical-affects EXOC7 Reactome NA Translocation of SLC2A4 (GLUT4) to the plasma membrane http://identifiers.org/reactome/R-HSA-5358685;http://identifiers.org/reactome/R-HSA-2316352 | |
| CHEBI:29108 chemical-affects EXOC8 Reactome NA Translocation of SLC2A4 (GLUT4) to the plasma membrane http://identifiers.org/reactome/R-HSA-5358685;http://identifiers.org/reactome/R-HSA-2316352 | |
| CHEBI:29108 chemical-affects F10 Reactome NA Common Pathway of Fibrin Clot Formation;Extrinsic Pathway of Fibrin Clot Formation;Intrinsic Pathway of Fibrin Clot Formation http://pathwaycommons.org/pc12/Complex_44d3939c6178d46a744d37910fe4e683;http://pathwaycommons.org/pc12/Complex_1b4e7d7fbab885b3b8172f6e96c5fd19;http://pathwaycommons.org/pc12/Complex_9b4f097351a3656cf115e700a402d9b2;http://pathwaycommons.org/pc12/Complex_a88d0f9e9671a1a363ad9fd93b333135 | |
| CHEBI:29108 chemical-affects F11 Reactome 10781579;11696542;11833835;12167623;12231555;14691562;17506785;1930190;1998667;2019570;21932952;2384594;3017409;588558;8338946;893417;9459334;9469622;9888880 Intrinsic Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-158419;http://identifiers.org/reactome/R-HSA-5607094;http://identifiers.org/reactome/R-HSA-9015384;http://identifiers.org/reactome/R-HSA-5607787;http://pathwaycommons.org/pc12/Catalysis_f0989fcbfa9b52f844baab35334b2864 | |
| CHEBI:29108 chemical-affects F13A1 Reactome 11833835;17506785;1930190;21932952;2384594;2866798;9459334;9469622 Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-140599;http://pathwaycommons.org/pc12/Catalysis_d1bdc360c0e2af43d245560983dc8b90;http://identifiers.org/reactome/R-HSA-9015388;http://identifiers.org/reactome/R-HSA-5607786;http://pathwaycommons.org/pc12/Complex_1e1ae4cf3d60af6a0603df8c10ef79f4;http://identifiers.org/reactome/R-HSA-5607098 | |
| CHEBI:29108 chemical-affects F13B Reactome 11833835;17506785;1930190;21932952;2384594;2866798;9459334;9469622 Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-140599;http://pathwaycommons.org/pc12/Catalysis_d1bdc360c0e2af43d245560983dc8b90;http://identifiers.org/reactome/R-HSA-9015388;http://identifiers.org/reactome/R-HSA-5607786;http://identifiers.org/reactome/R-HSA-5607098 | |
| CHEBI:29108 chemical-affects F2RL1 Reactome NA G alpha (q) signalling events;Peptide ligand-binding receptors http://pathwaycommons.org/pc12/Complex_82d457491dccd221d7d019cdaa2cca90 | |
| CHEBI:29108 chemical-affects F2RL2 Reactome 1672265;9087410;9618465 G alpha (q) signalling events;Peptide ligand-binding receptors;Thrombin signalling through proteinase activated receptors (PARs) http://identifiers.org/reactome/R-HSA-114697;http://pathwaycommons.org/pc12/Complex_82d457491dccd221d7d019cdaa2cca90;http://pathwaycommons.org/pc12/Catalysis_6be46eeb1ecff283736b329e0970004e | |
| CHEBI:29108 chemical-affects F2RL3 Reactome 1672265;9087410;9618465 G alpha (q) signalling events;Peptide ligand-binding receptors;Thrombin signalling through proteinase activated receptors (PARs) http://identifiers.org/reactome/R-HSA-114697;http://pathwaycommons.org/pc12/Complex_82d457491dccd221d7d019cdaa2cca90;http://pathwaycommons.org/pc12/Catalysis_6be46eeb1ecff283736b329e0970004e | |
| CHEBI:29108 chemical-affects F2R Reactome 1672265;9087410;9618465 Common Pathway of Fibrin Clot Formation;G alpha (q) signalling events;Peptide ligand-binding receptors;Thrombin signalling through proteinase activated receptors (PARs) http://identifiers.org/reactome/R-HSA-114697;http://pathwaycommons.org/pc12/Complex_82d457491dccd221d7d019cdaa2cca90;http://pathwaycommons.org/pc12/Catalysis_6be46eeb1ecff283736b329e0970004e;http://pathwaycommons.org/pc12/Complex_4bfe80a33cd9114d5e259f2bb418fc3a | |
| CHEBI:29108 chemical-affects F2 Reactome NA Common Pathway of Fibrin Clot Formation;G alpha (q) signalling events;Intrinsic Pathway of Fibrin Clot Formation;Peptide ligand-binding receptors;Platelet Aggregation (Plug Formation);Regulation of Complement cascade;Regulation of IGF Activity by IGFBP;Thrombin signalling through proteinase activated receptors (PARs) http://pathwaycommons.org/pc12/Complex_d2e9759249c3008761c80817524f75ae;http://pathwaycommons.org/pc12/Complex_c66dfb6fe7abf350f9cffc93d0bf8ccd | |
| CHEBI:29108 chemical-affects F3 Reactome NA Extrinsic Pathway of Fibrin Clot Formation http://pathwaycommons.org/pc12/Complex_44d3939c6178d46a744d37910fe4e683;http://pathwaycommons.org/pc12/Complex_125723438be1d979068339e61f7870a8;http://pathwaycommons.org/pc12/Complex_a0e855185e815bed963ca8df9a3d1e66 | |
| CHEBI:29108 chemical-affects F5 Reactome 10688829;12595311;16935856;21730834;7499257;7673148;7989361;8144529;8822928 Common Pathway of Fibrin Clot Formation http://pathwaycommons.org/pc12/Complex_4bcc7a4fc6b876370b086c621100eddb;http://pathwaycommons.org/pc12/Complex_9b4f097351a3656cf115e700a402d9b2;http://pathwaycommons.org/pc12/Catalysis_895247441a612ba119b019eb4c6edee3;http://pathwaycommons.org/pc12/Complex_912d53b762abd31e8474140f9f8f4533;http://identifiers.org/reactome/R-HSA-5591040 | |
| CHEBI:29108 chemical-affects F7 Reactome NA Extrinsic Pathway of Fibrin Clot Formation http://pathwaycommons.org/pc12/Complex_44d3939c6178d46a744d37910fe4e683;http://pathwaycommons.org/pc12/Complex_23ed2e7117017867c29efd096d7e048b;http://pathwaycommons.org/pc12/Complex_a0e855185e815bed963ca8df9a3d1e66;http://pathwaycommons.org/pc12/Complex_fe82c30df42f2428d3dc860f19f45002;http://pathwaycommons.org/pc12/Complex_0aa2d33769160168a5ee0bfb5b2a6f98 | |
| CHEBI:29108 chemical-affects F8 Reactome 10688829;11833835;12595311;14684146;16935856;17506785;18424440;1902833;1930190;21932952;2384594;2502206;2505252;3082357;3134349;7499257;8144529;8626656;8822928;9459334;9469622 Common Pathway of Fibrin Clot Formation;Intrinsic Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-5607097;http://pathwaycommons.org/pc12/Catalysis_910a33f75144aebc93215024e0394424;http://identifiers.org/reactome/R-HSA-158137;http://identifiers.org/reactome/R-HSA-5607002;http://identifiers.org/reactome/R-HSA-9015345;http://identifiers.org/reactome/R-HSA-158278;http://pathwaycommons.org/pc12/Catalysis_7ed7f71c5b59181addd9243e2c607d20;http://identifiers.org/reactome/R-HSA-5607784;http://identifiers.org/reactome/R-HSA-158645 | |
| CHEBI:29108 chemical-affects F9 Reactome 11342438;14684146;2040636;2248955;681330;8626656 Extrinsic Pathway of Fibrin Clot Formation;Intrinsic Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-158278;http://identifiers.org/reactome/R-HSA-158643;http://pathwaycommons.org/pc12/Catalysis_3f122a7c066498ad13489f795bb37d28;http://identifiers.org/reactome/R-HSA-140823;http://identifiers.org/reactome/R-HSA-158645 | |
| CHEBI:29108 chemical-affects FAM114A2 Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects FAM131B Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects FCN1 Reactome NA Ficolins bind to repetitive carbohydrate structures on the target cell surface;Initial triggering of complement;Lectin pathway of complement activation http://pathwaycommons.org/pc12/Complex_07acdde53acc3374a9d3a4bb60f38e88;http://pathwaycommons.org/pc12/Complex_60aef73cc10ff434b099e40b3937422c | |
| CHEBI:29108 chemical-affects FCN2 Reactome NA Ficolins bind to repetitive carbohydrate structures on the target cell surface;Initial triggering of complement;Lectin pathway of complement activation http://pathwaycommons.org/pc12/Complex_f49bccba957b1f60bfaa3625ad75e13a;http://pathwaycommons.org/pc12/Complex_b153606fd324ba303ef4b4a540c8d44d | |
| CHEBI:29108 chemical-affects FCN3 Reactome NA Ficolins bind to repetitive carbohydrate structures on the target cell surface;Initial triggering of complement;Lectin pathway of complement activation http://pathwaycommons.org/pc12/Complex_75f1d4ad71e597ba131f2cc933b4a873;http://pathwaycommons.org/pc12/Complex_102ab27a07d3738319f82f077aa293a3 | |
| CHEBI:29108 chemical-affects FGA Reactome 11833835;17506785;1930190;21932952;2384594;2742826;9459334;9469622 Common Pathway of Fibrin Clot Formation;GRB2:SOS provides linkage to MAPK signaling for Integrins;Integrin alphaIIb beta3 signaling;p130Cas linkage to MAPK signaling for integrins http://pathwaycommons.org/pc12/Complex_6c5ceab1ba2073e49cb1896a925dc573;http://identifiers.org/reactome/R-HSA-140840;http://identifiers.org/reactome/R-HSA-140851;http://pathwaycommons.org/pc12/Complex_2357686c4db0ca1c4d0ab9a210130449;http://pathwaycommons.org/pc12/Complex_16978f376c59bd9933e4875566f69baf;http://pathwaycommons.org/pc12/Complex_97a0978414a8036daa7bf22a7d04587e;http://identifiers.org/reactome/R-HSA-9015387;http://pathwaycommons.org/pc12/Catalysis_ba770f1d279683b55464723fa90b23f3;http://identifiers.org/reactome/R-HSA-5607099;http://pathwaycommons.org/pc12/Catalysis_0f45c9af5c7ddbb6f9ffbc9383d379df;http://pathwaycommons.org/pc12/Complex_23c4b5044f972d0062e4816c7ae0ad45 | |
| CHEBI:29108 chemical-affects FGB Reactome 11833835;17506785;1930190;21932952;2384594;2742826;9459334;9469622 Common Pathway of Fibrin Clot Formation;GRB2:SOS provides linkage to MAPK signaling for Integrins;Integrin alphaIIb beta3 signaling;p130Cas linkage to MAPK signaling for integrins http://pathwaycommons.org/pc12/Complex_6c5ceab1ba2073e49cb1896a925dc573;http://identifiers.org/reactome/R-HSA-140840;http://identifiers.org/reactome/R-HSA-140851;http://pathwaycommons.org/pc12/Complex_2357686c4db0ca1c4d0ab9a210130449;http://pathwaycommons.org/pc12/Complex_16978f376c59bd9933e4875566f69baf;http://pathwaycommons.org/pc12/Complex_97a0978414a8036daa7bf22a7d04587e;http://identifiers.org/reactome/R-HSA-9015387;http://pathwaycommons.org/pc12/Catalysis_ba770f1d279683b55464723fa90b23f3;http://identifiers.org/reactome/R-HSA-5607099;http://pathwaycommons.org/pc12/Catalysis_0f45c9af5c7ddbb6f9ffbc9383d379df;http://pathwaycommons.org/pc12/Complex_23c4b5044f972d0062e4816c7ae0ad45 | |
| CHEBI:29108 chemical-affects FGG Reactome 11833835;17506785;1930190;21932952;2384594;2742826;9459334;9469622 Common Pathway of Fibrin Clot Formation;GRB2:SOS provides linkage to MAPK signaling for Integrins;Integrin alphaIIb beta3 signaling;p130Cas linkage to MAPK signaling for integrins http://pathwaycommons.org/pc12/Complex_6c5ceab1ba2073e49cb1896a925dc573;http://identifiers.org/reactome/R-HSA-140840;http://identifiers.org/reactome/R-HSA-140851;http://pathwaycommons.org/pc12/Complex_2357686c4db0ca1c4d0ab9a210130449;http://pathwaycommons.org/pc12/Complex_16978f376c59bd9933e4875566f69baf;http://pathwaycommons.org/pc12/Complex_97a0978414a8036daa7bf22a7d04587e;http://identifiers.org/reactome/R-HSA-9015387;http://pathwaycommons.org/pc12/Catalysis_ba770f1d279683b55464723fa90b23f3;http://identifiers.org/reactome/R-HSA-5607099;http://pathwaycommons.org/pc12/Catalysis_0f45c9af5c7ddbb6f9ffbc9383d379df;http://pathwaycommons.org/pc12/Complex_23c4b5044f972d0062e4816c7ae0ad45 | |
| CHEBI:29108 consumption-controlled-by FKBP1A Reactome 11030334;11231878;7523407;7657645;8524402;8684469;9106655;9312192 Calcineurin activates NFAT http://identifiers.org/reactome/R-HSA-2025882;http://identifiers.org/reactome/R-HSA-2026021 | |
| CHEBI:29108 chemical-affects FLG Reactome 11380615;14638864;15803139;16061697;17515931;20179351;21997417;23629652;7499312;9207214 Formation of the cornified envelope http://pathwaycommons.org/pc12/Catalysis_98ba4c218ee91afc873fc1391143095c;http://identifiers.org/reactome/R-HSA-8934819 | |
| CHEBI:29108 chemical-affects FN1 Reactome NA GRB2:SOS provides linkage to MAPK signaling for Integrins;Integrin alphaIIb beta3 signaling;p130Cas linkage to MAPK signaling for integrins http://pathwaycommons.org/pc12/Complex_6c5ceab1ba2073e49cb1896a925dc573;http://pathwaycommons.org/pc12/Complex_2357686c4db0ca1c4d0ab9a210130449;http://pathwaycommons.org/pc12/Complex_16978f376c59bd9933e4875566f69baf;http://pathwaycommons.org/pc12/Complex_97a0978414a8036daa7bf22a7d04587e;http://pathwaycommons.org/pc12/Complex_23c4b5044f972d0062e4816c7ae0ad45 | |
| CHEBI:29108 chemical-affects FURIN Reactome NA NGF processing http://pathwaycommons.org/pc12/Complex_47fac0b57b8d4e45ce6b746ac2fc00fe | |
| CHEBI:29108 chemical-affects FXR1 Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects FZD4 Reactome 12958364;17199046 WNT5A-dependent internalization of FZD4 http://identifiers.org/reactome/R-HSA-5138432;http://pathwaycommons.org/pc12/Catalysis_378d8b8a83ffcc6b7ad6194e098e558c | |
| CHEBI:29108 chemical-affects GCG Reactome 12651102 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) http://pathwaycommons.org/pc12/Catalysis_18a6a7b43af0583129fe07e1cb7b5d26;http://identifiers.org/reactome/R-HSA-381798 | |
| CHEBI:29108 chemical-affects GHRL Reactome 18396350;19280057;19628676 Synthesis, secretion, and deacylation of Ghrelin http://identifiers.org/reactome/R-HSA-422021;http://pathwaycommons.org/pc12/Catalysis_b7dfe873db3d6b4b470ca7f65c6493cb | |
| CHEBI:29108 chemical-affects GIP Reactome NA Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) http://pathwaycommons.org/pc12/Catalysis_fbb03456471b0d3f7def6a141db3dfe3;http://identifiers.org/reactome/R-HSA-400492 | |
| CHEBI:29108 chemical-affects GIT1 Reactome 18184567 Activation of RAC1 downstream of NMDARs http://pathwaycommons.org/pc12/Catalysis_17560a6f06a9b07d5921c9dd913a7a18;http://identifiers.org/reactome/R-HSA-9619783 | |
| CHEBI:29108 chemical-affects GNA11 Reactome NA G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNA14 Reactome NA G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNA15 Reactome NA G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNAI1 Reactome NA G alpha (i) signalling events http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39 | |
| CHEBI:29108 chemical-affects GNAI2 Reactome NA G alpha (i) signalling events http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39 | |
| CHEBI:29108 chemical-affects GNAI3 Reactome NA G alpha (i) signalling events http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39 | |
| CHEBI:29108 chemical-affects GNAQ Reactome NA G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNAT3 Reactome NA G alpha (i) signalling events http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39 | |
| CHEBI:29108 chemical-affects GNAZ Reactome NA G alpha (z) signalling events http://pathwaycommons.org/pc12/Complex_ccf5f4fde222d7ba7e2427a85bc71464;http://pathwaycommons.org/pc12/Complex_94f7bb0ed2cfb33a091b08e22eb5b4e7 | |
| CHEBI:29108 chemical-affects GNB1 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNB2 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNB3 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNB4 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNB5 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNG10 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNG11 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNG12 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNG13 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNG2 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNG3 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNG4 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNG5 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNG7 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNG8 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNGT1 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GNGT2 Reactome NA G alpha (i) signalling events;G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_0b9947dc35f04811dfec578af5dd2e1c;http://pathwaycommons.org/pc12/Complex_e6dd74ed59bbd8753d316da70b7dd132;http://pathwaycommons.org/pc12/Complex_23021e9f3afcc81cd56967d5ec5fec39;http://pathwaycommons.org/pc12/Complex_5fbd93fb2ef4d253105ef770a969d3b8 | |
| CHEBI:29108 chemical-affects GP1BA Reactome 10781579;11696542;11833835;12167623;12231555;14691562;17506785;1930190;1998667;2019570;21932952;2384594;3017409;588558;8338946;893417;9459334;9469622;9888880 Intrinsic Pathway of Fibrin Clot Formation;Platelet Aggregation (Plug Formation) http://identifiers.org/reactome/R-HSA-158419;http://identifiers.org/reactome/R-HSA-5607094;http://pathwaycommons.org/pc12/Complex_e139df10680005c824ee8a00c6551800;http://identifiers.org/reactome/R-HSA-9015384;http://identifiers.org/reactome/R-HSA-5607787;http://pathwaycommons.org/pc12/Catalysis_f0989fcbfa9b52f844baab35334b2864 | |
| CHEBI:29108 chemical-affects GP1BB Reactome 10781579;11696542;11833835;12167623;12231555;14691562;17506785;1930190;1998667;2019570;21932952;2384594;3017409;588558;8338946;893417;9459334;9469622;9888880 Intrinsic Pathway of Fibrin Clot Formation;Platelet Aggregation (Plug Formation) http://identifiers.org/reactome/R-HSA-158419;http://identifiers.org/reactome/R-HSA-5607094;http://pathwaycommons.org/pc12/Complex_e139df10680005c824ee8a00c6551800;http://identifiers.org/reactome/R-HSA-9015384;http://identifiers.org/reactome/R-HSA-5607787;http://pathwaycommons.org/pc12/Catalysis_f0989fcbfa9b52f844baab35334b2864 | |
| CHEBI:29108 chemical-affects GP5 Reactome 10781579;11696542;11833835;12167623;12231555;14691562;17506785;1930190;1998667;2019570;21932952;2384594;3017409;588558;8338946;893417;9459334;9469622;9888880 Intrinsic Pathway of Fibrin Clot Formation;Platelet Aggregation (Plug Formation) http://identifiers.org/reactome/R-HSA-158419;http://identifiers.org/reactome/R-HSA-5607094;http://pathwaycommons.org/pc12/Complex_e139df10680005c824ee8a00c6551800;http://identifiers.org/reactome/R-HSA-9015384;http://identifiers.org/reactome/R-HSA-5607787;http://pathwaycommons.org/pc12/Catalysis_f0989fcbfa9b52f844baab35334b2864 | |
| CHEBI:29108 chemical-affects GP9 Reactome 10781579;11696542;11833835;12167623;12231555;14691562;17506785;1930190;1998667;2019570;21932952;2384594;3017409;588558;8338946;893417;9459334;9469622;9888880 Intrinsic Pathway of Fibrin Clot Formation;Platelet Aggregation (Plug Formation) http://identifiers.org/reactome/R-HSA-158419;http://identifiers.org/reactome/R-HSA-5607094;http://pathwaycommons.org/pc12/Complex_e139df10680005c824ee8a00c6551800;http://identifiers.org/reactome/R-HSA-9015384;http://identifiers.org/reactome/R-HSA-5607787;http://pathwaycommons.org/pc12/Catalysis_f0989fcbfa9b52f844baab35334b2864 | |
| CHEBI:29108 chemical-affects GPRC6A Reactome NA Class C/3 (Metabotropic glutamate/pheromone receptors);G alpha (q) signalling events http://pathwaycommons.org/pc12/Complex_8d732581fb1365e41203dc792ce243a3 | |
| CHEBI:29108 chemical-affects GPS2 Reactome 21240272;21925568;23770565;23770587 Regulation of MECP2 expression and activity http://pathwaycommons.org/pc12/Control_a1ba3478207416f47b4b6c44bd7eb6e4;http://identifiers.org/reactome/R-HSA-8986939 | |
| CHEBI:29108 chemical-affects GRB2 Reactome NA GRB2:SOS provides linkage to MAPK signaling for Integrins http://pathwaycommons.org/pc12/Complex_c2a496b298ebe687b7ab614e9726dc06 | |
| CHEBI:29108 chemical-affects GRIA1 Reactome 15664178;16055064;20670832;21135237;8385275;9153188;9197267;9405465 Long-term potentiation;Trafficking of GluR2-containing AMPA receptors http://pathwaycommons.org/pc12/Catalysis_8e4f2b41a642b052ea0a9c9077258fa2;http://pathwaycommons.org/pc12/Catalysis_6f3133eef0abe6b6cdaabc45eb5bc17d;http://pathwaycommons.org/pc12/Catalysis_159940d16c72d644b5774ca1a71f1722;http://identifiers.org/reactome/R-HSA-421007;http://identifiers.org/reactome/R-HSA-416639;http://identifiers.org/reactome/R-HSA-9618750 | |
| CHEBI:29108 chemical-affects GRIA2 Reactome 15664178;16055064;20670832;21135237;8385275;9153188;9197267;9405465 Long-term potentiation;Trafficking of GluR2-containing AMPA receptors http://pathwaycommons.org/pc12/Catalysis_8e4f2b41a642b052ea0a9c9077258fa2;http://pathwaycommons.org/pc12/Catalysis_6f3133eef0abe6b6cdaabc45eb5bc17d;http://pathwaycommons.org/pc12/Catalysis_159940d16c72d644b5774ca1a71f1722;http://identifiers.org/reactome/R-HSA-421007;http://identifiers.org/reactome/R-HSA-416639;http://identifiers.org/reactome/R-HSA-9618750 | |
| CHEBI:29108 chemical-affects GRIA3 Reactome 16055064 Trafficking of GluR2-containing AMPA receptors http://pathwaycommons.org/pc12/Catalysis_8e4f2b41a642b052ea0a9c9077258fa2;http://pathwaycommons.org/pc12/Catalysis_159940d16c72d644b5774ca1a71f1722;http://identifiers.org/reactome/R-HSA-421007;http://identifiers.org/reactome/R-HSA-416639 | |
| CHEBI:29108 chemical-affects GRIA4 Reactome 16055064 Trafficking of GluR2-containing AMPA receptors http://pathwaycommons.org/pc12/Catalysis_8e4f2b41a642b052ea0a9c9077258fa2;http://pathwaycommons.org/pc12/Catalysis_159940d16c72d644b5774ca1a71f1722;http://identifiers.org/reactome/R-HSA-421007;http://identifiers.org/reactome/R-HSA-416639 | |
| CHEBI:29108 chemical-affects GRIN1 Reactome NA Long-term potentiation;Negative regulation of NMDA receptor-mediated neuronal transmission;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Complex_b26a71b84e441dbc672615cce19cf62e;http://pathwaycommons.org/pc12/Complex_e242f1b69c19f98d5f989fff7d0c1117;http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded | |
| CHEBI:29108 chemical-affects GRIN2A Reactome NA Negative regulation of NMDA receptor-mediated neuronal transmission http://pathwaycommons.org/pc12/Complex_b26a71b84e441dbc672615cce19cf62e | |
| CHEBI:29108 chemical-affects GRIN2B Reactome NA Long-term potentiation;Negative regulation of NMDA receptor-mediated neuronal transmission;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Complex_b26a71b84e441dbc672615cce19cf62e;http://pathwaycommons.org/pc12/Complex_e242f1b69c19f98d5f989fff7d0c1117;http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded | |
| CHEBI:29108 chemical-affects GRIN2C Reactome NA Negative regulation of NMDA receptor-mediated neuronal transmission http://pathwaycommons.org/pc12/Complex_b26a71b84e441dbc672615cce19cf62e | |
| CHEBI:29108 chemical-affects GRIN2D Reactome NA Long-term potentiation;Negative regulation of NMDA receptor-mediated neuronal transmission;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Complex_b26a71b84e441dbc672615cce19cf62e;http://pathwaycommons.org/pc12/Complex_e242f1b69c19f98d5f989fff7d0c1117;http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded | |
| CHEBI:29108 chemical-affects GRIP1 Reactome 16055064 Trafficking of GluR2-containing AMPA receptors http://pathwaycommons.org/pc12/Catalysis_8e4f2b41a642b052ea0a9c9077258fa2;http://pathwaycommons.org/pc12/Catalysis_159940d16c72d644b5774ca1a71f1722;http://identifiers.org/reactome/R-HSA-421007;http://identifiers.org/reactome/R-HSA-416639 | |
| CHEBI:29108 chemical-affects GRIP2 Reactome 16055064 Trafficking of GluR2-containing AMPA receptors http://pathwaycommons.org/pc12/Catalysis_8e4f2b41a642b052ea0a9c9077258fa2;http://pathwaycommons.org/pc12/Catalysis_159940d16c72d644b5774ca1a71f1722;http://identifiers.org/reactome/R-HSA-421007;http://identifiers.org/reactome/R-HSA-416639 | |
| CHEBI:29108 chemical-affects GRK1 Reactome NA Inactivation, recovery and regulation of the phototransduction cascade http://pathwaycommons.org/pc12/Complex_293804b3f9a02a35073fcb4706882fe8 | |
| CHEBI:29108 chemical-affects GRK2 Reactome 11042191 Calmodulin induced events http://pathwaycommons.org/pc12/Catalysis_b77933bae383327826536179f2d25d42;http://identifiers.org/reactome/R-HSA-111970;http://pathwaycommons.org/pc12/Complex_509f6bd996f5716a073f56acf98f165d | |
| CHEBI:29108 chemical-affects GUCA1A Reactome NA Inactivation, recovery and regulation of the phototransduction cascade http://pathwaycommons.org/pc12/Complex_ef9d1b87c97473d6bf7ee900b8fc173e;http://pathwaycommons.org/pc12/Complex_b39614868f34c8b96499c77300d6272b | |
| CHEBI:29108 chemical-affects GUCA1B Reactome NA Inactivation, recovery and regulation of the phototransduction cascade http://pathwaycommons.org/pc12/Complex_13f77b6d94cfe7376b6a97db19fe71cb;http://pathwaycommons.org/pc12/Complex_c4d4d1ab1ec8be0188ba408f107fca36 | |
| CHEBI:29108 chemical-affects GUCA1C Reactome NA Inactivation, recovery and regulation of the phototransduction cascade http://pathwaycommons.org/pc12/Complex_5d089b7fb1e30786940ca978c833d585 | |
| CHEBI:29108 chemical-affects H2AFB1 Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects H2AFX Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects H2AFZ Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects H2BFS Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects H3F3A Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects H3F3B Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HDAC3 Reactome 21240272;21925568;23770565;23770587 Regulation of MECP2 expression and activity http://pathwaycommons.org/pc12/Control_a1ba3478207416f47b4b6c44bd7eb6e4;http://identifiers.org/reactome/R-HSA-8986939 | |
| CHEBI:29108 chemical-affects HIST1H2AB Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2AC Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2AD Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2AE Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2AJ Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2BA Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2BB Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2BC Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2BD Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2BE Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2BF Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2BG Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2BH Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2BI Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2BJ Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2BK Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2BL Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2BM Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2BN Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H2BO Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H3A Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H3B Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H3C Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H3D Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H3E Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H3F Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H3G Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H3H Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H3I Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H3J Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H4A Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H4B Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H4C Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H4D Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H4E Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H4F Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H4H Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H4I Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H4J Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H4K Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST1H4L Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST2H2AA3 Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST2H2AA4 Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST2H2AC Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST2H2BE Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST2H3A Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST2H3C Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST2H3D Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST2H4A Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST2H4B Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST3H2BB Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HIST4H4 Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_d36bb71af81070357f56daf320f4fe87 | |
| CHEBI:29108 chemical-affects HMMR Reactome NA Hyaluronan uptake and degradation http://pathwaycommons.org/pc12/Complex_8eea59cd1481d67d38c5fb297b709834 | |
| CHEBI:29108 chemical-affects HRAS Reactome 10196222;10205168;10373510;10486198;10712905;10722704;10777492;10835426;10934204;11032810;11157491;11221888;11325826;11429702;12147692;12244094;12551923;12639709;1371879;1377053;14622581;15035987;15118125;15284455;1569084;15710605;15899852;16024644;16093354;16129412;16364920;16483568;16508002;16573649;17018604;17052120;17097642;1721591;17227708;17283063;17462920;18294816;18381441;18452557;18662992;18757403;19103595;19158341;19933846;19946327;20130576;20141835;20179196;20179705;20820846;21102635;21160078;21372320;21615729;21666749;21711248;21779496;22043453;22510884;22592532;23303910;23680146;23993095;24202393;24588013;24937142;24957944;25371820;25435214;25467007;25907612;7542586;7637786;7731718;7970720;8388543;8493579;8530489;8530511;8622888;8752100;8876196;9020159;9038378;9070211;9078261;9234708;9632781;9690470;9739761;9823899;9857065 Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK2 signals through RAS;Activated NTRK3 signals through RAS;Activation of RAS in B cells;CD209 (DC-SIGN) signaling;Constitutive Signaling by EGFRvIII;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;DAP12 signaling;Downstream signal transduction;EGFR Transactivation by Gastrin;Erythropoietin activates RAS;FCERI mediated MAPK activation;FLT3 Signaling;FRS-mediated FGFR1 signaling;FRS-mediated FGFR2 signaling;FRS-mediated FGFR3 signaling;FRS-mediated FGFR4 signaling;GRB2 events in EGFR signaling;GRB2 events in ERBB2 signaling;Insulin receptor signalling cascade;MAP2K and MAPK activation;MET activates RAS signaling;NCAM signaling for neurite out-growth;Paradoxical activation of RAF signaling by kinase inactive BRAF;RAF activation;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;SHC-mediated cascade:FGFR1;SHC-mediated cascade:FGFR2;SHC-mediated cascade:FGFR3;SHC-mediated cascade:FGFR4;SHC-related events triggered by IGF1R;SHC1 events in EGFR signaling;SHC1 events in ERBB2 signaling;SHC1 events in ERBB4 signaling;SOS-mediated signalling;Signaling by FGFR1 in disease;Signaling by FGFR2 in disease;Signaling by FGFR3 fusions in cancer;Signaling by FGFR3 point mutants in cancer;Signaling by FGFR4 in disease;Signaling by RAS mutants;Signaling by SCF-KIT;Signaling by moderate kinase activity BRAF mutants;Signalling to RAS;Tie2 Signaling http://pathwaycommons.org/pc12/Catalysis_4b66558229db0440bcfbace623060ef0;http://pathwaycommons.org/pc12/Complex_99f08589f0e5024718269b930d0288e8;http://pathwaycommons.org/pc12/Complex_1c9f438d1db34b7384fdfa8bb13a2f0d;http://pathwaycommons.org/pc12/Complex_24eebdb420a48d1df31ce470b63917e2;http://pathwaycommons.org/pc12/Catalysis_03b016b44a92d28bd88142c5780253f8;http://pathwaycommons.org/pc12/Catalysis_d1076b99bcec87a38eaa26ff1c4a4070;http://pathwaycommons.org/pc12/Catalysis_fd9991c8fd61be157ed4b2e5be7acef9;http://pathwaycommons.org/pc12/Complex_a9afcce8661dd885cef40e47037a185f;http://pathwaycommons.org/pc12/Complex_411c1b271808c064387f09c3c20b6304;http://pathwaycommons.org/pc12/Complex_07bcf74dbac68a47917e1f7a40acd849;http://pathwaycommons.org/pc12/Complex_3adde65e3e4efaeeb03ad9e8acf79d2a;http://pathwaycommons.org/pc12/Complex_3811ddf05925c006e5b9ba92ef63ffad;http://identifiers.org/reactome/R-HSA-9026891;http://identifiers.org/reactome/R-HSA-5672969;http://pathwaycommons.org/pc12/Catalysis_1c35b9ddce2a70d0629b481931d815c1;http://identifiers.org/reactome/R-HSA-6802941;http://identifiers.org/reactome/R-HSA-6802924;http://pathwaycommons.org/pc12/Complex_d7c23e33867ba9a0550337f60e5447f8;http://pathwaycommons.org/pc12/Complex_a02123277a4a9e4a0fdba06dcb2d40cd;http://pathwaycommons.org/pc12/Catalysis_61ec17c7e9d636a6e70ed622c1d8641f;http://pathwaycommons.org/pc12/Complex_c0cf37acbfc4c8467f39affddaced3ca;http://pathwaycommons.org/pc12/Complex_3fcbd062120dcb929eabeb6cba72d4c3;http://identifiers.org/reactome/R-HSA-6802916 | |
| CHEBI:29108 chemical-affects HSP90AA1 Reactome NA Extra-nuclear estrogen signaling;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;VEGFR2 mediated vascular permeability;eNOS activation http://pathwaycommons.org/pc12/Complex_64975730f966015614d2371ccf3befe5;http://pathwaycommons.org/pc12/Complex_99b641268762438314c57ba32f29bdc2;http://pathwaycommons.org/pc12/Complex_30b628c7535e2437234d3692be1cf89a;http://pathwaycommons.org/pc12/Complex_4f484ee1ad8c540ebbb9cf91e086e240 | |
| CHEBI:29108 chemical-affects HSPG2 Reactome NA Amyloid fiber formation http://pathwaycommons.org/pc12/Complex_e97c128371b30e9ba28e03eb82875fdb | |
| CHEBI:29108 chemical-affects HYAL2 Reactome NA Hyaluronan uptake and degradation http://pathwaycommons.org/pc12/Complex_8eea59cd1481d67d38c5fb297b709834 | |
| CHEBI:29108 chemical-affects ICAM3 Reactome NA CD209 (DC-SIGN) signaling http://pathwaycommons.org/pc12/Complex_b8dea77a28d962a01cf3247d302fe795 | |
| CHEBI:29108 chemical-affects IDS Reactome NA CS/DS degradation;HS-GAG degradation;MPS II - Hunter syndrome http://pathwaycommons.org/pc12/Complex_950aa086f91f2ca427750d6f5cef26ba;http://pathwaycommons.org/pc12/Complex_1966f6496ae1b96c5af3f5b289c3cdee | |
| CHEBI:29108 chemical-affects IGF1 Reactome 11739083;12379487;12466191;17047378;8817670 Regulation of IGF Activity by IGFBP http://pathwaycommons.org/pc12/Catalysis_7481cae835c2e9d26d1f05f8dce63a4d;http://identifiers.org/reactome/R-HSA-381446 | |
| CHEBI:29108 chemical-affects IGF2 Reactome 11739083;12379487;12466191;17047378;8817670 Regulation of IGF Activity by IGFBP http://pathwaycommons.org/pc12/Catalysis_7481cae835c2e9d26d1f05f8dce63a4d;http://identifiers.org/reactome/R-HSA-381446 | |
| CHEBI:29108 chemical-affects IGFALS Reactome 11739083;12379487;12466191;17047378;8817670 Regulation of IGF Activity by IGFBP http://pathwaycommons.org/pc12/Catalysis_7481cae835c2e9d26d1f05f8dce63a4d;http://identifiers.org/reactome/R-HSA-381446 | |
| CHEBI:29108 chemical-affects IGFBP3 Reactome 11739083;12379487;12466191;17047378;8817670 Regulation of IGF Activity by IGFBP http://pathwaycommons.org/pc12/Catalysis_7481cae835c2e9d26d1f05f8dce63a4d;http://identifiers.org/reactome/R-HSA-381446 | |
| CHEBI:29108 chemical-affects IGHG1 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHG2 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHG3 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHG4 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV1-2 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV1-46 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV1-69 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV2-5 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV2-70 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV3-11 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV3-13 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV3-23 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV3-30 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV3-33 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV3-48 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV3-53 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV3-7 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV3-9 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV4-34 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV4-39 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGHV4-59 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKC Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV1-12 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV1-16 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV1-17 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV1-33 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV1-39 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV1-5 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV1D-12 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV1D-16 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV1D-33 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV1D-39 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV2-28 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV2-29 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV2-30 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV2D-28 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV2D-30 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV2D-40 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV3-11 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV3-15 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV3-20 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV3D-20 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV4-1 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGKV5-2 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLC1 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLC2 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLC3 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLC6 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLC7 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLV1-40 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLV1-44 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLV1-47 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLV1-51 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLV2-11 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLV2-14 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLV2-23 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLV2-8 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLV3-19 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLV3-1 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLV3-21 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLV3-25 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLV3-27 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLV6-57 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects IGLV7-43 Reactome 1249422;13726743 Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173626;http://identifiers.org/reactome/R-HSA-977428 | |
| CHEBI:29108 chemical-affects INS Reactome NA Insulin processing;Regulation of insulin secretion http://pathwaycommons.org/pc12/Complex_be25b32a1bd4fbd878333b30fe90d39f;http://pathwaycommons.org/pc12/Complex_2c92ee02933e42d35bf21b708bc4d323;http://pathwaycommons.org/pc12/Complex_db724260205714951a2c16a02325d244;http://pathwaycommons.org/pc12/Complex_596d1b495252f496281d657313701ed0;http://pathwaycommons.org/pc12/Complex_1dce8186358dfe0eb21c816f32b9cd0c;http://pathwaycommons.org/pc12/Complex_d82d60d59c045bec91b20e9667922bf3;http://pathwaycommons.org/pc12/Complex_d682926dc064d08eb57d592f0c98e43d | |
| CHEBI:29108 chemical-affects IQGAP1 Reactome 17244649;21730051;8756646;9199170;9368021 RHO GTPases activate IQGAPs http://pathwaycommons.org/pc12/Complex_361d8d9e10cab53425a1ec16c3df8267;http://identifiers.org/reactome/R-HSA-5626507;http://identifiers.org/reactome/R-HSA-5626550;http://pathwaycommons.org/pc12/Complex_072c82f475ea60d741ff46a81c833d05 | |
| CHEBI:29108 chemical-affects IQGAP2 Reactome 17244649;21730051;8756646;9199170;9368021 RHO GTPases activate IQGAPs http://identifiers.org/reactome/R-HSA-5626507;http://identifiers.org/reactome/R-HSA-5626550;http://pathwaycommons.org/pc12/Complex_072c82f475ea60d741ff46a81c833d05 | |
| CHEBI:29108 chemical-affects IQGAP3 Reactome 17244649;21730051;8756646;9199170;9368021 RHO GTPases activate IQGAPs http://identifiers.org/reactome/R-HSA-5626507;http://identifiers.org/reactome/R-HSA-5626550;http://pathwaycommons.org/pc12/Complex_072c82f475ea60d741ff46a81c833d05 | |
| CHEBI:29108 chemical-affects ITGA1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects ITGA2B Reactome NA GRB2:SOS provides linkage to MAPK signaling for Integrins;Integrin alphaIIb beta3 signaling;p130Cas linkage to MAPK signaling for integrins http://pathwaycommons.org/pc12/Complex_6c5ceab1ba2073e49cb1896a925dc573;http://pathwaycommons.org/pc12/Complex_2357686c4db0ca1c4d0ab9a210130449;http://pathwaycommons.org/pc12/Complex_16978f376c59bd9933e4875566f69baf;http://pathwaycommons.org/pc12/Complex_97a0978414a8036daa7bf22a7d04587e;http://pathwaycommons.org/pc12/Complex_23c4b5044f972d0062e4816c7ae0ad45 | |
| CHEBI:29108 chemical-affects ITGB3 Reactome NA GRB2:SOS provides linkage to MAPK signaling for Integrins;Integrin alphaIIb beta3 signaling;p130Cas linkage to MAPK signaling for integrins http://pathwaycommons.org/pc12/Complex_6c5ceab1ba2073e49cb1896a925dc573;http://pathwaycommons.org/pc12/Complex_2357686c4db0ca1c4d0ab9a210130449;http://pathwaycommons.org/pc12/Complex_16978f376c59bd9933e4875566f69baf;http://pathwaycommons.org/pc12/Complex_97a0978414a8036daa7bf22a7d04587e;http://pathwaycommons.org/pc12/Complex_23c4b5044f972d0062e4816c7ae0ad45 | |
| CHEBI:29108 chemical-affects ITGB5 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects ITLN1 Reactome NA Antimicrobial peptides http://pathwaycommons.org/pc12/Complex_552da31829705605231e7ad87a787cad | |
| CHEBI:29108 chemical-affects ITPKA Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_2292550180462b099e9a0fb9128e0817 | |
| CHEBI:29108 chemical-affects ITPKB Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_c3ffa706c1204a5c4e3904ddcbb8a7f2 | |
| CHEBI:29108 chemical-affects ITPKC Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_100fd7311332739b3a9736a6c042da78 | |
| CHEBI:29108 chemical-affects ITPR1 Reactome NA Effects of PIP2 hydrolysis;Ion homeostasis http://pathwaycommons.org/pc12/Complex_681a292626217c0abccbcb5abe6a588a | |
| CHEBI:29108 chemical-affects ITPR2 Reactome NA Effects of PIP2 hydrolysis;Ion homeostasis http://pathwaycommons.org/pc12/Complex_681a292626217c0abccbcb5abe6a588a | |
| CHEBI:29108 chemical-affects ITPR3 Reactome NA Effects of PIP2 hydrolysis;Ion homeostasis http://pathwaycommons.org/pc12/Complex_681a292626217c0abccbcb5abe6a588a | |
| CHEBI:29108 chemical-affects IVL Reactome 10196183;10510474;10588656;11443109;12210515;2461365;6105840;73346 Formation of the cornified envelope http://pathwaycommons.org/pc12/Catalysis_399933b4d215d5b33201c64821d4b301;http://identifiers.org/reactome/R-HSA-6810894 | |
| CHEBI:29108 chemical-affects KDM7A Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects KIAA1549 Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects KRAS Reactome 10196222;10205168;10373510;10486198;10712905;10722704;10777492;10835426;10934204;11032810;11157491;11221888;11325826;11429702;12147692;12244094;12551923;12639709;1371879;1377053;14622581;15035987;15118125;15284455;1569084;15710605;15899852;16024644;16093354;16129412;16364920;16483568;16508002;16573649;17018604;17052120;17097642;1721591;17227708;17283063;17462920;18294816;18381441;18452557;18662992;18757403;19103595;19158341;19933846;19946327;20130576;20141835;20179196;20179705;20820846;21102635;21160078;21372320;21615729;21666749;21711248;21779496;22043453;22510884;22592532;23303910;23680146;23993095;24202393;24588013;24937142;24957944;25371820;25435214;25467007;25907612;7542586;7637786;7731718;7970720;8388543;8493579;8530489;8530511;8622888;8752100;8876196;9020159;9038378;9070211;9078261;9234708;9632781;9690470;9739761;9823899;9857065 Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK2 signals through RAS;Activated NTRK3 signals through RAS;Activation of RAS in B cells;CD209 (DC-SIGN) signaling;Constitutive Signaling by EGFRvIII;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;DAP12 signaling;Downstream signal transduction;EGFR Transactivation by Gastrin;Erythropoietin activates RAS;FCERI mediated MAPK activation;FLT3 Signaling;FRS-mediated FGFR1 signaling;FRS-mediated FGFR2 signaling;FRS-mediated FGFR3 signaling;FRS-mediated FGFR4 signaling;GRB2 events in EGFR signaling;GRB2 events in ERBB2 signaling;Insulin receptor signalling cascade;MAP2K and MAPK activation;MET activates RAS signaling;NCAM signaling for neurite out-growth;Paradoxical activation of RAF signaling by kinase inactive BRAF;RAF activation;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;SHC-mediated cascade:FGFR1;SHC-mediated cascade:FGFR2;SHC-mediated cascade:FGFR3;SHC-mediated cascade:FGFR4;SHC-related events triggered by IGF1R;SHC1 events in EGFR signaling;SHC1 events in ERBB2 signaling;SHC1 events in ERBB4 signaling;SOS-mediated signalling;Signaling by FGFR1 in disease;Signaling by FGFR2 in disease;Signaling by FGFR3 fusions in cancer;Signaling by FGFR3 point mutants in cancer;Signaling by FGFR4 in disease;Signaling by RAS mutants;Signaling by SCF-KIT;Signaling by moderate kinase activity BRAF mutants;Signalling to RAS;Tie2 Signaling http://pathwaycommons.org/pc12/Catalysis_4b66558229db0440bcfbace623060ef0;http://pathwaycommons.org/pc12/Complex_99f08589f0e5024718269b930d0288e8;http://pathwaycommons.org/pc12/Complex_1c9f438d1db34b7384fdfa8bb13a2f0d;http://pathwaycommons.org/pc12/Complex_24eebdb420a48d1df31ce470b63917e2;http://pathwaycommons.org/pc12/Catalysis_03b016b44a92d28bd88142c5780253f8;http://pathwaycommons.org/pc12/Catalysis_d1076b99bcec87a38eaa26ff1c4a4070;http://pathwaycommons.org/pc12/Catalysis_fd9991c8fd61be157ed4b2e5be7acef9;http://pathwaycommons.org/pc12/Complex_a9afcce8661dd885cef40e47037a185f;http://pathwaycommons.org/pc12/Complex_411c1b271808c064387f09c3c20b6304;http://pathwaycommons.org/pc12/Complex_07bcf74dbac68a47917e1f7a40acd849;http://pathwaycommons.org/pc12/Complex_3adde65e3e4efaeeb03ad9e8acf79d2a;http://pathwaycommons.org/pc12/Complex_3811ddf05925c006e5b9ba92ef63ffad;http://identifiers.org/reactome/R-HSA-9026891;http://identifiers.org/reactome/R-HSA-5672969;http://pathwaycommons.org/pc12/Catalysis_1c35b9ddce2a70d0629b481931d815c1;http://identifiers.org/reactome/R-HSA-6802941;http://identifiers.org/reactome/R-HSA-6802924;http://pathwaycommons.org/pc12/Complex_d7c23e33867ba9a0550337f60e5447f8;http://pathwaycommons.org/pc12/Complex_a02123277a4a9e4a0fdba06dcb2d40cd;http://pathwaycommons.org/pc12/Catalysis_61ec17c7e9d636a6e70ed622c1d8641f;http://pathwaycommons.org/pc12/Complex_c0cf37acbfc4c8467f39affddaced3ca;http://pathwaycommons.org/pc12/Complex_3fcbd062120dcb929eabeb6cba72d4c3;http://identifiers.org/reactome/R-HSA-6802916 | |
| CHEBI:29108 chemical-affects KSR1 Reactome 10205168;10712905;11032810;12244094;12551923;15710605;15899852;16093354;17097642;18294816;18662992;19158341;20820846;21779496;22592532;23993095;7542586;8876196;9020159;9234708;9823899 MAP2K and MAPK activation;RAF activation http://pathwaycommons.org/pc12/Complex_1c9f438d1db34b7384fdfa8bb13a2f0d;http://identifiers.org/reactome/R-HSA-5672969;http://pathwaycommons.org/pc12/Catalysis_1c35b9ddce2a70d0629b481931d815c1;http://pathwaycommons.org/pc12/Complex_d7c23e33867ba9a0550337f60e5447f8;http://pathwaycommons.org/pc12/Complex_c0cf37acbfc4c8467f39affddaced3ca | |
| CHEBI:29108 chemical-affects LEMD2 Reactome 22986494;8034666;8463284 Depolymerisation of the Nuclear Lamina http://identifiers.org/reactome/R-HSA-5229194;http://pathwaycommons.org/pc12/Catalysis_ca4c2b90ced928f3342033ba2ded919f | |
| CHEBI:29108 chemical-affects LEMD3 Reactome 22986494;8034666;8463284 Depolymerisation of the Nuclear Lamina http://identifiers.org/reactome/R-HSA-5229194;http://pathwaycommons.org/pc12/Catalysis_ca4c2b90ced928f3342033ba2ded919f | |
| CHEBI:29108 chemical-affects LMNA Reactome 15630448;18974108;20526349;21424530;22745804;22986494;23583981;24135138;24345920;25204415;25907612;8034666;8463284 Depolymerisation of the Nuclear Lamina;Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://identifiers.org/reactome/R-HSA-5229194;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://pathwaycommons.org/pc12/Catalysis_ca4c2b90ced928f3342033ba2ded919f;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects LMNB1 Reactome 22986494;8034666;8463284 Depolymerisation of the Nuclear Lamina http://identifiers.org/reactome/R-HSA-5229194;http://pathwaycommons.org/pc12/Catalysis_ca4c2b90ced928f3342033ba2ded919f | |
| CHEBI:29108 chemical-affects LMOD1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects LRRC7 Reactome NA Long-term potentiation;Negative regulation of NMDA receptor-mediated neuronal transmission;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Complex_b26a71b84e441dbc672615cce19cf62e;http://pathwaycommons.org/pc12/Complex_e242f1b69c19f98d5f989fff7d0c1117;http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded | |
| CHEBI:29108 chemical-affects LTC4S Reactome NA Synthesis of Leukotrienes (LT) and Eoxins (EX);Synthesis of Lipoxins (LX) http://pathwaycommons.org/pc12/Complex_d5cea0c1d341c16f938c056854bc30d1 | |
| CHEBI:29108 chemical-affects LY96 Reactome NA Regulation of TLR by endogenous ligand http://pathwaycommons.org/pc12/Complex_cbf9dbc1cdb229be5ed7a1dfd7f8796b | |
| CHEBI:29108 chemical-affects LYVE1 Reactome NA Hyaluronan uptake and degradation http://pathwaycommons.org/pc12/Complex_8eea59cd1481d67d38c5fb297b709834 | |
| CHEBI:29108 chemical-affects MAP2K1 Reactome NA MAP2K and MAPK activation;Paradoxical activation of RAF signaling by kinase inactive BRAF;Signaling by BRAF and RAF fusions;Signaling by RAS mutants;Signaling by high-kinase activity BRAF mutants;Signaling by moderate kinase activity BRAF mutants http://pathwaycommons.org/pc12/Complex_99f08589f0e5024718269b930d0288e8;http://pathwaycommons.org/pc12/Complex_1c9f438d1db34b7384fdfa8bb13a2f0d;http://pathwaycommons.org/pc12/Complex_24eebdb420a48d1df31ce470b63917e2;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://pathwaycommons.org/pc12/Complex_a9afcce8661dd885cef40e47037a185f;http://pathwaycommons.org/pc12/Complex_411c1b271808c064387f09c3c20b6304;http://pathwaycommons.org/pc12/Complex_2d6078881f15d454db237f3d3dfd388e;http://pathwaycommons.org/pc12/Complex_07bcf74dbac68a47917e1f7a40acd849;http://pathwaycommons.org/pc12/Complex_3adde65e3e4efaeeb03ad9e8acf79d2a;http://pathwaycommons.org/pc12/Complex_3811ddf05925c006e5b9ba92ef63ffad;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_d7c23e33867ba9a0550337f60e5447f8;http://pathwaycommons.org/pc12/Complex_a02123277a4a9e4a0fdba06dcb2d40cd;http://pathwaycommons.org/pc12/Complex_f388bb088eaf2764bccb3723e9dec7a4;http://pathwaycommons.org/pc12/Complex_c0cf37acbfc4c8467f39affddaced3ca;http://pathwaycommons.org/pc12/Complex_3fcbd062120dcb929eabeb6cba72d4c3;http://pathwaycommons.org/pc12/Complex_c735504e9aa67a7c9cd901858ccebf74 | |
| CHEBI:29108 chemical-affects MAP2K2 Reactome NA MAP2K and MAPK activation;Paradoxical activation of RAF signaling by kinase inactive BRAF;Signaling by BRAF and RAF fusions;Signaling by RAS mutants;Signaling by high-kinase activity BRAF mutants;Signaling by moderate kinase activity BRAF mutants http://pathwaycommons.org/pc12/Complex_99f08589f0e5024718269b930d0288e8;http://pathwaycommons.org/pc12/Complex_1c9f438d1db34b7384fdfa8bb13a2f0d;http://pathwaycommons.org/pc12/Complex_24eebdb420a48d1df31ce470b63917e2;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://pathwaycommons.org/pc12/Complex_a9afcce8661dd885cef40e47037a185f;http://pathwaycommons.org/pc12/Complex_411c1b271808c064387f09c3c20b6304;http://pathwaycommons.org/pc12/Complex_2d6078881f15d454db237f3d3dfd388e;http://pathwaycommons.org/pc12/Complex_07bcf74dbac68a47917e1f7a40acd849;http://pathwaycommons.org/pc12/Complex_3adde65e3e4efaeeb03ad9e8acf79d2a;http://pathwaycommons.org/pc12/Complex_3811ddf05925c006e5b9ba92ef63ffad;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_d7c23e33867ba9a0550337f60e5447f8;http://pathwaycommons.org/pc12/Complex_a02123277a4a9e4a0fdba06dcb2d40cd;http://pathwaycommons.org/pc12/Complex_f388bb088eaf2764bccb3723e9dec7a4;http://pathwaycommons.org/pc12/Complex_c0cf37acbfc4c8467f39affddaced3ca;http://pathwaycommons.org/pc12/Complex_3fcbd062120dcb929eabeb6cba72d4c3;http://pathwaycommons.org/pc12/Complex_c735504e9aa67a7c9cd901858ccebf74 | |
| CHEBI:29108 chemical-affects MAPK1 Reactome NA MAP2K and MAPK activation;Paradoxical activation of RAF signaling by kinase inactive BRAF;Signaling by BRAF and RAF fusions;Signaling by RAS mutants;Signaling by high-kinase activity BRAF mutants;Signaling by moderate kinase activity BRAF mutants http://pathwaycommons.org/pc12/Complex_99f08589f0e5024718269b930d0288e8;http://pathwaycommons.org/pc12/Complex_1c9f438d1db34b7384fdfa8bb13a2f0d;http://pathwaycommons.org/pc12/Complex_24eebdb420a48d1df31ce470b63917e2;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://pathwaycommons.org/pc12/Complex_a9afcce8661dd885cef40e47037a185f;http://pathwaycommons.org/pc12/Complex_411c1b271808c064387f09c3c20b6304;http://pathwaycommons.org/pc12/Complex_2d6078881f15d454db237f3d3dfd388e;http://pathwaycommons.org/pc12/Complex_07bcf74dbac68a47917e1f7a40acd849;http://pathwaycommons.org/pc12/Complex_3adde65e3e4efaeeb03ad9e8acf79d2a;http://pathwaycommons.org/pc12/Complex_3811ddf05925c006e5b9ba92ef63ffad;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_d7c23e33867ba9a0550337f60e5447f8;http://pathwaycommons.org/pc12/Complex_a02123277a4a9e4a0fdba06dcb2d40cd;http://pathwaycommons.org/pc12/Complex_f388bb088eaf2764bccb3723e9dec7a4;http://pathwaycommons.org/pc12/Complex_c0cf37acbfc4c8467f39affddaced3ca;http://pathwaycommons.org/pc12/Complex_3fcbd062120dcb929eabeb6cba72d4c3;http://pathwaycommons.org/pc12/Complex_c735504e9aa67a7c9cd901858ccebf74 | |
| CHEBI:29108 chemical-affects MAPK3 Reactome NA MAP2K and MAPK activation;Paradoxical activation of RAF signaling by kinase inactive BRAF;Signaling by BRAF and RAF fusions;Signaling by RAS mutants;Signaling by high-kinase activity BRAF mutants;Signaling by moderate kinase activity BRAF mutants http://pathwaycommons.org/pc12/Complex_99f08589f0e5024718269b930d0288e8;http://pathwaycommons.org/pc12/Complex_1c9f438d1db34b7384fdfa8bb13a2f0d;http://pathwaycommons.org/pc12/Complex_24eebdb420a48d1df31ce470b63917e2;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://pathwaycommons.org/pc12/Complex_a9afcce8661dd885cef40e47037a185f;http://pathwaycommons.org/pc12/Complex_411c1b271808c064387f09c3c20b6304;http://pathwaycommons.org/pc12/Complex_2d6078881f15d454db237f3d3dfd388e;http://pathwaycommons.org/pc12/Complex_07bcf74dbac68a47917e1f7a40acd849;http://pathwaycommons.org/pc12/Complex_3adde65e3e4efaeeb03ad9e8acf79d2a;http://pathwaycommons.org/pc12/Complex_3811ddf05925c006e5b9ba92ef63ffad;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_d7c23e33867ba9a0550337f60e5447f8;http://pathwaycommons.org/pc12/Complex_a02123277a4a9e4a0fdba06dcb2d40cd;http://pathwaycommons.org/pc12/Complex_f388bb088eaf2764bccb3723e9dec7a4;http://pathwaycommons.org/pc12/Complex_c0cf37acbfc4c8467f39affddaced3ca;http://pathwaycommons.org/pc12/Complex_3fcbd062120dcb929eabeb6cba72d4c3;http://pathwaycommons.org/pc12/Complex_c735504e9aa67a7c9cd901858ccebf74 | |
| CHEBI:29108 chemical-affects MARK3 Reactome 10205168;10712905;11032810;12244094;12551923;15710605;15899852;16093354;17097642;18294816;18662992;19158341;20820846;21779496;22592532;23993095;7542586;8876196;9020159;9234708;9823899 MAP2K and MAPK activation;RAF activation http://pathwaycommons.org/pc12/Complex_1c9f438d1db34b7384fdfa8bb13a2f0d;http://identifiers.org/reactome/R-HSA-5672969;http://pathwaycommons.org/pc12/Catalysis_1c35b9ddce2a70d0629b481931d815c1;http://pathwaycommons.org/pc12/Complex_d7c23e33867ba9a0550337f60e5447f8;http://pathwaycommons.org/pc12/Complex_c0cf37acbfc4c8467f39affddaced3ca | |
| CHEBI:29108 chemical-affects MASP1 Reactome NA Ficolins bind to repetitive carbohydrate structures on the target cell surface;Initial triggering of complement;Lectin pathway of complement activation http://pathwaycommons.org/pc12/Complex_a19d0177c7b82f06623c1318fa02e849;http://pathwaycommons.org/pc12/Complex_0535b20b4135059369e6cea973bfc438;http://pathwaycommons.org/pc12/Complex_07acdde53acc3374a9d3a4bb60f38e88;http://pathwaycommons.org/pc12/Complex_f49bccba957b1f60bfaa3625ad75e13a;http://pathwaycommons.org/pc12/Complex_75f1d4ad71e597ba131f2cc933b4a873;http://pathwaycommons.org/pc12/Complex_4075b212518e0d6e340c34d657e91569;http://pathwaycommons.org/pc12/Complex_102ab27a07d3738319f82f077aa293a3;http://pathwaycommons.org/pc12/Complex_60aef73cc10ff434b099e40b3937422c;http://pathwaycommons.org/pc12/Complex_b153606fd324ba303ef4b4a540c8d44d | |
| CHEBI:29108 chemical-affects MASP2 Reactome NA Ficolins bind to repetitive carbohydrate structures on the target cell surface;Initial triggering of complement;Lectin pathway of complement activation http://pathwaycommons.org/pc12/Complex_a19d0177c7b82f06623c1318fa02e849;http://pathwaycommons.org/pc12/Complex_0535b20b4135059369e6cea973bfc438;http://pathwaycommons.org/pc12/Complex_07acdde53acc3374a9d3a4bb60f38e88;http://pathwaycommons.org/pc12/Complex_f49bccba957b1f60bfaa3625ad75e13a;http://pathwaycommons.org/pc12/Complex_75f1d4ad71e597ba131f2cc933b4a873;http://pathwaycommons.org/pc12/Complex_4075b212518e0d6e340c34d657e91569;http://pathwaycommons.org/pc12/Complex_102ab27a07d3738319f82f077aa293a3;http://pathwaycommons.org/pc12/Complex_60aef73cc10ff434b099e40b3937422c;http://pathwaycommons.org/pc12/Complex_b153606fd324ba303ef4b4a540c8d44d | |
| CHEBI:29108 chemical-affects MBL2 Reactome NA Initial triggering of complement;Lectin pathway of complement activation http://pathwaycommons.org/pc12/Complex_0535b20b4135059369e6cea973bfc438;http://pathwaycommons.org/pc12/Complex_4075b212518e0d6e340c34d657e91569 | |
| CHEBI:29108 chemical-affects MECP2 Reactome 17046689;19225110;21240272;21925568;22262897;23770565;23770587;25420914 Loss of phosphorylation of MECP2 at T308;Regulation of MECP2 expression and activity http://pathwaycommons.org/pc12/Control_a1ba3478207416f47b4b6c44bd7eb6e4;http://identifiers.org/reactome/R-HSA-8986939;http://pathwaycommons.org/pc12/Catalysis_3a141876cf6cf2e1ef43273afffa45c2;http://identifiers.org/reactome/R-HSA-8986937;http://identifiers.org/reactome/R-HSA-9005561;http://identifiers.org/reactome/R-HSA-9006992;http://pathwaycommons.org/pc12/Catalysis_ae7f7c7d0fbebe8424873a4d613e692b;http://pathwaycommons.org/pc12/Catalysis_a64c41c3ee42f01fdda15d3007e6c2e4 | |
| CHEBI:29108 chemical-affects MEN1 Reactome NA RHO GTPases activate IQGAPs http://pathwaycommons.org/pc12/Complex_361d8d9e10cab53425a1ec16c3df8267 | |
| CHEBI:29108 chemical-affects MPRIP Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects MYBPC1 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects MYBPC2 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects MYBPC3 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects MYH10 Reactome 12185584;12778124;12802051;17151359;2966156;3079756;3839510;8702756;9619630 EPHA-mediated growth cone collapse;RHO GTPases Activate ROCKs;RHO GTPases activate CIT;RHO GTPases activate PAKs;Sema4D induced cell migration and growth-cone collapse http://identifiers.org/reactome/R-HSA-3928616;http://pathwaycommons.org/pc12/Catalysis_e341f6b1d3ddda5a083ba77429ee0760 | |
| CHEBI:29108 chemical-affects MYH11 Reactome 12185584;12778124;12802051;17151359;2966156;3079756;3839510;8702756;9619630 EPHA-mediated growth cone collapse;RHO GTPases Activate ROCKs;RHO GTPases activate CIT;RHO GTPases activate PAKs;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-3928616;http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Catalysis_e341f6b1d3ddda5a083ba77429ee0760;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects MYH14 Reactome 12185584;12778124;12802051;17151359;2966156;3079756;3839510;8702756;9619630 EPHA-mediated growth cone collapse;RHO GTPases Activate ROCKs;RHO GTPases activate CIT;RHO GTPases activate PAKs;Sema4D induced cell migration and growth-cone collapse http://identifiers.org/reactome/R-HSA-3928616;http://pathwaycommons.org/pc12/Catalysis_e341f6b1d3ddda5a083ba77429ee0760 | |
| CHEBI:29108 chemical-affects MYH3 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects MYH6 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects MYH8 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects MYH9 Reactome 12185584;12778124;12802051;17151359;2966156;3079756;3839510;8702756;9619630 EPHA-mediated growth cone collapse;RHO GTPases Activate ROCKs;RHO GTPases activate CIT;RHO GTPases activate PAKs;Sema4D induced cell migration and growth-cone collapse http://identifiers.org/reactome/R-HSA-3928616;http://pathwaycommons.org/pc12/Catalysis_e341f6b1d3ddda5a083ba77429ee0760 | |
| CHEBI:29108 chemical-affects MYL10 Reactome 2526655;2764880;3780718 Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-9034487;http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://identifiers.org/reactome/R-HSA-445813;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Catalysis_c57ed00228d3424283730adeda4ec26e;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects MYL12A Reactome 2526655;2764880;3780718 Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-9034487;http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://identifiers.org/reactome/R-HSA-445813;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Catalysis_c57ed00228d3424283730adeda4ec26e;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects MYL12B Reactome 12185584;12778124;12802051;17151359;2526655;2764880;2966156;3079756;3780718;3839510;8702756;9619630 EPHA-mediated growth cone collapse;RHO GTPases Activate ROCKs;RHO GTPases activate CIT;RHO GTPases activate PAKs;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-9034487;http://identifiers.org/reactome/R-HSA-3928616;http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://identifiers.org/reactome/R-HSA-445813;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Catalysis_c57ed00228d3424283730adeda4ec26e;http://pathwaycommons.org/pc12/Catalysis_e341f6b1d3ddda5a083ba77429ee0760;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects MYL1 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects MYL2 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects MYL3 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects MYL4 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects MYL5 Reactome 2526655;2764880;3780718 Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-9034487;http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://identifiers.org/reactome/R-HSA-445813;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Catalysis_c57ed00228d3424283730adeda4ec26e;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects MYL6B Reactome 2526655;2764880;3780718 Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-9034487;http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://identifiers.org/reactome/R-HSA-445813;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Catalysis_c57ed00228d3424283730adeda4ec26e;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects MYL6 Reactome 12185584;12778124;12802051;17151359;2526655;2764880;2966156;3079756;3780718;3839510;8702756;9619630 EPHA-mediated growth cone collapse;RHO GTPases Activate ROCKs;RHO GTPases activate CIT;RHO GTPases activate PAKs;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-9034487;http://identifiers.org/reactome/R-HSA-3928616;http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://identifiers.org/reactome/R-HSA-445813;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Catalysis_c57ed00228d3424283730adeda4ec26e;http://pathwaycommons.org/pc12/Catalysis_e341f6b1d3ddda5a083ba77429ee0760;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects MYL7 Reactome 2526655;2764880;3780718 Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-9034487;http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://identifiers.org/reactome/R-HSA-445813;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Catalysis_c57ed00228d3424283730adeda4ec26e;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects MYL9 Reactome 12185584;12778124;12802051;17151359;2526655;2764880;2966156;3079756;3780718;3839510;8702756;9619630 EPHA-mediated growth cone collapse;RHO GTPases Activate ROCKs;RHO GTPases activate CIT;RHO GTPases activate PAKs;Sema4D induced cell migration and growth-cone collapse;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-9034487;http://identifiers.org/reactome/R-HSA-3928616;http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://identifiers.org/reactome/R-HSA-445813;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Catalysis_c57ed00228d3424283730adeda4ec26e;http://pathwaycommons.org/pc12/Catalysis_e341f6b1d3ddda5a083ba77429ee0760;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects MYLK Reactome NA RHO GTPases activate PAKs;Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_097f301bcac340ecce91c2dd3ae4dedb | |
| CHEBI:29108 chemical-affects MYLPF Reactome 2526655;2764880;3780718 Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-9034487;http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://identifiers.org/reactome/R-HSA-445813;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Catalysis_c57ed00228d3424283730adeda4ec26e;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects MYO1C Reactome NA Translocation of SLC2A4 (GLUT4) to the plasma membrane http://identifiers.org/reactome/R-HSA-5358685;http://identifiers.org/reactome/R-HSA-2316352 | |
| CHEBI:29108 chemical-affects NCF1 Reactome NA RHO GTPases Activate NADPH Oxidases http://pathwaycommons.org/pc12/Complex_940658ed0ee8c537e938ffbb68d0ab84 | |
| CHEBI:29108 chemical-affects NCF2 Reactome NA RHO GTPases Activate NADPH Oxidases http://pathwaycommons.org/pc12/Complex_940658ed0ee8c537e938ffbb68d0ab84 | |
| CHEBI:29108 chemical-affects NCF4 Reactome NA RHO GTPases Activate NADPH Oxidases http://pathwaycommons.org/pc12/Complex_940658ed0ee8c537e938ffbb68d0ab84 | |
| CHEBI:29108 chemical-affects NCOR1 Reactome 21240272;21925568;23770565;23770587 Regulation of MECP2 expression and activity http://pathwaycommons.org/pc12/Control_a1ba3478207416f47b4b6c44bd7eb6e4;http://identifiers.org/reactome/R-HSA-8986939 | |
| CHEBI:29108 chemical-affects NCOR2 Reactome 21240272;21925568;23770565;23770587 Regulation of MECP2 expression and activity http://pathwaycommons.org/pc12/Control_a1ba3478207416f47b4b6c44bd7eb6e4;http://identifiers.org/reactome/R-HSA-8986939 | |
| CHEBI:29108 chemical-affects NEB Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_1a2dfeb8092eea766c7560c066c83a46 | |
| CHEBI:29108 chemical-affects NEFL Reactome NA Long-term potentiation;Negative regulation of NMDA receptor-mediated neuronal transmission;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Complex_b26a71b84e441dbc672615cce19cf62e;http://pathwaycommons.org/pc12/Complex_e242f1b69c19f98d5f989fff7d0c1117;http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded | |
| CHEBI:29108 chemical-affects NFATC1 Reactome NA CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization http://pathwaycommons.org/pc12/Complex_c28057caaf581cdb79d4181eb1627775;http://pathwaycommons.org/pc12/Complex_6a134a0acb944a62b05df67f5a6add8e;http://pathwaycommons.org/pc12/Complex_267318ad03c8f5ac4e0d5c3eb5710f56;http://pathwaycommons.org/pc12/Complex_9f918fc514c58b15c3146a474f8b1403;http://pathwaycommons.org/pc12/Complex_c48da25f9f8fbe784e88bfbafed639ea | |
| CHEBI:29108 chemical-affects NFATC2 Reactome NA CLEC7A (Dectin-1) induces NFAT activation;Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization http://pathwaycommons.org/pc12/Complex_6a134a0acb944a62b05df67f5a6add8e;http://pathwaycommons.org/pc12/Complex_9f918fc514c58b15c3146a474f8b1403;http://pathwaycommons.org/pc12/Complex_c48da25f9f8fbe784e88bfbafed639ea | |
| CHEBI:29108 chemical-affects NFATC3 Reactome NA CLEC7A (Dectin-1) induces NFAT activation;Calcineurin activates NFAT;FCERI mediated Ca+2 mobilization http://pathwaycommons.org/pc12/Complex_6a134a0acb944a62b05df67f5a6add8e;http://pathwaycommons.org/pc12/Complex_9f918fc514c58b15c3146a474f8b1403;http://pathwaycommons.org/pc12/Complex_c48da25f9f8fbe784e88bfbafed639ea | |
| CHEBI:29108 chemical-affects NGF Reactome 16025106;18204444;8615794 NGF processing http://identifiers.org/reactome/R-HSA-187020;http://pathwaycommons.org/pc12/Catalysis_e9f7167590e735a38e93a4b9a06b33c5 | |
| CHEBI:29108 chemical-affects NOS3 Reactome NA Extra-nuclear estrogen signaling;Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation;VEGFR2 mediated vascular permeability;eNOS activation http://pathwaycommons.org/pc12/Complex_64975730f966015614d2371ccf3befe5;http://pathwaycommons.org/pc12/Complex_99b641268762438314c57ba32f29bdc2;http://pathwaycommons.org/pc12/Complex_30b628c7535e2437234d3692be1cf89a;http://pathwaycommons.org/pc12/Complex_1646611a468b89f143cf0939f70ffe3a;http://pathwaycommons.org/pc12/Complex_4f484ee1ad8c540ebbb9cf91e086e240 | |
| CHEBI:29108 chemical-affects NRAS Reactome 10196222;10205168;10373510;10486198;10712905;10722704;10777492;10835426;10934204;11032810;11157491;11221888;11325826;11429702;12147692;12244094;12551923;12639709;1371879;1377053;14622581;15035987;15118125;15284455;1569084;15710605;15899852;16024644;16093354;16129412;16364920;16483568;16508002;16573649;17018604;17052120;17097642;1721591;17227708;17283063;17462920;18294816;18381441;18452557;18662992;18757403;19103595;19158341;19933846;19946327;20130576;20141835;20179196;20179705;20820846;21102635;21160078;21372320;21615729;21666749;21711248;21779496;22043453;22510884;22592532;23303910;23680146;23993095;24202393;24588013;24937142;24957944;25371820;25435214;25467007;25907612;7542586;7637786;7731718;7970720;8388543;8493579;8530489;8530511;8622888;8752100;8876196;9020159;9038378;9070211;9078261;9234708;9632781;9690470;9739761;9823899;9857065 Activated NTRK2 signals through FRS2 and FRS3;Activated NTRK2 signals through RAS;Activated NTRK3 signals through RAS;Activation of RAS in B cells;CD209 (DC-SIGN) signaling;Constitutive Signaling by EGFRvIII;Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants;DAP12 signaling;Downstream signal transduction;EGFR Transactivation by Gastrin;Erythropoietin activates RAS;FCERI mediated MAPK activation;FLT3 Signaling;FRS-mediated FGFR1 signaling;FRS-mediated FGFR2 signaling;FRS-mediated FGFR3 signaling;FRS-mediated FGFR4 signaling;GRB2 events in EGFR signaling;GRB2 events in ERBB2 signaling;Insulin receptor signalling cascade;MAP2K and MAPK activation;MET activates RAS signaling;NCAM signaling for neurite out-growth;Paradoxical activation of RAF signaling by kinase inactive BRAF;RAF activation;RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor;SHC-mediated cascade:FGFR1;SHC-mediated cascade:FGFR2;SHC-mediated cascade:FGFR3;SHC-mediated cascade:FGFR4;SHC-related events triggered by IGF1R;SHC1 events in EGFR signaling;SHC1 events in ERBB2 signaling;SHC1 events in ERBB4 signaling;SOS-mediated signalling;Signaling by FGFR1 in disease;Signaling by FGFR2 in disease;Signaling by FGFR3 fusions in cancer;Signaling by FGFR3 point mutants in cancer;Signaling by FGFR4 in disease;Signaling by RAS mutants;Signaling by SCF-KIT;Signaling by moderate kinase activity BRAF mutants;Signalling to RAS;Tie2 Signaling http://pathwaycommons.org/pc12/Catalysis_4b66558229db0440bcfbace623060ef0;http://pathwaycommons.org/pc12/Complex_99f08589f0e5024718269b930d0288e8;http://pathwaycommons.org/pc12/Complex_1c9f438d1db34b7384fdfa8bb13a2f0d;http://pathwaycommons.org/pc12/Complex_24eebdb420a48d1df31ce470b63917e2;http://pathwaycommons.org/pc12/Catalysis_03b016b44a92d28bd88142c5780253f8;http://pathwaycommons.org/pc12/Catalysis_d1076b99bcec87a38eaa26ff1c4a4070;http://pathwaycommons.org/pc12/Catalysis_fd9991c8fd61be157ed4b2e5be7acef9;http://pathwaycommons.org/pc12/Complex_a9afcce8661dd885cef40e47037a185f;http://pathwaycommons.org/pc12/Complex_411c1b271808c064387f09c3c20b6304;http://pathwaycommons.org/pc12/Complex_07bcf74dbac68a47917e1f7a40acd849;http://pathwaycommons.org/pc12/Complex_3adde65e3e4efaeeb03ad9e8acf79d2a;http://pathwaycommons.org/pc12/Complex_3811ddf05925c006e5b9ba92ef63ffad;http://identifiers.org/reactome/R-HSA-9026891;http://identifiers.org/reactome/R-HSA-5672969;http://pathwaycommons.org/pc12/Catalysis_1c35b9ddce2a70d0629b481931d815c1;http://identifiers.org/reactome/R-HSA-6802941;http://identifiers.org/reactome/R-HSA-6802924;http://pathwaycommons.org/pc12/Complex_d7c23e33867ba9a0550337f60e5447f8;http://pathwaycommons.org/pc12/Complex_a02123277a4a9e4a0fdba06dcb2d40cd;http://pathwaycommons.org/pc12/Catalysis_61ec17c7e9d636a6e70ed622c1d8641f;http://pathwaycommons.org/pc12/Complex_c0cf37acbfc4c8467f39affddaced3ca;http://pathwaycommons.org/pc12/Complex_3fcbd062120dcb929eabeb6cba72d4c3;http://identifiers.org/reactome/R-HSA-6802916 | |
| CHEBI:29108 chemical-affects PADI1 Reactome NA Chromatin modifying enzymes http://pathwaycommons.org/pc12/Complex_3457d347077af68a8f72e5cf3d6f504a | |
| CHEBI:29108 chemical-affects PADI2 Reactome NA Chromatin modifying enzymes http://pathwaycommons.org/pc12/Complex_3457d347077af68a8f72e5cf3d6f504a | |
| CHEBI:29108 chemical-affects PADI3 Reactome NA Chromatin modifying enzymes http://pathwaycommons.org/pc12/Complex_3457d347077af68a8f72e5cf3d6f504a | |
| CHEBI:29108 chemical-affects PADI4 Reactome NA Chromatin modifying enzymes http://pathwaycommons.org/pc12/Complex_3457d347077af68a8f72e5cf3d6f504a | |
| CHEBI:29108 chemical-affects PADI6 Reactome NA Chromatin modifying enzymes http://pathwaycommons.org/pc12/Complex_3457d347077af68a8f72e5cf3d6f504a | |
| CHEBI:29108 chemical-affects PAPSS1 Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects PCSK1 Reactome NA Insulin processing;Peptide hormone biosynthesis;Synthesis, secretion, and deacylation of Ghrelin;Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1);Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) http://pathwaycommons.org/pc12/Complex_4daa46ff5a6b07a441aaa2f2422c5b0a | |
| CHEBI:29108 chemical-affects PCSK5 Reactome NA NGF processing http://pathwaycommons.org/pc12/Complex_47fac0b57b8d4e45ce6b746ac2fc00fe | |
| CHEBI:29108 chemical-affects PCSK6 Reactome NA NGF processing http://pathwaycommons.org/pc12/Complex_47fac0b57b8d4e45ce6b746ac2fc00fe | |
| CHEBI:29108 chemical-affects PDE1A Reactome 15272012;18335582 Cam-PDE 1 activation http://identifiers.org/reactome/R-HSA-1489501;http://identifiers.org/reactome/R-HSA-111956 | |
| CHEBI:29108 chemical-affects PDE1B Reactome 15272012;18335582 Cam-PDE 1 activation http://identifiers.org/reactome/R-HSA-1489501;http://identifiers.org/reactome/R-HSA-111956 | |
| CHEBI:29108 chemical-affects PDE1C Reactome 15272012;18335582 Cam-PDE 1 activation http://identifiers.org/reactome/R-HSA-1489501;http://identifiers.org/reactome/R-HSA-111956 | |
| CHEBI:29108 chemical-affects PICK1 Reactome 16055064 Trafficking of GluR2-containing AMPA receptors http://pathwaycommons.org/pc12/Catalysis_8e4f2b41a642b052ea0a9c9077258fa2;http://pathwaycommons.org/pc12/Catalysis_159940d16c72d644b5774ca1a71f1722;http://identifiers.org/reactome/R-HSA-421007;http://identifiers.org/reactome/R-HSA-416639 | |
| CHEBI:29108 chemical-affects PIK3C2A Reactome NA Synthesis of PIPs at the Golgi membrane;Synthesis of PIPs at the early endosome membrane;Synthesis of PIPs at the late endosome membrane;Synthesis of PIPs at the plasma membrane http://pathwaycommons.org/pc12/Complex_c5e28b90b459724bc09d0340ab13bb47 | |
| CHEBI:29108 chemical-affects PIK3C2B Reactome NA Synthesis of PIPs at the plasma membrane http://pathwaycommons.org/pc12/Complex_138d455c530c84f21e8cf9d6ecc2599e | |
| CHEBI:29108 chemical-affects PLA2G10 Reactome NA Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PG;Acyl chain remodelling of PI;Acyl chain remodelling of PS;Synthesis of PA http://pathwaycommons.org/pc12/Complex_2d2845ea3dea2003429b6af7c95e25a0 | |
| CHEBI:29108 chemical-affects PLA2G12A Reactome NA Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PG;Acyl chain remodelling of PI;Acyl chain remodelling of PS;Synthesis of PA http://pathwaycommons.org/pc12/Complex_bce585b3f33e757db11646a32531e929 | |
| CHEBI:29108 chemical-affects PLA2G1B Reactome NA Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PG;Acyl chain remodelling of PI;Acyl chain remodelling of PS;Synthesis of PA http://pathwaycommons.org/pc12/Complex_1101a2b96be708d28f10b30b212365fb | |
| CHEBI:29108 chemical-affects PLA2G2A Reactome NA Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PG;Acyl chain remodelling of PI;Acyl chain remodelling of PS;Antimicrobial peptides;Synthesis of PA http://pathwaycommons.org/pc12/Complex_fd6bb11b8215087ddb70a1fe3bdcd69e;http://pathwaycommons.org/pc12/Complex_f5bd20288ec2f8ac1a57bef06713b867 | |
| CHEBI:29108 chemical-affects PLA2G2D Reactome NA Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PG;Acyl chain remodelling of PI;Acyl chain remodelling of PS;Synthesis of PA http://pathwaycommons.org/pc12/Complex_b6e633cca1e667582ffa8735657a95a5 | |
| CHEBI:29108 chemical-affects PLA2G2E Reactome NA Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PG;Acyl chain remodelling of PI;Acyl chain remodelling of PS;Synthesis of PA http://pathwaycommons.org/pc12/Complex_ab2b15a480e9e7a70f50545ef36f6079 | |
| CHEBI:29108 chemical-affects PLA2G2F Reactome NA Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PG;Acyl chain remodelling of PI;Acyl chain remodelling of PS;Synthesis of PA http://pathwaycommons.org/pc12/Complex_9fe6b4a2f9681837b9f661d33c99d208 | |
| CHEBI:29108 chemical-affects PLA2G3 Reactome NA Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PG http://pathwaycommons.org/pc12/Complex_b10fd3245a783da97de704b88db76881 | |
| CHEBI:29108 chemical-affects PLA2G4A Reactome NA Acyl chain remodeling of CL;Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PG;Acyl chain remodelling of PI;Acyl chain remodelling of PS;Arachidonic acid metabolism;Hydrolysis of LPC;Synthesis of PA;phospho-PLA2 pathway http://pathwaycommons.org/pc12/Complex_662ecf356c98ce35f2535d4e09deffa2;http://pathwaycommons.org/pc12/Complex_0a03fb60a1bc3c03b6ffc74c02e7de23;http://pathwaycommons.org/pc12/Complex_c133b5686d4ece888846ed5affe2f579 | |
| CHEBI:29108 chemical-affects PLA2G5 Reactome NA Acyl chain remodelling of PC;Acyl chain remodelling of PE;Acyl chain remodelling of PG;Acyl chain remodelling of PI;Acyl chain remodelling of PS;Synthesis of PA http://pathwaycommons.org/pc12/Complex_683f5e238aef0dccb0d5add08311ab6b | |
| CHEBI:29108 chemical-affects PLCB1 Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_78232fb8e3b24d5b0bf9bef5e20b2e17 | |
| CHEBI:29108 chemical-affects PLCB2 Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_59da71f0b473eca33877b9de169ff60f | |
| CHEBI:29108 chemical-affects PLCB3 Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_237ecc8c4368684b42e1aaced59c11f2 | |
| CHEBI:29108 chemical-affects PLCB4 Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_a649cc965f17f6b7a33140abb4245740 | |
| CHEBI:29108 chemical-affects PLCD1 Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_00165f20179db04930236558160e1063 | |
| CHEBI:29108 chemical-affects PLCD3 Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_af642256d52c68f41d44aa6774f83135 | |
| CHEBI:29108 chemical-affects PLCD4 Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_b9fb3588261fbdd5fbef58a32b572a4a | |
| CHEBI:29108 chemical-affects PLCE1 Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_004139337c8deaf940999cca68f72009 | |
| CHEBI:29108 chemical-affects PLCG1 Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_c687196946977695915891fe2533ca52 | |
| CHEBI:29108 chemical-affects PLCG2 Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_1448050c23c6006d12d86f91f3ab76fc | |
| CHEBI:29108 chemical-affects PLCH1 Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_9bc6158549f2be63daac2372be2d2214 | |
| CHEBI:29108 chemical-affects PLCH2 Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_72aeb579db2be6fd5de4644e609f1685 | |
| CHEBI:29108 chemical-affects PLCZ1 Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_3b71445c7558f47c34ee08136b1d911d | |
| CHEBI:29108 chemical-affects PLD4 Reactome NA Synthesis of IP3 and IP4 in the cytosol http://pathwaycommons.org/pc12/Complex_17f99aa3553190a732d68583f4a3ea40 | |
| CHEBI:29108 chemical-affects POMC Reactome 14463577;9207799 Peptide hormone biosynthesis http://identifiers.org/reactome/R-HSA-265301;http://pathwaycommons.org/pc12/Catalysis_10dd73c0908f4fee7f88af3d621d46dd | |
| CHEBI:29108 chemical-affects PON1 Reactome NA Synthesis of 5-eicosatetraenoic acids http://pathwaycommons.org/pc12/Complex_0b03aa833ca906f57f4fe32e01462fe2 | |
| CHEBI:29108 chemical-affects PON2 Reactome NA Synthesis of 5-eicosatetraenoic acids http://pathwaycommons.org/pc12/Complex_33545bfb46fa98a60ebbc51517d7a3a2 | |
| CHEBI:29108 chemical-affects PON3 Reactome NA Synthesis of 5-eicosatetraenoic acids http://pathwaycommons.org/pc12/Complex_9acaef80c46df45d6642b6f9da6bc401 | |
| CHEBI:29108 chemical-affects PPFIA1 Reactome 12519779;16990140;17478680;17891149 Glutamate Neurotransmitter Release Cycle http://identifiers.org/reactome/R-HSA-210503;http://identifiers.org/reactome/R-HSA-210430 | |
| CHEBI:29108 chemical-affects PPFIA2 Reactome 12519779;16990140;17478680;17891149 Glutamate Neurotransmitter Release Cycle http://identifiers.org/reactome/R-HSA-210503;http://identifiers.org/reactome/R-HSA-210430 | |
| CHEBI:29108 chemical-affects PPFIA3 Reactome 12519779;16990140;17478680;17891149 Glutamate Neurotransmitter Release Cycle http://identifiers.org/reactome/R-HSA-210503;http://identifiers.org/reactome/R-HSA-210430 | |
| CHEBI:29108 chemical-affects PPFIA4 Reactome 12519779;16990140;17478680;17891149 Glutamate Neurotransmitter Release Cycle http://identifiers.org/reactome/R-HSA-210503;http://identifiers.org/reactome/R-HSA-210430 | |
| CHEBI:29108 consumption-controlled-by PPIA Reactome 11030334;11231878;12218175;7523407;7657645;8684469;9106655;9312192 Calcineurin activates NFAT http://identifiers.org/reactome/R-HSA-2026015;http://identifiers.org/reactome/R-HSA-2025882 | |
| CHEBI:29108 chemical-affects PPL Reactome 10196183;10510474;10588656;11443109;12210515;2461365;6105840;73346 Formation of the cornified envelope http://pathwaycommons.org/pc12/Catalysis_399933b4d215d5b33201c64821d4b301;http://identifiers.org/reactome/R-HSA-6810894 | |
| CHEBI:29108 chemical-affects PPP1R1B Reactome 6330098 DARPP-32 events http://identifiers.org/reactome/R-HSA-201787;http://pathwaycommons.org/pc12/Catalysis_c057bfd7b3ca012212c4021192850933 | |
| CHEBI:29108 chemical-affects PPP3CA Reactome NA CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;Calcineurin activates NFAT;DARPP-32 events;FCERI mediated Ca+2 mobilization http://pathwaycommons.org/pc12/Complex_8278d7e8371b75a9fa61e95f569fc802;http://pathwaycommons.org/pc12/Complex_40bc4e491a3a1dc958c830f180598cc0;http://pathwaycommons.org/pc12/Complex_2a657d2c9443d60161b08371d4863df8;http://pathwaycommons.org/pc12/Complex_5ff86d70cd9f72c2ac7ced1095c99fe5;http://pathwaycommons.org/pc12/Complex_17c537e2fe7c5062d96582647505fc8c | |
| CHEBI:29108 chemical-affects PPP3CB Reactome NA CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;Calcineurin activates NFAT;DARPP-32 events;FCERI mediated Ca+2 mobilization http://pathwaycommons.org/pc12/Complex_8278d7e8371b75a9fa61e95f569fc802;http://pathwaycommons.org/pc12/Complex_40bc4e491a3a1dc958c830f180598cc0;http://pathwaycommons.org/pc12/Complex_2a657d2c9443d60161b08371d4863df8;http://pathwaycommons.org/pc12/Complex_5ff86d70cd9f72c2ac7ced1095c99fe5;http://pathwaycommons.org/pc12/Complex_17c537e2fe7c5062d96582647505fc8c | |
| CHEBI:29108 chemical-affects PPP3CC Reactome NA DARPP-32 events http://pathwaycommons.org/pc12/Complex_8278d7e8371b75a9fa61e95f569fc802 | |
| CHEBI:29108 chemical-affects PPP3R1 Reactome NA CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;Calcineurin activates NFAT;DARPP-32 events;FCERI mediated Ca+2 mobilization http://pathwaycommons.org/pc12/Complex_8ad01a63d3328baa32ac829846d9b3f8;http://pathwaycommons.org/pc12/Complex_2a657d2c9443d60161b08371d4863df8;http://pathwaycommons.org/pc12/Complex_5ff86d70cd9f72c2ac7ced1095c99fe5;http://pathwaycommons.org/pc12/Complex_8b12ce193f1ccad21370dd96b8695242;http://pathwaycommons.org/pc12/Complex_0068f9c7dc9b52e09c98af7260a3d462 | |
| CHEBI:29108 chemical-affects PRKAA1 Reactome 11018120;11797013;14511394;14614828;14985505;15579580;15889149;16054041;16054096;17486097;17712357;8779952 Activation of AMPK downstream of NMDARs;Energy dependent regulation of mTOR by LKB1-AMPK http://pathwaycommons.org/pc12/Catalysis_c2d38bfa951a078632369d3c12e7ab15;http://identifiers.org/reactome/R-HSA-9619478 | |
| CHEBI:29108 chemical-affects PRKAA2 Reactome 11018120;11797013;14511394;14614828;14985505;15579580;15889149;16054041;16054096;17486097;17712357;8779952 Activation of AMPK downstream of NMDARs;Energy dependent regulation of mTOR by LKB1-AMPK http://pathwaycommons.org/pc12/Catalysis_c2d38bfa951a078632369d3c12e7ab15;http://identifiers.org/reactome/R-HSA-9619478 | |
| CHEBI:29108 chemical-affects PRKAB1 Reactome 11018120;11797013;14511394;14614828;14985505;15579580;15889149;16054041;16054096;17486097;17712357;8779952 Activation of AMPK downstream of NMDARs;Energy dependent regulation of mTOR by LKB1-AMPK http://pathwaycommons.org/pc12/Catalysis_c2d38bfa951a078632369d3c12e7ab15;http://identifiers.org/reactome/R-HSA-9619478 | |
| CHEBI:29108 chemical-affects PRKAB2 Reactome 11018120;11797013;14511394;14614828;14985505;15579580;15889149;16054041;16054096;17486097;17712357;8779952 Activation of AMPK downstream of NMDARs;Energy dependent regulation of mTOR by LKB1-AMPK http://pathwaycommons.org/pc12/Catalysis_c2d38bfa951a078632369d3c12e7ab15;http://identifiers.org/reactome/R-HSA-9619478 | |
| CHEBI:29108 chemical-affects PRKAG1 Reactome 11018120;11797013;14511394;14614828;14985505;15579580;15889149;16054041;16054096;17486097;17712357;8779952 Activation of AMPK downstream of NMDARs;Energy dependent regulation of mTOR by LKB1-AMPK http://pathwaycommons.org/pc12/Catalysis_c2d38bfa951a078632369d3c12e7ab15;http://identifiers.org/reactome/R-HSA-9619478 | |
| CHEBI:29108 chemical-affects PRKAG2 Reactome 11018120;11797013;14511394;14614828;14985505;15579580;15889149;16054041;16054096;17486097;17712357;8779952 Activation of AMPK downstream of NMDARs;Energy dependent regulation of mTOR by LKB1-AMPK http://pathwaycommons.org/pc12/Catalysis_c2d38bfa951a078632369d3c12e7ab15;http://identifiers.org/reactome/R-HSA-9619478 | |
| CHEBI:29108 chemical-affects PRKAG3 Reactome 11018120;11797013;14511394;14614828;14985505;15579580;15889149;16054041;16054096;17486097;17712357;8779952 Activation of AMPK downstream of NMDARs;Energy dependent regulation of mTOR by LKB1-AMPK http://pathwaycommons.org/pc12/Catalysis_c2d38bfa951a078632369d3c12e7ab15;http://identifiers.org/reactome/R-HSA-9619478 | |
| CHEBI:29108 chemical-affects PRKCA Reactome NA Ca2+ pathway;Calmodulin induced events;Depolymerisation of the Nuclear Lamina;Disinhibition of SNARE formation;G alpha (z) signalling events;Response to elevated platelet cytosolic Ca2+;SHC1 events in ERBB2 signaling;Trafficking of GluR2-containing AMPA receptors;VEGFR2 mediated cell proliferation;WNT5A-dependent internalization of FZD4 http://pathwaycommons.org/pc12/Complex_8ed48a0609272ddd727445cdb659a9a4;http://pathwaycommons.org/pc12/Complex_5fa0611d0238337fd529e8843f95d4d3;http://pathwaycommons.org/pc12/Complex_27fcc209446abe4a523bc2b050338906;http://pathwaycommons.org/pc12/Complex_fd02f9ef9bdea88b45df3427ccd37dbf;http://pathwaycommons.org/pc12/Complex_e4593e5fcc479758d13ab686c8197d22 | |
| CHEBI:29108 chemical-affects PRKCB Reactome NA Activation of NF-kappaB in B cells;Depolymerisation of the Nuclear Lamina;Disinhibition of SNARE formation;G alpha (z) signalling events;Response to elevated platelet cytosolic Ca2+;Trafficking of GluR2-containing AMPA receptors;VEGFR2 mediated cell proliferation;WNT5A-dependent internalization of FZD4 http://pathwaycommons.org/pc12/Complex_58cdac9a7293c199e2cc415fd9226f57;http://pathwaycommons.org/pc12/Complex_5fa0611d0238337fd529e8843f95d4d3;http://pathwaycommons.org/pc12/Complex_fd02f9ef9bdea88b45df3427ccd37dbf | |
| CHEBI:29108 chemical-affects PRKCD Reactome NA Calmodulin induced events;VEGFR2 mediated cell proliferation http://pathwaycommons.org/pc12/Complex_8ed48a0609272ddd727445cdb659a9a4;http://pathwaycommons.org/pc12/Complex_fd02f9ef9bdea88b45df3427ccd37dbf | |
| CHEBI:29108 chemical-affects PRKCG Reactome NA Calmodulin induced events;Disinhibition of SNARE formation;G alpha (z) signalling events;Response to elevated platelet cytosolic Ca2+;Trafficking of GluR2-containing AMPA receptors;WNT5A-dependent internalization of FZD4 http://pathwaycommons.org/pc12/Complex_8ed48a0609272ddd727445cdb659a9a4;http://pathwaycommons.org/pc12/Complex_50667850a521e404bd00289f59fc933d | |
| CHEBI:29108 chemical-affects PRKCZ Reactome NA VEGFR2 mediated cell proliferation http://pathwaycommons.org/pc12/Complex_fd02f9ef9bdea88b45df3427ccd37dbf | |
| CHEBI:29108 chemical-affects PROCR Reactome 11238108;24741378;7929370;8816778 Cell surface interactions at the vascular wall;Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-5591052;http://pathwaycommons.org/pc12/Complex_161a4ffa637bf3acb9b11a5f03a44d75;http://identifiers.org/reactome/R-HSA-5610119;http://pathwaycommons.org/pc12/Complex_53dd08647c9ed60f89d218d1fde18388 | |
| CHEBI:29108 chemical-affects PROC Reactome 11238108;24741378;7929370;8816778 Cell surface interactions at the vascular wall;Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-5591052;http://identifiers.org/reactome/R-HSA-5610119;http://pathwaycommons.org/pc12/Complex_9d7189c07c998682274423dbc627695a | |
| CHEBI:29108 consumption-controlled-by PROC Reactome 16935856;21730834;2538457;7499257;7673148;7989361 Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-141026;http://pathwaycommons.org/pc12/Catalysis_97ef44a47d40595c3a2a625a23c448cb | |
| CHEBI:29108 chemical-affects PROS1 Reactome NA Common Pathway of Fibrin Clot Formation http://pathwaycommons.org/pc12/Complex_e2381c78dcf82d37aab7aa6b30e32afd | |
| CHEBI:29108 consumption-controlled-by PROS1 Reactome 16935856;21730834;2538457;7499257;7673148;7989361 Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-141026;http://pathwaycommons.org/pc12/Catalysis_97ef44a47d40595c3a2a625a23c448cb | |
| CHEBI:29108 chemical-affects PTK2 Reactome NA GRB2:SOS provides linkage to MAPK signaling for Integrins;Integrin alphaIIb beta3 signaling;p130Cas linkage to MAPK signaling for integrins http://pathwaycommons.org/pc12/Complex_9fd2b76766dcc507ef74c5be58d5d5cf;http://pathwaycommons.org/pc12/Complex_e42d0b5a247b536021358604ff6f5791;http://pathwaycommons.org/pc12/Complex_dd9e5aa1a1bcd82905fb024479ab2e59 | |
| CHEBI:29108 chemical-affects PXN Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects PYGB Reactome 2667896 Glycogen breakdown (glycogenolysis) http://identifiers.org/reactome/R-HSA-453337;http://identifiers.org/reactome/R-HSA-9034527 | |
| CHEBI:29108 chemical-affects PYGL Reactome 10487978;12825073;12930917;13115432;5461220;7847371;8896567 Glycogen breakdown (glycogenolysis) http://identifiers.org/reactome/R-HSA-71589;http://identifiers.org/reactome/R-HSA-71588 | |
| CHEBI:29108 chemical-affects PYGM Reactome 10487978;12825073;13115432;5461220 Glycogen breakdown (glycogenolysis) http://identifiers.org/reactome/R-HSA-71541;http://identifiers.org/reactome/R-HSA-71542 | |
| CHEBI:29108 chemical-affects QKI Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects RAB3A Reactome 12519779;16990140;17478680;17891149 Glutamate Neurotransmitter Release Cycle http://identifiers.org/reactome/R-HSA-210503;http://identifiers.org/reactome/R-HSA-210430 | |
| CHEBI:29108 chemical-affects RAC1 Reactome 17244649;21730051;8756646;9199170;9368021 RHO GTPases activate IQGAPs http://identifiers.org/reactome/R-HSA-5626507;http://identifiers.org/reactome/R-HSA-5626550;http://pathwaycommons.org/pc12/Complex_072c82f475ea60d741ff46a81c833d05 | |
| CHEBI:29108 chemical-affects RAC2 Reactome NA RHO GTPases Activate NADPH Oxidases http://pathwaycommons.org/pc12/Complex_940658ed0ee8c537e938ffbb68d0ab84 | |
| CHEBI:29108 chemical-affects RAF1 Reactome 10205168;10712905;11032810;11325826;12244094;12551923;15035987;15710605;15899852;16093354;16364920;16508002;17018604;17097642;18294816;18662992;19158341;19933846;20130576;20141835;20179705;20820846;21779496;22043453;22510884;22592532;23680146;23993095;24202393;24957944;25435214;25907612;7542586;8876196;9020159;9234708;9823899 MAP2K and MAPK activation;Paradoxical activation of RAF signaling by kinase inactive BRAF;RAF activation;Signaling by RAS mutants;Signaling by moderate kinase activity BRAF mutants http://pathwaycommons.org/pc12/Catalysis_4b66558229db0440bcfbace623060ef0;http://pathwaycommons.org/pc12/Complex_99f08589f0e5024718269b930d0288e8;http://pathwaycommons.org/pc12/Complex_1c9f438d1db34b7384fdfa8bb13a2f0d;http://pathwaycommons.org/pc12/Complex_24eebdb420a48d1df31ce470b63917e2;http://pathwaycommons.org/pc12/Catalysis_d1076b99bcec87a38eaa26ff1c4a4070;http://pathwaycommons.org/pc12/Catalysis_fd9991c8fd61be157ed4b2e5be7acef9;http://pathwaycommons.org/pc12/Complex_a9afcce8661dd885cef40e47037a185f;http://pathwaycommons.org/pc12/Complex_411c1b271808c064387f09c3c20b6304;http://pathwaycommons.org/pc12/Complex_07bcf74dbac68a47917e1f7a40acd849;http://pathwaycommons.org/pc12/Complex_3adde65e3e4efaeeb03ad9e8acf79d2a;http://pathwaycommons.org/pc12/Complex_3811ddf05925c006e5b9ba92ef63ffad;http://identifiers.org/reactome/R-HSA-5672969;http://pathwaycommons.org/pc12/Catalysis_1c35b9ddce2a70d0629b481931d815c1;http://identifiers.org/reactome/R-HSA-6802941;http://identifiers.org/reactome/R-HSA-6802924;http://pathwaycommons.org/pc12/Complex_d7c23e33867ba9a0550337f60e5447f8;http://pathwaycommons.org/pc12/Complex_a02123277a4a9e4a0fdba06dcb2d40cd;http://pathwaycommons.org/pc12/Complex_c0cf37acbfc4c8467f39affddaced3ca;http://pathwaycommons.org/pc12/Complex_3fcbd062120dcb929eabeb6cba72d4c3;http://identifiers.org/reactome/R-HSA-6802916 | |
| CHEBI:29108 chemical-affects RALA Reactome NA Translocation of SLC2A4 (GLUT4) to the plasma membrane http://identifiers.org/reactome/R-HSA-5358685;http://identifiers.org/reactome/R-HSA-2316352 | |
| CHEBI:29108 chemical-affects RAP1A Reactome 10753869;12006644;12585966;15334074;15469846;16076873;16757337 GRB2:SOS provides linkage to MAPK signaling for Integrins;Integrin alphaIIb beta3 signaling;MET activates RAP1 and RAC1;Rap1 signalling;p130Cas linkage to MAPK signaling for integrins http://pathwaycommons.org/pc12/Complex_6c5ceab1ba2073e49cb1896a925dc573;http://pathwaycommons.org/pc12/Catalysis_31608980d1cc5e71fc37bfe4e5425b03;http://pathwaycommons.org/pc12/Complex_2357686c4db0ca1c4d0ab9a210130449;http://pathwaycommons.org/pc12/Complex_16978f376c59bd9933e4875566f69baf;http://pathwaycommons.org/pc12/Complex_97a0978414a8036daa7bf22a7d04587e;http://identifiers.org/reactome/R-HSA-8875568;http://pathwaycommons.org/pc12/Complex_23c4b5044f972d0062e4816c7ae0ad45 | |
| CHEBI:29108 chemical-affects RAP1B Reactome 10753869;12006644;12585966;15334074;15469846;16076873;16757337 GRB2:SOS provides linkage to MAPK signaling for Integrins;Integrin alphaIIb beta3 signaling;MET activates RAP1 and RAC1;Rap1 signalling;p130Cas linkage to MAPK signaling for integrins http://pathwaycommons.org/pc12/Complex_6c5ceab1ba2073e49cb1896a925dc573;http://pathwaycommons.org/pc12/Catalysis_31608980d1cc5e71fc37bfe4e5425b03;http://pathwaycommons.org/pc12/Complex_2357686c4db0ca1c4d0ab9a210130449;http://pathwaycommons.org/pc12/Complex_16978f376c59bd9933e4875566f69baf;http://pathwaycommons.org/pc12/Complex_97a0978414a8036daa7bf22a7d04587e;http://identifiers.org/reactome/R-HSA-8875568;http://pathwaycommons.org/pc12/Complex_23c4b5044f972d0062e4816c7ae0ad45 | |
| CHEBI:29108 chemical-affects RASGRF1 Reactome NA RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded | |
| CHEBI:29108 chemical-affects RASGRF2 Reactome NA RAF/MAP kinase cascade;Ras activation upon Ca2+ influx through NMDA receptor http://pathwaycommons.org/pc12/Complex_aa702ce7f516c92e6cc5bde335418ded | |
| CHEBI:29108 chemical-affects RASGRP1 Reactome NA Effects of PIP2 hydrolysis;FCERI mediated NF-kB activation;Integrin alphaIIb beta3 signaling http://pathwaycommons.org/pc12/Complex_dfd8a34edf29dfee2739f41c5878a991;http://pathwaycommons.org/pc12/Complex_7b46d769a2b92110a61b1d2e320f2dc2 | |
| CHEBI:29108 chemical-affects RASGRP2 Reactome NA Effects of PIP2 hydrolysis;FCERI mediated NF-kB activation;Integrin alphaIIb beta3 signaling http://pathwaycommons.org/pc12/Complex_dfd8a34edf29dfee2739f41c5878a991;http://pathwaycommons.org/pc12/Complex_7b46d769a2b92110a61b1d2e320f2dc2 | |
| CHEBI:29108 chemical-affects RASGRP4 Reactome NA FCERI mediated NF-kB activation http://pathwaycommons.org/pc12/Complex_dfd8a34edf29dfee2739f41c5878a991 | |
| CHEBI:29108 chemical-affects RCVRN Reactome NA Inactivation, recovery and regulation of the phototransduction cascade http://pathwaycommons.org/pc12/Complex_a9f9b3b5736b72edbc4c435b0f761ded;http://pathwaycommons.org/pc12/Complex_293804b3f9a02a35073fcb4706882fe8 | |
| CHEBI:29108 chemical-affects RHO Reactome 11713293;11754336;1387789;15946941;18803695;20430952;22658984;2540796;2550422;2558719;3164688;8626439;8706659;8812493;9430683 Inactivation, recovery and regulation of the phototransduction cascade http://identifiers.org/reactome/R-HSA-74948;http://identifiers.org/reactome/R-HSA-2581474;http://identifiers.org/reactome/R-HSA-3223247;http://identifiers.org/reactome/R-HSA-3223249;http://identifiers.org/reactome/R-HSA-2648999 | |
| CHEBI:29108 chemical-affects RIMS1 Reactome 12519779;16990140;17478680;17891149 Glutamate Neurotransmitter Release Cycle http://identifiers.org/reactome/R-HSA-210503;http://identifiers.org/reactome/R-HSA-210430 | |
| CHEBI:29108 chemical-affects RPS27A Reactome NA InlA-mediated entry of Listeria monocytogenes into host cells http://pathwaycommons.org/pc12/Complex_d14fd20e7d04c6b6c80ae25eba644705;http://pathwaycommons.org/pc12/Complex_72252a597af31ca7a925dc40f25213f4 | |
| CHEBI:29108 chemical-affects S100A1 Reactome NA Regulation of TLR by endogenous ligand http://pathwaycommons.org/pc12/Complex_f0c01870bbb4fb20e2b235e62d0c3913 | |
| CHEBI:29108 chemical-affects S100A7A Reactome NA Metal sequestration by antimicrobial proteins http://pathwaycommons.org/pc12/Complex_b61a7c50607c6a90f663abbf011664ea | |
| CHEBI:29108 chemical-affects S100A7 Reactome NA Metal sequestration by antimicrobial proteins http://pathwaycommons.org/pc12/Complex_b61a7c50607c6a90f663abbf011664ea | |
| CHEBI:29108 chemical-affects S100A8 Reactome NA Metal sequestration by antimicrobial proteins;RHO GTPases Activate NADPH Oxidases http://pathwaycommons.org/pc12/Complex_ae92020899969fb2106ea91767155168;http://pathwaycommons.org/pc12/Complex_db3ef70cd57784a9b4fbf20494fcfb6b;http://pathwaycommons.org/pc12/Complex_bcb7dec7988679d5874049ca346b8086 | |
| CHEBI:29108 chemical-affects S100A9 Reactome NA Metal sequestration by antimicrobial proteins;RHO GTPases Activate NADPH Oxidases http://pathwaycommons.org/pc12/Complex_ae92020899969fb2106ea91767155168;http://pathwaycommons.org/pc12/Complex_db3ef70cd57784a9b4fbf20494fcfb6b;http://pathwaycommons.org/pc12/Complex_bcb7dec7988679d5874049ca346b8086 | |
| CHEBI:29108 chemical-affects SERPINA5 Reactome NA Common Pathway of Fibrin Clot Formation;Intrinsic Pathway of Fibrin Clot Formation http://pathwaycommons.org/pc12/Complex_f82754ef5e20a557e3d5d0f11c3559da | |
| CHEBI:29108 chemical-affects SERPINC1 Reactome NA Common Pathway of Fibrin Clot Formation;Intrinsic Pathway of Fibrin Clot Formation http://pathwaycommons.org/pc12/Complex_7b0874405ea0b495d9e55d627d9c426b;http://pathwaycommons.org/pc12/Complex_479caee00239aec61a42814dd3107289;http://pathwaycommons.org/pc12/Complex_ffe1f4591b48b3b69a12dcdef47b8da5 | |
| CHEBI:29108 chemical-affects SERPIND1 Reactome NA Common Pathway of Fibrin Clot Formation;Intrinsic Pathway of Fibrin Clot Formation http://pathwaycommons.org/pc12/Complex_64f88622b15a4da45ff021ca44c9bde6 | |
| CHEBI:29108 chemical-affects SERPINE2 Reactome NA Common Pathway of Fibrin Clot Formation;Intrinsic Pathway of Fibrin Clot Formation http://pathwaycommons.org/pc12/Complex_adc04ac36029b99d83e3804ed4924da5 | |
| CHEBI:29108 chemical-affects SHC1 Reactome 12052829;7929214 SHC1 events in ERBB2 signaling http://identifiers.org/reactome/R-HSA-8934446;http://pathwaycommons.org/pc12/Catalysis_c0150c7991788dbf420d84382f5f82ca | |
| CHEBI:29108 chemical-affects SHH Reactome NA Common Pathway of Fibrin Clot Formation;Intrinsic Pathway of Fibrin Clot Formation http://pathwaycommons.org/pc12/Complex_313c8814f2eb4d707045582ce7f42f86 | |
| CHEBI:29108 chemical-affects SHMT1 Reactome NA Common Pathway of Fibrin Clot Formation;Intrinsic Pathway of Fibrin Clot Formation http://pathwaycommons.org/pc12/Complex_313c8814f2eb4d707045582ce7f42f86 | |
| CHEBI:29108 chemical-affects SLC17A7 Reactome 12519779;16990140;17478680;17891149 Glutamate Neurotransmitter Release Cycle http://identifiers.org/reactome/R-HSA-210503;http://identifiers.org/reactome/R-HSA-210430 | |
| CHEBI:29108 consumption-controlled-by SLC24A1 Reactome 20850105 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) http://pathwaycommons.org/pc12/Catalysis_e38a4a3dec45e0101e575cc474b447dd;http://identifiers.org/reactome/R-HSA-5625841 | |
| CHEBI:29108 consumption-controlled-by SLC24A4 Reactome 23375655;24621671 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) http://pathwaycommons.org/pc12/Catalysis_4154e342af1ca919875b5d38842159ec;http://identifiers.org/reactome/R-HSA-5626270 | |
| CHEBI:29108 consumption-controlled-by SLC24A5 Reactome 23010199;23364476 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) http://identifiers.org/reactome/R-HSA-5626356;http://pathwaycommons.org/pc12/Catalysis_ba327a3d296145cfb14bd811df4315bf | |
| CHEBI:29108 chemical-affects SLC9A1 Reactome NA Hyaluronan uptake and degradation http://pathwaycommons.org/pc12/Complex_266f6b95cca3270fc11f2fa64b5bfd8f | |
| CHEBI:29108 chemical-affects SNAP25 Reactome 12519779;16990140;17478680;17891149 Glutamate Neurotransmitter Release Cycle;Regulation of insulin secretion http://identifiers.org/reactome/R-HSA-210503;http://pathwaycommons.org/pc12/Complex_4bd59e17d37ba9990b80bfe2629a7258;http://identifiers.org/reactome/R-HSA-210430 | |
| CHEBI:29108 chemical-affects SND1 Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects SORBS1 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects SORBS3 Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects SOS1 Reactome NA GRB2:SOS provides linkage to MAPK signaling for Integrins http://pathwaycommons.org/pc12/Complex_d4803f4efe133d9dea78f53dbd737895 | |
| CHEBI:29108 chemical-affects SPARC Reactome NA ECM proteoglycans http://pathwaycommons.org/pc12/Complex_843b1dafe5db1b195b6da05147bca808 | |
| CHEBI:29108 chemical-affects SPHK1 Reactome 12391145;14532121 VEGFR2 mediated cell proliferation http://identifiers.org/reactome/R-HSA-5218823;http://pathwaycommons.org/pc12/Catalysis_2011edeb5d01078f4211795062e7abf5 | |
| CHEBI:29108 chemical-affects SRC Reactome 11836526;12134161;17553930;17627624;20144995;8672527 GRB2:SOS provides linkage to MAPK signaling for Integrins;InlA-mediated entry of Listeria monocytogenes into host cells;Integrin alphaIIb beta3 signaling;p130Cas linkage to MAPK signaling for integrins http://pathwaycommons.org/pc12/Complex_6c5ceab1ba2073e49cb1896a925dc573;http://identifiers.org/reactome/R-HSA-112333;http://pathwaycommons.org/pc12/Complex_2357686c4db0ca1c4d0ab9a210130449;http://pathwaycommons.org/pc12/Complex_16978f376c59bd9933e4875566f69baf;http://pathwaycommons.org/pc12/Complex_97a0978414a8036daa7bf22a7d04587e;http://pathwaycommons.org/pc12/Complex_23c4b5044f972d0062e4816c7ae0ad45;http://identifiers.org/reactome/R-HSA-8876920 | |
| CHEBI:29108 chemical-affects STAB2 Reactome NA Hyaluronan uptake and degradation http://pathwaycommons.org/pc12/Complex_8eea59cd1481d67d38c5fb297b709834 | |
| CHEBI:29108 chemical-affects STIM1 Reactome NA Antigen activates B Cell Receptor (BCR) leading to generation of second messengers http://pathwaycommons.org/pc12/Complex_97a0daf0e9acb8f832b6550a3ea39859 | |
| CHEBI:29108 chemical-affects STS Reactome NA Glycosphingolipid metabolism http://pathwaycommons.org/pc12/Complex_91ebb625c441de3c32951416bca9a7b2 | |
| CHEBI:29108 chemical-affects STX1A Reactome 12519779;16990140;17478680;17891149 Glutamate Neurotransmitter Release Cycle;Regulation of insulin secretion http://identifiers.org/reactome/R-HSA-210503;http://pathwaycommons.org/pc12/Complex_4bd59e17d37ba9990b80bfe2629a7258;http://identifiers.org/reactome/R-HSA-210430 | |
| CHEBI:29108 chemical-affects STX4 Reactome 10856305 Disinhibition of SNARE formation http://identifiers.org/reactome/R-HSA-114684;http://pathwaycommons.org/pc12/Catalysis_442d4b092f69bf9c6a8a77031b1798fe | |
| CHEBI:29108 chemical-affects STXBP1 Reactome 12519779;16990140;17478680;17891149 Glutamate Neurotransmitter Release Cycle http://identifiers.org/reactome/R-HSA-210503;http://identifiers.org/reactome/R-HSA-210430 | |
| CHEBI:29108 chemical-affects STXBP3 Reactome 10194441 Disinhibition of SNARE formation http://identifiers.org/reactome/R-HSA-114683;http://pathwaycommons.org/pc12/Catalysis_0d1de9616f1d52245d873843a566cd24 | |
| CHEBI:29108 chemical-affects SYK Reactome NA Integrin alphaIIb beta3 signaling http://pathwaycommons.org/pc12/Complex_6a36790acef352d3c462d999042b4344;http://pathwaycommons.org/pc12/Complex_db1dc0250369c16874c917977d42ecda | |
| CHEBI:29108 chemical-affects SYT1 Reactome 12519779;16990140;17478680;17891149 Glutamate Neurotransmitter Release Cycle http://identifiers.org/reactome/R-HSA-210503;http://identifiers.org/reactome/R-HSA-210430 | |
| CHEBI:29108 chemical-affects SYT5 Reactome NA Regulation of insulin secretion http://pathwaycommons.org/pc12/Complex_4bd59e17d37ba9990b80bfe2629a7258 | |
| CHEBI:29108 chemical-affects TBL1XR1 Reactome 21240272;21925568;23770565;23770587 Regulation of MECP2 expression and activity http://pathwaycommons.org/pc12/Control_a1ba3478207416f47b4b6c44bd7eb6e4;http://identifiers.org/reactome/R-HSA-8986939 | |
| CHEBI:29108 chemical-affects TBL1X Reactome 21240272;21925568;23770565;23770587 Regulation of MECP2 expression and activity http://pathwaycommons.org/pc12/Control_a1ba3478207416f47b4b6c44bd7eb6e4;http://identifiers.org/reactome/R-HSA-8986939 | |
| CHEBI:29108 chemical-affects TCAP Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects TENT4A Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects TFPI Reactome NA Extrinsic Pathway of Fibrin Clot Formation http://pathwaycommons.org/pc12/Complex_44d3939c6178d46a744d37910fe4e683 | |
| CHEBI:29108 chemical-affects TGM1 Reactome 10196183;10510474;10588656;11443109;12210515;2461365;6105840;73346 Formation of the cornified envelope http://pathwaycommons.org/pc12/Catalysis_399933b4d215d5b33201c64821d4b301;http://identifiers.org/reactome/R-HSA-6810894;http://pathwaycommons.org/pc12/Complex_6b926880cd80887a6d45ea2273ed6cad | |
| CHEBI:29108 chemical-affects TGM5 Reactome NA Formation of the cornified envelope http://pathwaycommons.org/pc12/Complex_cc955032ff5701f585799eb17e018bb1 | |
| CHEBI:29108 chemical-affects THBD Reactome NA Common Pathway of Fibrin Clot Formation http://pathwaycommons.org/pc12/Complex_96adf71321c1cdddadde53e8b7305d64 | |
| CHEBI:29108 chemical-affects TLN1 Reactome NA GRB2:SOS provides linkage to MAPK signaling for Integrins;Integrin alphaIIb beta3 signaling;Smooth Muscle Contraction;p130Cas linkage to MAPK signaling for integrins http://pathwaycommons.org/pc12/Complex_6c5ceab1ba2073e49cb1896a925dc573;http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_2357686c4db0ca1c4d0ab9a210130449;http://pathwaycommons.org/pc12/Complex_16978f376c59bd9933e4875566f69baf;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_97a0978414a8036daa7bf22a7d04587e;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10;http://pathwaycommons.org/pc12/Complex_23c4b5044f972d0062e4816c7ae0ad45 | |
| CHEBI:29108 chemical-affects TLR4 Reactome NA Regulation of TLR by endogenous ligand http://pathwaycommons.org/pc12/Complex_cbf9dbc1cdb229be5ed7a1dfd7f8796b | |
| CHEBI:29108 chemical-affects TMOD1 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_1a2dfeb8092eea766c7560c066c83a46 | |
| CHEBI:29108 chemical-affects TMOD2 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_1a2dfeb8092eea766c7560c066c83a46 | |
| CHEBI:29108 chemical-affects TMOD3 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_1a2dfeb8092eea766c7560c066c83a46 | |
| CHEBI:29108 chemical-affects TMOD4 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_1a2dfeb8092eea766c7560c066c83a46 | |
| CHEBI:29108 chemical-affects TMPO Reactome 22986494;8034666;8463284 Depolymerisation of the Nuclear Lamina http://identifiers.org/reactome/R-HSA-5229194;http://pathwaycommons.org/pc12/Catalysis_ca4c2b90ced928f3342033ba2ded919f | |
| CHEBI:29108 chemical-affects TNNC1 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_12e91ed45a3dedb221d854e3ee199a4d | |
| CHEBI:29108 chemical-affects TNNC2 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_12e91ed45a3dedb221d854e3ee199a4d | |
| CHEBI:29108 chemical-affects TNNI1 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5ee68c3a18e54e113db264c72091938e | |
| CHEBI:29108 chemical-affects TNNI2 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5ee68c3a18e54e113db264c72091938e | |
| CHEBI:29108 chemical-affects TNNI3 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5ee68c3a18e54e113db264c72091938e | |
| CHEBI:29108 chemical-affects TNNT1 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5ee68c3a18e54e113db264c72091938e | |
| CHEBI:29108 chemical-affects TNNT2 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5ee68c3a18e54e113db264c72091938e | |
| CHEBI:29108 chemical-affects TNNT3 Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5ee68c3a18e54e113db264c72091938e | |
| CHEBI:29108 chemical-affects TPM1 Reactome NA Smooth Muscle Contraction;Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_1a2dfeb8092eea766c7560c066c83a46;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects TPM2 Reactome NA Smooth Muscle Contraction;Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_1a2dfeb8092eea766c7560c066c83a46;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects TPM3 Reactome NA Smooth Muscle Contraction;Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_1a2dfeb8092eea766c7560c066c83a46;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects TPM4 Reactome NA Smooth Muscle Contraction;Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_1a2dfeb8092eea766c7560c066c83a46;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects TRAK1 Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects TRIM24 Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| CHEBI:29108 chemical-affects TRIM72 Reactome 11532985;14506282;19380584;22421042 Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-5263628;http://identifiers.org/reactome/R-HSA-5333034;http://identifiers.org/reactome/R-HSA-5333036;http://identifiers.org/reactome/R-HSA-5263633 | |
| CHEBI:29108 chemical-affects TSPOAP1 Reactome 12519779;16990140;17478680;17891149 Glutamate Neurotransmitter Release Cycle http://identifiers.org/reactome/R-HSA-210503;http://identifiers.org/reactome/R-HSA-210430 | |
| CHEBI:29108 chemical-affects TTN Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects UBA52 Reactome NA InlA-mediated entry of Listeria monocytogenes into host cells http://pathwaycommons.org/pc12/Complex_d14fd20e7d04c6b6c80ae25eba644705;http://pathwaycommons.org/pc12/Complex_72252a597af31ca7a925dc40f25213f4 | |
| CHEBI:29108 chemical-affects UBB Reactome NA InlA-mediated entry of Listeria monocytogenes into host cells http://pathwaycommons.org/pc12/Complex_d14fd20e7d04c6b6c80ae25eba644705;http://pathwaycommons.org/pc12/Complex_72252a597af31ca7a925dc40f25213f4 | |
| CHEBI:29108 chemical-affects UBC Reactome NA InlA-mediated entry of Listeria monocytogenes into host cells http://pathwaycommons.org/pc12/Complex_d14fd20e7d04c6b6c80ae25eba644705;http://pathwaycommons.org/pc12/Complex_72252a597af31ca7a925dc40f25213f4 | |
| CHEBI:29108 chemical-affects UNC13B Reactome 12519779;16990140;17478680;17891149 Glutamate Neurotransmitter Release Cycle http://identifiers.org/reactome/R-HSA-210503;http://identifiers.org/reactome/R-HSA-210430 | |
| CHEBI:29108 chemical-affects VAMP2 Reactome 12519779;16990140;17478680;17891149 Glutamate Neurotransmitter Release Cycle;Regulation of insulin secretion http://identifiers.org/reactome/R-HSA-210503;http://pathwaycommons.org/pc12/Complex_4bd59e17d37ba9990b80bfe2629a7258;http://identifiers.org/reactome/R-HSA-210430 | |
| CHEBI:29108 chemical-affects VCL Reactome NA Smooth Muscle Contraction http://pathwaycommons.org/pc12/Complex_0518f6295b1ef06468655bd97bab06cd;http://pathwaycommons.org/pc12/Complex_c0fb59281e2cbea8227d357ffd78f564;http://pathwaycommons.org/pc12/Complex_7ce19e179684585ac557dffb61f6bb02;http://pathwaycommons.org/pc12/Complex_73a822be281ea321fb7bbc8d3b2e5b10 | |
| CHEBI:29108 chemical-affects VIM Reactome NA Striated Muscle Contraction http://pathwaycommons.org/pc12/Complex_5572a5174a9d18efce36e27aaa99379b;http://pathwaycommons.org/pc12/Complex_6bbb47dfe170d45fb7c5f551b0236ff6;http://pathwaycommons.org/pc12/Complex_271a84d7525562a9bf713bf88cf32945 | |
| CHEBI:29108 chemical-affects VWF Reactome 11833835;17506785;1930190;21932952;2384594;2502206;2505252;3082357;3134349;9459334;9469622 GRB2:SOS provides linkage to MAPK signaling for Integrins;Integrin alphaIIb beta3 signaling;Intrinsic Pathway of Fibrin Clot Formation;Platelet Aggregation (Plug Formation);p130Cas linkage to MAPK signaling for integrins http://identifiers.org/reactome/R-HSA-5607097;http://pathwaycommons.org/pc12/Complex_6c5ceab1ba2073e49cb1896a925dc573;http://pathwaycommons.org/pc12/Complex_2357686c4db0ca1c4d0ab9a210130449;http://pathwaycommons.org/pc12/Complex_16978f376c59bd9933e4875566f69baf;http://pathwaycommons.org/pc12/Complex_e139df10680005c824ee8a00c6551800;http://pathwaycommons.org/pc12/Complex_97a0978414a8036daa7bf22a7d04587e;http://identifiers.org/reactome/R-HSA-158137;http://identifiers.org/reactome/R-HSA-9015345;http://pathwaycommons.org/pc12/Catalysis_7ed7f71c5b59181addd9243e2c607d20;http://identifiers.org/reactome/R-HSA-5607784;http://pathwaycommons.org/pc12/Complex_23c4b5044f972d0062e4816c7ae0ad45 | |
| CHEBI:29108 chemical-affects WNT5A Reactome 12958364;17199046 WNT5A-dependent internalization of FZD4 http://identifiers.org/reactome/R-HSA-5138432;http://pathwaycommons.org/pc12/Catalysis_378d8b8a83ffcc6b7ad6194e098e558c | |
| CHEBI:29108 chemical-affects YWHAB Reactome 10205168;10712905;11032810;11325826;12244094;12551923;15035987;15710605;15899852;16093354;16364920;16508002;17018604;17097642;18294816;18662992;19158341;19933846;20130576;20141835;20179705;20820846;21779496;22043453;22510884;22592532;23680146;23993095;24202393;24957944;25435214;25907612;7542586;8876196;9020159;9234708;9823899 MAP2K and MAPK activation;Paradoxical activation of RAF signaling by kinase inactive BRAF;RAF activation;Signaling by RAS mutants;Signaling by moderate kinase activity BRAF mutants http://pathwaycommons.org/pc12/Catalysis_4b66558229db0440bcfbace623060ef0;http://pathwaycommons.org/pc12/Complex_99f08589f0e5024718269b930d0288e8;http://pathwaycommons.org/pc12/Complex_1c9f438d1db34b7384fdfa8bb13a2f0d;http://pathwaycommons.org/pc12/Complex_24eebdb420a48d1df31ce470b63917e2;http://pathwaycommons.org/pc12/Catalysis_d1076b99bcec87a38eaa26ff1c4a4070;http://pathwaycommons.org/pc12/Catalysis_fd9991c8fd61be157ed4b2e5be7acef9;http://pathwaycommons.org/pc12/Complex_a9afcce8661dd885cef40e47037a185f;http://pathwaycommons.org/pc12/Complex_411c1b271808c064387f09c3c20b6304;http://pathwaycommons.org/pc12/Complex_07bcf74dbac68a47917e1f7a40acd849;http://pathwaycommons.org/pc12/Complex_3adde65e3e4efaeeb03ad9e8acf79d2a;http://pathwaycommons.org/pc12/Complex_3811ddf05925c006e5b9ba92ef63ffad;http://identifiers.org/reactome/R-HSA-5672969;http://pathwaycommons.org/pc12/Catalysis_1c35b9ddce2a70d0629b481931d815c1;http://identifiers.org/reactome/R-HSA-6802941;http://identifiers.org/reactome/R-HSA-6802924;http://pathwaycommons.org/pc12/Complex_d7c23e33867ba9a0550337f60e5447f8;http://pathwaycommons.org/pc12/Complex_a02123277a4a9e4a0fdba06dcb2d40cd;http://pathwaycommons.org/pc12/Complex_c0cf37acbfc4c8467f39affddaced3ca;http://pathwaycommons.org/pc12/Complex_3fcbd062120dcb929eabeb6cba72d4c3;http://identifiers.org/reactome/R-HSA-6802916 | |
| CHEBI:29108 chemical-affects ZC3HAV1 Reactome 15630448;18974108;20526349;21424530;22745804;23583981;24135138;24345920;25204415;25907612 Signaling by BRAF and RAF fusions http://pathwaycommons.org/pc12/Catalysis_7870f4dfee733e1574c74fcf0ddeb17a;http://pathwaycommons.org/pc12/Complex_af6f85ce3ca6ae5425749e0d34973633;http://pathwaycommons.org/pc12/Complex_93560c0b5901f3f1fe00684940657329;http://pathwaycommons.org/pc12/Complex_8232bcba0e643f46caa0df357cb0d2d8;http://identifiers.org/reactome/R-HSA-6802927 | |
| ABI1 in-complex-with ACTB Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ABI1 in-complex-with ACTG1 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ABI2 in-complex-with ACTB Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ABI2 in-complex-with ACTG1 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| ACTN2 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ACTN2 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ACTN2 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-629595 | |
| AHCYL1 controls-state-change-of ACTA2 Reactome 11457814;12471263;15545263;16920709;1930128 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;DAG and IP3 signaling;FCERI mediated Ca+2 mobilization;Ion homeostasis;PLC beta mediated events;Regulation of insulin secretion;Role of phospholipids in phagocytosis;Smooth Muscle Contraction;VEGFR2 mediated cell proliferation http://identifiers.org/reactome/R-HSA-5674039;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://identifiers.org/reactome/R-HSA-4420052 | |
| AHCYL1 controls-state-change-of ACTG2 Reactome 11457814;12471263;15545263;16920709;1930128 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;DAG and IP3 signaling;FCERI mediated Ca+2 mobilization;Ion homeostasis;PLC beta mediated events;Regulation of insulin secretion;Role of phospholipids in phagocytosis;Smooth Muscle Contraction;VEGFR2 mediated cell proliferation http://identifiers.org/reactome/R-HSA-5674039;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://identifiers.org/reactome/R-HSA-4420052 | |
| AHCYL1 controls-transport-of-chemical CHEBI:29108 Reactome 12471263;15545263;16920709 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;DAG and IP3 signaling;FCERI mediated Ca+2 mobilization;Ion homeostasis;PLC beta mediated events;Regulation of insulin secretion;Role of phospholipids in phagocytosis;VEGFR2 mediated cell proliferation http://identifiers.org/reactome/R-HSA-5674039;http://identifiers.org/reactome/R-HSA-4420052 | |
| AKAP1 controls-state-change-of ACTA2 Reactome 11457814;1930128 Mitochondrial calcium ion transport;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a7e25bd4a8020bfe8225a8cef4b1d630;http://identifiers.org/reactome/R-HSA-8949703;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| AKAP1 controls-state-change-of ACTG2 Reactome 11457814;1930128 Mitochondrial calcium ion transport;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a7e25bd4a8020bfe8225a8cef4b1d630;http://identifiers.org/reactome/R-HSA-8949703;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| AKAP1 controls-transport-of-chemical CHEBI:29108 Reactome NA Mitochondrial calcium ion transport http://pathwaycommons.org/pc12/Catalysis_a7e25bd4a8020bfe8225a8cef4b1d630;http://identifiers.org/reactome/R-HSA-8949703 | |
| APP controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://identifiers.org/reactome/R-HSA-8867561;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| APP controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://identifiers.org/reactome/R-HSA-8867561;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| APP controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://identifiers.org/reactome/R-HSA-8867561 | |
| ASPH controls-state-change-of ACTA2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ASPH controls-state-change-of ACTG2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ASPH controls-transport-of-chemical CHEBI:29108 Reactome 10830164;15050380;15147738;15916532;17699613;17881003;19278523;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Stimuli-sensing channels http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020 | |
| ATP2A1 controls-transport-of-chemical CHEBI:29108 Reactome 12167852;15754088;23362265;2844796;2953725;7702581;7929371 Ion homeostasis;Ion transport by P-type ATPases;Reduction of cytosolic Ca++ levels http://identifiers.org/reactome/R-HSA-427910;http://pathwaycommons.org/pc12/Catalysis_9d1a2c5f8f6a62bfea159d7619cf50b5;http://pathwaycommons.org/pc12/Catalysis_6ef6c9de60c754e52849eabb8c7410ce;http://identifiers.org/reactome/R-HSA-418365 | |
| ATP2A2 controls-transport-of-chemical CHEBI:29108 Reactome 12167852;15754088;23362265;2844796;2953725;7702581;7929371 Ion homeostasis;Ion transport by P-type ATPases;Reduction of cytosolic Ca++ levels http://identifiers.org/reactome/R-HSA-427910;http://pathwaycommons.org/pc12/Catalysis_9d1a2c5f8f6a62bfea159d7619cf50b5;http://pathwaycommons.org/pc12/Catalysis_6ef6c9de60c754e52849eabb8c7410ce;http://identifiers.org/reactome/R-HSA-418365 | |
| ATP2A3 controls-transport-of-chemical CHEBI:29108 Reactome 12167852;15754088;23362265;2844796;2953725;7702581;7929371 Ion homeostasis;Ion transport by P-type ATPases;Reduction of cytosolic Ca++ levels http://identifiers.org/reactome/R-HSA-427910;http://pathwaycommons.org/pc12/Catalysis_9d1a2c5f8f6a62bfea159d7619cf50b5;http://pathwaycommons.org/pc12/Catalysis_6ef6c9de60c754e52849eabb8c7410ce;http://identifiers.org/reactome/R-HSA-418365 | |
| ATP2B1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_8d9d0776e7bc6e148c2a1703b68f7b18;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ATP2B1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_8d9d0776e7bc6e148c2a1703b68f7b18;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ATP2B1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_8d9d0776e7bc6e148c2a1703b68f7b18 | |
| ATP2B2 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_8d9d0776e7bc6e148c2a1703b68f7b18;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ATP2B2 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_8d9d0776e7bc6e148c2a1703b68f7b18;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ATP2B2 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_8d9d0776e7bc6e148c2a1703b68f7b18 | |
| ATP2B3 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_8d9d0776e7bc6e148c2a1703b68f7b18;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ATP2B3 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_8d9d0776e7bc6e148c2a1703b68f7b18;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ATP2B3 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_8d9d0776e7bc6e148c2a1703b68f7b18 | |
| ATP2B4 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_8d9d0776e7bc6e148c2a1703b68f7b18;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ATP2B4 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_8d9d0776e7bc6e148c2a1703b68f7b18;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ATP2B4 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_8d9d0776e7bc6e148c2a1703b68f7b18 | |
| ATP2C1 controls-transport-of-chemical CHEBI:29108 Reactome 10615129;10767338;15831496 Ion transport by P-type ATPases http://pathwaycommons.org/pc12/Catalysis_3ece30f6651d46467103b353240113c0;http://identifiers.org/reactome/R-HSA-936883 | |
| ATP2C2 controls-transport-of-chemical CHEBI:29108 Reactome 10615129;10767338;15831496 Ion transport by P-type ATPases http://pathwaycommons.org/pc12/Catalysis_3ece30f6651d46467103b353240113c0;http://identifiers.org/reactome/R-HSA-936883 | |
| CACFD1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_1f5c0f996c8f9e02f43320c1e09182c3;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACFD1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_1f5c0f996c8f9e02f43320c1e09182c3;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACFD1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_1f5c0f996c8f9e02f43320c1e09182c3;http://identifiers.org/reactome/R-HSA-629595 | |
| CACNA1A controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA1A controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA1A controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb | |
| CACNA1B controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA1B controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA1B controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb | |
| CACNA1C controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA1C controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA1C controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815450;11815460;11815462;11815463;11816716;11873862;12172541;12403834;12521992;12684222;12810063;12815021;12887316;12913094;1309948;14514350;15000524;15000528;15087444;15504896;15572341;15585596;15590058;15709690;16368572;16443778;16513675;16714477;16868246;17224452;17227845;17486119;17660294;17900700;18162464;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;7641683;8107964;8782898;8825650;8997178;9565569;9625352;9914469 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-265166;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://identifiers.org/reactome/R-HSA-741369;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e | |
| CACNA1D controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA1D controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA1D controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815450;11815460;11815462;11815463;11816716;11873862;12172541;12403834;12521992;12684222;12810063;12815021;12887316;12913094;1309948;14514350;15000524;15000528;15087444;15504896;15572341;15585596;15590058;15709690;16368572;16443778;16513675;16714477;16868246;17224452;17227845;17486119;17660294;17900700;18162464;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;7641683;8107964;8782898;8825650;8997178;9565569;9625352;9914469 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-265166;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://identifiers.org/reactome/R-HSA-741369;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e | |
| CACNA1E controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA1E controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA1E controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb | |
| CACNA1F controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA1F controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA1F controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595 | |
| CACNA1S controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA1S controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA1S controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595 | |
| CACNA2D1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA2D1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA2D1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595 | |
| CACNA2D2 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA2D2 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA2D2 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815450;11815460;11815462;11815463;11816716;11873862;12172541;12403834;12521992;12684222;12810063;12815021;12887316;12913094;1309948;14514350;15000524;15000528;15087444;15504896;15572341;15585596;15590058;15709690;16368572;16443778;16513675;16714477;16868246;17224452;17227845;17486119;17660294;17900700;18162464;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;7641683;8107964;8782898;8825650;8997178;9565569;9625352;9914469 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-265166;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://identifiers.org/reactome/R-HSA-741369;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb | |
| CACNA2D3 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA2D3 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA2D3 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb | |
| CACNA2D4 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA2D4 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNA2D4 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595 | |
| CACNB1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNB1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNB1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb | |
| CACNB2 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNB2 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNB2 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815450;11815460;11815462;11815463;11816716;11873862;12172541;12403834;12521992;12684222;12810063;12815021;12887316;12913094;1309948;14514350;15000524;15000528;15087444;15504896;15572341;15585596;15590058;15709690;16368572;16443778;16513675;16714477;16868246;17224452;17227845;17486119;17660294;17900700;18162464;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;7641683;8107964;8782898;8825650;8997178;9565569;9625352;9914469 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-265166;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://identifiers.org/reactome/R-HSA-741369;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb | |
| CACNB3 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNB3 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNB3 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815450;11815460;11815462;11815463;11816716;11873862;12172541;12403834;12521992;12684222;12810063;12815021;12887316;12913094;1309948;14514350;15000524;15000528;15087444;15504896;15572341;15585596;15590058;15709690;16368572;16443778;16513675;16714477;16868246;17224452;17227845;17486119;17660294;17900700;18162464;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;7641683;8107964;8782898;8825650;8997178;9565569;9625352;9914469 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-265166;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://identifiers.org/reactome/R-HSA-741369;http://pathwaycommons.org/pc12/Catalysis_20ad5f2ef76f32f85ae310b43669c01e;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb | |
| CACNB4 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNB4 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNB4 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb | |
| CACNG1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595 | |
| CACNG2 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG2 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG2 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb | |
| CACNG3 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG3 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG3 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595 | |
| CACNG4 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG4 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG4 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_1822b9152cf45e18ea896252785020cb | |
| CACNG5 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG5 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG5 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595 | |
| CACNG6 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG6 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG6 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595 | |
| CACNG7 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG7 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG7 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595 | |
| CACNG8 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG8 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CACNG8 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Control_c7b86ecce9cc3a7cccaa2c724d98bcf2;http://identifiers.org/reactome/R-HSA-8943668;http://pathwaycommons.org/pc12/Catalysis_9bc82cb742b5df69a77a958402317d09;http://identifiers.org/reactome/R-HSA-629595 | |
| CALM1 controls-state-change-of ACTA2 Reactome 10424882;10830164;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15050380;15087444;15147738;15504896;15585596;15590058;15709690;15916532;16368572;16513675;16868246;17224452;17227845;17486119;17660294;17699613;17881003;18769136;18995841;19118095;19278523;1930128;19434403;19737521;20025796;20388639;20648059;20716668;20961976;21412339;22054663;22210847;22343826;22510460;2298749;2321095;23530196;2457808;2536303;2844759;5961668;6218823;7588753;8107964;8782898;8809036;8825650;9395096;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;Stimuli-sensing channels;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-6809103;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CALM1 controls-state-change-of ACTG2 Reactome 10424882;10830164;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15050380;15087444;15147738;15504896;15585596;15590058;15709690;15916532;16368572;16513675;16868246;17224452;17227845;17486119;17660294;17699613;17881003;18769136;18995841;19118095;19278523;1930128;19434403;19737521;20025796;20388639;20648059;20716668;20961976;21412339;22054663;22210847;22343826;22510460;2298749;2321095;23530196;2457808;2536303;2844759;5961668;6218823;7588753;8107964;8782898;8809036;8825650;9395096;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;Stimuli-sensing channels;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-6809103;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CALM1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830164;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12167852;12172541;12406570;12521992;12810063;12815021;12913094;1309948;1374913;15000524;15000528;15050380;15087444;15147738;15504896;15585596;15590058;15709690;15754088;15916532;16368572;16513675;16868246;17224452;17227845;17486119;17660294;17699613;17881003;18769136;18995841;19118095;19278523;19434403;19737521;20025796;20298697;20388639;20648059;20716668;20961976;21412339;22054663;22210847;22343826;22510460;2298749;2321095;23362265;23530196;2457808;25303525;2536303;26421717;2844759;2844796;2953725;29934532;5961668;6218823;7588753;7702581;7929371;8021246;8107964;8782898;8809036;8825650;9395096;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CaMK IV-mediated phosphorylation of CREB;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sodium/Calcium exchangers;Sperm Motility And Taxes;Stimuli-sensing channels;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-6809103;http://identifiers.org/reactome/R-HSA-629595;http://identifiers.org/reactome/R-HSA-427910;http://identifiers.org/reactome/R-HSA-2855020;http://identifiers.org/reactome/R-HSA-6809095;http://identifiers.org/reactome/R-HSA-425661;http://identifiers.org/reactome/R-HSA-6809098;http://pathwaycommons.org/pc12/Control_656defa0440dd838b21dca1ca1196c61;http://identifiers.org/reactome/R-HSA-444792 | |
| CAMK2A controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CAMK2A controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CAMK2A controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12167852;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;15754088;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23362265;23530196;2457808;2844759;2844796;2953725;5961668;6218823;7702581;7929371;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-427910;http://identifiers.org/reactome/R-HSA-629595;http://identifiers.org/reactome/R-HSA-6809098 | |
| CAMK2B controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CAMK2B controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CAMK2B controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12167852;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;15754088;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23362265;23530196;2457808;25303525;2844759;2844796;2953725;29934532;5961668;6218823;7702581;7929371;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde;CaMK IV-mediated phosphorylation of CREB;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-427910;http://identifiers.org/reactome/R-HSA-629595;http://identifiers.org/reactome/R-HSA-6809098;http://pathwaycommons.org/pc12/Control_656defa0440dd838b21dca1ca1196c61;http://identifiers.org/reactome/R-HSA-444792 | |
| CAMK2D controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CAMK2D controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CAMK2D controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12167852;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;15754088;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23362265;23530196;2457808;2844759;2844796;2953725;5961668;6218823;7702581;7929371;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-629595;http://identifiers.org/reactome/R-HSA-427910;http://identifiers.org/reactome/R-HSA-6809098 | |
| CAMK2G controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CAMK2G controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CAMK2G controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12167852;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;15754088;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23362265;23530196;2457808;2844759;2844796;2953725;5961668;6218823;7702581;7929371;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-629595;http://identifiers.org/reactome/R-HSA-427910;http://identifiers.org/reactome/R-HSA-6809098 | |
| CATSPER1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CATSPER1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CATSPER1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595 | |
| CATSPER2 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CATSPER2 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CATSPER2 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595 | |
| CATSPER3 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CATSPER3 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CATSPER3 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595 | |
| CATSPER4 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CATSPER4 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CATSPER4 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595 | |
| CATSPERB controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CATSPERB controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CATSPERB controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595 | |
| CATSPERD controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CATSPERD controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CATSPERD controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595 | |
| CATSPERG controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CATSPERG controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CATSPERG controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_a9ec5a165483837f5cf4721a472d84c4;http://identifiers.org/reactome/R-HSA-629595 | |
| CHEBI:15351 consumption-controlled-by ACTB Reactome 10966108;12963728;14966270;15647280 HATs acetylate histones http://pathwaycommons.org/pc12/Catalysis_7f68500391e54c06c505b2b34d6b8427;http://identifiers.org/reactome/R-HSA-3321975 | |
| CHEBI:16618 chemical-affects ACTB Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| CHEBI:16618 chemical-affects ACTG1 Reactome NA RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82 | |
| CHEBI:18348 chemical-affects ACTB Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| CHEBI:18348 chemical-affects ACTG1 Reactome NA EPHB-mediated forward signaling;RHO GTPases Activate WASPs and WAVEs;Regulation of actin dynamics for phagocytic cup formation http://pathwaycommons.org/pc12/Complex_081b3c49ced46754e779b8bfc942fd82;http://pathwaycommons.org/pc12/Complex_7b9eff3445700d38e00947ce7e382bfa | |
| CHEBI:29101 reacts-with CHEBI:29108 Reactome 20850105;23010199;23364476;23375655;24621671 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D);Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI);Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) http://identifiers.org/reactome/R-HSA-5626356;http://identifiers.org/reactome/R-HSA-5625841;http://identifiers.org/reactome/R-HSA-5626270 | |
| CHEBI:29103 reacts-with CHEBI:29108 Reactome 20850105;23010199;23364476;23375655;24621671 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D);Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI);Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) http://identifiers.org/reactome/R-HSA-5626356;http://identifiers.org/reactome/R-HSA-5625841;http://identifiers.org/reactome/R-HSA-5626270 | |
| CHRNA1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6 | |
| CHRNA2 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA2 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA2 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6 | |
| CHRNA3 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA3 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA3 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6 | |
| CHRNA4 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA4 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA4 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6 | |
| CHRNA5 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA5 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA5 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6 | |
| CHRNA6 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA6 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA6 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6 | |
| CHRNA7 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA7 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA7 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6 | |
| CHRNA9 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA9 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNA9 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6 | |
| CHRNB2 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNB2 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNB2 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6 | |
| CHRNB3 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNB3 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNB3 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6 | |
| CHRNB4 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNB4 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CHRNB4 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_d556c2b797bcd5eafae46b32bb627729;http://pathwaycommons.org/pc12/Catalysis_3fb395b3a21a35f7c45edbac088c88d6 | |
| CLIC2 controls-state-change-of ACTA2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-2855180;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CLIC2 controls-state-change-of ACTG2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-2855180;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| CLIC2 controls-transport-of-chemical CHEBI:29108 Reactome 10830164;15050380;15147738;15916532;17699613;17881003;19278523;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-2855180;http://identifiers.org/reactome/R-HSA-2855020 | |
| CNGA1 controls-state-change-of ACTA2 Reactome 11457814;12432397;12467591;12467592;1379636;16460277;1930128;2422346;2457685;2578616;7682292 Activation of the phototransduction cascade;Smooth Muscle Contraction http://pathwaycommons.org/pc12/Catalysis_d8efdc930b0afe7fd5d0324d0bbb2553;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://identifiers.org/reactome/R-HSA-2514867 | |
| CNGA1 controls-state-change-of ACTG2 Reactome 11457814;12432397;12467591;12467592;1379636;16460277;1930128;2422346;2457685;2578616;7682292 Activation of the phototransduction cascade;Smooth Muscle Contraction http://pathwaycommons.org/pc12/Catalysis_d8efdc930b0afe7fd5d0324d0bbb2553;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://identifiers.org/reactome/R-HSA-2514867 | |
| CNGA1 controls-transport-of-chemical CHEBI:29108 Reactome 12432397;12467591;12467592;1379636;16460277;2422346;2457685;2578616;7682292 Activation of the phototransduction cascade http://pathwaycommons.org/pc12/Catalysis_d8efdc930b0afe7fd5d0324d0bbb2553;http://identifiers.org/reactome/R-HSA-2514867 | |
| CNGB1 controls-state-change-of ACTA2 Reactome 11457814;12432397;12467591;12467592;1379636;16460277;1930128;2422346;2457685;2578616;7682292 Activation of the phototransduction cascade;Smooth Muscle Contraction http://pathwaycommons.org/pc12/Catalysis_d8efdc930b0afe7fd5d0324d0bbb2553;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://identifiers.org/reactome/R-HSA-2514867 | |
| CNGB1 controls-state-change-of ACTG2 Reactome 11457814;12432397;12467591;12467592;1379636;16460277;1930128;2422346;2457685;2578616;7682292 Activation of the phototransduction cascade;Smooth Muscle Contraction http://pathwaycommons.org/pc12/Catalysis_d8efdc930b0afe7fd5d0324d0bbb2553;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://identifiers.org/reactome/R-HSA-2514867 | |
| CNGB1 controls-transport-of-chemical CHEBI:29108 Reactome 12432397;12467591;12467592;1379636;16460277;2422346;2457685;2578616;7682292 Activation of the phototransduction cascade http://pathwaycommons.org/pc12/Catalysis_d8efdc930b0afe7fd5d0324d0bbb2553;http://identifiers.org/reactome/R-HSA-2514867 | |
| CREBBP controls-expression-of ACTA2 Reactome 18239137 NOTCH4 Intracellular Domain Regulates Transcription http://pathwaycommons.org/pc12/Control_881743f59f5b5059282f7b8b346e4bf2;http://identifiers.org/reactome/R-HSA-9604664 | |
| DLG1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| DLG1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| DLG1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-629595 | |
| DLG2 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| DLG2 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| DLG2 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-629595 | |
| DLG3 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| DLG3 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| DLG3 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-629595 | |
| DLG4 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| DLG4 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| DLG4 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-629595 | |
| EP300 controls-expression-of ACTA2 Reactome 18239137 NOTCH4 Intracellular Domain Regulates Transcription http://pathwaycommons.org/pc12/Control_881743f59f5b5059282f7b8b346e4bf2;http://identifiers.org/reactome/R-HSA-9604664 | |
| F10 controls-production-of CHEBI:29108 Reactome 14982929;16161994;19170587;19297154;21434944;21830957;23683607;24385535;24455237;24554904;25352938;25855704;26780737;3052293 Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-140700;http://identifiers.org/reactome/R-HSA-9015052;http://identifiers.org/reactome/R-HSA-9015053;http://pathwaycommons.org/pc12/Catalysis_6d38755eb412c0c8b0deebfecee03ae6;http://pathwaycommons.org/pc12/Catalysis_2e668f8cc64372c032f5ebd6e16d32fd | |
| F2 controls-production-of CHEBI:29108 Reactome 14982929;2538457;468991 Cell surface interactions at the vascular wall;Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-5607095;http://identifiers.org/reactome/R-HSA-140696;http://pathwaycommons.org/pc12/Catalysis_83a26e2011459cc136d07b3cc5fada26;http://pathwaycommons.org/pc12/Catalysis_b8bd2880463202b778105e4a54a7c390;http://identifiers.org/reactome/R-HSA-5607785;http://identifiers.org/reactome/R-HSA-141040 | |
| F3 controls-production-of CHEBI:29108 Reactome 3275472;3527261;6980899 Extrinsic Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-140777;http://pathwaycommons.org/pc12/Catalysis_dcec3acda3c6c958349ce5d4887a7f31 | |
| F5 controls-production-of CHEBI:29108 Reactome 14982929;16161994;19170587;19297154;21434944;21830957;23683607;24385535;24455237;24554904;25352938;25855704;26780737;3052293 Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-140700;http://identifiers.org/reactome/R-HSA-9015053;http://pathwaycommons.org/pc12/Catalysis_2e668f8cc64372c032f5ebd6e16d32fd | |
| F7 controls-production-of CHEBI:29108 Reactome 3275472;3527261;6980899 Extrinsic Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-140777;http://pathwaycommons.org/pc12/Catalysis_dcec3acda3c6c958349ce5d4887a7f31 | |
| FKBP1B controls-state-change-of ACTA2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| FKBP1B controls-state-change-of ACTG2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| FKBP1B controls-transport-of-chemical CHEBI:29108 Reactome 10830164;15050380;15147738;15916532;17699613;17881003;19278523;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Stimuli-sensing channels http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020 | |
| GNAI1 controls-transport-of-chemical CHEBI:29108 Reactome 11815450;11815463;11873862;12403834;12684222;12887316;14514350;15572341;16443778;16714477;17900700;18162464;7641683;8997178;9914469 Regulation of insulin secretion http://identifiers.org/reactome/R-HSA-265166;http://identifiers.org/reactome/R-HSA-422251 | |
| GNAI2 controls-transport-of-chemical CHEBI:29108 Reactome 11815450;11815463;11873862;12403834;12684222;12887316;14514350;15572341;16443778;16714477;17900700;18162464;7641683;8997178;9914469 Regulation of insulin secretion http://identifiers.org/reactome/R-HSA-265166;http://identifiers.org/reactome/R-HSA-422251 | |
| GRIA1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://pathwaycommons.org/pc12/Catalysis_9f3b7dd7c03f33dee8e6b73b3870d8da | |
| GRIA1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://pathwaycommons.org/pc12/Catalysis_9f3b7dd7c03f33dee8e6b73b3870d8da | |
| GRIA1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_9f3b7dd7c03f33dee8e6b73b3870d8da | |
| GRIA3 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://pathwaycommons.org/pc12/Catalysis_9f3b7dd7c03f33dee8e6b73b3870d8da | |
| GRIA3 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://pathwaycommons.org/pc12/Catalysis_9f3b7dd7c03f33dee8e6b73b3870d8da | |
| GRIA3 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_9f3b7dd7c03f33dee8e6b73b3870d8da | |
| GRIA4 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://pathwaycommons.org/pc12/Catalysis_9f3b7dd7c03f33dee8e6b73b3870d8da | |
| GRIA4 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://pathwaycommons.org/pc12/Catalysis_9f3b7dd7c03f33dee8e6b73b3870d8da | |
| GRIA4 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_9f3b7dd7c03f33dee8e6b73b3870d8da | |
| GRIK1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIK1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIK1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-629595 | |
| GRIK2 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIK2 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIK2 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-629595 | |
| GRIK3 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIK3 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIK3 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-629595 | |
| GRIK4 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIK4 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIK4 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-629595 | |
| GRIK5 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIK5 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIK5 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-629595 | |
| GRIN1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIN1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIN1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-629595 | |
| GRIN2A controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIN2A controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIN2A controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-629595 | |
| GRIN2B controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIN2B controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIN2B controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-629595 | |
| GRIN2C controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIN2C controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIN2C controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-629595 | |
| GRIN2D controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIN2D controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| GRIN2D controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-629595 | |
| GSK3B controls-state-change-of ACTB Reactome 15558034;16514417;16603771;21559432;23555303;24901984;24952918 B-WICH complex positively regulates rRNA expression http://identifiers.org/reactome/R-HSA-5250947;http://identifiers.org/reactome/R-HSA-6808617 | |
| HTR3A controls-state-change-of ACTA2 Reactome 11457814;16116092;17392525;18761359;1930128;26238288;7565620;9950429 Neurotransmitter receptors and postsynaptic signal transmission;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-975311;http://pathwaycommons.org/pc12/Catalysis_ed2c335b2fb0320dda2aefe1705ec17f;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| HTR3A controls-state-change-of ACTG2 Reactome 11457814;16116092;17392525;18761359;1930128;26238288;7565620;9950429 Neurotransmitter receptors and postsynaptic signal transmission;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-975311;http://pathwaycommons.org/pc12/Catalysis_ed2c335b2fb0320dda2aefe1705ec17f;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| HTR3A controls-transport-of-chemical CHEBI:29108 Reactome 16116092;17392525;18761359;26238288;7565620;9950429 Neurotransmitter receptors and postsynaptic signal transmission http://identifiers.org/reactome/R-HSA-975311;http://pathwaycommons.org/pc12/Catalysis_ed2c335b2fb0320dda2aefe1705ec17f | |
| HTR3B controls-state-change-of ACTA2 Reactome 11457814;16116092;17392525;18761359;1930128;26238288;7565620;9950429 Neurotransmitter receptors and postsynaptic signal transmission;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-975311;http://pathwaycommons.org/pc12/Catalysis_ed2c335b2fb0320dda2aefe1705ec17f;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| HTR3B controls-state-change-of ACTG2 Reactome 11457814;16116092;17392525;18761359;1930128;26238288;7565620;9950429 Neurotransmitter receptors and postsynaptic signal transmission;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-975311;http://pathwaycommons.org/pc12/Catalysis_ed2c335b2fb0320dda2aefe1705ec17f;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| HTR3B controls-transport-of-chemical CHEBI:29108 Reactome 16116092;17392525;18761359;26238288;7565620;9950429 Neurotransmitter receptors and postsynaptic signal transmission http://identifiers.org/reactome/R-HSA-975311;http://pathwaycommons.org/pc12/Catalysis_ed2c335b2fb0320dda2aefe1705ec17f | |
| HTR3C controls-state-change-of ACTA2 Reactome 11457814;16116092;17392525;18761359;1930128;26238288;7565620;9950429 Neurotransmitter receptors and postsynaptic signal transmission;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-975311;http://pathwaycommons.org/pc12/Catalysis_ed2c335b2fb0320dda2aefe1705ec17f;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| HTR3C controls-state-change-of ACTG2 Reactome 11457814;16116092;17392525;18761359;1930128;26238288;7565620;9950429 Neurotransmitter receptors and postsynaptic signal transmission;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-975311;http://pathwaycommons.org/pc12/Catalysis_ed2c335b2fb0320dda2aefe1705ec17f;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| HTR3C controls-transport-of-chemical CHEBI:29108 Reactome 16116092;17392525;18761359;26238288;7565620;9950429 Neurotransmitter receptors and postsynaptic signal transmission http://identifiers.org/reactome/R-HSA-975311;http://pathwaycommons.org/pc12/Catalysis_ed2c335b2fb0320dda2aefe1705ec17f | |
| HTR3D controls-state-change-of ACTA2 Reactome 11457814;16116092;17392525;18761359;1930128;26238288;7565620;9950429 Neurotransmitter receptors and postsynaptic signal transmission;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-975311;http://pathwaycommons.org/pc12/Catalysis_ed2c335b2fb0320dda2aefe1705ec17f;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| HTR3D controls-state-change-of ACTG2 Reactome 11457814;16116092;17392525;18761359;1930128;26238288;7565620;9950429 Neurotransmitter receptors and postsynaptic signal transmission;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-975311;http://pathwaycommons.org/pc12/Catalysis_ed2c335b2fb0320dda2aefe1705ec17f;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| HTR3D controls-transport-of-chemical CHEBI:29108 Reactome 16116092;17392525;18761359;26238288;7565620;9950429 Neurotransmitter receptors and postsynaptic signal transmission http://identifiers.org/reactome/R-HSA-975311;http://pathwaycommons.org/pc12/Catalysis_ed2c335b2fb0320dda2aefe1705ec17f | |
| HTR3E controls-state-change-of ACTA2 Reactome 11457814;16116092;17392525;18761359;1930128;26238288;7565620;9950429 Neurotransmitter receptors and postsynaptic signal transmission;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-975311;http://pathwaycommons.org/pc12/Catalysis_ed2c335b2fb0320dda2aefe1705ec17f;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| HTR3E controls-state-change-of ACTG2 Reactome 11457814;16116092;17392525;18761359;1930128;26238288;7565620;9950429 Neurotransmitter receptors and postsynaptic signal transmission;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-975311;http://pathwaycommons.org/pc12/Catalysis_ed2c335b2fb0320dda2aefe1705ec17f;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| HTR3E controls-transport-of-chemical CHEBI:29108 Reactome 16116092;17392525;18761359;26238288;7565620;9950429 Neurotransmitter receptors and postsynaptic signal transmission http://identifiers.org/reactome/R-HSA-975311;http://pathwaycommons.org/pc12/Catalysis_ed2c335b2fb0320dda2aefe1705ec17f | |
| ITPR1 controls-state-change-of ACTA2 Reactome 11413485;11457814;12471263;15545263;16920709;1693919;17429043;18187424;18596693;19249086;1930128 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;DAG and IP3 signaling;Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;FCERI mediated Ca+2 mobilization;Ion homeostasis;PLC beta mediated events;Regulation of insulin secretion;Role of phospholipids in phagocytosis;Smooth Muscle Contraction;VEGFR2 mediated cell proliferation http://pathwaycommons.org/pc12/Catalysis_7e94d05f030c82da4ce4ef9dc7ef2425;http://identifiers.org/reactome/R-HSA-5674039;http://identifiers.org/reactome/R-HSA-139854;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_0cb7806bfe4840b361ee5d6505e86dea;http://pathwaycommons.org/pc12/Catalysis_35252f8f2924ee213ffac283fa8f09bb;http://pathwaycommons.org/pc12/Catalysis_4120a5df32986e95ef3dd645c388ad29;http://identifiers.org/reactome/R-HSA-1168376;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://identifiers.org/reactome/R-HSA-4420052 | |
| ITPR1 controls-state-change-of ACTG2 Reactome 11413485;11457814;12471263;15545263;16920709;1693919;17429043;18187424;18596693;19249086;1930128 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;DAG and IP3 signaling;Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;FCERI mediated Ca+2 mobilization;Ion homeostasis;PLC beta mediated events;Regulation of insulin secretion;Role of phospholipids in phagocytosis;Smooth Muscle Contraction;VEGFR2 mediated cell proliferation http://pathwaycommons.org/pc12/Catalysis_7e94d05f030c82da4ce4ef9dc7ef2425;http://identifiers.org/reactome/R-HSA-5674039;http://identifiers.org/reactome/R-HSA-139854;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_0cb7806bfe4840b361ee5d6505e86dea;http://pathwaycommons.org/pc12/Catalysis_35252f8f2924ee213ffac283fa8f09bb;http://pathwaycommons.org/pc12/Catalysis_4120a5df32986e95ef3dd645c388ad29;http://identifiers.org/reactome/R-HSA-1168376;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://identifiers.org/reactome/R-HSA-4420052 | |
| ITPR1 controls-transport-of-chemical CHEBI:29108 Reactome 11413485;12471263;15545263;16920709;1693919;17429043;18187424;18596693;19249086 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;DAG and IP3 signaling;Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;FCERI mediated Ca+2 mobilization;Ion homeostasis;PLC beta mediated events;Regulation of insulin secretion;Role of phospholipids in phagocytosis;VEGFR2 mediated cell proliferation http://identifiers.org/reactome/R-HSA-139854;http://pathwaycommons.org/pc12/Catalysis_7e94d05f030c82da4ce4ef9dc7ef2425;http://identifiers.org/reactome/R-HSA-5674039;http://pathwaycommons.org/pc12/Catalysis_0cb7806bfe4840b361ee5d6505e86dea;http://pathwaycommons.org/pc12/Catalysis_35252f8f2924ee213ffac283fa8f09bb;http://pathwaycommons.org/pc12/Catalysis_4120a5df32986e95ef3dd645c388ad29;http://identifiers.org/reactome/R-HSA-1168376;http://identifiers.org/reactome/R-HSA-4420052 | |
| ITPR2 controls-state-change-of ACTA2 Reactome 11413485;11457814;12471263;15545263;16920709;1693919;17429043;18187424;18596693;19249086;1930128 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;DAG and IP3 signaling;Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;FCERI mediated Ca+2 mobilization;Ion homeostasis;PLC beta mediated events;Regulation of insulin secretion;Role of phospholipids in phagocytosis;Smooth Muscle Contraction;VEGFR2 mediated cell proliferation http://pathwaycommons.org/pc12/Catalysis_7e94d05f030c82da4ce4ef9dc7ef2425;http://identifiers.org/reactome/R-HSA-5674039;http://identifiers.org/reactome/R-HSA-139854;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_0cb7806bfe4840b361ee5d6505e86dea;http://pathwaycommons.org/pc12/Catalysis_35252f8f2924ee213ffac283fa8f09bb;http://pathwaycommons.org/pc12/Catalysis_4120a5df32986e95ef3dd645c388ad29;http://identifiers.org/reactome/R-HSA-1168376;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://identifiers.org/reactome/R-HSA-4420052 | |
| ITPR2 controls-state-change-of ACTG2 Reactome 11413485;11457814;12471263;15545263;16920709;1693919;17429043;18187424;18596693;19249086;1930128 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;DAG and IP3 signaling;Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;FCERI mediated Ca+2 mobilization;Ion homeostasis;PLC beta mediated events;Regulation of insulin secretion;Role of phospholipids in phagocytosis;Smooth Muscle Contraction;VEGFR2 mediated cell proliferation http://pathwaycommons.org/pc12/Catalysis_7e94d05f030c82da4ce4ef9dc7ef2425;http://identifiers.org/reactome/R-HSA-5674039;http://identifiers.org/reactome/R-HSA-139854;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_0cb7806bfe4840b361ee5d6505e86dea;http://pathwaycommons.org/pc12/Catalysis_35252f8f2924ee213ffac283fa8f09bb;http://pathwaycommons.org/pc12/Catalysis_4120a5df32986e95ef3dd645c388ad29;http://identifiers.org/reactome/R-HSA-1168376;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://identifiers.org/reactome/R-HSA-4420052 | |
| ITPR2 controls-transport-of-chemical CHEBI:29108 Reactome 11413485;12471263;15545263;16920709;1693919;17429043;18187424;18596693;19249086 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;DAG and IP3 signaling;Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;FCERI mediated Ca+2 mobilization;Ion homeostasis;PLC beta mediated events;Regulation of insulin secretion;Role of phospholipids in phagocytosis;VEGFR2 mediated cell proliferation http://identifiers.org/reactome/R-HSA-139854;http://pathwaycommons.org/pc12/Catalysis_7e94d05f030c82da4ce4ef9dc7ef2425;http://identifiers.org/reactome/R-HSA-5674039;http://pathwaycommons.org/pc12/Catalysis_0cb7806bfe4840b361ee5d6505e86dea;http://pathwaycommons.org/pc12/Catalysis_35252f8f2924ee213ffac283fa8f09bb;http://pathwaycommons.org/pc12/Catalysis_4120a5df32986e95ef3dd645c388ad29;http://identifiers.org/reactome/R-HSA-1168376;http://identifiers.org/reactome/R-HSA-4420052 | |
| ITPR3 controls-state-change-of ACTA2 Reactome 11413485;11457814;12471263;15545263;16920709;1693919;17429043;18187424;18596693;19249086;1930128 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;DAG and IP3 signaling;Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;FCERI mediated Ca+2 mobilization;Ion homeostasis;PLC beta mediated events;Regulation of insulin secretion;Role of phospholipids in phagocytosis;Smooth Muscle Contraction;VEGFR2 mediated cell proliferation http://pathwaycommons.org/pc12/Catalysis_7e94d05f030c82da4ce4ef9dc7ef2425;http://identifiers.org/reactome/R-HSA-5674039;http://identifiers.org/reactome/R-HSA-139854;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_0cb7806bfe4840b361ee5d6505e86dea;http://pathwaycommons.org/pc12/Catalysis_35252f8f2924ee213ffac283fa8f09bb;http://pathwaycommons.org/pc12/Catalysis_4120a5df32986e95ef3dd645c388ad29;http://identifiers.org/reactome/R-HSA-1168376;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://identifiers.org/reactome/R-HSA-4420052 | |
| ITPR3 controls-state-change-of ACTG2 Reactome 11413485;11457814;12471263;15545263;16920709;1693919;17429043;18187424;18596693;19249086;1930128 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;DAG and IP3 signaling;Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;FCERI mediated Ca+2 mobilization;Ion homeostasis;PLC beta mediated events;Regulation of insulin secretion;Role of phospholipids in phagocytosis;Smooth Muscle Contraction;VEGFR2 mediated cell proliferation http://pathwaycommons.org/pc12/Catalysis_7e94d05f030c82da4ce4ef9dc7ef2425;http://identifiers.org/reactome/R-HSA-5674039;http://identifiers.org/reactome/R-HSA-139854;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_0cb7806bfe4840b361ee5d6505e86dea;http://pathwaycommons.org/pc12/Catalysis_35252f8f2924ee213ffac283fa8f09bb;http://pathwaycommons.org/pc12/Catalysis_4120a5df32986e95ef3dd645c388ad29;http://identifiers.org/reactome/R-HSA-1168376;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954;http://identifiers.org/reactome/R-HSA-4420052 | |
| ITPR3 controls-transport-of-chemical CHEBI:29108 Reactome 11413485;12471263;15545263;16920709;1693919;17429043;18187424;18596693;19249086 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;CLEC7A (Dectin-1) induces NFAT activation;Ca2+ pathway;DAG and IP3 signaling;Effects of PIP2 hydrolysis;Elevation of cytosolic Ca2+ levels;FCERI mediated Ca+2 mobilization;Ion homeostasis;PLC beta mediated events;Regulation of insulin secretion;Role of phospholipids in phagocytosis;VEGFR2 mediated cell proliferation http://identifiers.org/reactome/R-HSA-139854;http://pathwaycommons.org/pc12/Catalysis_7e94d05f030c82da4ce4ef9dc7ef2425;http://identifiers.org/reactome/R-HSA-5674039;http://pathwaycommons.org/pc12/Catalysis_0cb7806bfe4840b361ee5d6505e86dea;http://pathwaycommons.org/pc12/Catalysis_35252f8f2924ee213ffac283fa8f09bb;http://pathwaycommons.org/pc12/Catalysis_4120a5df32986e95ef3dd645c388ad29;http://identifiers.org/reactome/R-HSA-1168376;http://identifiers.org/reactome/R-HSA-4420052 | |
| KAT2A controls-expression-of ACTA2 Reactome 18239137 NOTCH4 Intracellular Domain Regulates Transcription http://pathwaycommons.org/pc12/Control_881743f59f5b5059282f7b8b346e4bf2;http://identifiers.org/reactome/R-HSA-9604664 | |
| KAT2B controls-expression-of ACTA2 Reactome 18239137 NOTCH4 Intracellular Domain Regulates Transcription http://pathwaycommons.org/pc12/Control_881743f59f5b5059282f7b8b346e4bf2;http://identifiers.org/reactome/R-HSA-9604664 | |
| LETM1 controls-transport-of-chemical CHEBI:29108 Reactome 15904662;18628306;19797662;23716663;24344246;24898248;25077561;27669901 Mitochondrial calcium ion transport http://pathwaycommons.org/pc12/Catalysis_e6228661fc5c249d67e66943f9b6b9df;http://identifiers.org/reactome/R-HSA-8949687 | |
| LRRC7 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| LRRC7 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| LRRC7 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-629595 | |
| MAML1 controls-expression-of ACTA2 Reactome 18239137 NOTCH4 Intracellular Domain Regulates Transcription http://pathwaycommons.org/pc12/Control_881743f59f5b5059282f7b8b346e4bf2;http://identifiers.org/reactome/R-HSA-9604664 | |
| MAML2 controls-expression-of ACTA2 Reactome 18239137 NOTCH4 Intracellular Domain Regulates Transcription http://pathwaycommons.org/pc12/Control_881743f59f5b5059282f7b8b346e4bf2;http://identifiers.org/reactome/R-HSA-9604664 | |
| MAML3 controls-expression-of ACTA2 Reactome 18239137 NOTCH4 Intracellular Domain Regulates Transcription http://pathwaycommons.org/pc12/Control_881743f59f5b5059282f7b8b346e4bf2;http://identifiers.org/reactome/R-HSA-9604664 | |
| MAMLD1 controls-expression-of ACTA2 Reactome 18239137 NOTCH4 Intracellular Domain Regulates Transcription http://pathwaycommons.org/pc12/Control_881743f59f5b5059282f7b8b346e4bf2;http://identifiers.org/reactome/R-HSA-9604664 | |
| MCOLN1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| MCOLN1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| MCOLN1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| MCOLN2 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| MCOLN2 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| MCOLN2 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| MCOLN3 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| MCOLN3 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| MCOLN3 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| MCUB controls-transport-of-chemical CHEBI:29108 Reactome 20693986;21685886;21685888;23409044;23755363;23900286;24162235;24231807;24503055;24560927;25565209;25753332;26976564;27099988;7399049 Mitochondrial calcium ion transport http://identifiers.org/reactome/R-HSA-8949178;http://pathwaycommons.org/pc12/Catalysis_0ef884c68faf93326f80d262507a835f | |
| MCU controls-transport-of-chemical CHEBI:29108 Reactome 20693986;21685886;21685888;23409044;23755363;23900286;24162235;24231807;24503055;24560927;25565209;25753332;26976564;27099988;7399049 Mitochondrial calcium ion transport http://identifiers.org/reactome/R-HSA-8949178;http://pathwaycommons.org/pc12/Catalysis_0ef884c68faf93326f80d262507a835f | |
| MICU1 controls-transport-of-chemical CHEBI:29108 Reactome 20693986;21685886;21685888;23409044;23755363;23900286;24162235;24231807;24503055;24560927;25565209;25753332;26976564;27099988;7399049 Mitochondrial calcium ion transport http://identifiers.org/reactome/R-HSA-8949178;http://pathwaycommons.org/pc12/Catalysis_0ef884c68faf93326f80d262507a835f | |
| MICU2 controls-transport-of-chemical CHEBI:29108 Reactome 20693986;21685886;21685888;23409044;23755363;23900286;24162235;24231807;24503055;24560927;25565209;25753332;26976564;27099988;7399049 Mitochondrial calcium ion transport http://identifiers.org/reactome/R-HSA-8949178;http://pathwaycommons.org/pc12/Catalysis_0ef884c68faf93326f80d262507a835f | |
| MICU3 controls-transport-of-chemical CHEBI:29108 Reactome 20693986;21685886;21685888;23409044;23755363;23900286;24162235;24231807;24503055;24560927;25565209;25753332;26976564;27099988;7399049 Mitochondrial calcium ion transport http://identifiers.org/reactome/R-HSA-8949178;http://pathwaycommons.org/pc12/Catalysis_0ef884c68faf93326f80d262507a835f | |
| NCALD controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| NCALD controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| NCALD controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_eb0e538df36fb2c6535581928d6e7d1c;http://identifiers.org/reactome/R-HSA-629595 | |
| NEFL controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| NEFL controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| NEFL controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_b823b33c02910fc403b96a60416f6d94;http://identifiers.org/reactome/R-HSA-629595 | |
| NOTCH1 controls-expression-of ACTA2 Reactome 18239137 NOTCH4 Intracellular Domain Regulates Transcription http://pathwaycommons.org/pc12/Control_881743f59f5b5059282f7b8b346e4bf2;http://identifiers.org/reactome/R-HSA-9604664 | |
| NOTCH2 controls-expression-of ACTA2 Reactome 18239137 NOTCH4 Intracellular Domain Regulates Transcription http://pathwaycommons.org/pc12/Control_881743f59f5b5059282f7b8b346e4bf2;http://identifiers.org/reactome/R-HSA-9604664 | |
| NOTCH4 controls-expression-of ACTA2 Reactome 18239137 NOTCH4 Intracellular Domain Regulates Transcription http://pathwaycommons.org/pc12/Control_881743f59f5b5059282f7b8b346e4bf2;http://identifiers.org/reactome/R-HSA-9604664 | |
| ORAI1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_d920ac3891f29fd34e6c8369aa04ff36;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ORAI1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_d920ac3891f29fd34e6c8369aa04ff36;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ORAI1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_d920ac3891f29fd34e6c8369aa04ff36;http://identifiers.org/reactome/R-HSA-629595 | |
| ORAI2 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_d920ac3891f29fd34e6c8369aa04ff36;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ORAI2 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_d920ac3891f29fd34e6c8369aa04ff36;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| ORAI2 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_d920ac3891f29fd34e6c8369aa04ff36;http://identifiers.org/reactome/R-HSA-629595 | |
| P2RX1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| P2RX1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| P2RX1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-629595 | |
| P2RX2 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| P2RX2 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| P2RX2 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-629595 | |
| P2RX3 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| P2RX3 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| P2RX3 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-629595 | |
| P2RX4 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| P2RX4 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| P2RX4 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-629595 | |
| P2RX5 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| P2RX5 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| P2RX5 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-629595 | |
| P2RX6 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| P2RX6 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| P2RX6 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-629595 | |
| P2RX7 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| P2RX7 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| P2RX7 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_8cbda294ced7133064e2e95547fe7bd4;http://identifiers.org/reactome/R-HSA-629595 | |
| PF4 controls-production-of CHEBI:29108 Reactome 15118540;2538457;468991 Cell surface interactions at the vascular wall;Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-203103;http://identifiers.org/reactome/R-HSA-141040 | |
| PF4V1 controls-production-of CHEBI:29108 Reactome 15118540;2538457;468991 Cell surface interactions at the vascular wall;Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-203103;http://identifiers.org/reactome/R-HSA-141040 | |
| PLN controls-transport-of-chemical CHEBI:29108 Reactome 12167852;15754088;23362265;2844796;2953725;7702581;7929371 Ion homeostasis;Ion transport by P-type ATPases http://identifiers.org/reactome/R-HSA-5578840;http://identifiers.org/reactome/R-HSA-427910;http://identifiers.org/reactome/R-HSA-5578834 | |
| PRKCA controls-transport-of-chemical CHEBI:29108 Reactome 11042191;8910504;9753452 Calmodulin induced events http://identifiers.org/reactome/R-HSA-111972;http://identifiers.org/reactome/R-HSA-111966 | |
| PRKCD controls-transport-of-chemical CHEBI:29108 Reactome 11042191;8910504;9753452 Calmodulin induced events http://identifiers.org/reactome/R-HSA-111972;http://identifiers.org/reactome/R-HSA-111966 | |
| PRKCG controls-transport-of-chemical CHEBI:29108 Reactome 11042191;8910504;9753452 Calmodulin induced events http://identifiers.org/reactome/R-HSA-111972;http://identifiers.org/reactome/R-HSA-111966 | |
| PROC controls-production-of CHEBI:29108 Reactome 14982929 Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-5607095;http://identifiers.org/reactome/R-HSA-140696 | |
| RBPJ controls-expression-of ACTA2 Reactome 18239137 NOTCH4 Intracellular Domain Regulates Transcription http://pathwaycommons.org/pc12/Control_881743f59f5b5059282f7b8b346e4bf2;http://identifiers.org/reactome/R-HSA-9604664 | |
| RYR1 controls-state-change-of ACTA2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| RYR1 controls-state-change-of ACTG2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| RYR1 controls-transport-of-chemical CHEBI:29108 Reactome 10830164;15050380;15147738;15916532;17699613;17881003;19278523;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Stimuli-sensing channels http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020 | |
| RYR2 controls-state-change-of ACTA2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| RYR2 controls-state-change-of ACTG2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| RYR2 controls-transport-of-chemical CHEBI:29108 Reactome 10830164;15050380;15147738;15916532;17699613;17881003;19278523;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Stimuli-sensing channels http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020 | |
| RYR3 controls-state-change-of ACTA2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| RYR3 controls-state-change-of ACTG2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| RYR3 controls-transport-of-chemical CHEBI:29108 Reactome 10830164;15050380;15147738;15916532;17699613;17881003;19278523;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Stimuli-sensing channels http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020 | |
| SERPINA5 controls-production-of CHEBI:29108 Reactome 14982929 Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-5607095;http://identifiers.org/reactome/R-HSA-140696 | |
| SERPINC1 controls-production-of CHEBI:29108 Reactome 14982929 Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-5607095;http://identifiers.org/reactome/R-HSA-140696 | |
| SERPIND1 controls-production-of CHEBI:29108 Reactome 14982929 Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-5607095;http://identifiers.org/reactome/R-HSA-140696 | |
| SERPINE2 controls-production-of CHEBI:29108 Reactome 14982929 Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-140696;http://identifiers.org/reactome/R-HSA-5607785 | |
| SLC24A1 controls-transport-of-chemical CHEBI:29108 Reactome 10662833;11294880;12379639;16357253;20850105;9478004;9856482 Activation of the phototransduction cascade;Sodium/Calcium exchangers http://pathwaycommons.org/pc12/Catalysis_998a83bafe1db04aa64a1df989feb5e2;http://identifiers.org/reactome/R-HSA-425678;http://pathwaycommons.org/pc12/Catalysis_c4a7fd4fa6142944b1d61f17080e03b7 | |
| SLC24A2 controls-transport-of-chemical CHEBI:29108 Reactome 10662833;11294880;12379639;16357253;20850105;9478004;9856482 Activation of the phototransduction cascade;Sodium/Calcium exchangers http://pathwaycommons.org/pc12/Catalysis_998a83bafe1db04aa64a1df989feb5e2;http://identifiers.org/reactome/R-HSA-425678 | |
| SLC24A3 controls-transport-of-chemical CHEBI:29108 Reactome 10662833;11294880;12379639;16357253;20850105;9478004;9856482 Activation of the phototransduction cascade;Sodium/Calcium exchangers http://pathwaycommons.org/pc12/Catalysis_998a83bafe1db04aa64a1df989feb5e2;http://identifiers.org/reactome/R-HSA-425678 | |
| SLC24A4 controls-transport-of-chemical CHEBI:29108 Reactome 10662833;11294880;12379639;16357253;20850105;9478004;9856482 Activation of the phototransduction cascade;Sodium/Calcium exchangers http://pathwaycommons.org/pc12/Catalysis_998a83bafe1db04aa64a1df989feb5e2;http://identifiers.org/reactome/R-HSA-425678 | |
| SLC24A5 controls-state-change-of ACTA2 Reactome 11457814;18166528;1930128 Smooth Muscle Contraction;Sodium/Calcium exchangers http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-5626316;http://pathwaycommons.org/pc12/Catalysis_9af1b6c070af7906695f327ae8a87ca0;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| SLC24A5 controls-state-change-of ACTG2 Reactome 11457814;18166528;1930128 Smooth Muscle Contraction;Sodium/Calcium exchangers http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-5626316;http://pathwaycommons.org/pc12/Catalysis_9af1b6c070af7906695f327ae8a87ca0;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| SLC24A5 controls-transport-of-chemical CHEBI:29108 Reactome 18166528 Sodium/Calcium exchangers http://identifiers.org/reactome/R-HSA-5626316;http://pathwaycommons.org/pc12/Catalysis_9af1b6c070af7906695f327ae8a87ca0 | |
| SLC8A1 controls-transport-of-chemical CHEBI:29108 Reactome 12406570;1374913;20298697;26421717;8021246 Ion homeostasis;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers http://pathwaycommons.org/pc12/Catalysis_5f426e39871c49a5f936908883dc23bb;http://identifiers.org/reactome/R-HSA-425661 | |
| SLC8A2 controls-transport-of-chemical CHEBI:29108 Reactome 12406570;1374913;20298697;26421717;8021246 Ion homeostasis;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers http://pathwaycommons.org/pc12/Catalysis_5f426e39871c49a5f936908883dc23bb;http://identifiers.org/reactome/R-HSA-425661 | |
| SLC8A3 controls-state-change-of ACTA2 Reactome 11457814;1930128 Mitochondrial calcium ion transport;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a7e25bd4a8020bfe8225a8cef4b1d630;http://identifiers.org/reactome/R-HSA-8949703;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| SLC8A3 controls-state-change-of ACTG2 Reactome 11457814;1930128 Mitochondrial calcium ion transport;Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_a7e25bd4a8020bfe8225a8cef4b1d630;http://identifiers.org/reactome/R-HSA-8949703;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| SLC8A3 controls-transport-of-chemical CHEBI:29108 Reactome 12406570;1374913;20298697;26421717;8021246 Ion homeostasis;Mitochondrial calcium ion transport;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers http://pathwaycommons.org/pc12/Catalysis_a7e25bd4a8020bfe8225a8cef4b1d630;http://identifiers.org/reactome/R-HSA-8949703;http://pathwaycommons.org/pc12/Catalysis_5f426e39871c49a5f936908883dc23bb;http://identifiers.org/reactome/R-HSA-425661 | |
| SLC8B1 controls-transport-of-chemical CHEBI:29108 Reactome 14625281;15060069;20018762;24898248 Mitochondrial calcium ion transport;Sodium/Calcium exchangers http://pathwaycommons.org/pc12/Catalysis_1a4246a9aec07c80dcb501a7263e8058;http://identifiers.org/reactome/R-HSA-425822;http://pathwaycommons.org/pc12/Catalysis_491cda9642bd2d3a9c693fe096e6b176;http://identifiers.org/reactome/R-HSA-8949688 | |
| SLN controls-transport-of-chemical CHEBI:29108 Reactome 12167852;15754088;23362265;2844796;2953725;7702581;7929371 Ion homeostasis;Ion transport by P-type ATPases http://identifiers.org/reactome/R-HSA-427910;http://identifiers.org/reactome/R-HSA-6809096 | |
| SMDT1 controls-transport-of-chemical CHEBI:29108 Reactome 20693986;21685886;21685888;23409044;23755363;23900286;24162235;24231807;24503055;24560927;25565209;25753332;26976564;27099988;7399049 Mitochondrial calcium ion transport http://identifiers.org/reactome/R-HSA-8949178;http://pathwaycommons.org/pc12/Catalysis_0ef884c68faf93326f80d262507a835f | |
| SNW1 controls-expression-of ACTA2 Reactome 18239137 NOTCH4 Intracellular Domain Regulates Transcription http://pathwaycommons.org/pc12/Control_881743f59f5b5059282f7b8b346e4bf2;http://identifiers.org/reactome/R-HSA-9604664 | |
| SRI controls-state-change-of ACTA2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-2855020;http://identifiers.org/reactome/R-HSA-5607089;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| SRI controls-state-change-of ACTG2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-2855020;http://identifiers.org/reactome/R-HSA-5607089;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| SRI controls-transport-of-chemical CHEBI:29108 Reactome 10830164;12167852;12406570;1374913;15050380;15147738;15754088;15916532;17699613;17881003;19278523;19434403;20298697;20388639;20961976;2298749;2321095;23362265;2536303;26421717;2844796;2953725;7588753;7702581;7929371;8021246;8809036;9395096 Ion homeostasis;Ion transport by P-type ATPases;Reduction of cytosolic Ca++ levels;Sodium/Calcium exchangers;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-427910;http://identifiers.org/reactome/R-HSA-2855020;http://identifiers.org/reactome/R-HSA-5607089;http://identifiers.org/reactome/R-HSA-425661;http://identifiers.org/reactome/R-HSA-6809099;http://identifiers.org/reactome/R-HSA-6809100 | |
| STIM1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_27ff3503e4541295d91738702cff5dfa;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_d920ac3891f29fd34e6c8369aa04ff36;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| STIM1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_27ff3503e4541295d91738702cff5dfa;http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_d920ac3891f29fd34e6c8369aa04ff36;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| STIM1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_27ff3503e4541295d91738702cff5dfa;http://pathwaycommons.org/pc12/Catalysis_d920ac3891f29fd34e6c8369aa04ff36;http://identifiers.org/reactome/R-HSA-629595 | |
| STX1A controls-transport-of-chemical CHEBI:29108 Reactome 11815450;11815463;11873862;12403834;12684222;12887316;14514350;15572341;16443778;16714477;17900700;18162464;7641683;8997178;9914469 Regulation of insulin secretion http://identifiers.org/reactome/R-HSA-265166;http://pathwaycommons.org/pc12/Catalysis_ee7e932bd34c61d2a4c001981c6bc9f8 | |
| THBD controls-production-of CHEBI:29108 Reactome 2538457;468991 Cell surface interactions at the vascular wall;Common Pathway of Fibrin Clot Formation http://pathwaycommons.org/pc12/Catalysis_83a26e2011459cc136d07b3cc5fada26;http://identifiers.org/reactome/R-HSA-141040 | |
| TPCN1 controls-state-change-of ACTA2 Reactome 11457814;1930128;19387438;19620632 Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_fff47dd5150658184bd3f0a38968da9e;http://identifiers.org/reactome/R-HSA-2685505;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TPCN1 controls-state-change-of ACTG2 Reactome 11457814;1930128;19387438;19620632 Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_fff47dd5150658184bd3f0a38968da9e;http://identifiers.org/reactome/R-HSA-2685505;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TPCN1 controls-transport-of-chemical CHEBI:29108 Reactome 19387438;19620632 Stimuli-sensing channels http://pathwaycommons.org/pc12/Catalysis_fff47dd5150658184bd3f0a38968da9e;http://identifiers.org/reactome/R-HSA-2685505 | |
| TPCN2 controls-state-change-of ACTA2 Reactome 11457814;1930128;19387438;19620632 Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_fff47dd5150658184bd3f0a38968da9e;http://identifiers.org/reactome/R-HSA-2685505;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TPCN2 controls-state-change-of ACTG2 Reactome 11457814;1930128;19387438;19620632 Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_fff47dd5150658184bd3f0a38968da9e;http://identifiers.org/reactome/R-HSA-2685505;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TPCN2 controls-transport-of-chemical CHEBI:29108 Reactome 19387438;19620632 Stimuli-sensing channels http://pathwaycommons.org/pc12/Catalysis_fff47dd5150658184bd3f0a38968da9e;http://identifiers.org/reactome/R-HSA-2685505 | |
| TRDN controls-state-change-of ACTA2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRDN controls-state-change-of ACTG2 Reactome 10830164;11457814;15050380;15147738;15916532;17699613;17881003;19278523;1930128;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Smooth Muscle Contraction;Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-445704;http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRDN controls-transport-of-chemical CHEBI:29108 Reactome 10830164;15050380;15147738;15916532;17699613;17881003;19278523;19434403;20388639;20961976;2298749;2321095;2536303;7588753;8809036;9395096 Ion homeostasis;Stimuli-sensing channels http://pathwaycommons.org/pc12/Catalysis_901ce92f4dc0ecd1edd6aa2a18c5426c;http://identifiers.org/reactome/R-HSA-2855020 | |
| TRPA1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPA1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPA1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPC1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://pathwaycommons.org/pc12/Catalysis_27ff3503e4541295d91738702cff5dfa;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPC1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://pathwaycommons.org/pc12/Catalysis_27ff3503e4541295d91738702cff5dfa;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPC1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://pathwaycommons.org/pc12/Catalysis_27ff3503e4541295d91738702cff5dfa;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPC3 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPC3 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPC3 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11805119;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17579562;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8646775;8782898;8825650;9565569;9625352;9930701 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-426223;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_af18bde48f67137ac84694cab05926ce | |
| TRPC4 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPC4 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPC4AP controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPC4AP controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPC4AP controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPC4 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPC5 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPC5 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPC5 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPC6 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPC6 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPC6 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11805119;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17579562;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8646775;8782898;8825650;9565569;9625352;9930701 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-426223;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_af18bde48f67137ac84694cab05926ce | |
| TRPC7 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPC7 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPC7 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11805119;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17579562;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8646775;8782898;8825650;9565569;9625352;9930701 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-426223;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/Catalysis_af18bde48f67137ac84694cab05926ce | |
| TRPM1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPM1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPM1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPM2 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPM2 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPM2 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPM3 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPM3 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPM3 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPM6 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPM6 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPM6 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPM7 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPM7 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPM7 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPM8 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPM8 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPM8 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPV1 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPV1 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPV1 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPV2 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPV2 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPV2 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPV3 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPV3 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPV3 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPV4 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPV4 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPV4 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPV5 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPV5 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPV5 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| TRPV6 controls-state-change-of ACTA2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPV6 controls-state-change-of ACTG2 Reactome 10424882;10830966;10945867;11457814;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;1930128;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Smooth Muscle Contraction;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-445704;http://identifiers.org/reactome/R-HSA-629595;http://pathwaycommons.org/pc12/SmallMolecule_fde79357221e69482eae084530af1954 | |
| TRPV6 controls-transport-of-chemical CHEBI:29108 Reactome 10424882;10830966;10945867;11595941;11815460;11815462;11815463;11816716;12172541;12521992;12810063;12815021;12913094;1309948;15000524;15000528;15087444;15504896;15585596;15590058;15709690;16368572;16513675;16868246;17224452;17227845;17486119;17660294;18769136;18995841;19118095;19737521;20025796;20648059;20716668;21412339;22054663;22210847;22343826;22510460;23530196;2457808;2844759;5961668;6218823;8107964;8782898;8825650;9565569;9625352 Activation of AMPA receptors;Activation of Ca-permeable Kainate Receptor;Antigen activates B Cell Receptor (BCR) leading to generation of second messengers;Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models;Elevation of cytosolic Ca2+ levels;Highly calcium permeable nicotinic acetylcholine receptors;Highly calcium permeable postsynaptic nicotinic acetylcholine receptors;Ion homeostasis;Ion transport by P-type ATPases;Phase 0 - rapid depolarisation;Phase 2 - plateau phase;Presynaptic depolarization and calcium channel opening;Reduction of cytosolic Ca++ levels;Regulation of insulin secretion;Sperm Motility And Taxes;TRP channels;Unblocking of NMDA receptors, glutamate binding and activation http://pathwaycommons.org/pc12/Catalysis_bc5c29377033e4bb37f9c02d23b9fe15;http://identifiers.org/reactome/R-HSA-629595 | |
| VAMP2 controls-transport-of-chemical CHEBI:29108 Reactome 11815450;11815463;11873862;12403834;12684222;12887316;14514350;15572341;16443778;16714477;17900700;18162464;7641683;8997178;9914469 Regulation of insulin secretion http://identifiers.org/reactome/R-HSA-265166;http://pathwaycommons.org/pc12/Catalysis_ee7e932bd34c61d2a4c001981c6bc9f8 | |
| VDAC1 controls-transport-of-chemical CHEBI:29108 Reactome 12438411;17178908;21720385;25171321 Mitochondrial calcium ion transport http://identifiers.org/reactome/R-HSA-8949145;http://pathwaycommons.org/pc12/Catalysis_7fde508a5d729c3c7f62b2d845f6c872 | |
| VDAC2 controls-transport-of-chemical CHEBI:29108 Reactome 12438411;17178908;21720385;25171321 Mitochondrial calcium ion transport http://identifiers.org/reactome/R-HSA-8949145;http://pathwaycommons.org/pc12/Catalysis_7fde508a5d729c3c7f62b2d845f6c872 | |
| VDAC3 controls-transport-of-chemical CHEBI:29108 Reactome 12438411;17178908;21720385;25171321 Mitochondrial calcium ion transport http://identifiers.org/reactome/R-HSA-8949145;http://pathwaycommons.org/pc12/Catalysis_7fde508a5d729c3c7f62b2d845f6c872 |
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| PKA-mediated phosphorylation of CREB http://identifiers.org/reactome/R-HSA-111931 CREB1 PRKACA PRKACB PRKACG PRKX | |
| CaMK IV-mediated phosphorylation of CREB http://identifiers.org/reactome/R-HSA-111932 CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CREB1 KPNA2 | |
| Calmodulin induced events http://identifiers.org/reactome/R-HSA-111933 CALM1 GRK2 PRKCA PRKCD PRKCG | |
| Cam-PDE 1 activation http://identifiers.org/reactome/R-HSA-111957 CALM1 PDE1A PDE1B PDE1C | |
| phospho-PLA2 pathway http://identifiers.org/reactome/R-HSA-111995 MAPK1 PLA2G4A | |
| CaM pathway http://identifiers.org/reactome/R-HSA-111997 CALM1 | |
| PLC beta mediated events http://identifiers.org/reactome/R-HSA-112043 AHCYL1 GNAI1 GNAI2 GNAI3 GNAO1 GNAT1 GNAT2 GNAT3 GNAZ ITPR1 ITPR2 ITPR3 PLCB1 PLCB2 PLCB3 PLCB4 | |
| Presynaptic depolarization and calcium channel opening http://identifiers.org/reactome/R-HSA-112308 CACFD1 CACNA1A CACNA1B CACNA1E CACNA2D2 CACNA2D3 CACNB1 CACNB2 CACNB3 CACNB4 CACNG2 CACNG4 | |
| Neurotransmitter receptors and postsynaptic signal transmission http://identifiers.org/reactome/R-HSA-112314 GLRA1 GLRA2 GLRA3 GLRA4 GLRB HTR3A HTR3B HTR3C HTR3D HTR3E | |
| SOS-mediated signalling http://identifiers.org/reactome/R-HSA-112412 GRB2 HRAS IRS1 IRS2 KRAS NRAS SOS1 | |
| Effects of PIP2 hydrolysis http://identifiers.org/reactome/R-HSA-114508 DGKA DGKB DGKD DGKE DGKG DGKH DGKI DGKK DGKQ DGKZ ITPR1 ITPR2 ITPR3 PRKCD PRKCE PRKCH PRKCQ RASGRP1 RASGRP2 TRPC3 TRPC6 TRPC7 | |
| Disinhibition of SNARE formation http://identifiers.org/reactome/R-HSA-114516 PRKCA PRKCB PRKCG STX4 STXBP3 | |
| Activation of NF-kappaB in B cells http://identifiers.org/reactome/R-HSA-1169091 BCL10 BTRC CARD11 CHUK CUL1 FBXW11 IKBKB IKBKG MALT1 MAP3K7 NFKB1 NFKBIA NFKBIB NFKBIE PRKCB PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 REL RELA RPS27A SEM1 SKP1 UBA52 UBB UBC | |
| Activation of RAS in B cells http://identifiers.org/reactome/R-HSA-1169092 HRAS KRAS NRAS RASGRP1 RASGRP3 | |
| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants http://identifiers.org/reactome/R-HSA-1236382 CBL CDC37 EGF EGFR GAB1 GRB2 HRAS HSP90AA1 KRAS NRAS PIK3CA PIK3R1 PLCG1 RPS27A SHC1 SOS1 UBA52 UBB UBC | |
| SHC1 events in ERBB2 signaling http://identifiers.org/reactome/R-HSA-1250196 BTC EGF EGFR ERBB2 ERBB3 ERBB4 EREG GRB2 HBEGF HRAS KRAS NRAS NRG1 NRG2 NRG3 NRG4 PRKCA PRKCD PRKCE PTPN12 SHC1 SOS1 | |
| SHC1 events in ERBB4 signaling http://identifiers.org/reactome/R-HSA-1250347 BTC ERBB4 EREG GRB2 HBEGF HRAS KRAS NRAS NRG1 NRG2 NRG3 NRG4 SHC1 SOS1 | |
| Sperm Motility And Taxes http://identifiers.org/reactome/R-HSA-1300642 CATSPER1 CATSPER2 CATSPER3 CATSPER4 CATSPERB CATSPERD CATSPERG HVCN1 KCNU1 | |
| Elevation of cytosolic Ca2+ levels http://identifiers.org/reactome/R-HSA-139853 ITPR1 ITPR2 ITPR3 ORAI1 ORAI2 P2RX1 P2RX2 P2RX3 P2RX4 P2RX5 P2RX6 P2RX7 STIM1 TRPC3 TRPC6 TRPC7 | |
| Extrinsic Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-140834 F10 F3 F7 F9 TFPI | |
| Intrinsic Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-140837 A2M C1QBP F10 F11 F12 F2 F8 F9 GP1BA GP1BB GP5 GP9 KLKB1 KNG1 PRCP PROC SERPINA5 SERPINC1 SERPIND1 SERPINE2 SERPING1 SHH SHMT1 VWF | |
| Common Pathway of Fibrin Clot Formation http://identifiers.org/reactome/R-HSA-140875 CD177 F10 F13A1 F13B F2 F2R F5 F8 FGA FGB FGG PF4 PF4V1 PROC PROCR PROS1 PRTN3 SERPINA5 SERPINC1 SERPIND1 SERPINE2 SHH SHMT1 THBD | |
| Signaling by SCF-KIT http://identifiers.org/reactome/R-HSA-1433557 CHEK1 CMA1 FER FES FYN GAB2 GRAP GRAP2 GRB10 GRB2 GRB7 HRAS JAK2 KIT KITLG KRAS LCK LYN MMP9 NRAS PIK3CA PIK3R1 PIK3R2 PIK3R3 PRKCA PTPN11 PTPRU RAC1 SOS1 SRC STAT1 STAT3 STAT5A STAT5B TEC VAV1 YES1 | |
| Translocation of SLC2A4 (GLUT4) to the plasma membrane http://identifiers.org/reactome/R-HSA-1445148 AKT1 AKT2 ASPSCR1 C2CD5 CALM1 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 KIF3A KIF3B KIFAP3 LNPEP MYH9 MYO1C MYO5A PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RAB10 RAB11A RAB13 RAB14 RAB4A RAB8A RAC1 RALA RALGAPA2 RALGAPB RHOQ SFN SLC2A4 SNAP23 STX4 STXBP3 TBC1D1 TBC1D4 VAMP2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ | |
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation http://identifiers.org/reactome/R-HSA-1474151 AKT1 CALM1 DHFR GCH1 GCHFR HSP90AA1 NOS3 PRKG2 PTS SPR | |
| Degradation of the extracellular matrix http://identifiers.org/reactome/R-HSA-1474228 A2M ACAN ADAM10 ADAM15 ADAM8 ADAMTS1 ADAMTS16 ADAMTS18 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 BCAN BMP1 BSG CAPN1 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPN15 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPNS1 CAPNS2 CASP3 CAST CD44 CDH1 CTSG CTSK CTSL CTSS CTSV DCN ELANE HSPG2 HTRA1 KLK7 LAMA3 LAMA5 LAMB1 LAMB3 LAMC1 LAMC2 MMP1 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP19 MMP2 MMP20 MMP3 MMP7 MMP8 MMP9 NCSTN NID1 OPTC PLG PSEN1 SCUBE1 SCUBE3 SPP1 TLL1 TLL2 TMPRSS6 | |
| Acyl chain remodelling of PC http://identifiers.org/reactome/R-HSA-1482788 LPCAT1 LPCAT2 LPCAT3 LPCAT4 MBOAT2 PLA2G10 PLA2G12A PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2G6 PLA2R1 PLAAT3 PLB1 PLBD1 PNPLA8 TMEM86B | |
| Acyl chain remodeling of CL http://identifiers.org/reactome/R-HSA-1482798 HADHA HADHB LCLAT1 PLA2G4A PLA2G6 TAZ | |
| Acyl chain remodelling of PS http://identifiers.org/reactome/R-HSA-1482801 LPCAT3 LPCAT4 MBOAT1 OSBPL10 OSBPL5 OSBPL8 PLA1A PLA2G10 PLA2G12A PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G4A PLA2G4B PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2R1 PLAAT3 | |
| Acyl chain remodelling of PE http://identifiers.org/reactome/R-HSA-1482839 ABHD4 LPCAT3 LPCAT4 MBOAT1 MBOAT2 PLA2G10 PLA2G12A PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2G6 PLA2R1 PLAAT1 PLAAT2 PLAAT3 PLAAT4 PLAAT5 PLBD1 PNPLA8 | |
| Acyl chain remodelling of PI http://identifiers.org/reactome/R-HSA-1482922 MBOAT7 PLA2G10 PLA2G12A PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G4A PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2R1 PLAAT3 PLBD1 | |
| Acyl chain remodelling of PG http://identifiers.org/reactome/R-HSA-1482925 CRLS1 LPCAT1 LPCAT4 LPGAT1 PLA2G10 PLA2G12A PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4D PLA2G4F PLA2G5 PLA2R1 | |
| Hydrolysis of LPC http://identifiers.org/reactome/R-HSA-1483115 GPCPD1 PLA2G15 PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLBD1 | |
| Synthesis of PA http://identifiers.org/reactome/R-HSA-1483166 ACP6 AGPAT1 AGPAT2 AGPAT3 AGPAT4 AGPAT5 ALPI DDHD1 DDHD2 GNPAT GPAM GPAT2 GPAT3 GPAT4 GPD1 GPD1L GPD2 LCLAT1 LIPH LIPI LPCAT1 LPCAT4 MIGA1 MIGA2 PLA2G10 PLA2G12A PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G4A PLA2G4B PLA2G4D PLA2G5 PLA2R1 PLD1 PLD2 PLD6 | |
| Glycerophospholipid biosynthesis http://identifiers.org/reactome/R-HSA-1483206 AGK CPNE1 CPNE3 CPNE6 CPNE7 | |
| DAG and IP3 signaling http://identifiers.org/reactome/R-HSA-1489509 AHCYL1 ITPR1 ITPR2 ITPR3 PLCG1 PRKCD PRKCE | |
| PKA activation http://identifiers.org/reactome/R-HSA-163615 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 CALM1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B | |
| Synthesis of PIPs at the plasma membrane http://identifiers.org/reactome/R-HSA-1660499 ARF1 BMX INPP4A INPP4B INPP5D INPP5J INPP5K INPPL1 MTM1 MTMR1 MTMR14 MTMR2 MTMR3 MTMR6 MTMR8 MTMR9 OCRL PI4K2A PI4K2B PIK3C2A PIK3C2B PIK3C2G PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLEKHA1 PLEKHA2 PLEKHA3 PLEKHA4 PLEKHA5 PLEKHA6 PLEKHA8 PTEN PTPN13 RAB14 RAB4A RAB5A RUFY1 SBF2 SYNJ1 SYNJ2 | |
| Synthesis of PIPs at the Golgi membrane http://identifiers.org/reactome/R-HSA-1660514 ARF1 ARF3 FIG4 INPP5E OCRL PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2G PIK3C3 PIK3R4 PIKFYVE SACM1L TPTE TPTE2 VAC14 | |
| Synthesis of PIPs at the early endosome membrane http://identifiers.org/reactome/R-HSA-1660516 FIG4 INPP4A INPP4B INPP5F MTM1 MTMR10 MTMR12 MTMR2 MTMR4 PI4K2A PI4K2B PIK3C2A PIK3C3 PIK3R4 PIKFYVE VAC14 | |
| Synthesis of PIPs at the late endosome membrane http://identifiers.org/reactome/R-HSA-1660517 FIG4 MTM1 MTMR2 MTMR4 MTMR7 MTMR9 PIK3C2A PIK3C3 PIK3R4 PIKFYVE VAC14 | |
| Glycosphingolipid metabolism http://identifiers.org/reactome/R-HSA-1660662 ARSA ARSB ARSD ARSE ARSF ARSG ARSH ARSI ARSJ ARSK ASAH1 ASAH2 B3GALNT1 B4GALNT1 CERK CPTP CTSA ENPP7 ESYT1 ESYT2 ESYT3 GALC GBA GBA2 GBA3 GLA GLB1 GLB1L GLTP GM2A HEXA HEXB NEU1 NEU2 NEU3 NEU4 PSAP SMPD1 SMPD2 SMPD3 SMPD4 STS SUMF1 SUMF2 UGCG UGT8 | |
| The activation of arylsulfatases http://identifiers.org/reactome/R-HSA-1663150 ARSA ARSB ARSD ARSE ARSF ARSG ARSH ARSI ARSJ ARSK STS SUMF1 SUMF2 | |
| Lectin pathway of complement activation http://identifiers.org/reactome/R-HSA-166662 COLEC10 COLEC11 FCN1 FCN2 FCN3 MASP1 MASP2 MBL2 | |
| Initial triggering of complement http://identifiers.org/reactome/R-HSA-166663 C1QA C1QB C1QC C1R C1S C2 C4A C4B C4B_2 COLEC10 COLEC11 FCN1 FCN2 FCN3 IGHG1 IGHG2 IGHG3 IGHG4 IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 MASP1 MASP2 MBL2 | |
| Signalling to RAS http://identifiers.org/reactome/R-HSA-167044 GRB2 HRAS KRAS NGF NRAS NTRK1 SHC1 SHC2 SHC3 SOS1 | |
| NGF processing http://identifiers.org/reactome/R-HSA-167060 FURIN NGF PCSK5 PCSK6 | |
| Classical antibody-mediated complement activation http://identifiers.org/reactome/R-HSA-173623 C1QA C1QB C1QC C1R C1S CRP IGHG1 IGHG2 IGHG3 IGHG4 IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 | |
| GRB2 events in EGFR signaling http://identifiers.org/reactome/R-HSA-179812 AREG BTC EGF EGFR EPGN EREG GRB2 HBEGF HRAS KRAS NRAS SOS1 TGFA | |
| DARPP-32 events http://identifiers.org/reactome/R-HSA-180024 CALM1 CDK5 PDE4A PDE4B PDE4C PDE4D PPP1CA PPP1R1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PPP3CA PPP3CB PPP3CC PPP3R1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B | |
| SHC1 events in EGFR signaling http://identifiers.org/reactome/R-HSA-180336 AREG BTC EGF EGFR EPGN EREG GRB2 HBEGF HRAS KRAS NRAS SHC1 SOS1 TGFA | |
| Synthesis of IP3 and IP4 in the cytosol http://identifiers.org/reactome/R-HSA-1855204 CALM1 INPP5B INPP5D INPP5J INPPL1 ITPK1 ITPKA ITPKB ITPKC OCRL PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCH1 PLCH2 PLCZ1 PLD4 PTEN SYNJ1 | |
| Downstream signal transduction http://identifiers.org/reactome/R-HSA-186763 BCAR1 CRK CRKL GRB2 GRB7 HRAS KRAS NCK1 NCK2 NRAS PDGFA PDGFB PDGFRA PDGFRB PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PTPN11 RAPGEF1 RASA1 SOS1 SRC STAT1 STAT3 STAT5A STAT5B STAT6 | |
| GRB2 events in ERBB2 signaling http://identifiers.org/reactome/R-HSA-1963640 BTC EGF EGFR ERBB2 ERBB4 EREG GRB2 HBEGF HRAS KRAS NRAS NRG1 NRG2 NRG3 NRG4 SOS1 | |
| AKT phosphorylates targets in the nucleus http://identifiers.org/reactome/R-HSA-198693 AKT1 AKT2 AKT3 CREB1 FOXO1 FOXO3 FOXO4 FOXO6 NR4A1 RPS6KB2 | |
| CREB phosphorylation http://identifiers.org/reactome/R-HSA-199920 ATF1 CREB1 MAPKAPK2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 | |
| HS-GAG degradation http://identifiers.org/reactome/R-HSA-2024096 AGRN GLB1 GLB1L GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GUSB HPSE HPSE2 HSPG2 IDS IDUA NAGLU SDC1 SDC2 SDC3 SDC4 SGSH | |
| CS/DS degradation http://identifiers.org/reactome/R-HSA-2024101 ARSB BCAN BGN CSPG4 CSPG5 DCN HEXA HEXB HYAL1 HYAL3 IDS IDUA NCAN VCAN | |
| Calcineurin activates NFAT http://identifiers.org/reactome/R-HSA-2025928 CALM1 FKBP1A NFATC1 NFATC2 NFATC3 PPIA PPP3CA PPP3CB PPP3R1 | |
| Cell surface interactions at the vascular wall http://identifiers.org/reactome/R-HSA-202733 APOB CD177 CD2 CD244 CD44 CD47 CD48 CD58 CD74 CD84 CD99 CD99L2 CEACAM1 CEACAM3 CEACAM5 CEACAM6 CEACAM8 CXADR EPCAM ESAM F11R F2 FCAMR FCER1G FN1 FYN GAS6 GLG1 GP6 GPC1 GYPA GYPB GYPC IGHA1 IGHA2 IGHM IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLL1 IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 ITGA4 ITGA5 ITGAL ITGAM ITGAX ITGB1 ITGB2 JAM2 JAM3 JAML JCHAIN LYN MERTK MIF OLR1 PECAM1 PF4 PF4V1 PICK1 PROC PROCR PROS1 PSG1 PSG11 PSG2 PSG3 PSG4 PSG5 PSG6 PSG7 PSG8 PSG9 SDC1 SDC2 SDC3 SDC4 SELE SELL SELP SELPLG SIRPA SIRPG SPN TGFB1 THBD TNFRSF10A TNFRSF10B TNFRSF10D TREM1 TSPAN7 VPREB1 VPREB3 | |
| Regulation of actin dynamics for phagocytic cup formation http://identifiers.org/reactome/R-HSA-2029482 ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BRK1 BTK CD247 CD3G CDC42 CFL1 CRK CYFIP1 CYFIP2 DOCK1 ELMO1 ELMO2 FCGR1A FCGR2A FCGR3A GRB2 HSP90AA1 HSP90AB1 IGHG1 IGHG2 IGHG3 IGHG4 IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 LIMK1 MAPK1 MAPK3 MYH2 MYH9 MYO10 MYO1C MYO5A MYO9B NCK1 NCKAP1 NCKAP1L NCKIPSD NF2 PAK1 PTK2 RAC1 SYK VAV1 VAV2 VAV3 WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 | |
| Role of phospholipids in phagocytosis http://identifiers.org/reactome/R-HSA-2029485 AHCYL1 CD247 CD3G FCGR1A FCGR2A FCGR3A IGHG1 IGHG2 IGHG3 IGHG4 IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 ITPR1 ITPR2 ITPR3 PIK3CA PIK3CB PIK3R1 PIK3R2 PLA2G6 PLCG1 PLCG2 PLD1 PLD2 PLD3 PLD4 PLPP4 PLPP5 PRKCD PRKCE SYK | |
| eNOS activation http://identifiers.org/reactome/R-HSA-203615 AKT1 CALM1 CAV1 CYGB DDAH1 DDAH2 HSP90AA1 LYPLA1 NOS3 SPR ZDHHC21 | |
| Peptide hormone biosynthesis http://identifiers.org/reactome/R-HSA-209952 PCSK1 POMC | |
| Glutamate Neurotransmitter Release Cycle http://identifiers.org/reactome/R-HSA-210500 ARL6IP5 CPLX1 GLS GLS2 PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RIMS1 SLC17A7 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 SLC38A2 SNAP25 STX1A STXBP1 SYT1 TSPOAP1 UNC13B VAMP2 | |
| Tie2 Signaling http://identifiers.org/reactome/R-HSA-210993 ANGPT1 ANGPT2 ANGPT4 DOK2 GRB14 GRB2 GRB7 HRAS KRAS NRAS PIK3CA PIK3CB PIK3R1 PIK3R2 PTPN11 SHC1 SOS1 TEK | |
| Phase I - Functionalization of compounds http://identifiers.org/reactome/R-HSA-211945 AADAC AHR AHRR ALDH3A1 AOC1 AOC2 AOC3 ARNT ARNT2 BPHL CBR3 CES1 CES2 CES3 CMBL CYB5B CYB5R3 EPHX1 MARC1 MARC2 NQO2 | |
| Synthesis of 5-eicosatetraenoic acids http://identifiers.org/reactome/R-HSA-2142688 ALOX5 ALOX5AP GPX1 GPX2 GPX4 LTC4S PON1 PON2 PON3 | |
| Synthesis of Leukotrienes (LT) and Eoxins (EX) http://identifiers.org/reactome/R-HSA-2142691 ABCC1 ALOX15 ALOX5 ALOX5AP CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F2 CYP4F22 CYP4F3 CYP4F8 DPEP1 DPEP2 DPEP3 GGT1 GGT5 LTA4H LTC4S MAPKAPK2 PTGR1 | |
| Synthesis of Lipoxins (LX) http://identifiers.org/reactome/R-HSA-2142700 ALOX12 ALOX5 ALOX5AP HPGD LTC4S PTGR1 | |
| Arachidonic acid metabolism http://identifiers.org/reactome/R-HSA-2142753 AWAT1 FAAH FAAH2 PLA2G4A | |
| Transcriptional activation of mitochondrial biogenesis http://identifiers.org/reactome/R-HSA-2151201 ACSS2 ALAS1 ATF2 ATP5F1B CALM1 CAMK4 CARM1 CHD9 CREB1 CREBBP CRTC1 CRTC2 CRTC3 CYCS ESRRA GABPA GABPB1 GLUD1 GLUD2 HCFC1 HDAC3 HELZ2 IDH2 MED1 MEF2C MEF2D MTERF1 NCOA1 NCOA2 NCOA6 NCOR1 NR1D1 NRF1 PERM1 POLG2 POLRMT PPARA PPARGC1A PPARGC1B PPRC1 RXRA SIRT3 SIRT4 SIRT5 SMARCD3 SOD2 SSBP1 TBL1X TBL1XR1 TFAM TFB1M TFB2M TGS1 TWNK USP46 | |
| Hyaluronan uptake and degradation http://identifiers.org/reactome/R-HSA-2160916 CD44 CHP1 GUSB HEXA HEXB HMMR HYAL1 HYAL2 HYAL3 LYVE1 SLC9A1 STAB2 | |
| EGFR Transactivation by Gastrin http://identifiers.org/reactome/R-HSA-2179392 EGFR GRB2 HBEGF HRAS KRAS MMP3 NRAS PRKCA SOS1 | |
| MPS VI - Maroteaux-Lamy syndrome http://identifiers.org/reactome/R-HSA-2206285 ARSB | |
| MPS II - Hunter syndrome http://identifiers.org/reactome/R-HSA-2206296 IDS | |
| DAP12 signaling http://identifiers.org/reactome/R-HSA-2424491 B2M BTK FYN GRAP2 GRB2 HLA-E HRAS KLRC2 KLRD1 KLRK1 KRAS LAT LCK LCP2 NRAS PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PLCG2 RAC1 SHC1 SOS1 SYK TREM2 TYROBP VAV2 VAV3 | |
| SHC-related events triggered by IGF1R http://identifiers.org/reactome/R-HSA-2428933 GRB2 HRAS IGF1 IGF1R IGF2 KRAS NRAS SHC1 SOS1 | |
| Activation of the phototransduction cascade http://identifiers.org/reactome/R-HSA-2485179 CNGA1 CNGB1 GNAT1 GNB1 GNGT1 PDE6A PDE6B PDE6G RHO SAG SLC24A1 | |
| Inactivation, recovery and regulation of the phototransduction cascade http://identifiers.org/reactome/R-HSA-2514859 CALM1 CAMKMT CNGA1 CNGB1 FNTA FNTB GNAT1 GNB1 GNB5 GNGT1 GRK1 GRK4 GRK7 GUCA1A GUCA1B GUCA1C GUCY2D GUCY2F METAP1 METAP2 NMT1 NMT2 PDE6A PDE6B PDE6G PPEF1 PRKCA PRKCQ RCVRN RGS9 RGS9BP RHO SAG | |
| Insulin processing http://identifiers.org/reactome/R-HSA-264876 CLTRN CPE ERO1A ERO1B EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 INS KIF5A KIF5B KIF5C MYO5A MYRIP PCSK1 PCSK2 RAB27A SLC30A5 SLC30A6 SLC30A7 SLC30A8 STX1A VAMP2 | |
| Stimuli-sensing channels http://identifiers.org/reactome/R-HSA-2672351 ANO1 ANO10 ANO2 ANO3 ANO4 ANO5 ANO6 ANO7 ANO8 ANO9 ASIC1 ASIC2 ASIC3 ASIC4 ASIC5 ASPH BEST1 BEST2 BEST3 BEST4 BSND CALM1 CLCA1 CLCA2 CLCA3P CLCA4 CLCN1 CLCN2 CLCN3 CLCN4 CLCN5 CLCN6 CLCN7 CLCNKA CLCNKB CLIC2 FKBP1B NALCN NEDD4L OSTM1 RAF1 RPS27A RYR1 RYR2 RYR3 SCNN1A SCNN1B SCNN1D SCNN1G SGK1 SGK2 SGK3 SLC17A3 SLC9B1 SLC9B2 SLC9C1 SLC9C2 SRI STOM STOML3 TPCN1 TPCN2 TRDN TSC22D3 TTYH1 TTYH2 TTYH3 UBA52 UBB UBC UNC79 UNC80 WNK1 WNK2 WNK3 WNK4 WWP1 | |
| Ficolins bind to repetitive carbohydrate structures on the target cell surface http://identifiers.org/reactome/R-HSA-2855086 FCN1 FCN2 FCN3 MASP1 MASP2 | |
| FCERI mediated MAPK activation http://identifiers.org/reactome/R-HSA-2871796 FOS GRAP2 GRB2 HRAS IGHE IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 JUN KRAS LAT LCP2 LYN MAP2K4 MAP2K7 MAP3K1 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 NRAS PAK1 PAK2 PLCG1 PLCG2 RAC1 SHC1 SOS1 SYK VAV1 VAV2 VAV3 | |
| FCERI mediated Ca+2 mobilization http://identifiers.org/reactome/R-HSA-2871809 AHCYL1 BTK CALM1 GRAP2 GRB2 IGHE IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 ITK ITPR1 ITPR2 ITPR3 LAT LCP2 LYN NFATC1 NFATC2 NFATC3 PLCG1 PLCG2 PPP3CA PPP3CB PPP3R1 SHC1 SOS1 SYK TEC TXK VAV1 VAV2 VAV3 | |
| FCERI mediated NF-kB activation http://identifiers.org/reactome/R-HSA-2871837 BCL10 BTRC CARD11 CDC34 CHUK CUL1 FBXW11 IGHE IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 IKBKB IKBKG LYN MALT1 MAP3K7 NFKB1 NFKBIA PDPK1 PRKCQ PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RASGRP1 RASGRP2 RASGRP4 RELA RPS27A SEM1 SKP1 TAB1 TAB2 TAB3 TRAF6 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2N UBE2V1 | |
| ECM proteoglycans http://identifiers.org/reactome/R-HSA-3000178 ACAN AGRN ASPN BCAN BGN COL9A1 COL9A2 COL9A3 COMP DAG1 DCN DMP1 DSPP FMOD HAPLN1 HSPG2 IBSP ITGA2 ITGA2B ITGA7 ITGA8 ITGA9 ITGAV ITGAX ITGB1 ITGB3 ITGB5 ITGB6 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMC1 LRP4 LUM MATN1 MATN3 MATN4 MUSK NCAM1 NCAN PTPRS SERPINE1 SPARC TGFB1 TGFB2 TGFB3 TNC TNN TNR TNXB VCAN VTN | |
| HATs acetylate histones http://identifiers.org/reactome/R-HSA-3214847 ACTB ACTL6A ATF2 ATXN7 ATXN7L3 BRD1 BRD8 BRPF1 BRPF3 CLOCK CREBBP DMAP1 DR1 ELP1 ELP2 ELP3 ELP4 ELP5 ELP6 ENY2 EP300 EP400 EPC1 HAT1 HCFC1 HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AG HIST1H2AH HIST1H2AI HIST1H2AJ HIST1H2AK HIST1H2AL HIST1H2AM HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AB HIST2H2AC HIST2H2BE HIST2H2BF HIST2H3A HIST2H3C HIST2H3D HIST2H4A HIST2H4B HIST3H2A HIST3H2BB HIST4H4 ING3 ING4 ING5 JADE1 JADE2 JADE3 KANSL1 KANSL2 KANSL3 KAT14 KAT2A KAT2B KAT5 KAT6A KAT6B KAT7 KAT8 MBIP MCRS1 MEAF6 MORF4L1 MORF4L2 MRGBP MSL1 MSL2 MSL3 NCOA1 NCOA2 OGT PAX3 PHF20 RBBP7 RUVBL1 RUVBL2 SAP130 SGF29 SUPT20H SUPT3H SUPT7L TADA1 TADA2A TADA2B TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TRRAP USP22 VPS72 WDR5 YEATS2 YEATS4 ZZZ3 | |
| Chromatin modifying enzymes http://identifiers.org/reactome/R-HSA-3247509 BRWD1 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST2H3A HIST2H3C HIST2H3D PADI1 PADI2 PADI3 PADI4 PADI6 SMARCA4 | |
| TRP channels http://identifiers.org/reactome/R-HSA-3295583 MCOLN1 MCOLN2 MCOLN3 TRPA1 TRPC1 TRPC3 TRPC4 TRPC4AP TRPC5 TRPC6 TRPC7 TRPM1 TRPM2 TRPM3 TRPM4 TRPM5 TRPM6 TRPM7 TRPM8 TRPV1 TRPV2 TRPV3 TRPV4 TRPV5 TRPV6 | |
| Integrin alphaIIb beta3 signaling http://identifiers.org/reactome/R-HSA-354192 AKT1 APBB1IP CSK FGA FGB FGG FN1 ITGA2B ITGB3 PDPK1 PTK2 PTPN1 RAP1A RAP1B RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 SHC1 SRC SYK TLN1 VWF | |
| GRB2:SOS provides linkage to MAPK signaling for Integrins http://identifiers.org/reactome/R-HSA-354194 APBB1IP FGA FGB FGG FN1 GRB2 ITGA2B ITGB3 PTK2 RAP1A RAP1B SOS1 SRC TLN1 VWF | |
| p130Cas linkage to MAPK signaling for integrins http://identifiers.org/reactome/R-HSA-372708 APBB1IP BCAR1 CRK FGA FGB FGG FN1 ITGA2B ITGB3 PTK2 RAP1A RAP1B SRC TLN1 VWF | |
| NCAM signaling for neurite out-growth http://identifiers.org/reactome/R-HSA-375165 CREB1 FGFR1 FYN GRB2 HRAS KRAS MAPK1 MAPK3 NCAM1 NRAS PTK2 PTPRA RPS6KA5 SOS1 SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 SRC | |
| Peptide ligand-binding receptors http://identifiers.org/reactome/R-HSA-375276 ACKR1 AGT AGTR1 AGTR2 APLN APLNR BDKRB1 BDKRB2 BRS3 C3 C3AR1 C5 C5AR1 C5AR2 CCK CCKAR CCKBR CORT CXCL8 ECE1 ECE2 EDN1 EDN2 EDN3 EDNRA EDNRB F2 F2R F2RL1 F2RL2 F2RL3 GAL GALR1 GALR2 GALR3 GHRL GHSR GPER1 GPR37 GPR37L1 GRP GRPR KEL KISS1 KISS1R KNG1 MC1R MC2R MC3R MC4R MC5R MCHR1 MCHR2 MLN MLNR NLN NMB NMBR NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPS NPSR1 NPW NPY NPY1R NPY2R NPY4R NPY5R NTS NTSR1 NTSR2 OPRD1 OPRK1 OPRL1 OPRM1 PDYN PENK PMCH PNOC POMC PPY PRLH PRLHR PROK1 PROK2 PROKR1 PROKR2 PSAP PYY SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 TRH TRHR UTS2 UTS2B UTS2R XK | |
| Energy dependent regulation of mTOR by LKB1-AMPK http://identifiers.org/reactome/R-HSA-380972 CAB39 CAB39L LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 MLST8 MTOR PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RHEB RPTOR RRAGA RRAGB RRAGD SLC38A9 STK11 STRADA STRADB TSC1 TSC2 | |
| Regulation of IGF Activity by IGFBP http://identifiers.org/reactome/R-HSA-381426 ADAM10 AFP AHSG ALB AMBN AMELX AMTN ANO8 APLP2 APOA1 APOA2 APOA5 APOB APOE APOL1 APP BMP15 BMP4 BPIFB2 C3 C4A CALU CCN1 CDH2 CHGB CHRDL1 CKAP4 CP CSF1 CST3 CTSG DMP1 DNAJC3 ENAM EVA1A F2 F5 FAM20A FAM20C FBN1 FGA FGF23 FGG FN1 FSTL1 FSTL3 FUCA2 GAS6 GOLM1 GPC3 GZMH HRC HSP90B1 IGF1 IGF2 IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IL6 ITIH2 KLK1 KLK13 KLK2 KLK3 KNG1 KTN1 LAMB1 LAMB2 LAMC1 LGALS1 LTBP1 MATN3 MBTPS1 MELTF MEN1 MEPE MFGE8 MGAT4A MIA3 MMP1 MMP2 MSLN MXRA8 NOTUM NUCB1 P4HB PAPPA PAPPA2 PCSK9 PDIA6 PENK PLG PNPLA2 PRKCSH PROC PRSS23 QSOX1 RCN1 SCG2 SCG3 SDC2 SERPINA1 SERPINA10 SERPINC1 SERPIND1 SHISA5 SPARCL1 SPP1 SPP2 STC2 TF TGOLN2 TIMP1 TMEM132A TNC VCAN VGF VWA1 WFS1 | |
| Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) http://identifiers.org/reactome/R-HSA-381771 CDX2 CTNNB1 DPP4 FFAR1 FFAR4 GCG GNAT3 GNB3 GNG13 GPR119 GRP LEP PAX6 PCSK1 SEC11A SEC11C SPCS1 SPCS2 SPCS3 TCF7L2 | |
| Prefoldin mediated transfer of substrate to CCT/TriC http://identifiers.org/reactome/R-HSA-389957 ACTB CCT2 CCT3 CCT4 CCT5 CCT6A CCT6B CCT7 CCT8 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TCP1 TUBA1A TUBA1C TUBA3C TUBA3D TUBA4A TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 VBP1 | |
| Folding of actin by CCT/TriC http://identifiers.org/reactome/R-HSA-390450 ACTB CCT2 CCT3 CCT4 CCT5 CCT6A CCT6B CCT7 CCT8 TCP1 | |
| Striated Muscle Contraction http://identifiers.org/reactome/R-HSA-390522 ACTN2 ACTN3 DES DMD MYBPC1 MYBPC2 MYBPC3 MYH3 MYH6 MYH8 MYL1 MYL2 MYL3 MYL4 NEB TCAP TMOD1 TMOD2 TMOD3 TMOD4 TNNC1 TNNC2 TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TNNT3 TPM1 TPM2 TPM3 TPM4 TTN VIM | |
| Rap1 signalling http://identifiers.org/reactome/R-HSA-392517 PRKACA PRKACB PRKACG PRKG1 RAF1 RAP1A RAP1B RAP1GAP RAP1GAP2 RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 SIPA1 YWHAB YWHAZ | |
| EPHB-mediated forward signaling http://identifiers.org/reactome/R-HSA-3928662 ACTB ACTG1 ACTR2 ACTR3 ARHGEF28 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CFL1 FYN GRIN1 GRIN2B HRAS ITSN1 KALRN LIMK1 LIMK2 LYN PAK1 PTK2 RAC1 RASA1 RHOA ROCK1 ROCK2 SDC2 SRC TIAM1 WASL YES1 | |
| EPHA-mediated growth cone collapse http://identifiers.org/reactome/R-HSA-3928663 FYN LYN MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 NGEF RHOA ROCK1 ROCK2 SRC YES1 | |
| Activation of AMPA receptors http://identifiers.org/reactome/R-HSA-399710 GRIA1 GRIA2 GRIA3 GRIA4 | |
| Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) http://identifiers.org/reactome/R-HSA-400511 DPP4 FFAR1 GATA4 GIP GPR119 ISL1 PAX6 PCSK1 SEC11A SEC11C SPCS1 SPCS2 SPCS3 | |
| Ca2+ pathway http://identifiers.org/reactome/R-HSA-4086398 AGO1 AGO2 AGO3 AGO4 AXIN2 CALM1 CAMK2A CTNNB1 FZD2 FZD3 FZD4 FZD5 FZD6 GNAO1 GNAT2 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 ITPR1 ITPR2 ITPR3 LEF1 MAP3K7 MOV10 MYC NFATC1 NLK PDE6A PDE6B PDE6G PLCB1 PLCB2 PLCB3 PPP3CA PPP3CB PPP3R1 PRKCA PRKG1 PRKG2 TCF7 TCF7L1 TCF7L2 TNRC6A TNRC6B TNRC6C WNT11 WNT5A | |
| G alpha (q) signalling events http://identifiers.org/reactome/R-HSA-416476 ADRA1A ADRA1B ADRA1D AGT AGTR1 ANXA1 APP ARHGEF25 AVP AVPR1A AVPR1B BDKRB1 BDKRB2 BRS3 BTK CASR CCK CCKAR CCKBR CCL23 CHRM1 CHRM3 CHRM5 CYSLTR1 CYSLTR2 EDN1 EDN2 EDN3 EDNRA EDNRB F2 F2R F2RL1 F2RL2 F2RL3 FFAR1 FFAR2 FFAR3 FFAR4 FPR2 GAST GCG GCGR GHRL GHSR GNA11 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GNRH1 GNRH2 GNRHR GNRHR2 GPR132 GPR143 GPR17 GPR39 GPR4 GPR65 GPR68 GPRC6A GRK2 GRK5 GRM1 GRM5 GRP GRPR HCRT HCRTR1 HCRTR2 HRH1 HTR2A HTR2B HTR2C KALRN KISS1 KISS1R KNG1 LPAR1 LPAR2 LPAR3 LPAR4 LPAR5 LPAR6 LTB4R LTB4R2 MCHR1 MCHR2 MLN MLNR MT-RNR2 NMB NMBR NMS NMU NMUR1 NMUR2 NPFF NPFFR1 NPFFR2 NPS NPSR1 NTS NTSR1 NTSR2 OPN4 OXT OXTR P2RY1 P2RY10 P2RY11 P2RY2 P2RY6 PIK3CA PIK3R1 PIK3R2 PIK3R3 PLCB1 PLCB2 PLCB3 PLCB4 PMCH PROK1 PROK2 PROKR1 PROKR2 PTAFR PTGER1 PTGFR QRFP QRFPR RGS1 RGS13 RGS16 RGS17 RGS18 RGS19 RGS2 RGS21 RGS3 RGS4 RGS5 RGSL1 SAA1 TAC1 TAC3 TACR1 TACR2 TACR3 TBXA2R TRH TRHR TRIO UTS2 UTS2B UTS2R XCL1 XCL2 XCR1 | |
| Sema4D induced cell migration and growth-cone collapse http://identifiers.org/reactome/R-HSA-416572 ARHGEF11 ARHGEF12 ERBB2 LIMK1 LIMK2 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 PLXNB1 RHOA RHOB RHOC RND1 ROCK1 ROCK2 SEMA4D | |
| Trafficking of GluR2-containing AMPA receptors http://identifiers.org/reactome/R-HSA-416993 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 GRIA1 GRIA2 GRIA3 GRIA4 GRIP1 GRIP2 NSF PICK1 PRKCA PRKCB PRKCG TSPAN7 | |
| Reduction of cytosolic Ca++ levels http://identifiers.org/reactome/R-HSA-418359 ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 CALM1 SLC8A1 SLC8A2 SLC8A3 SRI | |
| G alpha (i) signalling events http://identifiers.org/reactome/R-HSA-418594 ACKR3 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADORA1 ADORA3 ADRA2A ADRA2B ADRA2C AGT AGTR2 ANXA1 APLN APLNR APP BDKRB1 BDKRB2 C3 C3AR1 C5 C5AR1 CASR CCL1 CCL13 CCL16 CCL19 CCL20 CCL21 CCL23 CCL25 CCL27 CCL28 CCL4 CCL4L1 CCL4L2 CCL5 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CHRM2 CHRM4 CNR1 CNR2 CORT CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 DRD2 DRD3 DRD4 FPR1 FPR2 FPR3 GABBR1 GABBR2 GAL GALR1 GALR2 GALR3 GNAI1 GNAI2 GNAI3 GNAS GNAT1 GNAT2 GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GPER1 GPR17 GPR18 GPR183 GPR31 GPR37 GPR37L1 GPR55 GPSM1 GPSM2 GPSM3 GRM2 GRM3 GRM4 GRM6 GRM7 GRM8 HCAR1 HCAR2 HCAR3 HEBP1 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR5A INSL5 KNG1 LPAR1 LPAR2 LPAR3 LPAR5 MCHR1 MCHR2 MT-RNR2 MTNR1A MTNR1B NMS NMU NMUR1 NMUR2 NPB NPBWR1 NPBWR2 NPW NPY NPY1R NPY2R NPY4R NPY5R OPN1LW OPN1MW OPN1SW OPN3 OPN5 OPRD1 OPRK1 OPRL1 OPRM1 OXER1 OXGR1 P2RY12 P2RY13 P2RY14 P2RY4 PCP2 PDYN PENK PF4 PMCH PNOC POMC PPBP PPY PSAP PTGDR2 PTGER3 PYY RGR RGS1 RGS10 RGS11 RGS12 RGS13 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS21 RGS22 RGS3 RGS4 RGS5 RGS6 RGS7 RGS8 RGS9 RGSL1 RHO RLN3 RRH RXFP3 RXFP4 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SAA1 SRC SST SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 SUCNR1 TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 | |
| G alpha (z) signalling events http://identifiers.org/reactome/R-HSA-418597 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADRA2A ADRA2B ADRA2C GNAI1 GNAI2 GNAI3 GNAS GNAT3 GNAZ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCQ RGS16 RGS17 RGS19 RGS20 RGS4 RGSL1 | |
| Class C/3 (Metabotropic glutamate/pheromone receptors) http://identifiers.org/reactome/R-HSA-420499 CASR GABBR1 GABBR2 GPRC6A GRM1 GRM2 GRM3 GRM4 GRM5 GRM6 GRM7 GRM8 TAS1R1 TAS1R2 TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R19 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R42 TAS2R43 TAS2R45 TAS2R46 TAS2R5 TAS2R50 TAS2R60 TAS2R7 TAS2R8 TAS2R9 | |
| Synthesis, secretion, and deacylation of Ghrelin http://identifiers.org/reactome/R-HSA-422085 ACHE BCHE CRHR2 GCG GH1 GHRL IGF1 INS KLF4 LEP MBOAT4 PCSK1 PLA2G7 SEC11A SEC11C SPCS1 SPCS2 SPCS3 UCN | |
| Regulation of insulin secretion http://identifiers.org/reactome/R-HSA-422356 ABCC8 AHCYL1 CACNA1A CACNA1C CACNA1D CACNA1E CACNA2D2 CACNB2 CACNB3 GNAI1 GNAI2 INS ITPR1 ITPR2 ITPR3 KCNJ11 PRKACA PRKACB PRKACG RAPGEF3 RAPGEF4 SLC2A1 SLC2A2 SNAP25 STX1A STXBP1 SYT5 VAMP2 | |
| Sodium/Calcium exchangers http://identifiers.org/reactome/R-HSA-425561 CALM1 SLC24A1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC8A1 SLC8A2 SLC8A3 SLC8B1 SRI | |
| Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA http://identifiers.org/reactome/R-HSA-428359 ACTB CD44 IGF2 IGF2BP1 IGF2BP2 IGF2BP3 MYC | |
| Unblocking of NMDA receptors, glutamate binding and activation http://identifiers.org/reactome/R-HSA-438066 ACTN2 CALM1 CAMK2A CAMK2B CAMK2D CAMK2G DLG1 DLG2 DLG3 DLG4 GRIA1 GRIA2 GRIA3 GRIA4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D LRRC7 NEFL | |
| Depolymerisation of the Nuclear Lamina http://identifiers.org/reactome/R-HSA-4419969 CCNB1 CDK1 CNEP1R1 CTDNEP1 EMD LEMD2 LEMD3 LMNA LMNB1 LPIN1 LPIN2 LPIN3 PRKCA PRKCB TMPO | |
| CREB1 phosphorylation through the activation of Adenylate Cyclase http://identifiers.org/reactome/R-HSA-442720 ADCY1 ADCY8 CALM1 CREB1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKX | |
| CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde http://identifiers.org/reactome/R-HSA-442729 CALM1 CAMK2B CAMK2G CAMK4 CAMKK1 CAMKK2 CREB1 KPNA2 | |
| CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling http://identifiers.org/reactome/R-HSA-442742 CREB1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 | |
| Ras activation upon Ca2+ influx through NMDA receptor http://identifiers.org/reactome/R-HSA-442982 ACTN2 CALM1 CAMK2A CAMK2B CAMK2D CAMK2G DLG1 DLG2 DLG3 DLG4 GRIN1 GRIN2B GRIN2D HRAS KRAS LRRC7 NEFL NRAS RASGRF1 RASGRF2 | |
| Smooth Muscle Contraction http://identifiers.org/reactome/R-HSA-445355 ACTA2 ACTG2 ANXA1 ANXA2 ANXA6 CALD1 CALM1 CAV3 DYSF GUCY1A1 GUCY1A2 GUCY1B1 GUCY1B2 ITGA1 ITGB5 LMOD1 MYH11 MYL10 MYL12A MYL12B MYL5 MYL6 MYL6B MYL7 MYL9 MYLK MYLPF PAK1 PAK2 PXN SORBS1 SORBS3 TLN1 TPM1 TPM2 TPM3 TPM4 TRIM72 VCL | |
| Activation of Ca-permeable Kainate Receptor http://identifiers.org/reactome/R-HSA-451308 CALM1 DLG1 DLG3 DLG4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 NCALD | |
| Thrombin signalling through proteinase activated receptors (PARs) http://identifiers.org/reactome/R-HSA-456926 ARRB1 ARRB2 F2 F2R F2RL2 F2RL3 GNA11 GNA12 GNA13 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 MAPK1 MAPK3 SRC | |
| WNT5A-dependent internalization of FZD4 http://identifiers.org/reactome/R-HSA-5099900 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARRB2 CLTA CLTB CLTC DVL2 FZD4 PRKCA PRKCB PRKCG WNT5A | |
| Uptake and function of anthrax toxins http://identifiers.org/reactome/R-HSA-5210891 ANTXR1 ANTXR2 CALM1 FURIN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 PDCD6IP | |
| VEGFR2 mediated vascular permeability http://identifiers.org/reactome/R-HSA-5218920 AKT1 AKT2 AKT3 CALM1 CAV1 CDH5 CTNNA1 CTNNB1 CTNND1 HSP90AA1 JUP MAPKAP1 MLST8 MTOR NOS3 PAK1 PAK2 PAK3 PDPK1 PRR5 RAC1 RICTOR THEM4 TRIB3 VAV1 VAV2 VAV3 | |
| VEGFR2 mediated cell proliferation http://identifiers.org/reactome/R-HSA-5218921 AHCYL1 CALM1 HRAS ITPR1 ITPR2 ITPR3 KDR KRAS NRAS PDPK1 PLCG1 PRKCA PRKCB PRKCD PRKCZ RASA1 SPHK1 SRC VEGFA | |
| B-WICH complex positively regulates rRNA expression http://identifiers.org/reactome/R-HSA-5250924 ACTB BAZ1B CD3EAP DDX21 DEK EP300 ERCC6 GSK3B H2AFB1 H2AFJ H2AFV H2AFX H2AFZ H2BFS H3F3A H3F3B HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4A HIST2H4B HIST3H2BB HIST4H4 KAT2A KAT2B MYBBP1A MYO1C POLR1A POLR1B POLR1C POLR1D POLR1E POLR2E POLR2F POLR2H POLR2K POLR2L SF3B1 SMARCA5 TAF1A TAF1B TAF1C TAF1D TBP TWISTNB ZNRD1 | |
| Phase 0 - rapid depolarisation http://identifiers.org/reactome/R-HSA-5576892 CACNA1C CACNA1D CACNA1F CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CALM1 CAMK2A CAMK2B CAMK2D CAMK2G FGF11 FGF12 FGF13 FGF14 RANGRF SCN10A SCN11A SCN1A SCN1B SCN2A SCN2B SCN3A SCN3B SCN4A SCN4B SCN5A SCN7A SCN8A SCN9A | |
| Phase 2 - plateau phase http://identifiers.org/reactome/R-HSA-5576893 AKAP9 CACNA1C CACNA1D CACNA1F CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 KCNQ1 | |
| Ion homeostasis http://identifiers.org/reactome/R-HSA-5578775 ABCC9 AHCYL1 ASPH ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CLIC2 DMPK FKBP1B FXYD1 FXYD2 FXYD3 FXYD4 FXYD6 FXYD7 ITPR1 ITPR2 ITPR3 KCNJ11 NOS1 ORAI1 ORAI2 PLN PRKACA RYR1 RYR2 RYR3 SLC8A1 SLC8A2 SLC8A3 SLN SRI STIM1 TNNI3 TRDN TRPC1 | |
| CLEC7A (Dectin-1) induces NFAT activation http://identifiers.org/reactome/R-HSA-5607763 AHCYL1 CALM1 ITPR1 ITPR2 ITPR3 NFATC1 NFATC2 NFATC3 PPP3CA PPP3CB PPP3R1 | |
| Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) http://identifiers.org/reactome/R-HSA-5619036 SLC24A5 | |
| Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) http://identifiers.org/reactome/R-HSA-5619055 SLC24A4 | |
| Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) http://identifiers.org/reactome/R-HSA-5619077 SLC24A1 | |
| CD209 (DC-SIGN) signaling http://identifiers.org/reactome/R-HSA-5621575 CD209 CREBBP EP300 FYN HRAS ICAM2 ICAM3 KRAS LYN NFKB1 NRAS PAK1 PAK2 PAK3 PRKACA PRKACB PRKACG RAF1 RELA RELB RPS6KA5 | |
| RHO GTPases activate CIT http://identifiers.org/reactome/R-HSA-5625900 CDKN1B CIT DLG4 KIF14 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 PPP1CB PPP1R12A PPP1R12B PRC1 RAC1 RHOA RHOB RHOC | |
| RHO GTPases activate IQGAPs http://identifiers.org/reactome/R-HSA-5626467 CALM1 CDC42 CDH1 CLIP1 CTNNA1 CTNNB1 IQGAP1 IQGAP2 IQGAP3 MEN1 RAC1 | |
| RHO GTPases Activate ROCKs http://identifiers.org/reactome/R-HSA-5627117 CFL1 LIMK1 LIMK2 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 PAK1 PPP1CB PPP1R12A PPP1R12B RHOA RHOB RHOC ROCK1 ROCK2 | |
| RHO GTPases activate PAKs http://identifiers.org/reactome/R-HSA-5627123 CALM1 CDC42 CTTN FLNA LIMK1 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 MYLK NF2 PAK1 PAK2 PAK3 PPP1CB PPP1R12A PPP1R12B RAC1 | |
| Constitutive Signaling by EGFRvIII http://identifiers.org/reactome/R-HSA-5637810 CBL CDC37 EGF EGFR GAB1 GRB2 HRAS HSP90AA1 KRAS NRAS PIK3CA PIK3R1 PLCG1 SHC1 SOS1 | |
| SHC-mediated cascade:FGFR1 http://identifiers.org/reactome/R-HSA-5654688 FGF1 FGF10 FGF17 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 GRB2 HRAS KL KRAS NRAS SHC1 SOS1 | |
| FRS-mediated FGFR1 signaling http://identifiers.org/reactome/R-HSA-5654693 FGF1 FGF10 FGF17 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 FRS2 FRS3 GRB2 HRAS KL KRAS NRAS PTPN11 SOS1 | |
| SHC-mediated cascade:FGFR2 http://identifiers.org/reactome/R-HSA-5654699 FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 GRB2 HRAS KRAS NRAS SHC1 SOS1 | |
| FRS-mediated FGFR2 signaling http://identifiers.org/reactome/R-HSA-5654700 FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 FRS2 FRS3 GRB2 HRAS KRAS NRAS PTPN11 SOS1 | |
| SHC-mediated cascade:FGFR3 http://identifiers.org/reactome/R-HSA-5654704 FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 GRB2 HRAS KRAS NRAS SHC1 SOS1 | |
| FRS-mediated FGFR3 signaling http://identifiers.org/reactome/R-HSA-5654706 FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 FRS2 FRS3 GRB2 HRAS KRAS NRAS PTPN11 SOS1 | |
| FRS-mediated FGFR4 signaling http://identifiers.org/reactome/R-HSA-5654712 FGF1 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR4 FRS2 FRS3 GRB2 HRAS KLB KRAS NRAS PTPN11 SOS1 | |
| SHC-mediated cascade:FGFR4 http://identifiers.org/reactome/R-HSA-5654719 FGF1 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR4 GRB2 HRAS KLB KRAS NRAS SHC1 SOS1 | |
| Signaling by FGFR2 in disease http://identifiers.org/reactome/R-HSA-5655253 FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 FRS2 GAB1 GRB2 HRAS KRAS NRAS PIK3CA PIK3R1 PLCG1 SOS1 | |
| Signaling by FGFR4 in disease http://identifiers.org/reactome/R-HSA-5655291 FGFR4 FRS2 GAB1 GRB2 HRAS KRAS NRAS PIK3CA PIK3R1 PLCG1 SOS1 | |
| Signaling by FGFR1 in disease http://identifiers.org/reactome/R-HSA-5655302 BAG4 BCR CNTRL CPSF6 CUX1 ERLIN2 FGF1 FGF17 FGF2 FGF20 FGF23 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 FGFR1OP FGFR1OP2 FRS2 GAB1 GRB2 HRAS KRAS LRRFIP1 MYO18A NRAS PIK3CA PIK3R1 PLCG1 SOS1 TRIM24 ZMYM2 | |
| RHO GTPases Activate WASPs and WAVEs http://identifiers.org/reactome/R-HSA-5663213 ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BRK1 BTK CDC42 CYFIP1 CYFIP2 GRB2 MAPK1 MAPK3 NCK1 NCKAP1 NCKAP1L NCKIPSD PTK2 RAC1 WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 | |
| RHO GTPases Activate Formins http://identifiers.org/reactome/R-HSA-5663220 ACTB ACTG1 AHCTF1 AURKB B9D2 BIRC5 BUB1 BUB1B BUB3 CDC20 CDC42 CDCA8 CENPA CENPC CENPE CENPF CENPH CENPI CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPS CENPT CENPU CKAP5 CLASP1 CLASP2 CLIP1 DAAM1 DIAPH1 DIAPH2 DIAPH3 DSN1 DVL1 DVL2 DVL3 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 ERCC6L EVL FMNL1 FMNL2 FMNL3 INCENP ITGB1 ITGB3BP KIF18A KIF2A KIF2B KIF2C KNL1 KNTC1 MAD1L1 MAD2L1 MAPRE1 MIS12 MRTFA NDC80 NDE1 NDEL1 NSL1 NUDC NUF2 NUP107 NUP133 NUP160 NUP37 NUP43 NUP85 NUP98 PAFAH1B1 PFN1 PFN2 PLK1 PMF1 PPP1CC PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RAC1 RANBP2 RANGAP1 RCC2 RHOA RHOB RHOC RHOD RPS27 SCAI SEC13 SEH1L SGO1 SGO2 SKA1 SKA2 SPC24 SPC25 SPDL1 SRC SRF SRGAP2 TAOK1 XPO1 ZW10 ZWILCH ZWINT | |
| RHO GTPases Activate NADPH Oxidases http://identifiers.org/reactome/R-HSA-5668599 CYBA CYBB MAPK1 MAPK11 MAPK14 MAPK3 NCF1 NCF2 NCF4 NOX1 NOX3 NOXA1 NOXO1 PIK3C3 PIK3R4 PIN1 PRKCA PRKCB PRKCD PRKCZ RAC1 RAC2 S100A8 S100A9 | |
| RAF activation http://identifiers.org/reactome/R-HSA-5673000 ARAF BRAF BRAP CALM1 CAMK2A CAMK2B CAMK2D CAMK2G HRAS JAK2 KRAS KSR1 MAP2K1 MAP2K2 MAP3K11 MARK3 NRAS PHB PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RAF1 SRC YWHAB | |
| RAF/MAP kinase cascade http://identifiers.org/reactome/R-HSA-5673001 ACTN2 ANGPT1 AREG ARTN BTC CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CSF2 CSF2RA CSF2RB DLG1 DLG2 DLG3 DLG4 EGF EGFR EPGN ERBB2 ERBB3 ERBB4 EREG FGF1 FGF10 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FLT3LG FRS2 FRS3 FYN GDNF GFRA1 GFRA2 GFRA3 GFRA4 GRB2 GRIN1 GRIN2B GRIN2D HBEGF HGF HRAS IL2 IL2RA IL2RB IL2RG IL3 IL3RA IL5 IL5RA IRS1 IRS2 JAK1 JAK2 JAK3 KIT KITLG KL KLB KRAS LAT LRRC7 MAPK1 MAPK3 MET NCAM1 NEFL NRAS NRG1 NRG2 NRG3 NRG4 NRTN PDGFA PDGFB PDGFRA PDGFRB PEA15 PSPN PTK2 PTPRA RANBP9 RAPGEF2 RASGEF1A RASGRF1 RASGRF2 RASGRP1 RASGRP3 RASGRP4 RET SHC1 SHC2 SHC3 SOS1 SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 TEK TGFA | |
| MAP2K and MAPK activation http://identifiers.org/reactome/R-HSA-5674135 APBB1IP ARAF ARRB1 ARRB2 BRAF CNKSR1 CNKSR2 CSK FGA FGB FGG FN1 HRAS IL17RD IQGAP1 ITGA2B ITGB3 KRAS KSR1 KSR2 LAMTOR2 LAMTOR3 MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 NRAS PEBP1 RAF1 RAP1A RAP1B SRC TLN1 VCL VWF WDR83 YWHAB | |
| Constitutive Signaling by AKT1 E17K in Cancer http://identifiers.org/reactome/R-HSA-5674400 AKT1 AKT1S1 AKT2 AKT3 BAD CASP9 CDKN1A CDKN1B CHUK CREB1 FOXO1 FOXO3 FOXO4 FOXO6 GSK3A GSK3B MAPKAP1 MDM2 MLST8 MTOR NR4A1 PDPK1 PRR5 RICTOR RPS6KB2 TSC2 | |
| Regulation of TLR by endogenous ligand http://identifiers.org/reactome/R-HSA-5686938 APOB CD14 CD36 FGA FGB FGG HMGB1 LBP LY96 S100A1 S100A8 S100A9 TLR1 TLR2 TLR4 TLR6 | |
| UCH proteinases http://identifiers.org/reactome/R-HSA-5689603 ACTB ACTL6A ACTR5 ACTR8 ADRM1 ASXL1 ASXL2 BAP1 BARD1 FOXK1 FOXK2 HCFC1 HIST1H2AA HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AG HIST1H2AH HIST1H2AI HIST1H2AJ HIST1H2AK HIST1H2AL HIST1H2AM HIST2H2AA3 HIST2H2AA4 HIST2H2AB HIST2H2AC HIST3H2A INO80 INO80B INO80C INO80D INO80E KDM1B MBD5 MBD6 MCRS1 NEDD8 NFRKB OGT PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 RPS27A RUVBL1 SEM1 SENP8 SMAD7 TFPT TGFB1 TGFBR1 TGFBR2 UBA52 UBB UBC UCHL1 UCHL3 UCHL5 USP15 YY1 | |
| DNA Damage Recognition in GG-NER http://identifiers.org/reactome/R-HSA-5696394 ACTB ACTL6A ACTR5 ACTR8 CETN2 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CUL4A CUL4B DDB1 DDB2 GPS1 INO80 INO80B INO80C INO80D INO80E MCRS1 NFRKB PARP1 PARP2 RAD23A RAD23B RBX1 RPS27A RUVBL1 TFPT UBA52 UBB UBC XPC YY1 | |
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors http://identifiers.org/reactome/R-HSA-629594 CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 | |
| Highly calcium permeable nicotinic acetylcholine receptors http://identifiers.org/reactome/R-HSA-629597 CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNB2 CHRNB3 CHRNB4 | |
| Metal sequestration by antimicrobial proteins http://identifiers.org/reactome/R-HSA-6799990 LCN2 LTF S100A7 S100A7A S100A8 S100A9 | |
| Signaling by moderate kinase activity BRAF mutants http://identifiers.org/reactome/R-HSA-6802946 APBB1IP ARAF ARRB1 ARRB2 BRAF BRAP CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CNKSR1 CNKSR2 CSK FGA FGB FGG FN1 HRAS IQGAP1 ITGA2B ITGB3 JAK2 KRAS KSR1 KSR2 MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 NRAS PEBP1 PHB RAF1 RAP1A RAP1B SRC TLN1 VCL VWF YWHAB | |
| Signaling by high-kinase activity BRAF mutants http://identifiers.org/reactome/R-HSA-6802948 APBB1IP ARAF ARRB1 ARRB2 BRAF CNKSR1 CNKSR2 CSK FGA FGB FGG FN1 HRAS IQGAP1 ITGA2B ITGB3 KRAS KSR1 KSR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 NRAS PEBP1 RAF1 RAP1A RAP1B SRC TLN1 VCL VWF YWHAB | |
| Signaling by RAS mutants http://identifiers.org/reactome/R-HSA-6802949 APBB1IP ARAF ARRB1 ARRB2 BRAF BRAP CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CNKSR1 CNKSR2 CSK DAB2IP FGA FGB FGG FN1 HRAS IQGAP1 ITGA2B ITGB3 JAK2 KRAS KSR1 KSR2 MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 NF1 NRAS PEBP1 PHB RAF1 RAP1A RAP1B RASA1 RASA2 RASA3 RASA4 RASAL1 RASAL2 RASAL3 SPRED1 SPRED2 SPRED3 SRC SYNGAP1 TLN1 VCL VWF YWHAB | |
| Signaling by BRAF and RAF fusions http://identifiers.org/reactome/R-HSA-6802952 AGGF1 AGK AGTRAP AKAP9 AP3B1 APBB1IP ARAF ARRB1 ARRB2 ATG7 BCL2L11 BRAF CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CLCN6 CNKSR1 CNKSR2 CSK ESRP1 FAM114A2 FAM131B FGA FGB FGG FN1 FXR1 HRAS IQGAP1 ITGA2B ITGB3 JAK2 KDM7A KIAA1549 KRAS KSR1 KSR2 LMNA MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 MPRIP NRAS PAPSS1 PEBP1 QKI RAF1 RAP1A RAP1B SND1 SRC TENT4A TLN1 TRAK1 TRIM24 VCL VWF YWHAB ZC3HAV1 | |
| Paradoxical activation of RAF signaling by kinase inactive BRAF http://identifiers.org/reactome/R-HSA-6802955 APBB1IP ARAF ARRB1 ARRB2 BRAF BRAP CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CNKSR1 CNKSR2 CSK FGA FGB FGG FN1 HRAS IQGAP1 ITGA2B ITGB3 JAK2 KRAS KSR1 KSR2 MAP2K1 MAP2K2 MAP3K11 MAPK1 MAPK3 MARK3 NRAS PEBP1 PHB RAF1 RAP1A RAP1B SRC TLN1 VCL VWF YWHAB | |
| Antimicrobial peptides http://identifiers.org/reactome/R-HSA-6803157 BPI BPIFA1 BPIFA2 BPIFB1 BPIFB2 BPIFB4 BPIFB6 CAMP CHGA CLU CTSG DCD ELANE EPPIN EPPIN-WFDC6 GNLY HTN1 HTN3 ITLN1 LEAP2 LTF LYZ PGLYRP1 PGLYRP2 PGLYRP3 PGLYRP4 PI3 PLA2G2A PRSS2 PRSS3 PRTN3 REG3A REG3G RNASE3 RNASE6 RNASE7 RNASE8 SEMG1 | |
| Formation of the cornified envelope http://identifiers.org/reactome/R-HSA-6809371 CAPN1 CAPNS1 CASP14 CDSN CELA2A CSTA DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSG4 DSP EVPL FLG FURIN IVL JUP KAZN KLK12 KLK13 KLK14 KLK5 KLK8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LCE6A LELP1 LIPJ LIPK LIPM LIPN LOR PCSK6 PERP PI3 PKP1 PKP2 PKP3 PKP4 PPL PRSS8 RPTN SPINK5 SPINK6 SPINK9 SPRR1A SPRR1B SPRR2A SPRR2B SPRR2D SPRR2E SPRR2F SPRR2G SPRR3 ST14 TCHH TGM1 TGM5 | |
| Glycogen breakdown (glycogenolysis) http://identifiers.org/reactome/R-HSA-70221 AGL CALM1 GAA GYG1 GYG2 PGM2 PGM2L1 PHKA1 PHKA2 PHKB PHKG1 PHKG2 PYGB PYGL PYGM | |
| Insulin receptor signalling cascade http://identifiers.org/reactome/R-HSA-74751 GRB10 GRB2 HRAS INS INSR KRAS NRAS SHC1 SOS1 | |
| Response to elevated platelet cytosolic Ca2+ http://identifiers.org/reactome/R-HSA-76005 PRKCA PRKCB PRKCG | |
| Platelet Aggregation (Plug Formation) http://identifiers.org/reactome/R-HSA-76009 F2 GP1BA GP1BB GP5 GP9 MPL THPO VWF | |
| Gastrin-CREB signalling pathway via PKC and MAPK http://identifiers.org/reactome/R-HSA-881907 CCKBR CREB1 GAST MAPK1 MAPK3 MAPK7 RPS6KA1 RPS6KA2 RPS6KA3 | |
| Phosphate bond hydrolysis by NTPDase proteins http://identifiers.org/reactome/R-HSA-8850843 ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 ENTPD6 ENTPD7 ENTPD8 | |
| MET activates RAS signaling http://identifiers.org/reactome/R-HSA-8851805 GRB2 HGF HRAS KRAS MET MUC20 NRAS RANBP10 RANBP9 SHC1 SOS1 | |
| Signaling by FGFR3 fusions in cancer http://identifiers.org/reactome/R-HSA-8853334 FGFR3 FRS2 GAB1 GRB2 HRAS KRAS NRAS PIK3CA PIK3R1 SOS1 | |
| Signaling by FGFR3 point mutants in cancer http://identifiers.org/reactome/R-HSA-8853338 FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 FRS2 GAB1 GRB2 HRAS KRAS NRAS PIK3CA PIK3R1 PLCG1 SOS1 | |
| Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models http://identifiers.org/reactome/R-HSA-8862803 APP BCL2L11 CAPN1 CAPN2 CAPNS1 CAPNS2 CAST CDC25A CDC25B CDC25C CDK5 CDK5R1 FASLG FOXO3 GOLGA2 JUN LMNA LMNB1 PRDX1 PRDX2 SOD2 YWHAE | |
| MET activates RAP1 and RAC1 http://identifiers.org/reactome/R-HSA-8875555 CRK CRKL DOCK7 GAB1 GRB2 HGF MET RAC1 RAP1A RAP1B RAPGEF1 | |
| InlA-mediated entry of Listeria monocytogenes into host cells http://identifiers.org/reactome/R-HSA-8876493 CBLL1 CDH1 CTNNB1 CTNND1 RPS27A SRC UBA52 UBB UBC | |
| Mitochondrial calcium ion transport http://identifiers.org/reactome/R-HSA-8949215 AKAP1 LETM1 MCU MCUB MICU1 MICU2 MICU3 SLC8A3 SLC8B1 SMDT1 VDAC1 VDAC2 VDAC3 | |
| Extra-nuclear estrogen signaling http://identifiers.org/reactome/R-HSA-9009391 AKT1 AREG BTC CALM1 CAV1 CAV2 EGF EGFR EPGN EREG ESR1 ESR2 GNAI1 GNAI2 GNAI3 GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 HBEGF HSP90AA1 IGF1R MMP2 MMP3 MMP7 MMP9 NOS3 PIK3CA PIK3R1 PIK3R2 PIK3R3 PRMT1 PTK2 S1PR3 SHC1 SPHK1 SRC STRN TGFA ZDHHC21 ZDHHC7 | |
| NOTCH4 Intracellular Domain Regulates Transcription http://identifiers.org/reactome/R-HSA-9013695 ACTA2 CREBBP EP300 FLT4 HES1 HES5 HEY1 HEY2 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 NOTCH1 NOTCH2 NOTCH4 RBPJ SMAD3 SNW1 | |
| Loss of phosphorylation of MECP2 at T308 http://identifiers.org/reactome/R-HSA-9022535 CALM1 CAMK4 MECP2 PRKACA | |
| Regulation of MECP2 expression and activity http://identifiers.org/reactome/R-HSA-9022692 AGO1 AGO2 AGO3 AGO4 AURKB CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CREB1 FOXG1 GPS2 HDAC1 HDAC2 HDAC3 HIPK2 HTT LBR MECP2 MOV10 NCOR1 NCOR2 PRKACA SIN3A TBL1X TBL1XR1 TNRC6A TNRC6B TNRC6C | |
| Activated NTRK2 signals through RAS http://identifiers.org/reactome/R-HSA-9026519 BDNF GRB2 HRAS KRAS NRAS NTF4 NTRK2 SHC1 SOS1 | |
| Erythropoietin activates RAS http://identifiers.org/reactome/R-HSA-9027284 CRKL EPO EPOR GRB2 HRAS IRS2 JAK2 KRAS LYN NRAS RAPGEF1 SHC1 SOS1 VAV1 | |
| Activated NTRK2 signals through FRS2 and FRS3 http://identifiers.org/reactome/R-HSA-9028731 BDNF FRS2 FRS3 GRB2 HRAS KRAS NRAS NTF4 NTRK2 PTPN11 SOS1 | |
| Activated NTRK3 signals through RAS http://identifiers.org/reactome/R-HSA-9034864 GRB2 HRAS KRAS NRAS NTF3 NTRK3 SHC1 SOS1 | |
| Ion transport by P-type ATPases http://identifiers.org/reactome/R-HSA-936837 ATP10A ATP10B ATP10D ATP11A ATP11B ATP11C ATP12A ATP13A1 ATP13A2 ATP13A4 ATP13A5 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 ATP2C1 ATP2C2 ATP4A ATP4B ATP7A ATP7B ATP8A1 ATP8A2 ATP8B1 ATP8B2 ATP8B3 ATP8B4 ATP9A ATP9B CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CUTC FXYD1 FXYD2 FXYD3 FXYD4 FXYD6 FXYD7 PDZD11 PLN SLN SRI | |
| FLT3 Signaling http://identifiers.org/reactome/R-HSA-9607240 FLT3 FLT3LG FYN GAB2 GRB2 HCK HRAS KRAS NRAS PIK3R1 PTPN11 SOS1 | |
| Negative regulation of NMDA receptor-mediated neuronal transmission http://identifiers.org/reactome/R-HSA-9617324 ACTN2 CALM1 CAMK1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 DLG1 DLG2 DLG3 DLG4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D LRRC7 NEFL PPM1E PPM1F | |
| Activation of RAC1 downstream of NMDARs http://identifiers.org/reactome/R-HSA-9619229 ARHGEF7 CALM1 CAMK1 CAMKK1 CAMKK2 GIT1 RAC1 | |
| Activation of AMPK downstream of NMDARs http://identifiers.org/reactome/R-HSA-9619483 CALM1 CAMKK2 MAPT PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 | |
| Long-term potentiation http://identifiers.org/reactome/R-HSA-9620244 ACTN2 CALM1 CAMK2A CAMK2B CAMK2D CAMK2G DLG1 DLG2 DLG3 DLG4 ERBB4 GRIA1 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D LRRC7 NEFL NRG1 NRGN SRC | |
| Estrogen-dependent nuclear events downstream of ESR-membrane signaling http://identifiers.org/reactome/R-HSA-9634638 AKT1 AKT2 AKT3 AREG BCL2 BTC CCND1 CDKN1B CREB1 EGF EGFR ELK1 EPGN EREG FOS FOXO3 HBEGF MAPK1 MAPK3 PTK2 SRF TGFA UHMK1 XPO1 | |
| Amyloid fiber formation http://identifiers.org/reactome/R-HSA-977225 ADAM10 APCS APH1A APH1B APOA1 APOA4 APP B2M BACE1 CALB1 CALCA CST3 FGA FURIN GGA1 GGA2 GGA3 GSN H2AFB1 H2AFX H2AFZ H2BFS H3F3A H3F3B HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BH HIST1H2BI HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST1H4A HIST1H4B HIST1H4C HIST1H4D HIST1H4E HIST1H4F HIST1H4H HIST1H4I HIST1H4J HIST1H4K HIST1H4L HIST2H2AA3 HIST2H2AA4 HIST2H2AC HIST2H2BE HIST2H3A HIST2H3C HIST2H3D HIST2H4A HIST2H4B HIST3H2BB HIST4H4 HSPG2 IAPP INS ITM2B LTF LYZ MFGE8 NAT8 NAT8B NCSTN NPPA ODAM PRKN PRL PSENEN RPS27A SAA1 SEMG1 SIAH1 SIAH2 SNCA SNCAIP SORL1 TGFBI TSPAN14 TSPAN15 TSPAN33 TSPAN5 TTR UBA52 UBB UBC UBE2L6 USP9X | |
| Regulation of Complement cascade http://identifiers.org/reactome/R-HSA-977606 C1QA C1QB C1QC C1R C1S C2 C3 C3AR1 C4A C4B C4BPA C4BPB C4B_2 C5 C5AR1 C5AR2 C6 C7 C8A C8B C8G C9 CD19 CD46 CD55 CD59 CD81 CFB CFH CFHR1 CFHR2 CFHR3 CFHR4 CFHR5 CFI CLU CPB2 CPN1 CPN2 CR1 CR2 ELANE F2 IGHG1 IGHG2 IGHG3 IGHG4 IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 PROS1 SERPING1 VTN | |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers http://identifiers.org/reactome/R-HSA-983695 AHCYL1 BLK BLNK BTK CALM1 CD19 CD22 CD79A CD79B DAPP1 FYN GRB2 IGHD IGHM IGHV1-2 IGHV1-46 IGHV1-69 IGHV2-5 IGHV2-70 IGHV3-11 IGHV3-13 IGHV3-23 IGHV3-30 IGHV3-33 IGHV3-48 IGHV3-53 IGHV3-7 IGHV3-9 IGHV4-34 IGHV4-39 IGHV4-59 IGKC IGKV1-12 IGKV1-16 IGKV1-17 IGKV1-33 IGKV1-39 IGKV1-5 IGKV1D-12 IGKV1D-16 IGKV1D-33 IGKV1D-39 IGKV2-28 IGKV2-29 IGKV2-30 IGKV2D-28 IGKV2D-30 IGKV2D-40 IGKV3-11 IGKV3-15 IGKV3-20 IGKV3D-20 IGKV4-1 IGKV5-2 IGLC1 IGLC2 IGLC3 IGLC6 IGLC7 IGLV1-40 IGLV1-44 IGLV1-47 IGLV1-51 IGLV2-11 IGLV2-14 IGLV2-23 IGLV2-8 IGLV3-1 IGLV3-19 IGLV3-21 IGLV3-25 IGLV3-27 IGLV6-57 IGLV7-43 ITPR1 ITPR2 ITPR3 LYN NCK1 ORAI1 ORAI2 PIK3AP1 PIK3CD PIK3R1 PLCG2 PTPN6 SH3KBP1 SOS1 STIM1 SYK TRPC1 VAV1 |
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| library(paxtoolsr) | |
| library(igraph) | |
| # READ AND FILTER PATHWAY COMMONS SIF INTERACTION TABLE ---- | |
| # With the file PathwayCommons12.reactome.hgnc.txt.gz downloaded from | |
| # https://www.pathwaycommons.org/archives/PC2/v12/ and uncompressed | |
| # NOTE: Either download directly or use downloadPc2() | |
| # Read file | |
| dat <- readSifnx("PathwayCommons12.reactome.hgnc.txt") | |
| # Pathway Commons uses CHEBI identifiers for small molecules, chemicals, drugs, metabolites, etc. | |
| # IDs: | |
| # * Calcium: "CHEBI:29108" from https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:29108 | |
| # * Actins from https://www.genenames.org/data/genegroup/#!/group/929 | |
| ca2 <- "CHEBI:29108" | |
| actins <- c("ACTA1", "ACTA2", "ACTB", "ACTBL2", "ACTC1", "ACTG1", "ACTG2") | |
| # Subset the SIF interaction table to those entries with either calcium or actin | |
| # Use idsBothParticipants=TRUE if it must be both source and target nodes must come from ids parameter | |
| sif <- filterSif(dat$edges, ids=c(ca2, actins), idsBothParticipants=FALSE) | |
| sif_ids_both <- filterSif(dat$edges, ids=c(ca2, actins), idsBothParticipants=TRUE) | |
| write.table(sif, "calcium_actin_interactions.txt", sep="\t", quote=FALSE, row.names=FALSE) | |
| # > head(sif) | |
| # # A tibble: 6 × 7 | |
| # PARTICIPANT_A INTERACTION_TYPE PARTICIPANT_B INTERACTION_DATA_SO… INTERACTION_PUB… PATHWAY_NAMES MEDIATOR_IDS | |
| # <chr> <chr> <chr> <chr> <chr> <chr> <chr> | |
| # 1 ACTA2 in-complex-with CALD1 Reactome NA Smooth Muscl… http://path… | |
| # 2 ACTA2 in-complex-with ITGA1 Reactome NA Smooth Muscl… http://path… | |
| # 3 ACTA2 in-complex-with ITGB5 Reactome NA Smooth Muscl… http://path… | |
| # 4 ACTA2 in-complex-with LMOD1 Reactome NA Smooth Muscl… http://path… | |
| # 5 ACTA2 in-complex-with MYH11 Reactome NA Smooth Muscl… http://path… | |
| # 6 ACTA2 in-complex-with MYL10 Reactome NA Smooth Muscl… http://path… | |
| # TURN SIF INTO A IGRAPH OBJECT ---- | |
| # Make graph with igraph | |
| # Reorder for source and target nodes to be the first two columns as required by igraph | |
| sif2 <- sif[, c(1,3,2,4:7)] | |
| g <- graph_from_data_frame(sif2) | |
| idx1 <- which(V(g)$name == ca2) | |
| idx2 <- which(V(g)$name %in% actins) | |
| # Search for shortest paths between actin genes and calcium | |
| # NOTE: This only returned direct interactions so it was not useful | |
| x <- all_shortest_paths(g, from=idx1, to=idx2) | |
| # READ AND SUBSET GMT FILE ---- | |
| # Read file | |
| ## GMT Format: https://software.broadinstitute.org/cancer/software/gsea/wiki/index.php/Data_formats#GMT:_Gene_Matrix_Transposed_file_format_.28.2A.gmt.29 | |
| gmt <- readGmt("PathwayCommons12.reactome.hgnc.gmt", returnInfo = TRUE) | |
| pathways <- sort(unique(unlist(strsplit(sif$PATHWAY_NAMES, ";")))) | |
| # List of Booleans: TRUE if in pathway is in the SIF file, FALSE if not in the SIF | |
| y <- lapply(gmt, function(x) { | |
| x$name %in% pathways | |
| }) | |
| # Indices of just the TRUE entries | |
| idx <- which(unlist(y)) | |
| # A subset of the complete GMT | |
| gmt_sm <- gmt[idx] | |
| # EXPORT COMPLETE GENE SETS ---- | |
| r <- c() | |
| for(i in 1:length(gmt_sm)) { | |
| #i <- 1 | |
| tmp <- paste0(gmt_sm[[i]]$name, "\t", names(gmt_sm)[i], "\t", paste(gmt_sm[[i]]$geneSet, collapse="\t")) | |
| r <- c(r, tmp) | |
| } | |
| writeLines(r, "calcium_complete_gene_sets.txt") | |
| # EXPORT JUST THE CALCIUM RELATED GENES ---- | |
| calcium_related_genes <- unique(c(sif$PARTICIPANT_A, sif$PARTICIPANT_B)) | |
| r <- c() | |
| for(i in 1:length(gmt_sm)) { | |
| #i <- 1 | |
| g1 <- intersect(gmt_sm[[i]]$geneSet, calcium_related_genes) | |
| tmp <- paste0(gmt_sm[[i]]$name, "\t", names(gmt_sm)[i], "\t", paste(g1, collapse="\t")) | |
| r <- c(r, tmp) | |
| } | |
| writeLines(r, "calcium_calcium-related_gene_sets.txt") |
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